Characterization of thyroid hormone receptor α (TRα)-specific analogs with varying inner- and outer-ring substituents

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 2, 2008, Pages 762-770

  Ocasio, Cory A ^a   Scanlan, Thomas S ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Cardiac specific; CO23; CO23 analogs; GC 1; In vivo; Induced metamorphosis; Liver specific; Metamorphosis; Thyroid hormone receptor ; Thyroid hormone receptor ; Thyroid hormone receptors; Xenopus laevis

Indexed keywords

5 [4 (4 HYDROXYPHENOXY) 3,5 DIIODOBENZYL]IMIDAZOLIDINE 2,4 DIONE; BROMIDE; CO 23; CO 24; CO 26; CO 27; CO 28; CO 29; CO 30; CO 31; CO 32; IMIDAZOLIDINE DERIVATIVE; IODIDE; LIOTHYRONINE; RECEPTOR SUBTYPE; THYROID HORMONE RECEPTOR ALPHA; THYROMIMETIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BINDING COMPETITION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DERIVATIZATION; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG SYNTHESIS; FEMALE; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; METAMORPHOSIS; NONHUMAN; RECEPTOR AFFINITY; TADPOLE; TRANSACTIVATION;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; HYDANTOINS; LARVA; METAMORPHOSIS, BIOLOGICAL; MOLECULAR STRUCTURE; THYROID HORMONE RECEPTORS ALPHA; TUMOR CELLS, CULTURED; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 38549088519     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.040     Document Type: Article

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