Expression and activation of MMP -2, -3, -9, -14 are induced in rat colon after abdominal X-irradiation

Scandinavian Journal of Gastroenterology

Volumn 41, Issue 1, 2006, Pages 60-70

  Strup Perrot, Carine ^a   Vozenin Brotons, Marie Catherine ^a   Vandamme, Marie ^a   Benderitter, Marc ^a   Mathe, Denis ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

Author keywords

Colon; Cytokines; Irradiation; Matrix metalloproteinases

Indexed keywords

GELATINASE A; GELATINASE B; INTERLEUKIN 1BETA; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; PLASMIN; PLASMINOGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TUMOR NECROSIS FACTOR ALPHA;

ABDOMEN; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; COLON; COLON MUCOSA; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; EXTRACELLULAR FLUID; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; IONIZING RADIATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; X IRRADIATION; X RAY; ZYMOGRAPHY;

ANIMALS; COLON; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; INTERLEUKIN-1; INTESTINAL MUCOSA; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; PLASMINOGEN ACTIVATOR INHIBITOR 1; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 29744447032     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520510023963     Document Type: Article

References (26)

1. Hauer-Jensen M, Wang J, Denham JW. Bowel injury: current and evolving management strategies. Semin Radiat Oncol 2003;13:357-71.
2. Denton AS, Andreyev HJ, Forbes A, Maher EJ. Systematic review for non-surgical interventions for the management of late radiation proctitis. Br J Cancer 2002;87:134-43.
3. Hovdenak N, Fajardo LF, Hauer-Jensen M. Acute radiation proctitis: a sequential clinicopathologic study during pelvic radiotherapy. Int J Radiat Oncol Biol Phys 2000;48:1111-7.
4. Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 2001;17:463-516.
5. Nagase H, Woessner JF Jr. Matrix metalloproteinases. J Biol Chem 1999;274:21491-4.
6. Wang Z, Juttermann R, Soloway PD. TIMP-2 is required for efficient activation of proMMP-2 in vivo. J Biol Chem 2000;275:26411-5.
7. Baker AH, Edwards DR, Murphy G. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J Cell Sci 2002;115:3719-27.
8. Seifert WF, Wobbes T, Hoogenhout J, de Man BM, Hendriks T. Intra-operative irradiation prolongs the presence of matrix metalloproteinase activity in large bowel anastomoses of the rat. Radiat Res 1997;147:354-61.
9. Hovdenak N, Wang J, Sung CC, Kelly T, Fajardo LF, Hauer-Jensen M. Clinical significance of increased gelatinolytic activity in the rectal mucosa during external beam radiation therapy of prostate cancer. Int J Radiat Oncol Biol Phys 2002;53:919-27.
10. Kumar A, Collins HM, Scholefield JH, Watson SA. Increased type-IV collagenase (MMP-2 and MMP-9) activity following preoperative radiotherapy in rectal cancer. Br J Cancer 2000;82:960-5.
11. Raab Y, Gerdin B, Ahlstedt S, Hallgren R. Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin-8 in ulcerative colitis. Gut 1993;34:1203-6.
12. Rogler G, Gelbmann CM, Vogl D, Brunner M, Scholmerich J, Falk W, et al. Differential activation of cytokine secretion in primary human colonie fibroblast/myofibroblast cultures. Scand J Gastroenterol 2001;36:389-98.
13. Kleiner DE, Stetler-Stevenson WG. Quantitative zymography: detection of picogram quantities of gelatinases. Anal Biochem 1994;218:325-9.
14. Strup-Perrot C, Mathe D, Linard C, Violot D, Milliat F, Francois A, et al. Global gene expression profiles reveal an increase in mRNA levels of collagens, MMPs, and TIMPs in late radiation enteritis. Am J Physiol Gastrointest Liver Physiol 2004;287:G875-85.
15. Linard C, Ropenga A, Vozenin-Brotons MC, Chapel A, Mathe D. Abdominal irradiation increases inflammatory cytokine expression and activates NF-kappaB in rat ileal muscularis layer. Am J Physiol Gastrointest Liver Physiol 2003;285:G556-65.
16. MacNaughton WK, Leach KE, Prud'homme-Lalonde L, Ho W, Sharkey KA. Ionizing radiation reduces neurally evoked electrolyte transport in rat ileum through a mast cell-dependent mechanism. Gastroenterology 1994;106:324-35.
17. Rao JS, Rayford A, Yamamoto M, Ang KK, Tofilon P, Sawaya R. Modulation of fibrinolysis by ionizing radiation. J Neurooncol 1994;22:161-71.
18. Boothman DA, Wang M, Lee SW. Induction of tissue-type plasminogen activator by ionizing radiation in human malignant melanoma cells. Cancer Res 1991;51:5587-95.
19. Sawaya R, Rayford A, Kono S, Ang KK, Feng Y, Stephens LC, et al. Elevated levels of plasminogen activators in the pathogenesis of delayed radiation damage in rat cervical spinal cord in vivo. Radiat Res 1994;138:386-91.
20. Bailey CJ, Hembry RM, Alexander A, Irving MH, Grant ME, Shuttleworth CA. Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, collagenase in Crohn's disease and normal intestine. J Clin Pathol 1994;47:113-6.
21. Baugh MD, Perry MJ, Hollander AP, Davies DR, Cross SS, Lobo AJ, et al. Matrix metalloproteinase levels are elevated in inflammatory bowel disease. Gastroenterology 1999;117:814-22.
22. Heuschkel RB, MacDonald TT, Monteleone G, Bajaj-Elliott M, Smith JA, Pender SL. Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease. Gut 2000;47:57-62.
23. Louis E, Ribbens C, Godon A, Franchimont D, De Groote D, Hardy N, et al. Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease. Clin Exp Immunol 2000;120:241-6.
24. Saarialho-Kere UK, Vaalamo M, Puolakkainen P, Airola K, Parks WC, Karjalainen-Lindsberg ML. Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers. Am J Pathol 1996;148:519-26.
25. Eberhardt W, Huwiler A, Beck KF, Walpen S, Pfeilschifter J. Amplification of IL-1 eta-induced matrix metalloproteinase-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-kappa B and activating protein-1 and involves activation of the mitogen-activated protein kinase pathways. J Immunol 2000;165:5788-97.
26. Medina C, Videla S, Radomski A, Radomski MW, Antolin M, Guarner F, et al. Increased activity and expression of matrix metalloproteinase-9 in a rat model of distal colitis. Am J Physiol Gastrointest Liver Physiol 2003;284:G116-22.