A pairwise chemical genetic screen identifies new inhibitors of glucose transport

Chemistry and Biology

Volumn 18, Issue 2, 2011, Pages 222-230

  Ulanovskaya, Olesya A ^a   Cui, Jiayue ^a   Kron, Stephen J ^a   Kozmin, Sergey A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIMYCIN A1; GLUCOSE; GLUCOSE TRANSPORTER; LACTIC ACID;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CYCLE G1 PHASE; CELL LINE; CELL PROLIFERATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; DRUG SCREENING; GLYCOLYSIS; HUMAN; INTRACELLULAR SPACE; METABOLISM; METHODOLOGY; MITOCHONDRION; MOLECULAR LIBRARY; OXIDATIVE PHOSPHORYLATION; REPRODUCIBILITY; SYNTHESIS; TIME; TRANSPORT AT THE CELLULAR LEVEL;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIMYCIN A; BIOLOGICAL TRANSPORT; CELL LINE; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; G1 PHASE; GLUCOSE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; GLYCOLYSIS; HUMANS; INTRACELLULAR SPACE; LACTIC ACID; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; REPRODUCIBILITY OF RESULTS; SMALL MOLECULE LIBRARIES; TIME FACTORS;

EID: 79951815565     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2010.12.015     Document Type: Article

References (44)

1. E.M. Bonder, and M.S. Mooseker Cytochalasin B slows but does not prevent monomer addition at the barbed end of the actin filament J. Cell Biol. 102 1986 282 288 (Pubitemid 16155575)
2. M. Bredel, and E. Jacoby Chemogenomics: An emerging strategy for rapid target and drug discovery Nat. Rev. Genet. 5 2004 262 275 (Pubitemid 38435622)
3. J. Brown Effects of 2-deoxyglucose on carbohydrate metabolism: review of the literature and studies in the rat Metabolism 11 1962 1098 1112
4. R.S. Brown, and R.L. Wahl Overexpression of GLUT-1 glucose transporter in human breast cancer. An immunohistochemical study Cancer 72 1993 2979 2985 (Pubitemid 23335044)
5. G. Cantuaria, A. Fagotti, G. Ferrandina, A. Magalhaes, M. Nadji, R. Angioli, M. Penalver, S. Mancuso, and G. Scambia GLUT-1 expression in ovarian carcinoma: association with survival and response to chemotherapy Cancer 92 2001 1144 1150 (Pubitemid 32861663)
6. A. Carruthers, J. DeZutter, A. Gaunguly, and S.U. Devaskar Will the original glucose transporter isotype stand up! Am. J. Physiol. Endocrinol. Metab. 297 2009 E836 E848
7. C. Cavé, A. Gassama, J. Mahuteau, J. d'Angelo, and C. Riche Condensation of chiral imines and chiral β-enaminoesters with maleic and citraconic anhydrides Tetrahedron Lett. 38 1997 4773 4776 (Pubitemid 27277959)
8. J. Cui, K. Matsumoto, C.Y. Wang, M.E. Peter, and S.A. Kozmin Synthesis of high-purity chemical library reveals a potent inducer of oxidative stress ChemBioChem 11 2010 1224 1227
9. R.J. DeBerardinis, J.J. Lum, G. Hatzivassiliou, and C.B. Thompson The biology of cancer: metabolic reprogramming fuels cell growth and proliferation Cell Metab. 7 2008 11 20
10. R. Deves, and R.M. Krupka Cytochalasin B and the kinetics of inhibition of biological transport. A case of asymmetric binding to the glucose carrier Biochim. Biophys. Acta 510 1978 339 348 (Pubitemid 8361830)
11. L.J. Eichner, M.C. Perry, C.R. Dufour, N. Bertos, M. Park, J. St-Pierre, and V. Giguere miR-378* mediates metabolic shiftin breast cancer cells via the PGC-1β/ERRγ transcriptional pathway Cell Metab. 12 2010 352 361
12. A. Evans, V. Bates, H. Troy, S. Hewitt, S. Holbeck, Y. Chung, R. Phillips, M. Stubbs, J. Griffiths, and R. Airley GLUT-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies Cancer Chemother. Pharmacol. 61 2008 377 393 (Pubitemid 350275973)
13. P. Faik, M. Morgan, R.J. Naftalin, and R.J. Rist Transport and accumulation of 2-deoxy-D-glucose in wild-type and hexokinase-deficient cultured Chinese-hamster ovary (CHO) cells Biochem. J. 260 1989 153 155 (Pubitemid 19139909)
14. S.S. Gambhir Molecular imaging of cancer with positron emission tomography Nat. Rev. Cancer 4 2004 891 899
15. R.A. Gatenby, and R.J. Gillies Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 4 2004 891 899 (Pubitemid 39472955)
16. V.M. Gohil, S.A. Sheth, R. Nilsson, A.P. Wojtovich, J.H. Lee, F. Perocchi, W. Chen, C.B. Clish, C. Ayata, and P.S. Brookes Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis Nat. Biotechnol. 28 2010 249 255
17. R.S. Haber, A. Rathan, K.R. Weiser, A. Pritsker, S.H. Itzkowitz, C. Bodian, G. Slater, A. Weiss, and D.E. Burstein GLUT1 glucose transporter expression in colorectal carcinomas: a marker for poor prognosis Cancer 83 1998 34 40 (Pubitemid 28299626)
18. L.H. Hartwell, P. Szankasi, C.J. Roberts, A.W. Murray, and S.H. Friend Integrating genetic approaches into the discovery of anticancer drugs Science 278 1997 1064 1068 (Pubitemid 27517876)
19. M. Hatanaka Transport of sugars in tumor cell membranes Biochim. Biophys. Acta 355 1974 77 104
20. A.L. Helgerson, D.N. Hebert, S. Naderi, and A. Carruthers Characterization of two independent modes of action of ATP on human erythrocyte sugar transport Biochemistry 28 1989 6410 6417 (Pubitemid 19202032)
21. H. Lee, M. Suzuki, J. Cui, and S.A. Kozmin Synthesis of an Azide-Tagged Library of 2,3-dihydro-4-quinolones J. Org. Chem. 75 2010 1756 1759
22. J. Lehar, B.R. Stockwell, G. Giaever, and C. Nislow Combination chemical genetics Nat. Chem. Biol. 4 2008 674 681
23. H. Liu, Y.P. Hu, N. Savarai, W. Priebe, and T. Lampadis Hypersensitization of tumor cells to glycolytic inhibitors Biochemistry 40 2001 5542 5547 (Pubitemid 32458256)
24. A.R. Manolescu, K. Witkowska, A. Kinnaird, T. Cessford, and C. Cheeseman Facilitated hexose transporters: new perspectives on form and function Physiology (Bethesda) 22 2007 234 240
25. T. Nishioka, Y. Oda, Y. Seino, T. Yamamoto, N. Inagaki, H. Yano, H. Imura, R. Shigemoto, and H. Kikuchi Distribution of glucose transporters in human brain tumors Cancer Res. 52 1992 3972 3979
26. T. Ohnishi, and B.L. Trumpower Differential effects of antimycin on ubisemiquinone bound in different environments in isolated succinate-cytochrome c reductase complex J. Biol. Chem. 255 1980 3278 3284 (Pubitemid 10014659)
27. S. Omura, T. Fujimoto, K. Otoguro, K. Matsuzaki, R. Moriguchi, H. Tanaka, and Y. Sasaki Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells J. Antibiot. 44 1991 113 116
28. H. Pelicano, D.S. Martin, R. Xu, and P. Huang Glycolysis inhibition for anticancer treatment Oncogene 25 2006 4633 4646 (Pubitemid 44187614)
29. E. Racker History of the Pasteur effect and its pathobiology Mol. Cell. Biochem. 5 1974 17 23
30. C. Rudlowski, A.J. Becker, W. Schroder, W. Rath, R. Buttner, and M. Moser GLUT1 messenger RNA and protein induction relates to the malignant transformation of cervical cancer Am. J. Clin. Pathol. 120 2003 691 698 (Pubitemid 37339675)
31. M.I. Sabri, and S. Ochs Inhibition of glyceraldehydes-3-phoshate dehydrogenase in mammalian nerve by iodoacetic acid J. Neurochem. 18 1971 1509 1514
32. D. Segr, A. Deluna, G.M. Church, and R. Kishony Modular epistasis in yeast metabolism Nat. Genet. 37 2005 77 83 (Pubitemid 40070943)
33. B.R. Stockwell Chemical genetics: ligand-based discovery of gene function Nat. Rev. Genet. 1 2000 116 125
34. D.S. Tan Diversity-oriented synthesis: exploring the intersections between chemistry and biology Nat. Chem. Biol. 1 2005 74 84
35. D.A. Tennant, R.V. Durán, and E. Gottlieb Targeting metabolic transformation for cancer therapy Nat. Rev. Cancer 10 2010 267 277
36. A.H. Tong, M. Evangelista, A.B. Parsons, H. Xu, G.D. Bader, N. Pagé, M. Robinson, S. Raghibizadeh, C.W. Hogue, and H. Bussey Systematic genetic analysis with ordered arrays of yeast deletion mutants Science 294 2001 2364 2368 (Pubitemid 33140562)
37. A.H. Tong, G. Lesage, G.D. Bader, H. Ding, H. Xu, X. Xin, J. Young, G.F. Berriz, R.L. Brost, and M. Chang Global mapping of the yeast genetic interaction network Science 303 2004 808 813 (Pubitemid 38174652)
38. O. Ulanovskaya, J. Janjic, K. Matsumoto, P.T. Schumacker, S.J. Kron, and S.A. Kozmin Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide Nat. Chem. Biol. 4 2008 418 424 (Pubitemid 351860551)
39. M.G. Vander Heiden, L.C. Cantley, and C.B. Thompson Understanding the Warburg effect: the metabolic requirements of cell proliferation Science 324 2009 1029 1033
40. J.C. Vera, C.I. Ricas, J. Fischbarg, and D.W. Golde Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid Nature 364 1993 79 82 (Pubitemid 23233461)
41. J.C. Vera, A.M. Reyes, J.G. Carcamo, F.V. Velasques, C.I. Rivas, R.H. Zhang, P. Strobel, R. Iribarren, H. Scher, J.C. Slebe, and D.W. Golde Genistein is a natural inhibitor of hexose and dehydroascorbic acid transport through the glucose transporter, GLUT1 J. Biol. Chem. 271 1996 8719 8724 (Pubitemid 26123289)
42. O. Warburg On the origin of cancer cells Science 123 1956 309 314
43. T. Yamamoto, Y. Seino, H. Fukumoto, G. Koh, H. Yano, N. Inagaki, Y. Yamada, K. Inoue, T. Manabe, and H. Imura Over-expression of facilitative glucose transporter genes in human cancer Biochem. Biophys. Res. Commun. 170 1990 223 230 (Pubitemid 20249408)
44. C.S. Yost A new look at the respiratory stimulant doxapram CNS Drug Rev. 12 2006 236 249 (Pubitemid 46047790)