Elucidating the pre- and post-nuclear intracellular processing of 1,4-dihydropyridine based gene delivery carriers

Journal of Controlled Release

Volumn 162, Issue 1, 2012, Pages 167-175

  Hyvönen, Zanna ^a,b   Hämäläinen, Vesa ^a   Ruponen, Marika ^a   Lucas, Bart ^b   Rejman, Joanna ^b   Vercauteren, Dries ^b   Demeester, Jo ^b   De Smedt, Stefaan ^b   Braeckmans, Kevin ^b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

1,4 dihydropyridine amphiphiles; Gene expression; Intracellular trafficking; mRNA; Non viral gene delivery; Nuclei extraction

Indexed keywords

1 ,4-DIHYDROPYRIDINE; AMPHIPHILICS; BUFFERING CAPACITIES; CELL LINES; CELL NUCLEUS; CELLULAR UPTAKE; ENDOSOMAL MEMBRANE; FOLDING PROCESS; FREE CARRIERS; FUNCTIONAL PROTEINS; GENE DELIVERY; IN-VITRO; INTRACELLULAR COMPONENTS; INTRACELLULAR PROCESS; INTRACELLULAR TRAFFICKING; LIPID EXCHANGE; MOLECULAR COMPOUNDS; MRNA; MRNA EXPRESSION; NON-VIRAL GENE DELIVERY; POSITIVELY CHARGED; POST-TRANSLATIONAL MODIFICATIONS; PROTON SPONGE; RETINAL PIGMENT EPITHELIAL; STRUCTURE/ACTIVITY RELATIONSHIP; TARGET CELLS; THERAPEUTIC APPLICATION; TRANSGENE EXPRESSION;

CELL CULTURE; CELL MEMBRANES; DRUG THERAPY; GENE EXPRESSION; GENE TRANSFER; MOLECULAR BIOLOGY; PYRIDINE;

NUCLEIC ACIDS;

1,4 DIHYDROPYRIDINE; 1,4 DIHYDROPYRIDINE 10; 1,4 DIHYDROPYRIDINE 12; 1,4 DIHYDROPYRIDINE 12 METHYL; BUFFER; MESSENGER RNA; PLASMID DNA; UNCLASSIFIED DRUG;

ACIDIFICATION; AREA UNDER THE CURVE; ARTICLE; CELL MEMBRANE; CELL MIGRATION; CELL NUCLEUS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DNA DRUG COMPLEX; DRUG DELIVERY SYSTEM; DRUG UPTAKE; ENDOCYTOSIS; ENDOSOME; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTERNALIZATION; MAXIMUM PLASMA CONCENTRATION; MEMBRANE PERMEABILITY; NONVIRAL GENE DELIVERY SYSTEM; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSGENICS;

BIOLOGICAL TRANSPORT; CELL LINE; CELL NUCLEOLUS; DIHYDROPYRIDINES; DNA; ENDOCYTOSIS; ENDOSOMES; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; HUMANS; PLASMIDS; RETINAL PIGMENT EPITHELIUM; RNA, MESSENGER; TRANSFECTION; TRANSGENES;

EID: 84864680333     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.06.013     Document Type: Article

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