Dihydrofolate reductase: A potential drug target in trypanosomes and leishmania

Journal of Computer-Aided Molecular Design

Volumn 12, Issue 3, 1998, Pages 241-257

  Zuccotto, Fabio ^a   Martin, Andrew C R ^b   Laskowski, Roman A ^b,c   Thornton, Janet M ^b,c   Gilbert, Ian H ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Comparative molecular modelling; Dihydrofolate reductase; Drug design; Protein structure

Indexed keywords

CRYSTAL STRUCTURE; ENZYME ACTIVITY; PROTOZOA;

ACTIVE SITE; BACTERIAL ENZYMES; COMPARATIVE MOLECULAR MODELING; CRYSTALS STRUCTURES; DIHYDROFOLATE REDUCTASE; DRUG DESIGN; DRUG TARGETS; HUMAN ENZYMES; POTENTIAL DRUG TARGETS; PROTEINS STRUCTURES;

CHEMOTHERAPY;

DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; SOLVENT;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BINDING SITE; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; HUMAN; LEISHMANIA MAJOR; METABOLISM; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; FOLIC ACID ANTAGONISTS; HUMANS; LEISHMANIA MAJOR; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; SOLVENTS; TETRAHYDROFOLATE DEHYDROGENASE; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

EID: 0032059055     PISSN: 0920654X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016085005275     Document Type: Article

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