Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening

Journal of Medicinal Chemistry

Volumn 51, Issue 19, 2008, Pages 5984-5992

  Cho, Yoonsang ^a   Ioerger, Thomas R ^b   Sacchettini, James C ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE PHOSPHORIBOSYLTRANSFERASE; ENZYME INHIBITOR; KANAMYCIN; NITROBENZOTHIAZOLE INHIBITOR; UNCLASSIFIED DRUG;

ALGORITHM; ARTICLE; BACTERICIDAL ACTIVITY; CELL ASSAY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVE SITE; MOLECULAR DOCKING; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN;

ALGORITHMS; ATP PHOSPHORIBOSYLTRANSFERASE; BACTERIAL PROTEINS; BENZOTHIAZOLES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES;

EID: 53549091061     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800328v     Document Type: Article

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