메뉴 건너뛰기




Volumn 28, Issue 8, 2011, Pages 1919-1930

Laser-engineered dissolving microneedle arrays for transdermal macromolecular drug delivery

Author keywords

insulin; laser engineering; microneedles; transdermal drug delivery

Indexed keywords

GLUCOSE; INSULIN; POLY(METHYLVINYLETHER MALEIC ANHYDRIDE); POLYMER; UNCLASSIFIED DRUG;

EID: 79961173516     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0419-4     Document Type: Article
Times cited : (127)

References (47)
  • 1
    • 12344281758 scopus 로고    scopus 로고
    • Commercial challenges of protein drug delivery
    • DOI 10.1517/17425247.2.1.29
    • L Brown 2005 Commercial challenges of protein drug delivery Expert Opin Drug Del 2 1 29 42 10.1517/17425247.2.1.29 (Pubitemid 40123881)
    • (2005) Expert Opinion on Drug Delivery , vol.2 , Issue.1 , pp. 29-42
    • Brown, L.R.1
  • 2
    • 33746872198 scopus 로고    scopus 로고
    • Novel delivery technologies for protein and peptide therapeutics
    • DOI 10.2174/138920106777950852
    • T Kumar K Soppimath S Nachaegari 2006 Novel delivery technologies for protein and peptide therapeutics Curr Pharm Biotechnol 7 261 276 16918403 10.2174/138920106777950852 1:CAS:528:DC%2BD28Xpt1Sgur4%3D (Pubitemid 44194386)
    • (2006) Current Pharmaceutical Biotechnology , vol.7 , Issue.4 , pp. 261-276
    • Shantha Kumar, T.R.1    Soppimath, K.2    Nachaegari, S.K.3
  • 4
    • 77953416243 scopus 로고    scopus 로고
    • Recent trends in protein and peptide drug delivery systems
    • 10.4103/0973-8398.55041
    • H Gupta A Sharma 2009 Recent trends in protein and peptide drug delivery systems Asian J Pharm 3 2 69 75 10.4103/0973-8398.55041
    • (2009) Asian J Pharm , vol.3 , Issue.2 , pp. 69-75
    • Gupta, H.1    Sharma, A.2
  • 5
    • 53549130424 scopus 로고    scopus 로고
    • Proteins and peptides: Strategies for delivery to and across the skin
    • 18200531 10.1002/jps.21277 1:CAS:528:DC%2BD1cXhtVylt7bO
    • H Benson S Namjoshi 2008 Proteins and peptides: Strategies for delivery to and across the skin J Pharm Sci 97 9 3591 3610 18200531 10.1002/jps.21277 1:CAS:528:DC%2BD1cXhtVylt7bO
    • (2008) J Pharm Sci , vol.97 , Issue.9 , pp. 3591-3610
    • Benson, H.1    Namjoshi, S.2
  • 7
    • 0042884342 scopus 로고    scopus 로고
    • Electronically facilitated transdermal delivery of human parathyroid hormone (1-34)
    • DOI 10.1016/S0378-5173(03)00337-5
    • B Medi J Singh 2003 Electronically facilitated transdermal delivery of human parathyroid hormone (1-34) Int J Pharm 263 25 33 12954177 10.1016/S0378-5173(03)00337-5 1:CAS:528:DC%2BD3sXmvValtro%3D (Pubitemid 37087929)
    • (2003) International Journal of Pharmaceutics , vol.263 , Issue.1-2 , pp. 25-33
    • Medi, B.M.1    Singh, J.2
  • 8
    • 34249892536 scopus 로고    scopus 로고
    • Ultrasound mediated transdermal insulin delivery in pigs using a lightweight transducer
    • DOI 10.1007/s11095-007-9306-4
    • E Park J Werner N Smith 2007 Ultrasound mediated transdermal insulin delivery in pigs using a lightweight transducer Pharm Res 24 7 1396 1401 17443398 10.1007/s11095-007-9306-4 1:CAS:528:DC%2BD2sXnt1Cks7o%3D (Pubitemid 46870602)
    • (2007) Pharmaceutical Research , vol.24 , Issue.7 , pp. 1396-1401
    • Park, E.J.1    Werner, J.2    Smith, N.B.3
  • 9
    • 34249949043 scopus 로고    scopus 로고
    • Transdermal delivery of interferon alpha-2b using microporation and iontophoresis in hairless rats
    • DOI 10.1007/s11095-007-9308-2
    • A Badkar A Smith J Eppstein A Banga 2007 Transdermal delivery of interferon alpha-2B using microporation and iontophoresis in hairless rats Pharm Res 24 1389 1395 17443396 10.1007/s11095-007-9308-2 1:CAS:528: DC%2BD2sXnt1Cks70%3D (Pubitemid 46876496)
    • (2007) Pharmaceutical Research , vol.24 , Issue.7 , pp. 1389-1395
    • Badkar, A.V.1    Smith, A.M.2    Eppstein, J.A.3    Banga, A.K.4
  • 10
    • 7444222299 scopus 로고    scopus 로고
    • Transdermal delivery of macromolecules by erbium:YAG laser
    • DOI 10.1016/j.jconrel.2004.08.009, PII S0168365904003682
    • JY Fang WR Lee SC Shen HY Wang CL Fang CH Hu 2004 Transdermal delivery of macromolecules by erbium:YAG laser J Control Release 100 75 85 15491812 10.1016/j.jconrel.2004.08.009 1:CAS:528:DC%2BD2cXosFSktbs%3D (Pubitemid 39445987)
    • (2004) Journal of Controlled Release , vol.100 , Issue.1 , pp. 75-85
    • Fang, J.-Y.1    Lee, W.-R.2    Shen, S.-C.3    Wang, H.-Y.4    Fang, C.-L.5    Hu, C.-H.6
  • 11
    • 1542358759 scopus 로고    scopus 로고
    • Microneedles for transdermal drug delivery
    • DOI 10.1016/j.addr.2003.10.023, PII S0169409X03002394
    • MR Prausnitz 2004 Microneedles for transdermal drug delivery Adv Drug Deliv Rev 56 5 581 587 15019747 10.1016/j.addr.2003.10.023 1:CAS:528: DC%2BD2cXhvFWqsbw%3D (Pubitemid 38326934)
    • (2004) Advanced Drug Delivery Reviews , vol.56 , Issue.5 , pp. 581-587
    • Prausnitz, M.R.1
  • 13
    • 3042809905 scopus 로고    scopus 로고
    • Transdermal delivery of insulin using microneedles in vivo
    • DOI 10.1023/B:PHAM.0000029282.44140.2e
    • W Martanto SP Davis NR Holiday J Wang H Gill MR Prausnitz 2004 Transdermal delivery of insulin using microneedles in vivo Pharm Res 21 6 947 952 15212158 10.1023/B:PHAM.0000029282.44140.2e 1:CAS:528:DC%2BD2cXktlykurw%3D (Pubitemid 38870143)
    • (2004) Pharmaceutical Research , vol.21 , Issue.6 , pp. 947-952
    • Martanto, W.1    Davis, S.P.2    Holiday, N.R.3    Wang, J.4    Gill, H.S.5    Prausnitz, M.R.6
  • 14
    • 47349128121 scopus 로고    scopus 로고
    • Microneedle-mediated intradermal delivery of 5-aminolevulinic acid: Potential for enhanced topical photodynamic therapy
    • 18556084 10.1016/j.jconrel.2008.05.002 1:CAS:528:DC%2BD1cXovFOnu7Y%3D
    • RF Donnelly DIJ Morrow PA McCarron AD Woolfson A Morrissey P Juzenas A Juzeniene V Iani HO McCarthy J Moan 2008 Microneedle-mediated intradermal delivery of 5-aminolevulinic acid: Potential for enhanced topical photodynamic therapy J Control Release 129 154 162 18556084 10.1016/j.jconrel.2008.05.002 1:CAS:528:DC%2BD1cXovFOnu7Y%3D
    • (2008) J Control Release , vol.129 , pp. 154-162
    • Donnelly, R.F.1    Morrow, D.I.J.2    McCarron, P.A.3    Woolfson, A.D.4    Morrissey, A.5    Juzenas, P.6    Juzeniene, A.7    Iani, V.8    McCarthy, H.O.9    Moan, J.10
  • 15
    • 0036007129 scopus 로고    scopus 로고
    • Macroflux® microprojection array patch technology: A new and efficient approach for intracutaneous immunization
    • DOI 10.1023/A:1013607400040
    • JA Matriano M Cormier J Johnson WA Young M Buttery K Nyam PE Daddona 2002 Macroflux microprojection array patch technology: a new and efficient approach for intracutaneous immunization Pharm Res 19 1 63 70 11837701 10.1023/A:1013607400040 1:CAS:528:DC%2BD38XhtVSmsbg%3D (Pubitemid 34075108)
    • (2002) Pharmaceutical Research , vol.19 , Issue.1 , pp. 63-70
    • Matriano, J.A.1    Cormier, M.2    Johnson, J.3    Young, W.A.4    Buttery, M.5    Nyam, K.6    Daddona, P.E.7
  • 17
    • 40049112272 scopus 로고    scopus 로고
    • Dissolving microneedles for transdermal drug delivery
    • 18261792 10.1016/j.biomaterials.2007.12.048 1:CAS:528: DC%2BD1cXivFKntLk%3D
    • JW Lee JH Park MR Prausnitz 2008 Dissolving microneedles for transdermal drug delivery Biomaterials 29 13 2113 2124 18261792 10.1016/j.biomaterials.2007. 12.048 1:CAS:528:DC%2BD1cXivFKntLk%3D
    • (2008) Biomaterials , vol.29 , Issue.13 , pp. 2113-2124
    • Lee, J.W.1    Park, J.H.2    Prausnitz, M.R.3
  • 18
    • 33646882359 scopus 로고    scopus 로고
    • Polymer microneedles for controlled-release drug delivery
    • DOI 10.1007/s11095-006-0028-9
    • JH Park MG Allen MR Prausnitz 2006 Polymer microneedles for controlled-release drug delivery Pharm Res 23 5 1008 1019 16715391 10.1007/s11095-006-0028-9 1:CAS:528:DC%2BD28XkslKjtL4%3D (Pubitemid 43781409)
    • (2006) Pharmaceutical Research , vol.23 , Issue.5 , pp. 1008-1019
    • Park, J.-H.1    Allen, M.G.2    Prausnitz, M.R.3
  • 19
    • 18144410179 scopus 로고    scopus 로고
    • Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery
    • DOI 10.1016/j.jconrel.2005.02.002
    • JH Park MG Allen MR Prausnitz 2005 Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery J Control Release 104 51 66 15866334 10.1016/j.jconrel.2005.02.002 1:CAS:528:DC%2BD2MXjvVClsLg%3D (Pubitemid 40615235)
    • (2005) Journal of Controlled Release , vol.104 , Issue.1 , pp. 51-66
    • Park, J.-H.1    Allen, M.G.2    Prausnitz, M.R.3
  • 20
    • 55749108348 scopus 로고    scopus 로고
    • Transdermal drug delivery
    • 18997767 10.1038/nbt.1504 1:CAS:528:DC%2BD1cXhtlCktrrF
    • MR Prausnitz R Langer 2008 Transdermal drug delivery Nat Biotechnol 26 11 1261 1268 18997767 10.1038/nbt.1504 1:CAS:528:DC%2BD1cXhtlCktrrF
    • (2008) Nat Biotechnol , vol.26 , Issue.11 , pp. 1261-1268
    • Prausnitz, M.R.1    Langer, R.2
  • 21
    • 78651261187 scopus 로고    scopus 로고
    • Design, optimization and characterization of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique
    • 20490627 10.1007/s11095-010-0169-8 1:CAS:528:DC%2BC3cXmtlamsbY%3D
    • RF Donnelly R Majithiya R Singh D Morrow M Garland YK Demir K Migalska E Ryan D Gillen C Scott AD Woolfson 2011 Design, optimization and characterization of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique Pharm Res 28 1 41 57 20490627 10.1007/s11095-010-0169-8 1:CAS:528:DC%2BC3cXmtlamsbY%3D
    • (2011) Pharm Res , vol.28 , Issue.1 , pp. 41-57
    • Donnelly, R.F.1    Majithiya, R.2    Singh, R.3    Morrow, D.4    Garland, M.5    Demir, Y.K.6    Migalska, K.7    Ryan, E.8    Gillen, D.9    Scott, C.10    Woolfson, A.D.11
  • 22
    • 58149090295 scopus 로고    scopus 로고
    • Investigation of insulin loaded self-assembled microtubulus for drug release
    • 18986191 10.1021/bc800254n 1:CAS:528:DC%2BD1cXhtlemt7rF
    • M Henricus K Johnon I Banerje 2008 Investigation of insulin loaded self-assembled microtubulus for drug release Bioconjug Chem 19 2394 2400 18986191 10.1021/bc800254n 1:CAS:528:DC%2BD1cXhtlemt7rF
    • (2008) Bioconjug Chem , vol.19 , pp. 2394-2400
    • Henricus, M.1    Johnon, K.2    Banerje, I.3
  • 23
    • 0033777523 scopus 로고    scopus 로고
    • Formation of insulin amyloid fibrils followed by FTIR and simultaneously with CD and electron microscopy
    • 11106169 10.1110/ps.9.10.1960 1:CAS:528:DC%2BD3cXosFKksbg%3D
    • M Bouchard J Zurdo E Nettleton C Dobson C Robinson 2000 Formation of insulin amyloid fibrils followed by FTIR and simultaneously with CD and electron microscopy Protein Sci 9 1960 1967 11106169 10.1110/ps.9.10.1960 1:CAS:528:DC%2BD3cXosFKksbg%3D
    • (2000) Protein Sci , vol.9 , pp. 1960-1967
    • Bouchard, M.1    Zurdo, J.2    Nettleton, E.3    Dobson, C.4    Robinson, C.5
  • 24
    • 1542498664 scopus 로고    scopus 로고
    • Alternative routes of insulin delivery
    • DOI 10.1046/j.1464-5491.2003.01076.x
    • DR Owens B Zinman G Bolli 2003 Alternative routes of insulin delivery Diabet Med 20 886 898 14632713 10.1046/j.1464-5491.2003.01076.x 1:CAS:528:DC%2BD3sXpsFyku74%3D (Pubitemid 41701487)
    • (2003) Diabetic Medicine , vol.20 , Issue.11 , pp. 886-898
    • Owens, D.R.1    Zinman, B.2    Bolli, G.3
  • 25
    • 0742288421 scopus 로고    scopus 로고
    • Discovery of transdermal penetration enhancers by high-throughput screening
    • DOI 10.1038/nbt928
    • P Karande A Jain S Mitragotri 2004 Discovery of transdermal penetration enhancers by high-throughput screening Nat Biotechnol 22 2 192 197 14704682 10.1038/nbt928 1:CAS:528:DC%2BD2cXnvFeisQ%3D%3D (Pubitemid 38160534)
    • (2004) Nature Biotechnology , vol.22 , Issue.2 , pp. 192-197
    • Karande, P.1    Jain, A.2    Mitragotri, S.3
  • 26
    • 41549116858 scopus 로고    scopus 로고
    • Percutaneous absorption of interferon-α by self-dissolving micropiles
    • DOI 10.1080/10611860801902575, PII 791713899
    • Y Ito A Saeki K Shiroyama N Sugioka K Takada 2008 Percutaneous absorption of interferon-alpha by self-dissolving micropiles J Drug Target 16 3 243 249 18365886 10.1080/10611860801902575 1:CAS:528:DC%2BD1cXjs12nurc%3D (Pubitemid 351460653)
    • (2008) Journal of Drug Targeting , vol.16 , Issue.3 , pp. 243-249
    • Ito, Y.1    Saeki, A.2    Shiroyama, K.3    Sugioka, N.4    Takada, K.5
  • 27
    • 0032559176 scopus 로고    scopus 로고
    • Iontophoresis of monomeric insulin analogues in vitro: Effects of insulin charge and skin pretreatment
    • DOI 10.1016/S0168-3659(97)00155-7, PII S0168365997001557
    • L Langkjaer J Brange GM Grodsky R Guy 1998 Iontophoresis of monomeric insulin analogues in vitro: effects of insulin charge and skin pretreatment J Control Release 51 47 56 9685903 10.1016/S0168-3659(97)00155-7 1:CAS:528:DyaK1cXitlOrsg%3D%3D (Pubitemid 28064644)
    • (1998) Journal of Controlled Release , vol.51 , Issue.1 , pp. 47-56
    • Langkjaer, L.1    Brange, J.2    Grodsky, G.M.3    Guy, R.H.4
  • 28
    • 12244310451 scopus 로고    scopus 로고
    • Description of transdermal transport of hydrophilic solutes during low-frequency sonophoresis based on a modified porous pathway model
    • DOI 10.1002/jps.10299
    • A Tezel A Sens S Mitragotri 2003 Description of transdermal transport of hydrophilic solutes during low-frequency sonophoresis based on a modified porous pathway model J Pharm Sci 92 2 381 393 12532387 10.1002/jps.10299 1:CAS:528:DC%2BD3sXhtFantL4%3D (Pubitemid 36169310)
    • (2003) Journal of Pharmaceutical Sciences , vol.92 , Issue.2 , pp. 381-393
    • Tezel, A.1    Sens, A.2    Mitragotri, S.3
  • 29
    • 41549149466 scopus 로고    scopus 로고
    • Antihyperglycemic effect of insulin from self-dissolving micropiles in dogs
    • DOI 10.1248/cpb.56.243
    • Y Ito Y Ohashi A Saeki N Sugioka K Takada 2008 Antihyperglycemic effect of insulin from self-dissolving micropiles in dogs Chem Pharm Bull 56 3 243 246 10.1248/cpb.56.243 1:CAS:528:DC%2BD1cXmtlamu7Y%3D (Pubitemid 351463230)
    • (2008) Chemical and Pharmaceutical Bulletin , vol.56 , Issue.3 , pp. 243-246
    • Ito, Y.1    Ohashi, Y.2    Saeki, A.3    Sugioka, N.4    Takada, K.5
  • 30
    • 0038357909 scopus 로고    scopus 로고
    • Transdermal drug delivery of insulin with ultradeformable carriers
    • DOI 10.2165/00003088-200342050-00004
    • G Cevc 2003 Transdermal drug delivery of insulin with ultradeformable carriers Clin Pharmacokinet 42 5 461 474 12739984 10.2165/00003088-200342050- 00004 1:CAS:528:DC%2BD3sXkvFOjs78%3D (Pubitemid 36649039)
    • (2003) Clinical Pharmacokinetics , vol.42 , Issue.5 , pp. 461-474
    • Cevc, G.1
  • 31
    • 0036381740 scopus 로고    scopus 로고
    • Transdermal delivery of insulin from novel biphasic lipid system in diabetic rats
    • 10.1089/152091502760306562
    • M King I Badea J Solomon P Kumar K Gaspar M Foldvari 2002 Transdermal delivery of insulin from novel biphasic lipid system in diabetic rats Diab Technol The 4 4 479 488 10.1089/152091502760306562
    • (2002) Diab Technol the , vol.4 , Issue.4 , pp. 479-488
    • King, M.1    Badea, I.2    Solomon, J.3    Kumar, P.4    Gaspar, K.5    Foldvari, M.6
  • 33
    • 34249907569 scopus 로고    scopus 로고
    • Theme section: Transdermal delivery of proteins
    • DOI 10.1007/s11095-007-9323-3
    • A Banga 2007 Theme section: Transdermal delivery of proteins Pharm Res 24 7 1357 1359 17492493 10.1007/s11095-007-9323-3 (Pubitemid 46870603)
    • (2007) Pharmaceutical Research , vol.24 , Issue.7 , pp. 1357-1359
    • Banga, A.K.1
  • 34
    • 77950817386 scopus 로고    scopus 로고
    • Self-dissolving micropile array tips for percutaneous administration of insulin
    • 10.1007/s10856-009-3923-x 1:CAS:528:DC%2BC3cXhslKlu7c%3D
    • Y Ito T Yamazaki N Sugioka K Takada 2010 Self-dissolving micropile array tips for percutaneous administration of insulin J Mater Sci Mater M 21 835 841 10.1007/s10856-009-3923-x 1:CAS:528:DC%2BC3cXhslKlu7c%3D
    • (2010) J Mater Sci Mater M , vol.21 , pp. 835-841
    • Ito, Y.1    Yamazaki, T.2    Sugioka, N.3    Takada, K.4
  • 35
  • 36
    • 33747748467 scopus 로고    scopus 로고
    • Feasibility of microneedles for percutaneous absorption of insulin
    • DOI 10.1016/j.ejps.2006.05.011, PII S0928098706001618
    • Y Ito H Eiji S Atsushi S Nobuyuki T Kanji 2006 Feasibility of microneedles for percutaneous absorption of insulin Euro J Pharm Sci 29 1 82 88 10.1016/j.ejps.2006.05.011 1:CAS:528:DC%2BD28Xosl2iu7k%3D (Pubitemid 44279397)
    • (2006) European Journal of Pharmaceutical Sciences , vol.29 , Issue.1 , pp. 82-88
    • Ito, Y.1    Hagiwara, E.2    Saeki, A.3    Sugioka, N.4    Takada, K.5
  • 37
    • 54949120972 scopus 로고    scopus 로고
    • Minimally invasive protein delivery with rapidly dissolving polymer microneedles
    • 10.1002/adma.200701205 1:CAS:528:DC%2BD1cXlt1Wmtr4%3D
    • SP Sullivan N Murthy MR Prausnitz 2008 Minimally invasive protein delivery with rapidly dissolving polymer microneedles Adv Mater 20 933 938 10.1002/adma.200701205 1:CAS:528:DC%2BD1cXlt1Wmtr4%3D
    • (2008) Adv Mater , vol.20 , pp. 933-938
    • Sullivan, S.P.1    Murthy, N.2    Prausnitz, M.R.3
  • 38
    • 41649108815 scopus 로고    scopus 로고
    • Interaction of gold nanoparticles with protein: A spectroscopic study to monitor protein conformational changes
    • Wangoo N, Suri C, Shekawat G. Interaction of gold nanoparticles with protein: A spectroscopic study to monitor protein conformational changes. App. Phys. Lett. 2008;92(13) ID 133104
    • (2008) App. Phys. Lett. , vol.92 , Issue.13
    • Wangoo, N.1    Suri, C.2    Shekawat, G.3
  • 39
    • 33646774999 scopus 로고    scopus 로고
    • Adsorption-induced conformational changes of proteins onto ceramic particles: Differential scanning calorimetry and FTIR analysis
    • DOI 10.1016/j.jcis.2006.01.065, PII S0021979706000841
    • N Brandes P Welzel C Werner L Kroh 2006 Adsorption-induced conformational changes of proteins onto ceramic particles: Differential scanning calorimetry and FTIR analysis J Colloid Interf Sci 299 1 56 69 10.1016/j.jcis.2006.01.065 1:CAS:528:DC%2BD28XkvVajsL4%3D (Pubitemid 43765500)
    • (2006) Journal of Colloid and Interface Science , vol.299 , Issue.1 , pp. 56-69
    • Brandes, N.1    Welzel, P.B.2    Werner, C.3    Kroh, L.W.4
  • 40
    • 0018839155 scopus 로고
    • Insulin aggregation in artificial delivery systems
    • WD Lougheed H Woulfe-Flanagan JR Clement A Albisser 1980 Insulin aggregation in artificial delivery systems Diabetologia 19 1 9 6771181 10.1007/BF00258302 1:CAS:528:DyaL3cXlvFWqsbo%3D (Pubitemid 10063091)
    • (1980) Diabetologia , vol.19 , Issue.1 , pp. 1-9
    • Lougheed, W.D.1    Woulfe-Flanagan, H.2    Clement, J.R.3    Albisser, A.M.4
  • 41
    • 0037467175 scopus 로고    scopus 로고
    • Transdermal iontophoresis of insulin: II. Physicochemical considerations
    • DOI 10.1016/S0378-5173(03)00034-6
    • O Pillai S Borkute N Sivaprasad R Panchagnula 2003 Transdermal iontophoresis of insulin II. Physicochemical considerations Int J Pharm 254 271 280 12623203 10.1016/S0378-5173(03)00034-6 1:CAS:528:DC%2BD3sXhsFOqsr4%3D (Pubitemid 36298836)
    • (2003) International Journal of Pharmaceutics , vol.254 , Issue.2 , pp. 271-280
    • Pillai, O.1    Borkute, S.D.2    Sivaprasad, N.3    Panchagnula, R.4
  • 42
    • 0029864061 scopus 로고    scopus 로고
    • Stability of peptides during iontophoretic transdermal delivery
    • DOI 10.1016/0378-5173(95)04263-6
    • Y Huang S Wu 1996 Stability of peptides during iontophoretic transdermal delivery Int J Pharm 131 19 23 10.1016/0378-5173(95)04263-6 1:CAS:528: DyaK28XjtFSlu7Y%3D (Pubitemid 26143824)
    • (1996) International Journal of Pharmaceutics , vol.131 , Issue.1 , pp. 19-23
    • Huang, Y.-Y.1    Wu, S.-M.2
  • 43
    • 0024841175 scopus 로고
    • Transdermal iontophoretic drug delivery: mechanistic analysis and application to polypeptide delivery
    • V Srinivasan W Higuchi S Sims A Ghanem C Behl 1989 Transdermal iontophoretic drug delivery: Mechanistic analysis and application to polypeptide delivery J Pharm Sci 78 5 370 375 2664125 10.1002/jps.2600780506 1:CAS:528:DyaL1MXitlOjtL4%3D (Pubitemid 20070544)
    • (1989) Journal of Pharmaceutical Sciences , vol.78 , Issue.5 , pp. 370-375
    • Srinivasan, V.1    Higuchi, W.I.2    Sims, S.M.3    Ghanem, A.H.4    Behl, C.R.5
  • 45
    • 0027333642 scopus 로고
    • The influence of ionic strength and pH on the aggregation properties of zinc-free insulin studied by static and dynamic laser light scattering
    • DOI 10.1002/bip.360331103
    • W Kadima L Ogendal R Bauer N Kaarsholm K Brodersen JF Hansen P Porting 1993 The influence of ionic strength and pH on the aggregation properties of zinc-free insulin studied by static and dynamic laser light scattering Biopolymers 33 11 1643 1657 8241425 10.1002/bip.360331103 1:CAS:528:DyaK2cXhtVWi (Pubitemid 24009537)
    • (1993) Biopolymers , vol.33 , Issue.11 , pp. 1643-1657
    • Kadima, W.1    Ogendal, L.2    Bauer, R.3    Kaarsholm, N.4    Brodersen, K.5    Hansen, J.F.6    Porting, P.7
  • 46
    • 33750488402 scopus 로고    scopus 로고
    • Effect of electroporation and pH on the iontophoretic transdermal delivery of human insulin
    • DOI 10.1016/j.ijpharm.2006.07.002, PII S0378517306005515
    • S Tokumoto N Higo K Sugibayashi 2006 Effect of electroporation and pH on iontophoretic transdermal delivery of human insulin Int J Pharm 326 13 19 16920293 10.1016/j.ijpharm.2006.07.002 1:CAS:528:DC%2BD28XhtFKhsL3L (Pubitemid 44647740)
    • (2006) International Journal of Pharmaceutics , vol.326 , Issue.1-2 , pp. 13-19
    • Tokumoto, S.1    Higo, N.2    Sugibayashi, K.3
  • 47
    • 0032753055 scopus 로고    scopus 로고
    • Biological activity of insulin in GMO gels and the effect of agitation
    • DOI 10.1016/S0378-5173(99)00287-2, PII S0378517399002872
    • Y Sadhale J Shah 1999 Biological activity of insulin in GMO gels and the effect of agitation Int J Pharm 191 65 74 1:CAS:528:DyaK1MXotVGjsLo%3D (Pubitemid 29502178)
    • (1999) International Journal of Pharmaceutics , vol.191 , Issue.1 , pp. 65-74
    • Sadhale, Y.1    Shah, J.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.