Cell cycle dependent transcription, a determinant factor of heterogeneity in cationic lipid-mediated transgene expression

Journal of Gene Medicine

Volumn 9, Issue 3, 2007, Pages 197-207

  Akita, Hidetaka ^a,b   Ito, Rie ^a,b   Kamiya, Hiroyuki ^a,b   Kogure, Kentaro ^a,b   Harashima, Hideyoshi ^a,b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Gene transfer; HeLa; Heterogeneity; Non viral; Nuclear delivery; Transcription

Indexed keywords

BETA GALACTOSIDASE; PLASMID DNA;

ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL DIVISION; CELL NUCLEUS; CONTROLLED STUDY; DNA TRANSFER; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE TRANSFER; GENETIC HETEROGENEITY; HELA CELL; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; TRANSGENE; TRANSPORT KINETICS;

ACTIVE TRANSPORT, CELL NUCLEUS; BETA-GALACTOSIDASE; CATIONS; CELL CYCLE; CELL NUCLEUS; CYTOMEGALOVIRUS; DNA; HELA CELLS; HUMANS; LIPIDS; LIPOSOMES; LUCIFERASES; PLASMIDS; PROMOTER REGIONS (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSGENES;

EID: 34047108653     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1010     Document Type: Article

References (47)

1. Tseng WC, Haselton FR, Giorgio TD. Transfection by cationic liposomes using simultaneous single cell measurements of plasmid delivery and transgene expression. J Biol Chem 1997; 272: 25641-25647.
2. Wilke M, Fortunati E, van den Broek M, et al. Efficacy of a peptide-based gene delivery system depends on mitotic activity. Gene Ther 1996; 3: 1133-1142.
3. Newgard CB, Hwang PK, Fletterick RJ. The family of glycogen phosphorylases: structure and function. Crit Rev Biochem Mol Biol 1989; 24: 69-99.
4. Scholl B, Gervaz P, Martinet O, et al. Adenovirus-mediated gene transfer into selected liver segments using a vascular exclusion technique. Eur Surg Res 2001; 33: 348-354.
5. Brunner S, Furtbauer E, Sauer T, et al. Overcoming the nuclear barrier: cell cycle independent nonviral gene transfer with linear polyethylenimine or electroporation. Mol Ther 2002; 5: 80-86.
6. Brunner S, Sauer T, Carotta. S, et al. Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus. Gene Ther 2000; 7: 401-407.
7. Escriou V, Carriere M, Bussone F, et al. Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer. J Gene Med 2001; 3: 179-187.
8. Mortimer I, Tam P, MacLachlan I, et al. Cationic lipid-mediated transfection of cells in culture requires mitotic activity. Gene Ther 1999; 6: 403-411.
9. Tseng WC, Haselton FR, Giorgio TD. Mitosis enhances transgene expression of plasmid delivered by cationic liposomes. Biochim Biophys Acta 1999; 1445: 53-64.
10. James MB, Giorgio TD. Nuclear-associated plasmid, but not cell-associated plasmid, is correlated with transgene expression in cultured mammalian cells. Mol Ther 2000; 1: 339-346.
11. Greber UF, Suomalainen M, Stidwill RP, et al. The role of the nuclear pore complex in adenovirus DNA entry. EMBO J 1997; 16: 5998-6007.
12. Greber UF, Willetts M, Webster P, et al. Stepwise dismantling of adenovirus 2 during entry into cells. Cell 1993; 75: 477-486.
13. Trotman LC, Mosberger N, Fornerod M, et al. import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1. Nat Cell Biol 2001; 3: 1092-1100.
14. Akita H, Ito R. Khalil IA, et al. Quantitative three-dimensional analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene delivery system using confocal laser scanning microscopy. Mol Ther 2004; 9: 443-451.
15. Nakao M. Epigenetics: interaction of DNA methylation and chromatin. Gene 2001; 278: 25-31.
16. Umlauf D, Goto Y, Feil R. Site-specific analysis of histone methylation and acetylation. Methods Mol Biol 2004; 287: 99-120.
17. Brooks AR, Harkins RN, Wang P, et al. Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle. J Gene Med 2004; 6: 395-404.
18. Singal R, Ferris R, Little JA, et al. Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells. Proc Natl Acad Sci USA 1997; 94: 13724-13729.
19. Carmo-Fonseca M. The contribution of nuclear compartmentalization to gene regulation. Cell 2002; 108: 513-521.
20. Gasser SM. Visualizing chromatin dynamics in interphase nuclei. Science 2002; 296: 1412-1416.
21. Stein GS, Zaidi SK, Braastad CD, et al. Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair. Trends Cell Biol 2003; 13: 584-592.
22. Ochiai H, Harashima H, Kamiya H. Intranuclear disposition of exogenous DNA in vivo: silencing, methylation and fragmentation. FEBS Lett 2006; 580: 918-922.
23. Ochiai H. Harashima H, Kamiya H. Silencing of exogenous DNA in cultured cells. Biol Pharm Bull 2006; 29: 1294-1296.
24. Sasaki K, Murakami T, Kawasaki M. et al. The cell cycle associated change of the Ki-67 reactive nuclear antigen expression.,J Cell Physiol 1987; 133: 579-584.
25. Wersto RP, Chrest FJ, Leary JF, et al. Doublet discrimination in DNA cell-cycle analysis. Cytometry 2001; 46: 296-306.
26. Ito K, Suzuki H, Hirohashi T, et al. Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. J Biol Chem 1998; 273: 1684-1688.
27. Leclerc GM, Boockfor FR, Faught WJ, et al. Development of a destabilized firefly luciferase enzyme for measurement of gene expression. Biotechniques 2000; 29: 590-591, 594-S96, 598 passim.
28. Thompson JF, Hayes LS, Lloyd DB. Modulation of firefly luciferase stability and impact on studies of gene regulation. Gene 1991; 103: 171-177.
29. Yamada Y, Kamiya H, Harashima. H. Kinetic analysis of protein production after DNA transfection. Int J Pharm 2005; 299: 34-40.
30. Zabner J, Fasbender AJ, Moninger T, et al. Cellular and molecular barriers to gene transfer by a cationic lipid. J Biol Chem 1995; 270: 18997-19007.
31. Hama S, Akita H, Ito R, et al. Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems. Mol Ther 2006; 13: 786-794.
32. Fasbender A, Zabner J, Zeiher BG, et al. A low rate of cell proliferation and reduced DNA uptake limit cationic lipid-mediated gene transfer to primary cultures of ciliated human airway epithelia., Gene Ther 1997; 4: 1173-1180.
33. Jiang C, O'Connor SP, Fang SL, et al. Efficiency of cationic lipid-mediated transfection of polarized and differentiated airway epithelial cells in vitro and in vivo. Hum Gene Ther 1998; 9: 1531-1542.
34. Seidman MA, Hogan SM, Wendland RL, et al. Variation in adenovirus receptor expression and adenovirus vector-mediated transgene expression at defined stages of the cell cycle. Mol Ther 2001; 4: 13-21.
35. Koc A, Wheeler LJ, Mathews CK, et al. Hydroxyurea arrests DNA replication by a mechanism that preserves basal dNTP pools. J Biol Chem 2004; 279: 223-230.
36. Kumar S, Dodson GE, Trinh A, et al. ATR activation necessary but not sufficient for p53 induction and apoptosis in hydroxyurea-hypersensitive myeloid leukemia cells. Cell Cycle 2005; 4: 1667-1674.
37. Fingerman IM, Briggs SD. p53-mediated transcriptional activation: from test tube to cell. Cell 2004; 117: 690-691.
38. Pante N, Kann M. Nuclear pore complex is able to transport macromolecules with diameters of about 39 nm. Mol Biol Cell 2002; 13: 425-434.
39. Kamiya H, Fujimura Y, Matsuoka I, et al. Visualization of intracellular trafficking of exogenous DNA delivered by cationic liposomes. Biochem Biophys Res Commun 2002; 298: 591-597.
40. Friend DS, Papahadjopoulos D, Debs P.J. Endocytosis and intracellular processing accompanying transfection mediated by cationic liposomes. Biochim Biophys Acta 1996; 1278: 41-50.
41. Daum G. Lipids of mitochondria. Biochim Biophys Acta 1985; 822: 1-42.
42. Suomalainen M, Nakano MY, Boucke K, et al. Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus. EMBO J 2001; 20: 1310-1319.
43. Suomalainen M, Nakano MY, Keller S, et al. Microtubule-dependent plus and minus end-directed motilities are competing processes for nuclear targeting of adenovirus. J Cell Biol 1999; 144: 657-672.
44. Pollard H, Remy JS, Loussouarn G, et al. Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells. J Biol Chem 1998; 273: 7507-7511.
45. Tachibana R, Harashima H, Ishida T, et al. Effect of cationic liposomes in an in vitro transcription and translation system. Biol Pharm Bull 2002; 25: 529-531.
46. Heintz N, Sive HL, Roeder RG. Regulation of human histone gene expression: kinetics of accumulation and changes in the rate of synthesis and in the half-lives of individual histone mRNAs during the HeLa cell cycle. Mol Cell Biol 1983; 3: 539-550.
47. Sittman DB, Graves RA, Marzluff WF. Histone mRNA concentrations are regulated at the level of transcription and mRNA degradation. Proc Natl Acad Sci USA 1983; 80: 1849-1853.