Microtubule binding and disruption and induction of premature senescence by disorazole C 1

Journal of Pharmacology and Experimental Therapeutics

Volumn 328, Issue 3, 2009, Pages 715-722

  Tierno, Marni Brisson ^a,b   Kitchens, Carolyn A ^a,b   Petrik, Bethany ^a   Graham, Thomas H ^a   Wipf, Peter ^a   Xu, Fengfeng L ^a   Saunders, William S ^a   Raccor, Brianne S ^a   Balachandran, Raghavan ^a   Day, Billy W ^a   Stout, Jane R ^c   Walczak, Claire E ^c   Ducruet, Alexander P ^b   Reese, Celeste E ^a   Lazo, John S ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISORAZOLE A1; DISORAZOLE C1; DOLASTATIN; ELECTROPHILE; POLYKETIDE; RADIOLIGAND; TRITIUM; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL AGING; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL POPULATION; CELL PROLIFERATION; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; INTERPHASE; MICROTUBULE; MICROTUBULE ASSEMBLY; MITOSIS; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL;

AGING, PREMATURE; ANIMALS; APOPTOSIS; CATTLE; CELL AGING; CELL DIVISION; FIBROBLASTS; G2 PHASE; HELA CELLS; HUMANS; KINETICS; MICROTUBULES; MYXOCOCCALES; OXAZOLES; TUBULIN; VINBLASTINE;

EID: 62449223586     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.147330     Document Type: Article

References (26)

1. Arthur CR, Gupton JT, Kellogg GE, Yeudall WA, Cabot MC, Newsham IF, and Gewirtz DA (2007) Autophagic cell death, polyploidy and senescence induced in breast tumor cells by the substituted pyrrole JG-03-14, a novel microtubule poison. Biochem Pharm 74:981-991.
2. Bai R, Taylor GF, Cichacz ZA, Herald CL, Kepler JA, Pettit GR, and Hamel E (1995a) The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain. Biochemistry 34:9714-9721.
3. Bai R, Taylor GF, Schmidt JM, Williams MD, Kepler JA, Pettit GR, and Hamel E (1995b) Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions. Mol Pharmacol 47:965-976.
4. Blagosklonny MV (2003) Cell snescence and hypermitogenic arrest. EMBO Rep 4:358-362.
5. Chang BD, Broude EV, Dokmanovic M, Zhu H, Ruth A, Xuan Y, Kandel ES, Lausch E, Christov K, and Roninson IB (1999) A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res 59:3761-3767.
6. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, and Pereira-Smith O (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92:9363-9367.
7. Elnakady YA, Sasse F, Lünsdorf H, and Reichenbach H (2004) Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells. Biochem Pharmacol 67:927-935.
8. Eom YW, Kim MA, Park SS, Goo MJ, Kwon HJ, Sohn S, Kim WH, Yoon G, and Choi KS (2005) Two distinct modes of cell death induced by doxorubicin:apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype. Oncogene 24:4765-4777.
9. Hamel E and Lin CM (1984) Separation ofactive tubulin and microtubule-associated proteins by ultra centrifugation and isolation of a component causing the formation of microtubule bundles. Biochemistry 23:4173-4184.
10. Jansen R, Irschik H, Reichenbach H, Wray V, and Hofle G (1994) Disorazoles, highly cytotoxic metabolites from the sorangicin producing bacterium Sorangium cellulosum, strain So ce1. Liebigs Ann Chem 759-773.
11. Jordan MA and Wilson L (2004) Microtubules as a target for anticancer drugs. Nat Rev Cancer 4:253-265.
12. Kashiwabara K, Oyama T, Sano T, Fukuda T, and Nakajima T (1998) Correlation between methylation status of the p16/CDKN2 gene and the expression of p16 and Rb proteins in primary nonsmall cell lung cancers. Int J Cancer 79:215-220.
13. Klein LE, Freeze BS, Smith AB 3rd, and Horwitz SB (2005) The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence. Cell Cycle 4:501-507.
14. Kopp M, Irschik H, Pradella S, and Müller R (2005) Production of the tubulin destabilizer disorazol in Sorangium cellulosum: biosynthetic machinery and regulatory genes. Chembiochem 6:1277-1286.
15. Lee BY, Han JA, Im JS, Morrone A, Johung K, Goodwin EC, Kleijer WJ, DiMaio D, and Hwang ES (2006) Senescence-associated beta-galactosidase is lysosomal beta- galactosidase. Aging Cell 5:187-195.
16. McConnell BB, Starborg M, Brookes S, and Peters G (1998) Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr Biol 8:351-354.
17. Roninson IB (2003) Tumor cell senescence in cancer treatment. Cancer Res 63:2705-2715.
18. Schmitt CA (2007) Cellular senescence and cancer treatment. Biochim Biophys Acta 1775:5-20.
19. Serrano M (2007) Cancer regression by senescence. New Engl J Med 356:1996-1997.
20. Stein GH, Drullinger LF, Soulard A, and Dulić V (1999) Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol 19:2109-2117.
21. Stout JR, Rizk RS, Kline SL, and Walczak CE (2006) Deciphering protein function during mitosis in PtK cells using RNAi. BMC Cell Biol 7:26.
22. Tierno MB, Petrik B, Nickischer D, and Johnston P Application Note LC01612000, Thermo Scientific.
23. Wang Z, McPherson PA, Raccor BS, Balachandran R, Zhu G, Day BW, Vogt A, and Wipf P (2007) Structure-activity and high-content imaging analyses of novel tubulysins. Chem Biol Drug Des 70:75-86.
24. Wipf P and Graham TH (2004) Total synthesis of (-)-disorazole C1. J Am Chem Soc 126:15346-15347.
25. Wipf P, Graham TH, Vogt A, Sikorski RP, Ducruet AP, and Lazo JS (2006) Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product. Chem Biol Drug Des 67:66-73.
26. Yamada HY and Gorbsky GJ (2006) Spindle checkpoint function and cellular sensitivity to antimitotic drugs. Mol Cancer Ther 5:2963-2969.