TCA cycle defects and cancer: When metabolism tunes redox state

International Journal of Cell Biology

Volumn , Issue , 2012, Pages

  Cardaci, Simone ^a   Ciriolo, Maria Rosa ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; FUMARATE HYDRATASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ISOCITRATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE;

CANCER CELL; CARCINOGENESIS; CATALYST; CELL PROLIFERATION; CELL TRANSFORMATION; CITRIC ACID CYCLE; ELECTRON TRANSPORT; EPIGENETICS; GENE MUTATION; GENETIC DISORDER; HUMAN; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; TUMOR GENE;

EID: 84864950181     PISSN: 16878876     EISSN: 16878884     Source Type: Journal    
DOI: 10.1155/2012/161837     Document Type: Review

References (80)

1. Kroemer G., Pouyssegur J., Tumor cell metabolism: Cancer's Achilles' heel Cancer Cell 2008 13 6 472 482 (Pubitemid 351766797)
2. Warburg O., On the origin of cancer cells Science 1956 123 3191 309 314
3. Scheffler I. E., Mitochondria 2008 2nd John Wiley Sons
4. Wise D. R., Ward P. S., Shay J. E., Hypoxia promotes isocytrate dehydrogenase-dependent carboxylation of -ketoglutarate to citrate to support cell growth and viability Proceedings of the National Academy of Sciences USA 1961 108 49 19611 19616
5. Metallo C. M., Gameiro P. A., Bell E. L., Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia Nature 2011 481 7381 380 384
6. Mullen A. R., Wheaton W. W., Jin E. S., Reductive carboxylation supports growth in tumour cells with defective mitochondria Nature 2011 481 7381 385 388
7. Wallace D. C., Fan W., Procaccio V., Mitochondrial energetics and therapeutics Annual Review of Pathology 2010 5 297 348
8. Bardella C., Pollard P. J., Tomlinson I., SDH mutations in cancer Biochimica et Biophysica Acta 2011 1807 11 1432 1443
9. Baysal B. E., Ferrell R. E., Willett-Brozick J. E., Lawrence E. C., Myssiorek D., Bosch A., Van Der Mey A., Taschner P. E. M., Rubinstein W. S., Myers E. N., Richard C. W., Cornelisse C. J., Devilee P., Devlin B., Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma Science 2000 287 5454 848 851 (Pubitemid 30084326)
10. Niemann S., Mller U., Mutations in SDHC cause autosomal dominant paraganglioma, type 3 Nature Genetics 2000 26 3 268 270
11. Astuti D., Latif F., Dallol A., Dahia P. L. M., Douglas F., George E., Skldberg F., Husebye E. S., Eng C., Maher E. R., Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma American Journal of Human Genetics 2001 69 1 49 54 (Pubitemid 32614017)
12. Baysal B. E., Willett-Brozick J. E., Lawrence E. C., Drovdlic C. M., Savul S. A., McLeod D. R., Yee H. A., Brackmann D. E., Slattery W. H., Myers E. N., Ferrell R. E., Rubinstein W. S., Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas Journal of Medical Genetics 2002 39 3 178 183 (Pubitemid 34252553)
13. Hao H. X., Khalimonchuk O., Schraders M., Dephoure N., Bayley J. P., Kunst H., Devilee P., Cremers C. W. R. J., Schiffman J. D., Bentz B. G., Gygi S. P., Winge D. R., Kremer H., Rutter J., SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma Science 2009 325 5944 1139 1142
14. Bayley J. P., Kunst H. P. M., Cascon A., Sampietro M. L., Gaal J., Korpershoek E., Hinojar-Gutierrez A., Timmers H. J. L. M., Hoefsloot L. H., Hermsen M. A., Surez C., Hussain A. K., Vriends A. H. J. T., Hes F. J., Jansen J. C., Tops C. M., Corssmit E. P., de Knijff P., Lenders J. W. M., Cremers C. W. R. J., Devilee P., Dinjens W. N. M., de Krijger R. R., Robledo M., SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma The Lancet Oncology 2010 11 4 366 372
15. Burnichon N., Brire J. J., Libé R., Vescovo L., Rivire J., Tissier F., Jouanno E., Jeunemaitre X., Bénit P., Tzagoloff A., Rustin P., Bertherat J., Favier J., Gimenez-Roqueplo A. P., SDHA is a tumor suppressor gene causing paraganglioma Human Molecular Genetics 2010 19 15 3011 3020
16. Gottlieb E., Tomlinson I. P. M., Mitochondrial tumour suppressors: a genetic and biochemical update Nature Reviews Cancer 2005 5 11 857 866 (Pubitemid 41746030)
17. Zinn A. B., Kerr D. S., Hoppel C. L., Fumarase deficiency: a new cause of mitochondrial encephalomyopathy The New England Journal of Medicine 1986 315 8 469 475 (Pubitemid 16034147)
18. Launonen V., Vierimaa O., Kiuru M., Isola J., Roth S., Pukkala E., Sistonen P., Herva R., Aaltonen L. A., Inherited susceptibility to uterine leiomyomas and renal cell cancer Proceedings of the National Academy of Sciences of the United States of America 2001 98 6 3387 3392 (Pubitemid 32220855)
19. Tomlinson I. P. M., Alam N. A., Rowan A. J., Barclay E., Jaeger E. E. M., Kelsell D., Leigh I., Gorman P., Lamlum H., Rahman S., Roylance R. R., Olpin S., Bevan S., Barker K., Hearle N., Houlston R. S., Kiuru M., Lehtonen R., Karhu A., Vilkki S., Laiho P., Eklund C., Vierimaa O., Aittomki K., Hietala M., Sistonen P., Paetau A., Salovaara R., Herva R., Launonen V., Aaltonen L. A., Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer the multiple leiomyoma consortium Nature Genetics 2002 30 4 406 410
20. Carvajal-Carmona L. G., Alam N. A., Pollard P. J., Jones A. M., Barclay E., Wortham N., Pignatelli M., Freeman A., Pomplun S., Ellis I., Poulsom R., El-Bahrawy M. A., Berney D. M., Tomlinson I. P. M., Adult leydig cell tumors of the testis caused by germline fumarate hydratase mutations The Journal of Clinical Endocrinology and Metabolism 2006 91 8 3071 3075 (Pubitemid 44271757)
21. Lehtonen H. J., Kiuru M., Ylisaukko-Oja S. K., Salovaara R., Herva R., Koivisto P. A., Vierimaa O., Aittomki K., Pukkala E., Launonen V., Aaltonen L. A., Increased risk of cancer in patients with fumarate hydratase germline mutation Journal of Medical Genetics 2006 43 6 523 526 (Pubitemid 43927328)
22. King A., Selak M. A., Gottlieb E., Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer Oncogene 2006 25 34 4675 4682 (Pubitemid 44187617)
23. Dang L., Jin S., Su S. M., IDH mutations in glioma and acute myeloid leukemia Trends in Molecular Medicine 2010 16 9 392 397
24. Parsons D. W., Jones S., Zhang X., Lin J. C. H., Leary R. J., Angenendt P., Mankoo P., Carter H., Siu I. M., Gallia G. L., Olivi A., McLendon R., Rasheed B. A., Keir S., Nikolskaya T., Nikolsky Y., Busam D. A., Tekleab H., Diaz L. A., Hartigan J., Smith D. R., Strausberg R. L., Marie S. K. N., Shinjo S. M. O., Yan H., Riggins G. J., Bigner D. D., Karchin R., Papadopoulos N., Parmigiani G., Vogelstein B., Velculescu V. E., Kinzler K. W., An integrated genomic analysis of human glioblastoma multiforme Science 2008 321 5897 1807 1812
25. Yan H., Parsons D. W., Jin G., McLendon R., Rasheed B. A., Yuan W., Kos I., Batinic-Haberle I., Jones S., Riggins G. J., Friedman H., Friedman A., Reardon D., Herndon J., Kinzler K. W., Velculescu V. E., Vogelstein B., Bigner D. D., IDH1 and IDH2 mutations in gliomas The New England Journal of Medicine 2009 360 8 765 773
26. Cairns R. A., Iqbal J., Lemonnier F., IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma Blood 2012 119 8 1901 1903
27. Abbas S., Lugthart S., Kavelaars F. G., Schelen A., Koenders J. E., Zeilemaker A., Van Putten W. J. L., Rijneveld A. W., Lwenberg B., Valk P. J. M., Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value Blood 2010 116 12 2122 2126
28. Paschka P., Schlenk R. F., Gaidzik V. I., Habdank M., Krnke J., Bullinger L., Spth D., Kayser S., Zucknick M., Gtze K., Horst H. A., Germing U., Dhner H., Dhner K., IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication Journal of Clinical Oncology 2010 28 22 3636 3643
29. Kang M. R., Kim M. S., Oh J. E., Yoo R. K., Sang Y. S., Seong I. S., Ji Y. L., Nam J. Y., Sug H. L., Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers International Journal of Cancer 2009 125 2 353 355
30. Yen K. E., Bittinger M. A., Su S. M., Fantin V. R., Cancer-associated IDH mutations: biomarker and therapeutic opportunities Oncogene 2010 29 49 6409 6417
31. Dang L., White D. W., Gross S., Bennett B. D., Bittinger M. A., Driggers E. M., Fantin V. R., Jang H. G., Jin S., Keenan M. C., Marks K. M., Prins R. M., Ward P. S., Yen K. E., Liau L. M., Rabinowitz J. D., Cantley L. C., Thompson C. B., Vander Heiden M. G., Su S. M., Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Nature 2009 462 7274 739 744
32. Ward P. S., Patel J., Wise D. R., Abdel-Wahab O., Bennett B. D., Coller H. A., Cross J. R., Fantin V. R., Hedvat C. V., Perl A. E., Rabinowitz J. D., Carroll M., Su S. M., Sharp K. A., Levine R. L., Thompson C. B., The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting -ketoglutarate to 2-hydroxyglutarate Cancer Cell 2010 17 3 225 234
33. Gimenez-Roqueplo A. P., Favier J., Rustin P., Mourad J. J., Plouin P. F., Corvol P., Rtig A., Jeunemaitre X., The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway American Journal of Human Genetics 2001 69 6 1186 1197 (Pubitemid 33124200)
34. Dahia P. L. M., Ross K. N., Wright M. E., Hayashida C. Y., Santagata S., Barontini M., Kung A. L., Sanso G., Powers J. F., Tischler A. S., Hodin R., Heitritter S., Moore F., Dluhy R., Sosa J. A., Ocal I. T., Benn D. E., Marsh D. J., Robinson B. G., Schneider K., Garber J., Arum S. M., Korbonits M., Grossman A., Pigny P., Toledo S. P. A., Nose V., Li C., Stiles C. D., A HIf1 regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas PLoS Genetics 2005 1 1 72 80
35. Vanharanta S., Pollard P. J., Lehtonen H. J., Laiho P., Sjberg J., Leminen A., Aittomki K., Arola J., Kruhoffer M., rntoft T. F., Tomlinson I. P., Kiuru M., Arango D., Aaltonen L. A., Distinct expression profile in fumarate-hydratase-deficient uterine fibroids Human Molecular Genetics 2006 15 1 97 103 (Pubitemid 43020108)
36. Selak M. A., Armour S. M., MacKenzie E. D., Boulahbel H., Watson D. G., Mansfield K. D., Pan Y., Simon M. C., Thompson C. B., Gottlieb E., Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF- prolyl hydroxylase Cancer Cell 2005 7 1 77 85 (Pubitemid 40126384)
37. Ozer A., Bruick R. K., Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? Nature Chemical Biology 2007 3 3 144 153
38. Isaacs J. S., Yun J. J., Mole D. R., Lee S., Torres-Cabala C., Chung Y. L., Merino M., Trepel J., Zbar B., Toro J., Ratcliffe P. J., Linehan W. M., Neckers L., HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability Cancer Cell 2005 8 2 143 153 (Pubitemid 41132743)
39. Adam J., Hatipoglu E., O'Flaherty L., Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling Cancer Cell 2011 20 4 524 537
40. Koivunen P., Lee S., Duncan C. G., Kaelin C. G. Jr., Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation Nature 2012 483 484 488
41. Lee S., Nakamura E., Yang H., Wei W., Linggi M. S., Sajan M. P., Farese R. V., Freeman R. S., Carter B. D., Kaelin W. G., Schlisio S., Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer Cancer Cell 2005 8 2 155 167 (Pubitemid 41132744)
42. Schlisio S., Kenchappa R. S., Vredeveld L. C. W., George R. E., Stewart R., Greulich H., Shahriari K., Nguyen N. V., Pigny P., Dahia P. L., Pomeroy S. L., Maris J. M., Look A. T., Meyerson M., Peeper D. S., Carter B. D., Kaelin W. G., The kinesin KIF1B acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor Genes and Development 2008 22 7 884 893 (Pubitemid 351482842)
43. Chi P., Allis C. D., Wang G. G., Covalent histone modifications- miswritten, misinterpreted and mis-erased in human cancers Nature Reviews Cancer 2010 10 7 457 469
44. Caffarelli E., Filetici P., Epigenetic regulation in cancer development Frontiers in Bioscience 2011 1 17 2682 2694
45. Hou H., Yu H., Structural insights into histone lysine demethylation Current Opinion in Structural Biology 2010 20 6 739 748
46. Cervera A. M., Bayley J. P., Devilee P., McCreath K. J., Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells Molecular Cancer 2009 8, article 89
47. Smith E. H., Janknecht R., Maher J. L. III, Succinate inhibition of -ketoglutarate-dependent enzymes in a yeast model of paraganglioma Human Molecular Genetics 2007 16 24 3136 3148 (Pubitemid 350131331)
48. Chowdhury R., Yeoh K. K., Tian Y. M., Hillringhaus L., Bagg E. A., Rose N. R., Leung I. K. H., Li X. S., Woon E. C. Y., Yang M., McDonough M. A., King O. N., Clifton I. J., Klose R. J., Claridge T. D. W., Ratcliffe P. J., Schofield C. J., Kawamura A., The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases EMBO Reports 2011 12 5 463 469
49. Figueroa M. E., Abdel-Wahab O., Lu C., Ward P. S., Patel J., Shih A., Li Y., Bhagwat N., Vasanthakumar A., Fernandez H. F., Tallman M. S., Sun Z., Wolniak K., Peeters J. K., Liu W., Choe S. E., Fantin V. R., Paietta E., Lwenberg B., Licht J. D., Godley L. A., Delwel R., Valk P. J. M., Thompson C. B., Levine R. L., Melnick A., Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation Cancer Cell 2010 18 6 553 567
50. Fllgrabe J., Kavanagh E., Joseph B., Histone onco-modifications Oncogene 2011 30 31 3391 3403
51. Sarkies P., Sale J. E., Cellular epigenetic stability and cancer Trends in Genetics 2012 28 3 118 127
52. Szatrowski T. P., Nathan C. F., Production of large amounts of hydrogen peroxide by human tumor cells Cancer Research 1991 51 3 794 798
53. Toyokuni S., Persistent oxidative stress in cancer FEBS Letters 1995 358 1 1 3
54. Kawanishi S., Hiraku Y., Pinlaor S., Ma N., Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis Biological Chemistry 2006 387 4 365 372
55. Ishii N., Fujii M., Hartman P. S., Tsuda M., Yasuda K., Senoo-Matsuda N., Yanase S., Ayusawa D., Suzuki K., A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes Nature 1998 394 6694 694 697 (Pubitemid 28389798)
56. Senoo-Matsuda N., Yasuda K., Tsuda M., Ohkubo T., Yoshimura S., Nakazawa H., Hartman P. S., Ishii N., A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in caenorhabditis elegans The Journal of Biological Chemistry 2001 276 45 41553 41558
57. Ishii T., Yasuda K., Akatsuka A., Hino O., Hartman P. S., Ishii N., A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis Cancer Research 2005 65 1 203 209 (Pubitemid 40070811)
58. Guzy R. D., Sharma B., Bell E., Chandel N. S., Schumacker P. T., Loss of the SdhB, but not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis Molecular and Cellular Biology 2008 28 2 718 731
59. Chandel N. S., Maltepe E., Goldwasser E., Mathieu C. E., Simon M. C., Schumacker P. T., Mitochondrial reactive oxygen species trigger hypoxia-induced transcription Proceedings of the National Academy of Sciences of the United States of America 1998 95 20 11715 11720 (Pubitemid 28460480)
60. Chandel N. S., McClintock D. S., Feliciano C. E., Wood T. M., Melendez J. A., Rodriguez A. M., Schumacker P. T., Reactive oxygen species generated at mitochondrial Complex III stabilize hypoxia-inducible factor-1 during hypoxia: a mechanism of O 2 sensing Journal of Biological Chemistry 2000 275 33 25130 25138
61. Filomeni G., Rotilio G., Ciriolo M. R., Disulfide relays and phosphorylative cascades: partners in redox-mediated signaling pathways Cell Death and Differentiation 2005 12 12 1555 1563 (Pubitemid 41679161)
62. Reitman Z. J., Jin G., Karoly E. D., Spasojevic I., Yang J., Kinzler K. W., He Y., Bigner D. D., Vogelstein B., Yan H., Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome Proceedings of the National Academy of Sciences of the United States of America 2011 108 8 3270 3275
63. Matés J. M., Segura J. A., Campos-Sandoval J. A., Lobo C., Alonso L., Alonso F. J., Mrquez J., Glutamine homeostasis and mitochondrial dynamics International Journal of Biochemistry and Cell Biology 2009 41 10 2051 2061
64. Hu W., Zhang C., Wu R., Sun Y., Levine A., Feng Z., Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function Proceedings of the National Academy of Sciences of the United States of America 2010 107 16 7455 7460
65. Zhao S., Lin Y., Xu W., Jiang W., Zhai Z., Wang P., Yu W., Li Z., Gong L., Peng Y., Ding J., Lei Q., Guan K. L., Xiong Y., Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1 Science 2009 324 5924 261 265
66. Latini A., Scussiato K., Rosa R. B., Llesuy S., Bell-Klein A., Dutra-Filho C. S., Wajner M., D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats European Journal of Neuroscience 2003 17 10 2017 2022 (Pubitemid 36713962)
67. Klker S., Pawlak V., Ahlemeyer B., Okun J. G., Hrster F., Mayatepek E., Krieglstein J., Hoffmann G. F., Khr G., NMDA receptor activation and respiratory chain complex V inhibition contribute to neurodegeneration in D-2-hydroxyglutaric aciduria European Journal of Neuroscience 2002 16 1 21 28 (Pubitemid 35463594)
68. Sudarshan S., Sourbier C., Kong H. S., Block K., Valera Romero V. A., Yang Y., Galindo C., Mollapour M., Scroggins B., Goode N., Lee M. J., Gourlay C. W., Trepel J., Linehan W. M., Neckers L., Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1 stabilization by glucose-dependent generation of reactive oxygen species Molecular and Cellular Biology 2009 29 15 4080 4090
69. O'Flaherty L., Adam J., Heather L. C., Zhdanov A. V., Chung Y. L., Miranda M. X., Croft J., Olpin S., Clarke K., Pugh C. W., Griffiths J., Papkovsky D., Ashrafian H., Ratcliffe P. J., Pollard P. J., Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism Human Molecular Genetics 2010 19 19 3844 3851
70. Ooi A., Wong J. C., Petillo D., An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma Cancer Cell 2011 20 4 511 523
71. Villeneuve N. F., Lau A., Zhang D. D., Regulation of the Nrf2-keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases Antioxidants and Redox Signaling 2010 13 11 1699 1712
72. Hayes J. D., McMahon M., NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer Trends in Biochemical Sciences 2009 34 4 176 188
73. Denicola G. M., Karreth F. A., Humpton T. J., Gopinathan A., Wei C., Frese K., Mangal D., Yu K. H., Yeo C. J., Calhoun E. S., Scrimieri F., Winter J. M., Hruban R. H., Iacobuzio-Donahue C., Kern S. E., Blair I. A., Tuveson D. A., Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis Nature 2011 475 7354 106 110
74. Frezza C., Zheng L., Folger O., Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase Nature 2011 477 7363 225 228
75. Lau A., Villeneuve N. F., Sun Z., Wong P. K., Zhang D. D., Dual roles of Nrf2 in cancer Pharmacological Research 2008 58 5-6 262 270
76. Inami Y., Waguri S., Sakamoto A., Kouno T., Nakada K., Hino O., Watanabe S., Ando J., Iwadate M., Yamamoto M., Lee M. S., Tanaka K., Komatsu M., Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells The Journal of Cell Biology 2011 193 2 275 284
77. Pfaffenroth E. C., Linehan W. M., Genetic basis for kidney cancer: opportunity for disease-specific approaches to therapy Expert Opinion on Biological Therapy 2008 8 6 779 790 (Pubitemid 351860207)
78. Raimundo N., Ahtinen J., Fumi K., Bari I., Remes A. M., Renkonen R., Lapatto R., Suomalainen A., Differential metabolic consequences of fumarate hydratase and respiratory chain defects Biochimica et Biophysica Acta 2008 1782 5 287 294
79. Schafer F. Q., Buettner G. R., Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple Free Radical Biology and Medicine 2001 30 11 1191 1212 (Pubitemid 32463931)
80. Diehn M., Cho R. W., Lobo N. A., Kalisky T., Dorie M. J., Kulp A. N., Qian D., Lam J. S., Ailles L. E., Wong M., Joshua B., Kaplan M. J., Wapnir I., Dirbas F. M., Somlo G., Garberoglio C., Paz B., Shen J., Lau S. K., Quake S. R., Brown J. M., Weissman I. L., Clarke M. F., Association of reactive oxygen species levels and radioresistance in cancer stem cells Nature 2009 458 7239 780 783