Flotillin-dependent endocytosis and a phagocytosis-like mechanism for cellular internalization of disulfide-based poly(amido amine)/DNA polyplexes

Biomaterials

Volumn 32, Issue 11, 2011, Pages 3072-3084

  Vercauteren, Dries ^a   Piest, Martin ^b   van der Aa, Leonardus J ^b   Al Soraj, Monerah ^c   Jones, Arwyn T ^c   Engbersen, Johan F J ^b   De Smedt, Stefaan C ^a   Braeckmans, Kevin ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF TWENTE   (Netherlands)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Endocytosis; Non viral gene delivery; Polyplexes; Retinal pigment epithelium

Indexed keywords

BISACRYLAMIDE; CELL-SURFACE HEPARAN; CELLULAR ATTACHMENTS; CELLULAR DYNAMICS; CELLULAR INTERNALIZATION; COLOCALIZATION; CYSTAMINE; ENDOCYTIC PATHWAYS; ENDOCYTIC PROTEINS; ENDOCYTOSIS; ENDOCYTOSIS PATHWAY; GENE DELIVERY; IN-VITRO; LIVE CELL; NON-VIRAL GENE DELIVERY; NONVIRAL; POLY(AMIDO AMINE); POLYADDITION; POLYPLEXES; PROTEOGLYCANS; RETINAL PIGMENT EPITHELIUM; RPE CELL; SULFATE GROUPS; TARGET CELLS;

ALDEHYDES; ANTIGEN-ANTIBODY REACTIONS; CELL MEMBRANES; ENZYME ACTIVITY; GENE TRANSFER; MOLECULAR BIOLOGY; NUCLEIC ACIDS; OPHTHALMOLOGY; ORGANIC COMPOUNDS;

GENE THERAPY;

1 AMINO 4 BUTANOL; ACRYLAMIDE; ACTIN; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 6; AMINE; BUTANOL; CAVEOLIN 1; CLATHRIN; DISULFIDE; DYNAMIN; FLOTILLIN 1; N,N CYSTAMINE BISACRYLAMIDE; P21 ACTIVATED KINASE 1; POLY (AMINO AMINE); PROTEOHEPARAN SULFATE; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL MEMBRANE; CELL SURFACE; CHOLESTEROL BLOOD LEVEL; ENDOCYTOSIS; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE TARGETING; GENE THERAPY; HEAVY CHAIN; HUMAN; HUMAN CELL; INTERNALIZATION; MICROTUBULE; PHAGOCYTOSIS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RNA INTERFERENCE;

ANIMALS; CATTLE; CELL LINE; CELLS, CULTURED; DISULFIDES; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOCYTOSIS; FLOW CYTOMETRY; HUMANS; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; PHAGOCYTOSIS; POLYAMINES; TRANSFECTION;

EID: 79951579332     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.12.045     Document Type: Article

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