HIV-1 regulatory/accessory genes: Keys to unraveling viral and host cell biology

Science

Volumn 280, Issue 5371, 1998, Pages 1880-1884

  Emerman, Michael ^a   Malim, Michael H ^b  

^a USA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CYCLIN DEPENDENT KINASE; NEF PROTEIN; REV PROTEIN; TRANSACTIVATOR PROTEIN; VIF PROTEIN; VIRUS RNA; VPR PROTEIN; VPU PROTEIN;

ARTICLE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; RNA TRANSPORT; TRANSCRIPTION REGULATION; VIRUS CELL INTERACTION; VIRUS GENE; VIRUS REPLICATION;

ANIMALS; GENE PRODUCTS, NEF; GENE PRODUCTS, REV; GENE PRODUCTS, TAT; GENE PRODUCTS, VPU; GENES, VIRAL; HIV INFECTIONS; HIV-1; HUMANS; MEMBRANE PROTEINS; RNA, VIRAL; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; VIRAL REGULATORY PROTEINS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0032546817     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5371.1880     Document Type: Article

References (82)

1. See P. M. Sharp, D. L. Robertson, F. Gao, B. H. Hahn, AIDS 8, S27 (1994) or http://igs-server.cnrs-mrs.fr/anrs/hiv_evolution/hiv_evolution.doc.html for a description of the derivation of the five lineages and their genomic structures.
2. See J. M. Coffin, Fields Virology, B. Fields, D. M. Knipe, P. M. Howley, Eds. (Lippincott-Raven, Philadelphia, PA, ed. 3, 1996), pp. 1767-1848 or http:// www-micro.msb.le.ac.uk/335/Retroviruses.html for descriptions of the general retroviral life-cycle.
3. K. A. Jones, Genes Dev 11, 2593 (1997).
4. C. H. Herrmann and A. P. Rice, J. Virol. 69, 1612 (1995).
5. D. Reines, J. W. Conaway, R. C. Conaway, Trends Biochem. Sci. 21, 351 (1996).
6. H. S. Mancebo et al., Genes Dev. 11, 2633 (1997); X. Yang et al., Proc. Natl. Acad. Sci. U.S.A. 94, 12331 (1997); Y. Zhu et al., Genes Dev. 11, 2622 (1997).
7. H. S. Mancebo et al., Genes Dev. 11, 2633 (1997); X. Yang et al., Proc. Natl. Acad. Sci. U.S.A. 94, 12331 (1997); Y. Zhu et al., Genes Dev. 11, 2622 (1997).
8. H. S. Mancebo et al., Genes Dev. 11, 2633 (1997); X. Yang et al., Proc. Natl. Acad. Sci. U.S.A. 94, 12331 (1997); Y. Zhu et al., Genes Dev. 11, 2622 (1997).
9. P. Wei, M. E. Garber, S.-M. Fang, W. H. Fischer, K. A. Jones, Cell 92 451 (1998).
10. L. F. Garcia-Martinez et al., EMBO J. 16, 2836 (1997); T. P. Cujec et al., Genes Dev. 11, 2645 (1997); Q. Zhou and P. A. Sharp, Science 274, 605 (1996); C. Sune et al., Mol. Cell Biol. 17, 6029 (1997).
11. L. F. Garcia-Martinez et al., EMBO J. 16, 2836 (1997); T. P. Cujec et al., Genes Dev. 11, 2645 (1997); Q. Zhou and P. A. Sharp, Science 274, 605 (1996); C. Sune et al., Mol. Cell Biol. 17, 6029 (1997).
12. L. F. Garcia-Martinez et al., EMBO J. 16, 2836 (1997); T. P. Cujec et al., Genes Dev. 11, 2645 (1997); Q. Zhou and P. A. Sharp, Science 274, 605 (1996); C. Sune et al., Mol. Cell Biol. 17, 6029 (1997).
13. L. F. Garcia-Martinez et al., EMBO J. 16, 2836 (1997); T. P. Cujec et al., Genes Dev. 11, 2645 (1997); Q. Zhou and P. A. Sharp, Science 274, 605 (1996); C. Sune et al., Mol. Cell Biol. 17, 6029 (1997).
14. T. W. Chun et al., Nature 387, 183 (1997).
15. For example, the HIV-1 LTR in the presence of Tat is much stronger than the imediate early promoter from cytomegalovirus, which is considered a very strong promoter (M. Emerman, unpublished data).
16. X. Wei et al., Nature 373, 117 (1995); D. D. Ho et al., ibid., p. 123; A. S. Perelson, A. U. Neumann, M. Markowitz, J. M. Leonard, D. D. Ho, Science 271, 1582 (1996).
17. X. Wei et al., Nature 373, 117 (1995); D. D. Ho et al., ibid., p. 123; A. S. Perelson, A. U. Neumann, M. Markowitz, J. M. Leonard, D. D. Ho, Science 271, 1582 (1996).
18. X. Wei et al., Nature 373, 117 (1995); D. D. Ho et al., ibid., p. 123; A. S. Perelson, A. U. Neumann, M. Markowitz, J. M. Leonard, D. D. Ho, Science 271, 1582 (1996).
19. M. Emerman, Curr. Biol. 6, 1096 (1996).
20. W. C. Goh et al., Nature Med. 4, 65 (1998).
21. V. W. Pollard and M. H. Malim, Annu. Rev. Microbiol., in press.
22. B. Wolff, J.-J. Sanglier, Y. Wang, Chem. Biol. 4, 139 (1997).
23. N. K. Nishi et al., J. Biol. Chem. 269, 6320 (1994).
24. M. Ohno, M. Fornerod, I. W. Mattaj, Cell 92, 32 (1998).
25. M. Fornerod, M. Ohno, M. Yoshida, I. W. Mattaj, Cell 90, 1051 (1997); M. Fukuda et al., Nature 390, 308 (1997); M. Neville, F. Stutz, L. Lee, L. I. Davis, M. Rosbash, Curr. Biol. 7, 767 (1997); K. Stade, C. S. Ford, C. Guthrie, K. Weis, Cell 90, 1041 (1997).
26. M. Fornerod, M. Ohno, M. Yoshida, I. W. Mattaj, Cell 90, 1051 (1997); M. Fukuda et al., Nature 390, 308 (1997); M. Neville, F. Stutz, L. Lee, L. I. Davis, M. Rosbash, Curr. Biol. 7, 767 (1997); K. Stade, C. S. Ford, C. Guthrie, K. Weis, Cell 90, 1041 (1997).
27. M. Fornerod, M. Ohno, M. Yoshida, I. W. Mattaj, Cell 90, 1051 (1997); M. Fukuda et al., Nature 390, 308 (1997); M. Neville, F. Stutz, L. Lee, L. I. Davis, M. Rosbash, Curr. Biol. 7, 767 (1997); K. Stade, C. S. Ford, C. Guthrie, K. Weis, Cell 90, 1041 (1997).
28. M. Fornerod, M. Ohno, M. Yoshida, I. W. Mattaj, Cell 90, 1051 (1997); M. Fukuda et al., Nature 390, 308 (1997); M. Neville, F. Stutz, L. Lee, L. I. Davis, M. Rosbash, Curr. Biol. 7, 767 (1997); K. Stade, C. S. Ford, C. Guthrie, K. Weis, Cell 90, 1041 (1997).
29. H. P. Bogerd, R. A. Fridell, S. Madore, B. R. Cullen, Cell 82, 485 (1995); C. C. Fritz, M. L. Zapp, M. R. Green, Nature 376, 530 (1995); F. Stutz, M. Neville, M. Rosbash, Cell 82, 495 (1995); D. Bevec et al., Science 271, 1858 (1996).
30. H. P. Bogerd, R. A. Fridell, S. Madore, B. R. Cullen, Cell 82, 485 (1995); C. C. Fritz, M. L. Zapp, M. R. Green, Nature 376, 530 (1995); F. Stutz, M. Neville, M. Rosbash, Cell 82, 495 (1995); D. Bevec et al., Science 271, 1858 (1996).
31. H. P. Bogerd, R. A. Fridell, S. Madore, B. R. Cullen, Cell 82, 485 (1995); C. C. Fritz, M. L. Zapp, M. R. Green, Nature 376, 530 (1995); F. Stutz, M. Neville, M. Rosbash, Cell 82, 495 (1995); D. Bevec et al., Science 271, 1858 (1996).
32. H. P. Bogerd, R. A. Fridell, S. Madore, B. R. Cullen, Cell 82, 485 (1995); C. C. Fritz, M. L. Zapp, M. R. Green, Nature 376, 530 (1995); F. Stutz, M. Neville, M. Rosbash, Cell 82, 495 (1995); D. Bevec et al., Science 271, 1858 (1996).
33. U. Schubert et al., J. Virol. 72, 2280 (1998).
34. F. Margottin et al., Mol. Cell 1, 565 (1998).
35. B. Crise, L. Buonocore, J. K. Rose, J. Virol. 64, 5585 (1990).
36. M. E. Greenberg et al., EMBO J. 16, 6964 (1997); Le Gall et al., Immunity 8, 1 (1998); V. Piguet et al., EMBO J. 17, 2472 (1998).
37. M. E. Greenberg et al., EMBO J. 16, 6964 (1997); Le Gall et al., Immunity 8, 1 (1998); V. Piguet et al., EMBO J. 17, 2472 (1998).
38. M. E. Greenberg et al., EMBO J. 16, 6964 (1997); Le Gall et al., Immunity 8, 1 (1998); V. Piguet et al., EMBO J. 17, 2472 (1998).
39. M. Foti et al., J. Cell Biol. 139, 37 (1997).
40. R. L. Willey, F. Maldarelli, M. A. Martin, K. Strebel, J. Virol. 66, 226 (1992).
41. T. Kerkau et al., J. Exp. Med. 185, 1295 (1997); O. Schwartz, V. Marechal, S. Le Gall, F. Lemonnier, J. M. Heard, Nature Med. 2, 338 (1996); K. L. Collins, B. K. Chen, S. A. Kalams, B. D. Walker, D. Baltimore, Nature 391, 397 (1998).
42. T. Kerkau et al., J. Exp. Med. 185, 1295 (1997); O. Schwartz, V. Marechal, S. Le Gall, F. Lemonnier, J. M. Heard, Nature Med. 2, 338 (1996); K. L. Collins, B. K. Chen, S. A. Kalams, B. D. Walker, D. Baltimore, Nature 391, 397 (1998).
43. T. Kerkau et al., J. Exp. Med. 185, 1295 (1997); O. Schwartz, V. Marechal, S. Le Gall, F. Lemonnier, J. M. Heard, Nature Med. 2, 338 (1996); K. L. Collins, B. K. Chen, S. A. Kalams, B. D. Walker, D. Baltimore, Nature 391, 397 (1998).
44. D. Braaten, E. K. Franke, J. Luban, J. Virol. 70, 3551 (1996).
45. T. R. Gamble et al., Cell 87, 1285 (1996); D. Braaten et al., J. Virol. 70, 5170 (1996); A. Bukovsky, A. Weimann, M. A. Accola, H. G. Gottlinger, Proc. Natl. Acad. Sci. U.S.A. 94, 10943 (1997).
46. T. R. Gamble et al., Cell 87, 1285 (1996); D. Braaten et al., J. Virol. 70, 5170 (1996); A. Bukovsky, A. Weimann, M. A. Accola, H. G. Gottlinger, Proc. Natl. Acad. Sci. U.S.A. 94, 10943 (1997).
47. T. R. Gamble et al., Cell 87, 1285 (1996); D. Braaten et al., J. Virol. 70, 5170 (1996); A. Bukovsky, A. Weimann, M. A. Accola, H. G. Gottlinger, Proc. Natl. Acad. Sci. U.S.A. 94, 10943 (1997).
48. J. Luban, Cell 87, 1157 (1996); T. R. Gamble, et al., ibid., p. 1285.
49. J. Luban, Cell 87, 1157 (1996); T. R. Gamble, et al., ibid., p. 1285.
50. C. Cartier et al., J. Virol. 71, 4832 (1997); J.-M. Jacque et al., EMBO J. 17, 2607 (1998).
51. C. Cartier et al., J. Virol. 71, 4832 (1997); J.-M. Jacque et al., EMBO J. 17, 2607 (1998).
52. H. M. Simon and M. H. Malim, J. Virol. 70, 5297 (1996); J. H. Simon et al., ibid. 71, 5259 (1997); P. Sova and D. J. Volsky, ibid. 67, 6322 (1993); U. von Schwedler, J. Song, C. Aiken, D. Trono, ibid., p. 4945; J. Goncalves, Y. Korin, J. Zack, D. Gabuzda, ibid. 70, 8701 (1996).
53. H. M. Simon and M. H. Malim, J. Virol. 70, 5297 (1996); J. H. Simon et al., ibid. 71, 5259 (1997); P. Sova and D. J. Volsky, ibid. 67, 6322 (1993); U. von Schwedler, J. Song, C. Aiken, D. Trono, ibid., p. 4945; J. Goncalves, Y. Korin, J. Zack, D. Gabuzda, ibid. 70, 8701 (1996).
54. H. M. Simon and M. H. Malim, J. Virol. 70, 5297 (1996); J. H. Simon et al., ibid. 71, 5259 (1997); P. Sova and D. J. Volsky, ibid. 67, 6322 (1993); U. von Schwedler, J. Song, C. Aiken, D. Trono, ibid., p. 4945; J. Goncalves, Y. Korin, J. Zack, D. Gabuzda, ibid. 70, 8701 (1996).
55. H. M. Simon and M. H. Malim, J. Virol. 70, 5297 (1996); J. H. Simon et al., ibid. 71, 5259 (1997); P. Sova and D. J. Volsky, ibid. 67, 6322 (1993); U. von Schwedler, J. Song, C. Aiken, D. Trono, ibid., p. 4945; J. Goncalves, Y. Korin, J. Zack, D. Gabuzda, ibid. 70, 8701 (1996).
56. H. M. Simon and M. H. Malim, J. Virol. 70, 5297 (1996); J. H. Simon et al., ibid. 71, 5259 (1997); P. Sova and D. J. Volsky, ibid. 67, 6322 (1993); U. von Schwedler, J. Song, C. Aiken, D. Trono, ibid., p. 4945; J. Goncalves, Y. Korin, J. Zack, D. Gabuzda, ibid. 70, 8701 (1996).
57. C. Aiken and D. Trono, ibid. 69, 5048 (1995); O. Schwartz, V. Marechal, O. Danos, J. M. Heard, ibid., p. 4053.
58. C. Aiken and D. Trono, ibid. 69, 5048 (1995); O. Schwartz, V. Marechal, O. Danos, J. M. Heard, ibid., p. 4053.
59. C. Aiken, ibid. 71, 5871 (1997); T. Luo, J. L. Douglas, R. L. Livingston, J. V. Garcia, Virology 241, 224 (1998).
60. C. Aiken, ibid. 71, 5871 (1997); T. Luo, J. L. Douglas, R. L. Livingston, J. V. Garcia, Virology 241, 224 (1998).
61. The Fv-1 locus itself appears to have originated from another class of retroviruses [S. Best, P. Le Tissier, G. Towers, J. P. Stoye, Nature 382, 826 (1996); J. M. Coffin, ibid., p. 762].
62. The Fv-1 locus itself appears to have originated from another class of retroviruses [S. Best, P. Le Tissier, G. Towers, J. P. Stoye, Nature 382, 826 (1996); J. M. Coffin, ibid., p. 762].
63. O. Schwartz, V. Marechal, B. Friguet, F. Arenzana-Seisdedos, J.-M. Heard. J. Virol. 72 3845 (1998).
64. K. Mori, D. J. Ringler, R. C. Desrosiers, ibid. 67, 2807 (1993); B. Chackerian, E. M. Long, P. A. Luciw, J. Overbaugh, ibid. 71, 3932 (1997).
65. K. Mori, D. J. Ringler, R. C. Desrosiers, ibid. 67, 2807 (1993); B. Chackerian, E. M. Long, P. A. Luciw, J. Overbaugh, ibid. 71, 3932 (1997).
66. P. F. Lewis and M. Emerman, ibid. 68, 510 (1994); T. Roe, T. C. Reynolds, G. Yu, P. O. Brown, EMBO J. 12, 2099 (1993); M. I. Bukrinsky et al., Proc. Natl. Acad. Sci. U.S.A. 89, 6580 (1992); P. Lewis, M. Hensel, M. Emerman, EMBO J. 11, 3053 (1992).
67. P. F. Lewis and M. Emerman, ibid. 68, 510 (1994); T. Roe, T. C. Reynolds, G. Yu, P. O. Brown, EMBO J. 12, 2099 (1993); M. I. Bukrinsky et al., Proc. Natl. Acad. Sci. U.S.A. 89, 6580 (1992); P. Lewis, M. Hensel, M. Emerman, EMBO J. 11, 3053 (1992).
68. P. F. Lewis and M. Emerman, ibid. 68, 510 (1994); T. Roe, T. C. Reynolds, G. Yu, P. O. Brown, EMBO J. 12, 2099 (1993); M. I. Bukrinsky et al., Proc. Natl. Acad. Sci. U.S.A. 89, 6580 (1992); P. Lewis, M. Hensel, M. Emerman, EMBO J. 11, 3053 (1992).
69. P. F. Lewis and M. Emerman, ibid. 68, 510 (1994); T. Roe, T. C. Reynolds, G. Yu, P. O. Brown, EMBO J. 12, 2099 (1993); M. I. Bukrinsky et al., Proc. Natl. Acad. Sci. U.S.A. 89, 6580 (1992); P. Lewis, M. Hensel, M. Emerman, EMBO J. 11, 3053 (1992).
70. M. Stevenson, Trends Cell Biol. 6, 9 (1996); P. Gallay, T. Hope, D. Chin, D. Trono, Proc. Natl. Acad. Sci. USA. 94, 9825 (1997); P. Gallay, V. Stitt, C. Mundy, M. Oettinger, D. Trono, J. Virol. 70, 1027 (1996); R. A. M. Fouchier and M. H. Malim, Sem. Virol., in press.
71. M. Stevenson, Trends Cell Biol. 6, 9 (1996); P. Gallay, T. Hope, D. Chin, D. Trono, Proc. Natl. Acad. Sci. USA. 94, 9825 (1997); P. Gallay, V. Stitt, C. Mundy, M. Oettinger, D. Trono, J. Virol. 70, 1027 (1996); R. A. M. Fouchier and M. H. Malim, Sem. Virol., in press.
72. M. Stevenson, Trends Cell Biol. 6, 9 (1996); P. Gallay, T. Hope, D. Chin, D. Trono, Proc. Natl. Acad. Sci. USA. 94, 9825 (1997); P. Gallay, V. Stitt, C. Mundy, M. Oettinger, D. Trono, J. Virol. 70, 1027 (1996); R. A. M. Fouchier and M. H. Malim, Sem. Virol., in press.
73. M. Stevenson, Trends Cell Biol. 6, 9 (1996); P. Gallay, T. Hope, D. Chin, D. Trono, Proc. Natl. Acad. Sci. USA. 94, 9825 (1997); P. Gallay, V. Stitt, C. Mundy, M. Oettinger, D. Trono, J. Virol. 70, 1027 (1996); R. A. M. Fouchier and M. H. Malim, Sem. Virol., in press.
74. M. A. Vodicka, D. M. Koepp, P. A. Silver, M. Emerman, Genes Dev. 12, 175 (1998); S. Popov et al., EMBO J. 17, 909 (1998); R. A. M. Fouchier et al., J. Virol., in press.
75. M. A. Vodicka, D. M. Koepp, P. A. Silver, M. Emerman, Genes Dev. 12, 175 (1998); S. Popov et al., EMBO J. 17, 909 (1998); R. A. M. Fouchier et al., J. Virol., in press.
76. M. A. Vodicka, D. M. Koepp, P. A. Silver, M. Emerman, Genes Dev. 12, 175 (1998); S. Popov et al., EMBO J. 17, 909 (1998); R. A. M. Fouchier et al., J. Virol., in press.
77. M. J. Jin et al., EMBO J. 13, 2935(1994); J. S. Allan et al., J. Virol. 65, 2816 (1991).
78. M. J. Jin et al., EMBO J. 13, 2935(1994); J. S. Allan et al., J. Virol. 65, 2816 (1991).
79. V. Planelles et al., J. Virol. 70, 2516 (1996); G. L. Stivahtis, M. A. Soares, M. A. Vodicka, B. H. Hahn, M. Emerman, ibid. 71, 4331 (1997); J. H. M. Simon et al., EMBO J. 17, 1259 (1998).
80. V. Planelles et al., J. Virol. 70, 2516 (1996); G. L. Stivahtis, M. A. Soares, M. A. Vodicka, B. H. Hahn, M. Emerman, ibid. 71, 4331 (1997); J. H. M. Simon et al., EMBO J. 17, 1259 (1998).
81. V. Planelles et al., J. Virol. 70, 2516 (1996); G. L. Stivahtis, M. A. Soares, M. A. Vodicka, B. H. Hahn, M. Emerman, ibid. 71, 4331 (1997); J. H. M. Simon et al., EMBO J. 17, 1259 (1998).
82. We apologize to those whose work was not discussed or cited in this limited review. Interested readers are referred to A. D. Frankel and J. T. Young, Annu. Rev. Biochem. 67, in press, for a more comprehensive review of HIV molecular biology. We thank M. Bartolomei, P. Bates, S. Bartz, R. Fouchier, R. Gummuluru, J. Simon, G. Stivahtis, and M. Vodicka for comments on the manuscript and numerous colleagues who forwarded preprints of manuscripts to us.