In silico identification of candidate drug and vaccine targets from various pathways in Neisseria gonorrhoeae

In Silico Biology

Volumn 9, Issue 4, 2009, Pages 225-231

  Barh, Debmalya ^a   Kumar, Anil ^b  

^a Institute of Integrative Omics and Applied Biotechnology IIOAB   (India)

^b DEVI AHILYA UNIVERSITY   (India)

Author keywords

Candidate vaccine targets; Drug targets; Essential genes; Genome analysis; Metabolic pathways targets; Neisseria gonorrhoeae; Subtractive genomics

Indexed keywords

ABC TRANSPORTER IRON UPTAKE PERMEASE INNER MEMBRANE PROTEIN; ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE; BACTERIAL PROTEIN; FRUCTOSE BISPHOSPHATE ALDOLASE; INDOLE 3 GLYCEROL PHOSPHATE SYNTHASE; MEMBRANE PROTEIN; PERMEASE; PILIN; PILUS ASSEMBLY PROTEIN; SULFATE TRANSPORT PERMEASE PROTEIN C; TRANSFERRIN BINDING PROTEIN A; TRYPTOPHAN SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM PILUS; COMPUTER ANALYSIS; COMPUTER MODEL; CONTROLLED STUDY; DRUG TARGETING; ENZYME LOCALIZATION; GENE IDENTIFICATION; HOST PATHOGEN INTERACTION; METABOLISM; NEISSERIA GONORRHOEAE; NONHUMAN;

DATABASES, NUCLEIC ACID; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FEMALE; GENOME, BACTERIAL; GONORRHEA; HUMANS; METABOLIC NETWORKS AND PATHWAYS; NEISSERIA GONORRHOEAE; PREGNANCY; SIGNAL TRANSDUCTION;

EID: 70449380022     PISSN: 14343207     EISSN: None     Source Type: Journal    
DOI: 10.3233/ISB-2009-0399     Document Type: Article

References (39)

1. Gerbase, A. C., Rowley, J. T. and Mertens, T. E. (1998). Global epidemiology of sexually transmitted diseases. Lancet 351 Suppl. 3 2-4.
2. Edwards, J. L. and Apicella, M. A. (2004). The molecular mechanisms used by Neisseria gonorrhoeae to initiate infection differ between men and women. Clin. Microbiol. Rev. 17, 965-981.
3. Furuya, R. and Tanaka, M. (2009). Neisseria gonorrhoeae infections. Nippon Rinsho 67, 129-135.
4. Lareau, S. M. and Beigi, R. H. (2008). Pelvic inflammatory disease and tubo-ovarian abscess. Infect. Dis. Clin. North Am. 22, 693-708.
5. Van Vranken, M. (2007). Prevention and treatment of sexually transmitted diseases: An update. Am. Fam. Physician 76, 1827-1832.
6. Tapsall, J. (2006). Antibiotic resistance in Neisseria gonorrhoeae is diminishing available treatment options for gonorrhea: Some possible remedies. Expert Rev. Anti Infect. Ther. 4, 619-628.
7. Workowski, K. A., Berman, S. M. and Douglas, J. M., jr. (2008). Emerging antimicrobial resistance in Neisseria gonorrhoeae: Urgent need to strengthen prevention strategies. Ann. Intern. Med. 148, 606-613.
8. Snyder, L. A. S., Butcher, S. A. and Saunders, N. J. (2001). Comparative whole-genome analyses reveal over 100 putative phase-variable genes in the pathogenic Neisseria spp. Microbiology 147, 2321-2332.
9. Chandler, F.W., jr. and Kraus, S. J. (1976). Animal Model of Human Disease - Experimental Gonorrhea in the Chimpanzee. Am. J. Pathol. 82 437-440.
10. Arko, R. J. (1989). Animal Models for Pathogenic Neisseria Species. Clin. Microbiol. Rev. 2, S56-S59.
11. Plante, M., Jerse, A., Hamel, J., Couture, F., Rioux, C. R., Brodeur, B. R. and Martin, D. (2000). Intranasal immunization with gonococcal outer membrane preparations reduces the duration of vaginal colonization of mice by Neisseria gonorrhoeae. J. Infect. Dis. 182, 848-855.
12. Allsop, A. E. (1998). New antibiotic discovery, novel screens, novel targets and impact of microbial genomics. Curr. Opin. Microbiol. 1 530-534.
13. Schmid, M. B. (1998). Novel approaches to the discovery of antimicrobial agents. Curr. Opin. Chem. Biol. 2, 529-534.
14. Sakharkar, K. R., Sakharkar, M. K. and Chow, V. T. K. (2004). A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa. In Silico Biol. 4, 0028.
15. Perumal, D., Lim, C. S., Sakharkar, K. R. and Sakharkar, M. K. (2007). Differential genome analyses of metabolic enzymes in Pseudomonas aeruginosa for drug target identification. In Silico Biol. 7, 0032.
16. Salama, N. R., Shepherd, B. and Falkow, S. (2004). Global transposon mutagenesis and essential gene analysis of Helicobacter pylori. J. Bacteriol. 186, 7926-7935.
17. Dutta, A., Singh, S. K., Ghosh, P., Mukherjee, R., Mitter, S. and Bandyopadhyay, D. (2006). In silico identification of potential therapeutic targets in the human pathogen Helicobacter pylori. In Silico Biol. 6, 0005.
18. Chong, C. E., Lim, B. S., Nathan, S. and Mohamed, R. (2006). In silico analysis of Burkholderia pseudomallei genome sequence for potential drug targets. In Silico Biol. 6, 0031.
19. Sharma, V., Gupta, P. and Dixit, A. (2008). In silico identification of putative drug targets from different metabolic pathways of Aeromonas hydrophila. In Silico Biol. 8, 0026.
20. Zhang, R., Ou, H.-Y. and Zhang, C.-T. (2004). DEG: A database of essential genes. Nucleic Acids Res. 32, D271-D272.
21. Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H. and Kanehisa, M. (1999). KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids. Res. 27, 29-34.
22. Yu, C.-S., Lin, C.-J. and Hwang, J.-K. (2004). Predicting subcellular localization of proteins for Gram-negative bacteria by support vector machines based on n-peptide compositions. Protein Sci. 13, 1402-1406.
23. Bhasin, M., Garg, A. and Raghava, G. P. S. (2005). PSLpred: Prediction of subcellular localization of bacterial proteins. Bioinformatics 21 2522-2524.
24. Gardy, J. L., Laird, M. R., Chen, F., Rey, S., Walsh, C. J., Ester, M. and Brinkman, F. S. L. (2005). PSORTb v.2.0: Expanded prediction of bacterial protein subcellular localization and insights gained from comparative proteome analysis. Bioinformatics 21, 617-623.
25. Imai, K., Asakawa, N., Tsuji, T., Akazawa, F., Ino, A., Sonoyama, M. and Mitaku, S. (2008). SOSUI-GramN: High performance prediction for sub-cellular localization of proteins in Gram-negative bacteria. Bioinformation 2, 417-421.
26. Chen, L., Yang, J., Yu, J., Yao, Z., Sun, L., Shen, Y. and Jin, Q. (2005). VFDB: A reference database for bacterial virulence factors. Nucleic Acids Res. 33, D325-D328.
27. Singh, N. K., Selvam, S. M. and Chakravarthy, P. (2006). T-iDT: Tool for identification of drug target in bacteria and validation by Mycobacterium tuberculosis. In Silico Biol. 6, 0045.
28. Kohl, P. K., Meyer, T. F. and Petzoldt D. (1985). Gonococcal surface antigens and their significance for serotyping and vaccines. Hautarzt 36, 320-325.
29. Meyer, T. F. (1990). Pathogenic neisseriae- a model of bacterial virulence and genetic flexibility. Zentralbl. Bakteriol. 274, 135-154.
30. Lomholt, H., Lind, I. and Kilian, M. (1995). Neisseria gonorrhoeae IgA1 proteases share epitopes recognized by neutralizing antibodies. Vaccine 13, 1213-1219.
31. Barbosa-Cesnik, C. T., Gerbase, A. and Heymann, D. (1997). STD vaccines an overview. Genitourin. Med. 73, 336-342.
32. Gulati, S., Ngampasutadol, J., Yamasaki, R., McQuillen, D. P. and Rice, P. A. (2001). Strategies for mimicking Neisserial saccharide epitopes as vaccines. Int. Rev. Immunol. 20, 229-250.
33. Rothbard, J. B., Fernandez, R., Wang, L., Teng, N. N. H. and Schoolnik, G. K. (1985). Antibodies to peptides corresponding to a conserved sequence of gonococcal pilins block bacterial adhesion. Proc. Natl. Acad. Sci. USA 82, 915-919.
34. Hansen, J. K., Demick, K. P., Mansfield, J. M. and Forest, K. T. (2007). Conserved regions from Neisseria gonorrhoeae pilin are immunosilent and not immunosuppressive. Infect. Immun. 75, 4138-4147.
35. Zhu, W., Thomas, C. E. and Sparling, P. F. (2004). DNA immunization of mice with a plasmid encoding Neisseria gonorrhea PorB protein by intramuscular injection and epidermal particle bombardment. Vaccine 22, 660-669.
36. Bos, M. P., Tefsen, B., Voet, P., Weynants, V., van Putten, J. P. M. and Tommassen, J. (2005). Function of neisserial outer membrane phospholipase a in autolysis and assessment of its vaccine potential. Infect. Immun. 73, 2222-2231.
37. Thomas, C. E., Zhu, W., Van Dam, C. N., Davis, N. L., Johnston, R. E. and Sparling, P. F. (2006). Vaccination of mice with gonococcal TbpB expressed in vivo from Venezuelan equine encephalitis viral replicon particles. Infect. Immun. 74, 1612-1620.
38. Price, G. A., Russell, M. W. and Cornelissen, C. N. (2005). Intranasal administration of recombinant Neisseria gonorrhoeae transferrin binding proteins A and B conjugated to the cholera toxin B subunit induces systemic and vaginal antibodies in mice. Infect. Immun. 73 3945-3953.
39. Price, G. A., Masri, H. P., Hollander, A. M., Russell, M. W. and Cornelissen, C. N. (2007). Gonococcal transferrin binding protein chimeras induce bactericidal and growth inhibitory antibodies in mice. Vaccine 25, 7247-7260.