Nonenzymatic breakdown of the tetrahedral (α-carboxyketal phosphate) intermediates of MurA and AroA, two carboxyvinyl transferases. Protonation of different functional groups controls the rate and fate of breakdown

Journal of the American Chemical Society

Volumn 125, Issue 41, 2003, Pages 12541-12550

  Byczynski, Bartosz ^a,b   Mizyed, Shehadeh ^a,b   Berti, Paul J ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CHEMICAL BONDS; DEUTERIUM; IONIZATION; PHOSPHATES; REACTION KINETICS;

PROTONATION;

ENZYME KINETICS;

ACETAL DERIVATIVE; CARBOXYL GROUP; CARBOXYVINYLTRANSFERASE; DEUTERIUM; ESTER DERIVATIVE; FUNCTIONAL GROUP; HYDROXYL GROUP; METHANOL; PHOSPHATE; PROTEIN AROA; PROTEIN MURA; PYRUVIC ACID; SHIKIMIC ACID DERIVATIVE; TRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL BOND; DEGRADATION; ELIMINATION REACTION; IONIZATION; PH; PKA; PROTON TRANSPORT; REACTION ANALYSIS;

3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE; ALKYL AND ARYL TRANSFERASES; BUFFERS; HYDROGEN-ION CONCENTRATION; KINETICS; PROTONS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0141919817     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0349655     Document Type: Article

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