D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats

European Journal of Neuroscience

Volumn 17, Issue 10, 2003, Pages 2017-2022

  Latini, Alexandra ^a,b   Scussiato, Karina ^a   Rosa, Rafael Borba ^a   Llesuy, Susana ^a   Belló Klein, Adriane ^a   Dutra Filho, Carlos Severo ^a   Wajner, Moacir ^a,b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

D 2 hydroxyglutaric acid; D 2 hydroxyglutaric aciduria; Lipid peroxidation; Oxidative stress

Indexed keywords

ALPHA TOCOPHEROL DERIVATIVE; ASCORBIC ACID; CATALASE; DEXTRO 2 HYDROXYGLUTARIC ACID; GLUTARIC ACID DERIVATIVE; GLUTATHIONE PEROXIDASE; HYDROXYL RADICAL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; SCAVENGER; SUPEROXIDE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TROLOX C; UNCLASSIFIED DRUG;

ACIDURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN CORTEX; BRAIN INJURY; CHEMOLUMINESCENCE; CONTROLLED STUDY; DEXTRO 2 HYDROXYGLUTARIC ACIDURIA; ENZYME ACTIVITY; LIPID PEROXIDATION; MALE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SUPERNATANT;

AGE FACTORS; ANIMALS; CATALASE; CEREBRAL CORTEX; FREE RADICALS; GLUTARATES; GLUTATHIONE PEROXIDASE; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0038810144     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2003.02639.x     Document Type: Article

References (25)

1. Aebi, H. (1984) Catalase, in vitro. Meth. Enzymol., 105, 121-126.
2. Bast, A. (1993) Oxidative stress and calcium homeostasis. In Halliwell, B., & Aruoma, O.I. (eds), DNA and Free Radicals. Ellis Hardwood Limited, England, pp. 95-108.
3. Chalmers, R.A., Lawson, A.M. & Watts, R.W.E. (1980) D-2-hydroxyglutaric acid: case report and biochemical studies. J. Inherit. Metab. Dis., 3, 11-15.
4. Esterbauer, H. & Cheeseman, K.H. (1990) Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Meth. Enzymol., 186, 407-421.
5. Gibson, K.M., Craigen, W., Herman, G.E. & Jakobs, C. (1993) D-2-hydroxyglutaric aciduria in a newborn with neurological abnormalities: a new neurometabolic disorder?. J. Inherit. Metab. Dis., 16, 497-500.
6. González-Flecha, B., Llesuy, S. & Boveris, A. (1991) Hydroperoxide-initiated chemiluminescence: an assay for oxidative stress in biopsies of heart, liver and muscle. Free Rad. Biol. Med., 10, 93-100.
7. Halliwell, B. & Gutteridge, J.M.C. (1996) Oxygen radicals and nervous system. Trends Neurosci., 8, 22-26.
8. Halliwell, B. & Gutteridge, J.M.C. (2001a) Detection of free radicals and others reactive species: trapping and fingerprinting. In Halliwell, B. & Gutteridge, J.M.C. (eds), Free Radicals in Biology and Medicine, 3rd edn. Oxford University Press, Oxford, pp. 351-425.
9. Halliwell, B. & Gutteridge, J.M.C. (2001b) Antioxidant defences. In Halliwell, B. & Gutteridge, J.M.C. (eds), Free Radicals in Biology and Medicine, 3rd edn. Oxford University Press, Oxford, pp. 105-245.
10. Hoffmann, G.E, Gibson, K.M., Trefz, F.K., Nyhan, W.L., Bremer, H.J. & Rating, D. (1994) Neurological manifestations of organic acid disorders. Eur. J. Pediatr., 153 (Suppl. 1), S94-S100.
11. Karelson, E., Bogdanovic, N., Garlind, A., Winblad, B., Zilmer, K., Kullisaar, T., Vihalemm, T., Kairane, C. & Zilmer, M. (2001) The cerebrocortical areas in normal brain aging and in the Alzheimer's Disease: noticeable difference in the lipid peroxidation level and in antioxidant defense. Neurochem. Res., 26, 353-361.
12. van der Knaap, M.S., Jakobs, C., Hoffmann, G.F., Duran, M., Muntau, A.C., Schweitzer, S., Kelley, R.I., Parrot-Roulaud, F., Amiel, J., De Lonlay, P., Rabier, D. & Eeg-Olofsson, O. (1999b) D-2-hydroxyglutaric aciduria: further clinical delineation. J. Inherit. Metab. Dis., 22, 404-413.
13. van der Knaap, M.S., Jakobs, C., Hoffmann, G.F., Nyhan, W.L., Renier, W.O., Smeitink, J.A., Catsman-Berrevoets, C.E., Hjalmarson, O., Vallance, H., Sugita, K., Bowe, C.M., Herrin, J.T., Craigen, W.J., Buist, N.R., Brookfield, D.S. & Chalmers, R.A. (1999a) D-2-hydroxyglutaric aciduria: biochemical marker or clinical disease entity. Ann. Neurol., 45, 111-119.
14. Kölker, S., Pawlak, V., Ahlemeyer, B., Okun, J.G., Horster, F., Mayatepek, E., Krieglstein, J., Hoffmann, G.F. & Kohr, G. (2002) NMDA receptor activation and respiratory chain complex V inhibition contribute to neurodegeneration in D-2-hydroxyglutaric aciduria. Eur. J. Neurosci., 16, 21-28.
15. Lissi, E., Pascual, C. & Del Castillo, M.D. (1992) Luminol luminescence induced by 2,2′-azo-bis-(2-amidinopropane) thermolysis. Free Rad. Res. Commun., 17, 299-311.
16. Lissi, E., Salim-Hanna, M., Pascual, C. & Del Castillo, M.D. (1995) Evaluation of total antioxidant potential (TRAP) and total antioxidant reactivity from luminol-enhanced chemiluminescence measurements. Free Rad. Biol. Med., 18, 153-158.
17. Llesuy, S.F., Milei, J., Molina, H., Boveris, A. & Milei, S. (1985) Comparison of lipid peroxidation and myocardial damage induced by adriamycin and 4′-epiadriamycin in mice. Tumori, 71, 241-249.
18. Lowry, O.H., Rosebrough, N.J., Lewis-Farr, A. & Randall, R.J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275.
19. Méndez-Álvarez, E., Soto-Otero, R. Hermida-Aeijeiras, A., López-Real, A.M. & Labandeira-García, J.L. (2001) Effects of aluminium and zinc on the oxidative stress caused by 6-hydroxydopamine autoxidation: relevance for the pathogenesis of Parkinson's disease. Biochim. Biophys. Acta, 1586, 155-168.
20. Reznick, A.Z. & Packer, L. (1993) Free radicals and antioxidants in muscular neurological diseases and disorders. In Poli, G., Albano, E. & Dianzani, M.U. (eds), Free Radicals: from Basic Science to Medicine. Birkhäuser-Verlag, Basel, pp. 425-437.
21. Schulz, J.B., Lindenau, J., Seyfried, J. & Dichgans, J. (2000) Glutathione, oxidative stress and neurodegeneration. Eur. J. Biochem., 267, 4904-4911.
22. da Silva, C.G., Ribeiro, C.A., Leipnitz, G., Dutra-Filho, C.S., Wyse, A.T., Wannmacher, C.M., Sarkis, J.J., Jakobs, C. & Wajner, M. (2002) Inhibition of cytochrom c oxidase activity in rat cerebral cortex and human skeletal muscle by D-2-hydroxyglutaric acid in vitro. Biochim. Biophys. Acta, 1586, 81-91.
23. Wajner, M., Vargas, C.R., Funayama, C., Fernandez, A., Elias, M.L., Goodman, S.I., Jakobs, C. & van der Knaap, M.S. (2002) D-2-hydroxyglutaric aciduria in a patient with a severe clinical phenotype and unusual MRI findings. J. Inherit. Metab. Dis., 25, 28-34.
24. Wanders, R.J.A. & Mooyer, P. (1995) D-2-hydroxyglutaric acidaemia: identification of a new enzyme, D-2-hydroxyglutarate dehydrogenase, localized in mitocondria. J. Inherit. Metab. Dis., 18, 194-196.
25. Wendel, A. (1981) Glutathione peroxidase. Meth. Enzymol., 77, 325-332.