FimH Antagonists: Structure-Activity and Structure-Property Relationships for Biphenyl α-D-Mannopyranosides

ChemMedChem

Volumn 7, Issue 8, 2012, Pages 1404-1422

  Pang, Lijuan ^a   Kleeb, Simon ^a   Lemme, Katrin ^a   Rabbani, Said ^a   Scharenberg, Meike ^a   Zalewski, Adam ^a   Schädler, Florentina ^a   Schwardt, Oliver ^a   Ernst, Beat ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Bacterial adhesin; FimH antagonists; Flow cytometry; Isothermal titration calorimetry; Urinary tract infections

Indexed keywords

3 BROMOBENZYL 2,3,4,6 TETRA 2 ACETYL ALPHA DEXTRO MANNOPYRANOSIDE; 4 BROMO 2 CYANOPHENYL 2,3,4,6 TETRA 2 ACETYL ALPHA DEXTRO MANNOPYRANOSIDE; 4 BROMO 2 CYCLOPROPYLPHENYL 2,3,4,6 TETRA 2 ACETYL ALPHA DEXTRO MANNOPYRANOSIDE; 4 BROMO 2 FLUOROPHENYL 2,3,4,6 TETRA 2 ACETYL ALPHA DEXTRO MANNOPYRANOSIDE; 4 BROMO 2 METHOXYLPHENYL 2,3,4,6 TETRA 2 ACETYL ALPHA DEXTRO MANNOPYRANOSIDE; 4 BROMO 2 METHYLPHENYL 2,3,4,6 TETRA 2 ACETYL ALPHA DEXTRO MANNOPYRANOSIDE; 4 BROMO 2 TRIFLUOROMETHYLPHENYL 2,3,4,6 TETRA 2 ACETYL ALPHA DEXTRO MANNOPYRANOSIDE; 5 BROMO 2 CHLOROBENZYL 2,3,4,6 TETRA 2 ACETYL ALPHA DEXTRO MANNOPYRANOSIDE; ANTIINFECTIVE AGENT; BIPHENYL ALPHA DEXTRO MANNOPYRANOSIDE DERIVATIVE; FIMH PROTEIN INHIBITOR; METHYL 3' CYANO 4' (ALPHA DEXTRO MANNOPYRANOSYLOXY)BIPHENYL 4 CARBOXYLATE; METHYL 3' CYCLOPROPYL 4' (ALPHA DEXTRO MANNOPYRANOSYLOXY)BIPHENYL 4 CARBOXYLATE; METHYL 3' FLUORO 4' (ALPHA DEXTRO MANNOPYRANOSYLOXY)BIPHENYL 4 CARBOXYLATE; METHYL 3' TRIFLUOROMETHYL 4' (ALPHA DEXTRO MANNOPYRANOSYLOXY)BIPHENYL 4 CARBOXYLATE; METHYL 4' (2,3,4,6 TETRA 2 ACETYL ALPHA DEXTRO MANNOPYRANOSYLOXY) 3' CYANOBIPHENYL 4 CARBOXYLATE; METHYL 4' (2,3,4,6 TETRA 2 ACETYL ALPHA DEXTRO MANNOPYRANOSYLOXY) 3' CYCLOPROPYLBIPHENYL 4 CARBOXYLATE; METHYL 4' (2,3,4,6 TETRA 2 ACETYL ALPHA DEXTRO MANNOPYRANOSYLOXY) 3' FLUOROBIPHENYL 4 CARBOXYLATE; METHYL 4' (2,3,4,6 TETRA 2 ACETYL ALPHA DEXTRO MANNOPYRANOSYLOXY) 3' METHOXYBIPHENYL 4 CARBOXYLATE; METHYL 4' (2,3,4,6 TETRA 2 ACETYL ALPHA DEXTRO MANNOPYRANOSYLOXY) 3' METHYLBIPHENYL 4 CARBOXYLATE; METHYL 4' (2,3,4,6 TETRA 2 ACETYL ALPHA DEXTRO MANNOPYRANOSYLOXY) 3' TRIFLUOROMETHYLBIPHENYL 4 CARBOXYLATE; METHYL 4' (ALPHA DEXTRO MANNOPYRANOSYLOXY) 3' METHOXYBIPHENYL 4 CARBOXYLATE; METHYL 4' (ALPHA DEXTRO MANNOPYRANOSYLOXY) 3' METHYLBIPHENYL 4 CARBOXYLATE; SODIUM 3' CYANO 4' (ALPHA DEXTRO MANNOPYRANOSYLOXY)BIPHENYL 4 CARBOXYLATE; SODIUM 3' CYCLOPROPYL 4' (ALPHA DEXTRO MANNOPYRANOSYLOXY)BIPHENYL 4 CARBOXYLATE; SODIUM 3' FLUORO 4' (ALPHA DEXTRO MANNOPYRANOSYLOXY)BIPHENYL 4 CARBOXYLATE; SODIUM 3' TRIFLUOROMETHYL 4' (ALPHA DEXTRO MANNOPYRANOSYLOXY)BIPHENYL 4 CARBOXYLATE; SODIUM 4' (ALPHA DEXTRO MANNOPYRANOSYLOXY) 3' METHOXYBIPHENYL 4 CARBOXYLATE; SODIUM 4' (ALPHA DEXTRO MANNOPYRANOSYLOXY) 3' METHYLBIPHENYL 4 CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; ASSAY; BINDING AFFINITY; CELL MEMBRANE PERMEABILITY; DRUG BINDING; DRUG PENETRATION; DRUG SOLUBILITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; ISOTHERMAL TITRATION CALORIMETRY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE PROPERTY RELATION; STRUCTURE ACTIVITY RELATION;

ADHESINS, ESCHERICHIA COLI; BINDING SITES; BIPHENYL COMPOUNDS; CALORIMETRY; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; FIMBRIAE PROTEINS; HALF-LIFE; HUMANS; MANNOSE; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; URINARY TRACT INFECTIONS;

EID: 84864409295     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200125     Document Type: Article

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