Predicting the three-dimensional structure of the human facilitative glucose transporter Glut1 by a novel evolutionary homology strategy: Insights on the molecular mechanism of substrate migration, and binding for glucose and inhibitory molecules

Biophysical Journal

Volumn 87, Issue 5, 2004, Pages 2990-2999

  Salas Burgos, Alexis ^a   Iserovich, Pavel ^a   Zuniga, Felipe ^b   Vera, Juan Carlos ^b   Fischbarg, Jorge ^a  

^a Columbia University ^*  (United States)

^b UNIVERSITY OF CONCEPCIÓN   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; CYTOCHALASIN B; FORSKOLIN; GLUCOSE; GLUCOSE 6 PHOSPHATE TRANSLOCASE; GLUCOSE TRANSPORTER 1; PHLORETIN; UNCLASSIFIED DRUG; GLUCOSE TRANSPORTER; SLC2A1 PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; EVOLUTIONARY HOMOLOGY; HUMAN; MEMBRANE CHANNEL; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR RECOGNITION; MUTAGENESIS; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; THREE DIMENSIONAL IMAGING; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; ENZYME ACTIVATION; ENZYME SPECIFICITY; EVALUATION; GENETICS; MOLECULAR EVOLUTION; MOTION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

BINDING SITES; COMPUTER SIMULATION; ENZYME ACTIVATION; EVOLUTION, MOLECULAR; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; HUMANS; MODELS, MOLECULAR; MONOSACCHARIDE TRANSPORT PROTEINS; MOTION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 12344321851     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.104.047886     Document Type: Article

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