Structure-based drug design and optimization of mannoside bacterial fimH antagonists

Journal of Medicinal Chemistry

Volumn 53, Issue 12, 2010, Pages 4779-4792

  Han, Zhenfu ^a   Pinkner, Jerome S ^a   Ford, Bradley ^b   Obermann, Robert ^a   Nolan, William ^a   Wildman, Scott A ^a   Hobbs, Doug ^a   Ellenberger, Tom ^a   Cusumano, Corinne K ^a   Hultgren, Scott J ^a   Janetka, James W ^a  

^a Center for Womens Infectious Disease Research   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 CHLOROPHENOXY) 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 3,4,5 TRIOL; 2 (HYDROXYMETHYL) 6 (2 PHENYLPHENOXY)TETRAHYDROPYRAN 3,4,5 TRIOL; 2 (HYDROXYMETHYL) 6 (3 NITROPHENOXY)TETRAHYDROPYRAN 3,4,5 TRIOL (3H); 2 (HYDROXYMETHYL) 6 (4 METHOXYPHENOXY) TETRAHYDROPYRAN 3,4,5 TRIOL; 2 (HYDROXYMETHYL) 6 (4 PHENYLPHENOXY)TETRAHYDROPYRAN 3,4,5 TRIOL; 2 (HYDROXYMETHYL) 6 [(2 NAPHTHYLOXY)METHOCY]TETRAHYDROPYRAN 3,4,5 TRIOL; 2 (HYDROXYMETHYL) 6 [(4 NITROPHENYL)METHOCY]TETRAHYDROPYRAN 3,4,5 TRIOL; 2 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 2 YL]OXYBENZONITRILE; 2 BENZYLOXY 6 (HYDROXYMETHYL)TETRAHYDROTETRAHYDROPYRAN 3,4,5 TRIOL; 3 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 2 YL]OXYPHENYL]ACETAMIDE; 3 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYLTETRAHYDROPYRAN 2 YL]OXYPHENYL]ACETATE; 4 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 2 YL]OXYBENZAMIDE; 6 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETAHYDROPYRAN 2 YL]OXY 3A,7A DIHYDRO 3H 1,3 BENZOXAZOL 2 ONE; DIMETHYL 5 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 2 YL]OXYBENZENE 1,3 DICARBOXYLATE; DIMETHYL 5 [4 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 2 YL]OXYPHENYL]BENZENE 1,3 DICARBOXYLATE; METHYL 2 [4 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 2 YL]OXYPHENYL]ACETATE; METHYL 3 [ 3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 2 YL]OXYBENZOATE; METHYL 3 [4 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYLTETRAHYDROPYRAN 2 YL]OXYPHENYL]BENZOATE; METHYL 4 [ 3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 2 YL]OXYBENZOATE; METHYL 4 [3 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 2 YL]OXYPHENYL]BENZOATE; METHYL 4 [4 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 2 YL]OXYPHENYL]BENZOATE; METHYL 5 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETAHYDROPYRAN 2 YL]OXYBENZOTHIOPHENE CARBOXYLATE; METHYL 6 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETAHYDROPYRAN 2 YL]OXYBENZOTHIOPHENE 2 CARBOXYLATE; N [2 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 2 YL]OXYPHENYL]ACETAMIDE; N [3 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 2 YL]OXYPHENYL]ACETAMIDE; N [3 [4 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 2 YL]OXYPHENYL]PHENYL]ACETAMIDE; N [4 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 2 YL]OXYPHENYL]ACETAMIDE; PHENYL [3 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDROPYRAN 2 YL]OXYPHENYL]METHANONE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; CELL ACTIVITY; CELL ASSAY; DRUG DESIGN; DRUG STRUCTURE; FLUORESCENCE POLARIZATION; HEMAGGLUTINATION; HYDROGEN BOND; STATIC ELECTRICITY; X RAY CRYSTALLOGRAPHY;

ADHESINS, ESCHERICHIA COLI; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL ADHESION; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ESCHERICHIA COLI; FIMBRIAE PROTEINS; FLUORESCENCE POLARIZATION; GUINEA PIGS; HEMAGGLUTINATION TESTS; HYDROGEN BONDING; MANNOSIDES; MODELS, MOLECULAR; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77953765576     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100438s     Document Type: Article

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