Interaction of phosphonate analogues of the tetrahedral reaction intermediate with 5-enolpyruvylshikimate-3-phosphate synthase in atomic detail

Biochemistry

Volumn 44, Issue 9, 2005, Pages 3241-3248

  Priestman, Melanie A ^a   Healy, Martha L ^a   Becker, Andreas ^a   Alberg, David G ^b   Bartlett, Paul A ^b   Lushington, Gerald H ^a   Schönbrunn, Ernst ^a,c  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; ENZYME KINETICS; ESCHERICHIA COLI; HERBICIDES; PLANTS (BOTANY); REACTION KINETICS;

BROAD-SPECTRUM HERBICIDE GLYPHOSATE; DIASTEREOMERS; OPEN-CLOSED TRANSITION; STRUCTURAL ALTERATIONS;

PHOSPHORUS COMPOUNDS;

3 PHOSPHOSHIKIMATE 1 CARBOXYVINYLTRANSFERASE; LIGAND; PHOSPHOENOLPYRUVATE; PHOSPHONIC ACID DERIVATIVE; SHIKIMIC ACID; SHIKIMIC ACID 3 PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; ATOM; CALCULATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DIASTEREOISOMER; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STRUCTURE; ESCHERICHIA COLI; INHIBITION KINETICS; MATHEMATICAL ANALYSIS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; STEADY STATE;

3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE; ALKYL AND ARYL TRANSFERASES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; KINETICS; LIGANDS; PHOSPHONIC ACIDS; PROTEIN CONFORMATION; STEREOISOMERISM; THERMODYNAMICS;

EID: 14644427142     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi048198d     Document Type: Article

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