Transition state analysis of enolpyruvylshikimate 3-phosphate (EPSP) synthase (AroA)-catalyzed EPSP hydrolysis

Journal of the American Chemical Society

Volumn 134, Issue 31, 2012, Pages 12958-12969

  Lou, Meiyan ^a   Burger, Steven K ^a   Gilpin, Meghann E ^a   Gawuga, Vivian ^a   Capretta, Alfredo ^a   Berti, Paul J ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACID-CATALYZED REACTIONS; ACTIVE SITE; BOND FORMATION; BOND ORDERS; CARBON ATOMS; CATION INTERMEDIATES; CHARGED AMINO ACIDS; COMPUTATIONAL MODEL; ENERGETIC BARRIERS; HAMMOND; INORGANIC PHOSPHATES; KINETIC ISOTOPE EFFECTS; METHYLENE CARBONS; PHOSPHOENOLPYRUVATES; POSITIVE CHARGES; PROTONATING; REVERSE REACTIONS; STRONG COUPLING; SYNTHASES; TRANSITION STATE;

AMINO ACIDS; C (PROGRAMMING LANGUAGE); CARBON; CATALYSIS; DEUTERIUM; HYDROLYSIS; POSITIVE IONS; PROTONATION; THERMODYNAMICS;

REACTION INTERMEDIATES;

3 PHOSPHOSHIKIMATE 1 CARBOXYVINYLTRANSFERASE; ENOLPYRUVYLSHIKIMATE 3 PHOSPHATE; SHIKIMIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CHEMICAL REACTION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; HYDROLYSIS; MATHEMATICAL MODEL; PROTON TRANSPORT;

3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE; CARBON RADIOISOTOPES; CATALYSIS; CATALYTIC DOMAIN; COMPUTER SIMULATION; DEUTERIUM; MODELS, CHEMICAL; OXYGEN ISOTOPES; PHOSPHOENOLPYRUVATE; SHIKIMIC ACID; STATIC ELECTRICITY;

EID: 84864667677     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja304339h     Document Type: Article

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