Sustained release of insulin through skin by intradermal microdelivery system

Biomedical Microdevices

Volumn 12, Issue 4, 2010, Pages 665-671

  Wu, Yan ^a,b   Gao, Yunhua ^a   Qin, Guangjiong ^a,b   Zhang, Suohui ^a,b   Qiu, Yuqin ^a   Li, Fang ^a   Xu, Bai ^a,c  

^a TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c Suzhou Natong Bionanotechnology Co Ltd   (China)

Author keywords

Insulin; Intradermal; Microneedles; Percutaneous; Sustained release

Indexed keywords

BI-PHASIC; BLOOD GLUCOSE; CONTROLLED RELEASE; DIABETIC RATS; IN-VITRO; IN-VIVO; INFLUENCING FACTOR; INSULIN CONCENTRATIONS; INTRADERMAL; MICRONEEDLES; PERCUTANEOUS; PRE-TREATMENT; SUSTAINED RELEASE;

BLOOD; GLUCOSE; NEEDLES;

INSULIN;

BIPHASIC INSULIN; GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG TISSUE LEVEL; FEASIBILITY STUDY; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; MALE; NEEDLE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; SKIN PENETRATION; SKINFOLD THICKNESS; SUSTAINED DRUG RELEASE; TREATMENT DURATION; ANIMAL; BLOOD; DELAYED RELEASE FORMULATION; DOSE RESPONSE; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; METHODOLOGY; SKIN; SPRAGUE DAWLEY RAT; TIME;

RATTUS;

ADMINISTRATION, CUTANEOUS; ANIMALS; BLOOD GLUCOSE; DELAYED-ACTION PREPARATIONS; DIABETES MELLITUS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; FEASIBILITY STUDIES; INSULIN; MALE; RATS; RATS, SPRAGUE-DAWLEY; SKIN; TIME FACTORS;

EID: 77957356453     PISSN: 13872176     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10544-010-9419-0     Document Type: Article

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