MicroRNAs and HIV latency: A complex and promising relationship

AIDS Reviews

Volumn 14, Issue 3, 2012, Pages 188-194

  Detsika, Maria G ^a   Psarris, Alexandros ^a   Paraskevis, Dimitrios ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Cellular; HIV; Host; MicroRNAs; Transcription

Indexed keywords

MICRORNA;

GENE EXPRESSION; GENE SILENCING; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; REVIEW; RNA TRANSLATION; VIRUS GENOME; VIRUS LATENCY;

FEMALE; GENE EXPRESSION REGULATION, VIRAL; GENE SILENCING; HIV LONG TERMINAL REPEAT; HIV SEROPOSITIVITY; HIV-1; HUMANS; MALE; MICRORNAS; PROMOTER REGIONS, GENETIC; RNA STABILITY; VIRUS LATENCY;

EID: 84864642752     PISSN: 11396121     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (74)

1. Kim V. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol. 2005;6:376-85. (Pubitemid 40637855)
2. Zamore P, Haley B. Ribo-gnome: the big world of small RNAs. Science. 2005;309:1519-24. (Pubitemid 41266468)
3. Grey F, Meyers H, White E, Spector D, Nelson J. A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication. PLoS Pathog. 2007;3:e163.
4. Knight S, Bass B. A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science. 2001;293:2269-71. (Pubitemid 32900239)
5. Kozomara A, Griffiths-Jones S. miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res. 2011;39:D152-7.
6. Mineno J, Okamoto S, Ando T, et al. The expression profile of microRNAs in mouse embryos. Nucleic Acids Res. 2006;34:1765-71.
7. Reinhart B, Weinstein E, Rhoades M, Bartel B, Bartel D. MicroRNAs in plants. Genes Dev. 2002;16:1616-26. (Pubitemid 34743323)
8. Rodriguez A, Griffiths-Jones S, Ashurst J, Bradley A. Identification of mammalian microRNA host genes and transcription units. Genome Res. 2004;14:1902-10. (Pubitemid 39386503)
9. Du T, Zamore P. microPrimer: the biogenesis and function of microRNA. Development. 2005;132:4645-52. (Pubitemid 41685275)
10. Landthaler M, Yalcin A, Tuschl T. The human DiGeorge syndrome critical region gene 8 and its D melanogaster homolog are required for miRNA biogenesis. Curr Biol. 2004;14:2162-7. (Pubitemid 39623200)
11. Yi R, Qin Y, Macara I, Cullen B. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 2003;17:3011-16. (Pubitemid 38040764)
12. Bernstein E, Caudy A, Hammond S, Hannon G. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature. 2001;409:363-6. (Pubitemid 32151243)
13. Provost P, Dishart D, Doucet J, Frendewey D, Samuelsson B, Radmark O. Ribonuclease activity and RNA binding of recombinant human Dicer. EMBO J. 2002;21:5864-74. (Pubitemid 35315284)
14. Zhang H, Kolb F, Brondani V, Billy E, Filipowicz W. Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J. 2002;21:5875-85. (Pubitemid 35315285)
15. Chendrimada T, Gregory RI, Kumaraswamy E, et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature. 2005;436:740-4. (Pubitemid 41117280)
16. Schwarz D, Hutvagner G, Du T, Xu Z, Aronin N, Zamore P. Asymmetry in the assembly of the RNAi enzyme complex. Cell. 2003;115:199-208. (Pubitemid 37329583)
17. Matranga C, Tomari Y, Shin C, Bartel D, Zamore P. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell. 2005;123:607-20. (Pubitemid 41608464)
18. Bartel D. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:281-97.
19. Hannon G. RNA interference. Nature. 2002;418:244-51. (Pubitemid 34773784)
20. Liu J, Carmell MA, Rivas FV, et al. Argonaute2 is the catalytic engine of mammalian RNAi. Science. 2004;305:1437-41. (Pubitemid 39167657)
21. Mansfield J, Harfe BD, Nissen R, et al. MicroRNA-responsive 'sensor'transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004;36:1079-83. (Pubitemid 41184469)
22. Yekta S, Shih I, Bartel D. MicroRNA-directed cleavage of HOXB8 mRNA. Science. 2004;304:594-6. (Pubitemid 38541919)
23. Pfeffer S, Zavolan M, Grässer FA, et al. Identification of virus-encoded microRNAs. Science. 2004;304:734-6. (Pubitemid 38560879)
24. Olsen P, Ambros V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev Biol. 1999;216:671-80. (Pubitemid 30013313)
25. Doench J, Petersen C, Sharp P. siRNAs can function as miRNAs. Genes Dev. 2003;17:438-42. (Pubitemid 36258757)
26. Lewis B, Burge C, Bartel D. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120:15-20. (Pubitemid 40094598)
27. Liu J, Valencia-Sanchez M, Hannon G, Parker R. MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol. 2005;7:719-23. (Pubitemid 40975754)
28. Hall I, Shankaranarayana G, Noma K, Ayoub N, Cohen A, Grewal S. Establishment and maintenance of a heterochromatin domain. Science. 2002;297:2232-7.
29. Matzke M, Birchler J. RNAi-mediated pathways in the nucleus. Nat Rev Genet. 2005;6:24-35. (Pubitemid 39657895)
30. Volpe T, Kidner C, Hall I, Teng G, Grewal S, Martienssen R. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science. 2002;297:1833-7. (Pubitemid 35024336)
31. Bernstein E, Kim SY, Carmell M, et al. Dicer is essential for mouse development. Nat Genet. 2003;35:215-17. (Pubitemid 37363172)
32. Wienholds E, Koudijs M, van Eeden F, Cuppen E, Plasterk R. The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nat Genet. 2003;35:217-18. (Pubitemid 37363173)
33. Hatfield S, Shcherbata H, Fischer K, Nakahara K, Carthew R, Ruohola-Baker H. Stem cell division is regulated by the microRNA pathway. Nature. 2005;435:974-8. (Pubitemid 40896325)
34. Poy M, Eliasson L, Krutzfeldt J, et al. A pancreatic islet-specific microRNA regulates insulin secretion. Nature. 2004;432:226-30. (Pubitemid 39545853)
35. Stark A, Brennecke J, Russell R, Cohen S. Identification of Drosophila MicroRNA targets. PLoS Biol. 2003;1:E60.
36. Lum A, Wang B, Li L, Channa N, Bartha G, Wabl M. Retroviral activation of the mir-106a microRNA cistron in T lymphoma. Retrovirology. 2007;4:5.
37. Wang C, Wang BB, Bartha G, et al. Activation of an oncogenic microRNA cistron by provirus integration. Proc Natl Acad Sci USA. 2006;103:18680-4. (Pubitemid 44913470)
38. Scaria V, Jadhav V. microRNAs in viral oncogenesis. Retrovirology. 2007;4:82.
39. Taganov K, Boldin M, Chang K, Baltimore D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA. 2006;103:12481-6. (Pubitemid 44267285)
40. Lecellier C, Dunoyer P, Arar K, et al. A cellular microRNA mediates antiviral defense in human cells. Science. 2005;308:557-60. (Pubitemid 40570587)
41. Song L, Liu H, Gao S, Jiang W, Huang W. Cellular microRNAs inhibit replication of the H1N1 influenza A virus in infected cells. J Virol. 2010;84:8849-60.
42. Cai X, Lu S, Zhang Z, Gonzalez C, Damania B, Cullen B. Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc Natl Acad Sci USA. 2005;102:5570-5. (Pubitemid 40530298)
43. Klase Z; Kale P, Winograd R, et al. HIV-1 TAR element is processed by Dicer to yield a viral micro-RNA involved in chromatin remodeling of the viral LTR. BMC Mol Biol. 2007;8:63.
44. Sierra S, Kupfer B, Kaiser R. Basics of the virology of HIV-1 and its replication. J Clin Virol. 2005;34:233-44. (Pubitemid 41605438)
45. Harrich D, Hooker C, Parry E. The human immunodeficiency virus type 1 TAR RNA upper stem-loop plays distinct roles in reverse transcription and RNA packaging. J Virol. 2000;74:5639-46. (Pubitemid 30346598)
46. Provost P, Barat C, Plante I, Tremblay M. HIV-l and the microRNAguided silencing pathway: an intricate and multifaceted encounter. Virus Res. 2006;121:107-15. (Pubitemid 44444849)
47. Emerman M, Malim M. HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology. Science. 1998;280:1880-4. (Pubitemid 28299384)
48. Jeang K, Xiao H, Rich E. Multifaceted activities of the HIV-1 transactivator of transcription, Tat. J Biol Chem. 1999;274:28837-40.
49. Pollard V, Malim M. The HIV-1 Rev protein. Annu Rev Microbiol. 1998;52:491-532. (Pubitemid 28481200)
50. Bennasser Y, Le S, Yeung M, Jeang K. HIV-1 encoded candidate micro-RNAs and their cellular targets. Retrovirology. 2004;1:43.
51. Couturier J, Root-Bernstein R. HIV may produce inhibitory microRNAs (miRNAs) that block production of CD28, CD4 and some interleukins. J Theor Biol. 2005;235:169-84.
52. Omoto S, Fujii Y. Regulation of human immunodeficiency virus 1 transcription by nef microRNA. J Gen Virol. 2005;86:751-5. (Pubitemid 40331255)
53. Ouellet D, Plante I, Landry P, et al. Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element. Nucleic Acids Res. 2008;36:2353-65 (Pubitemid 351567008)
54. Kaul D, Flanders S, Beck J, Saint S. Brief report: incidence, etiology, risk factors, and outcome of hospital-acquired fever: a systematic, evidencebased review. J Gen Intern Med. 2006;21:1184-7.
55. Lin J, Cullen B. Analysis of the interaction of primate retroviruses with the human RNA interference machinery. J Virol. 2007;81:12218-26. (Pubitemid 350085837)
56. O'Brien WAaP, R. J. 1997. AIDS and other diseases due to HIV infection. New York: Raven Press
57. Piatak M, Saag M, Yang L, et al. 1993. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science. 1993;259:1749-54. (Pubitemid 23114661)
58. Embretson J, Zupancic M, Ribas J, et al. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature. 1993;362:359-62. (Pubitemid 23101311)
59. Peng H, Reinhart T, Retzel E, Staskus K, Zupancic M, Haase A. Single cell transcript analysis of human immunodeficiency virus gene expression in the transition from latent to productive infection. Virology. 1995;206:16-27.
60. Chun T, Justement J, Lempicki R, et al. Gene expression and viral production in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals. Proc Natl Acad Sci USA. 2003;100:1908-13. (Pubitemid 36254547)
61. Patterson B, McCallister S, Schutz M, et al. Persistence of intracellular HIV-1 mRNA correlates with HIV-1-specific immune responses in infected subjects on stable HAART. AIDS. 2001;15:1635-41. (Pubitemid 32923062)
62. Wang X, Ye L, Hou W, et al. Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection. Blood. 2009;113:671-4.
63. Sung T, Rice A. miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1. PLoS Pathog. 2009;5:e1000263.
64. Huang J, Wang F, Argyris E, et al. Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes. Nat Med. 2007;13:1241-7. (Pubitemid 47530631)
65. Lin X, Irwin D, Kanazawa S, et al. 2003. Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir. J Virol. 2003;77:8227-36. (Pubitemid 36871450)
66. Ahluwalia J, Khan S, Soni K, et al. Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication. Retrovirology. 2008;5:117.
67. Triboulet R, Mari B, Lin Y, et al. Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Science. 2007;315:1579-82. (Pubitemid 46449475)
68. Omoto S, Ito M, Tsutsumi Y, et al. HIV-1 nef suppression by virally encoded microRNA. Retrovirology. 2004;1:44.
69. Capodici J, Kariko K, Weissman D. Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference. J Immunol. 2002;169:5196-201. (Pubitemid 35217190)
70. Konstantinova P, ter Brake O, Haasnoot J, de Haan P, Berkhout B. Trans-inhibition of HIV-1 by a long hairpin RNA expressed within the viral genome. Retrovirology. 2007;4:15.
71. ter Brake O, Konstantinova P, Ceylan M, Berkhout B. Silencing of HIV-1 with RNA interference: a multiple shRNA approach. Mol Ther. 2006;14:883-92.
72. Liu Y, Haasnoot J, ter Brake O, Berkhout B, Konstantinova P. Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron. Nucleic Acids Res. 2008;36:2811-24. (Pubitemid 351737175)
73. O'Brien K, Liu J, King SL, et al. Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans. Nat Med. 2009;15:873-5.
74. A randomized, double-blind, placebo controlled safety and anti-viral proof of concept study of miravirsen, an oligonucleotide targeting miR- 122, in treatment naïve patients with genotype 1 chronic HCV infection. The Liver Meeting, San Francisco, 2011. [Abstract AASLD].