메뉴 건너뛰기




Volumn 86, Issue 1 I, 2004, Pages 254-263

Interaction of the Protein Transduction Domain of HIV-1 TAT with Heparan Sulfate: Binding Mechanism and Thermodynamic Parameters

Author keywords

[No Author keywords available]

Indexed keywords

DERMATAN SULFATE; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; HEPARIN; PROTEIN TRANSDUCTION DOMAIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

EID: 0346688716     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(04)74101-6     Document Type: Article
Times cited : (181)

References (56)
  • 2
    • 0026446924 scopus 로고
    • Effects of cytokines from activated immune cells on vascular cell-growth and HIV-1 gene-expression-implications for AIDS-Kaposi's Sarcoma pathogenesis
    • Barillari, G., L. Buonaguro, V. Fiorelli, J. Hoffman, F. Michaels, R. C. Gallo, and B. Ensoli. 1992. Effects of cytokines from activated immune cells on vascular cell-growth and HIV-1 gene-expression-implications for AIDS-Kaposi's Sarcoma pathogenesis. J. Immunol. 149:3727-3734.
    • (1992) J. Immunol. , vol.149 , pp. 3727-3734
    • Barillari, G.1    Buonaguro, L.2    Fiorelli, V.3    Hoffman, J.4    Michaels, F.5    Gallo, R.C.6    Ensoli, B.7
  • 4
    • 0037333830 scopus 로고    scopus 로고
    • Heparin sulfate proteoglycan as a plasma membrane carrier
    • Belting, M. 2003. Heparin sulfate proteoglycan as a plasma membrane carrier. Trends Biochem. Sci. 28:145-151.
    • (2003) Trends Biochem. Sci. , vol.28 , pp. 145-151
    • Belting, M.1
  • 5
    • 0030660196 scopus 로고    scopus 로고
    • Syndecans: Multifunctional cell-surface co-receptors
    • Carey, D. J. 1997. Syndecans: multifunctional cell-surface co-receptors. Biochem. J. 327:1-16.
    • (1997) Biochem. J. , vol.327 , pp. 1-16
    • Carey, D.J.1
  • 6
    • 0027452957 scopus 로고
    • High-affinity binding of TAR RNA by the HIV type-1 TAT protein requires base-pairs in the RNA stem and amino-acid residues flanking the basic region
    • Churcher, M. J., C. Lamont, F. Hamy, C. Dingwall, S. M. Green, A. D. Lowe, P. J. G. Butler, M. J. Gait, and J. Karn. 1993. High-affinity binding of TAR RNA by the HIV type-1 TAT protein requires base-pairs in the RNA stem and amino-acid residues flanking the basic region. J. Mol. Biol. 230:90-110.
    • (1993) J. Mol. Biol. , vol.230 , pp. 90-110
    • Churcher, M.J.1    Lamont, C.2    Hamy, F.3    Dingwall, C.4    Green, S.M.5    Lowe, A.D.6    Butler, P.J.G.7    Gait, M.J.8    Karn, J.9
  • 7
    • 0023026104 scopus 로고
    • Molecular cloning and polymorphism of the human immune deficiency virus type 2
    • Clavel, F., M. Guyader, D. Guetard, M. Salle, L. Montagnier, and M. Alizon. 1986. Molecular cloning and polymorphism of the human immune deficiency virus type 2. Nature. 324:691-695.
    • (1986) Nature , vol.324 , pp. 691-695
    • Clavel, F.1    Guyader, M.2    Guetard, D.3    Salle, M.4    Montagnier, L.5    Alizon, M.6
  • 8
    • 0029982569 scopus 로고    scopus 로고
    • Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent
    • Derossi, D., S. Calvet, A. Trembleau, A. Brunissen, G. Chassaing, and A. Prochiantz. 1996. Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent. J. Biol. Chem. 271:18188-18193.
    • (1996) J. Biol. Chem. , vol.271 , pp. 18188-18193
    • Derossi, D.1    Calvet, S.2    Trembleau, A.3    Brunissen, A.4    Chassaing, G.5    Prochiantz, A.6
  • 11
    • 0029886216 scopus 로고    scopus 로고
    • Characterization of glycosaminoglycan-binding domains present in insulin-like growth factor-binding protein-3
    • Fowlkes, J. L., and D. M. Serra. 1996. Characterization of glycosaminoglycan-binding domains present in insulin-like growth factor-binding protein-3. J. Biol. Chem. 271:14676-14679.
    • (1996) J. Biol. Chem. , vol.271 , pp. 14676-14679
    • Fowlkes, J.L.1    Serra, D.M.2
  • 12
    • 0024262589 scopus 로고
    • Cellular uptake of the TAT protein from human immunodeficiency virus
    • Frankel, A. D., and C. O. Pabo. 1988. Cellular uptake of the TAT protein from human immunodeficiency virus. Cell. 55:1189-1193.
    • (1988) Cell , vol.55 , pp. 1189-1193
    • Frankel, A.D.1    Pabo, C.O.2
  • 13
    • 0031711593 scopus 로고    scopus 로고
    • HIV-1: Fifteen proteins and an RNA
    • Frankel, A. D., and J. A. Young. 1998. HIV-1: fifteen proteins and an RNA. Annu. Rev. Biochem. 67:1-25.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 1-25
    • Frankel, A.D.1    Young, J.A.2
  • 14
    • 0348019063 scopus 로고    scopus 로고
    • TAT mediated protein transduction into cells: Examination phosphorylation status of the retinoblastoma protein in vivo
    • Gius, D., A. M. Vocero-Akbani, M. Wei, and S. F. Dowdy. 1997. TAT mediated protein transduction into cells: examination phosphorylation status of the retinoblastoma protein in vivo. Int. J. Radiat. Oncol. Biol. Phys. 39:160-160.
    • (1997) Int. J. Radiat. Oncol. Biol. Phys. , vol.39 , pp. 160-160
    • Gius, D.1    Vocero-Akbani, A.M.2    Wei, M.3    Dowdy, S.F.4
  • 15
    • 0024209811 scopus 로고
    • Autonomous functional domains of chemically synthesized human immunodeficiency virus TAT transactivator protein
    • Green, M., and P. M. Loewenstein. 1988. Autonomous functional domains of chemically synthesized human immunodeficiency virus TAT transactivator protein. Cell, 55:1179-1188.
    • (1988) Cell , vol.55 , pp. 1179-1188
    • Green, M.1    Loewenstein, P.M.2
  • 16
    • 0035863391 scopus 로고    scopus 로고
    • Synthetic protein transduction domains: Enhanced transduction potential in vitro and in vivo
    • Ho, A., S. R. Schwarze, S. J. Mermelstein, G. Waksman, and S. F. Dowdy. 2001. Synthetic protein transduction domains: enhanced transduction potential in vitro and in vivo. Cancer Res. 61:474-477.
    • (2001) Cancer Res. , vol.61 , pp. 474-477
    • Ho, A.1    Schwarze, S.R.2    Mermelstein, S.J.3    Waksman, G.4    Dowdy, S.F.5
  • 17
    • 0029846734 scopus 로고    scopus 로고
    • Genomic structure and nucleotide sequence analysis of a new HIV type 1 subtype A strain from Nigeria
    • Howard, T. M., and S. Rasheed. 1996. Genomic structure and nucleotide sequence analysis of a new HIV type 1 subtype A strain from Nigeria. AIDS Res. Hum. Retrovir. 12:1413-1425.
    • (1996) AIDS Res. Hum. Retrovir. , vol.12 , pp. 1413-1425
    • Howard, T.M.1    Rasheed, S.2
  • 18
    • 0029563675 scopus 로고
    • Endosomolytic activity of cationic liposomes enhances the delivery of human immunodeficiency virus-1 trans-activator protein (TAT) to mammalian cells
    • Huang, L., H. Farhood, N. Serbina, A. G. Teepe, and J. Barsoum. 1995. Endosomolytic activity of cationic liposomes enhances the delivery of human immunodeficiency virus-1 trans-activator protein (TAT) to mammalian cells. Biochem. Biophys. Res. Commun. 217:761-768.
    • (1995) Biochem. Biophys. Res. Commun. , vol.217 , pp. 761-768
    • Huang, L.1    Farhood, H.2    Serbina, N.3    Teepe, A.G.4    Barsoum, J.5
  • 19
    • 0024414213 scopus 로고
    • HIV-1 TAT protein increases transcriptional initiation and stabilizes elongation
    • Laspia, M. F., A. P. Rice, and M. B. Mathews. 1989. HIV-1 TAT protein increases transcriptional initiation and stabilizes elongation. Cell. 59:283-292.
    • (1989) Cell , vol.59 , pp. 283-292
    • Laspia, M.F.1    Rice, A.P.2    Mathews, M.B.3
  • 20
    • 0034006169 scopus 로고    scopus 로고
    • TAT peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells
    • Lewin, M., N. Carlesso, C. H. Tung, X. W. Tang, D. Cory, D. T. Scadden, and R. Weissleder. 2000. TAT peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat. Biotechnol. 18:410-414.
    • (2000) Nat. Biotechnol. , vol.18 , pp. 410-414
    • Lewin, M.1    Carlesso, N.2    Tung, C.H.3    Tang, X.W.4    Cory, D.5    Scadden, D.T.6    Weissleder, R.7
  • 23
    • 0029014899 scopus 로고
    • Interaction of HIV type-1 TAT-derived peptides with TAR RNA
    • Long, K. S., and D. M. Crothers. 1995. Interaction of HIV type-1 TAT-derived peptides with TAR RNA. Biochemistry. 34:8885-8895.
    • (1995) Biochemistry , vol.34 , pp. 8885-8895
    • Long, K.S.1    Crothers, D.M.2
  • 24
    • 0027234623 scopus 로고
    • Functional analysis of interactions between TAT and the transactivation response element of human immunodeficiency virus type 1 in cells
    • Luo, Y., S. J. Madore, T. G. Parslow, B. R. Cullen, and B. M. Peterlin. 1993. Functional analysis of interactions between TAT and the transactivation response element of human immunodeficiency virus type 1 in cells. J. Virol. 67:5617-5622.
    • (1993) J. Virol. , vol.67 , pp. 5617-5622
    • Luo, Y.1    Madore, S.J.2    Parslow, T.G.3    Cullen, B.R.4    Peterlin, B.M.5
  • 25
    • 0025826124 scopus 로고
    • Lethal neurotoxicity in mice of the basic domains of HIV and SIV REV proteins-study of these regions by circular-dichroism
    • Mabrouk, K., J. Vanrietschoten, E. Vives, H. Darbon, H. Rochat, and J. M. Sabatier. 1991. Lethal neurotoxicity in mice of the basic domains of HIV and SIV REV proteins-study of these regions by circular-dichroism. FEBS Lett. 289:13-17.
    • (1991) FEBS Lett. , vol.289 , pp. 13-17
    • Mabrouk, K.1    Vanrietschoten, J.2    Vives, E.3    Darbon, H.4    Rochat, H.5    Sabatier, J.M.6
  • 26
    • 0037119348 scopus 로고    scopus 로고
    • Efficiency of protein transduction is cell type-dependent and is enhanced by dextran sulfate
    • Mai, J. C., H. M. Shen, S. C. Watkins, T. Cheng, and P. D. Robbins. 2002. Efficiency of protein transduction is cell type-dependent and is enhanced by dextran sulfate. J. Biol. Chem. 277:30208-30218.
    • (2002) J. Biol. Chem. , vol.277 , pp. 30208-30218
    • Mai, J.C.1    Shen, H.M.2    Watkins, S.C.3    Cheng, T.4    Robbins, P.D.5
  • 27
    • 0025797055 scopus 로고
    • Endocytosis and targeting of exogenous HIV-1 TAT protein
    • Mann, D. A., and A. D. Frankel. 1991. Endocytosis and targeting of exogenous HIV-1 TAT protein. EMBO J. 10:1733-1739.
    • (1991) EMBO J. , vol.10 , pp. 1733-1739
    • Mann, D.A.1    Frankel, A.D.2
  • 29
    • 0033794501 scopus 로고    scopus 로고
    • Polyarginine enters cells more efficiently than other polycationic homopolymers
    • Mitchell, D. J., D. T. Kim, L. Steinman, C. G. Fathman, and J. B. Rothbard. 2000. Polyarginine enters cells more efficiently than other polycationic homopolymers. J. Pept. Res. 56:318-325.
    • (2000) J. Pept. Res. , vol.56 , pp. 318-325
    • Mitchell, D.J.1    Kim, D.T.2    Steinman, L.3    Fathman, C.G.4    Rothbard, J.B.5
  • 30
    • 0030068995 scopus 로고    scopus 로고
    • Identification of a human immunodeficiency virus type-1 TAT epitope that is neuroexcitatory and neurotoxic
    • Nath, A., K. Psooy, C. Martin, B. Knudsen, D. S. K. Magnuson, N. Haughey, and J. D. Geiger. 1996. Identification of a human immunodeficiency virus type-1 TAT epitope that is neuroexcitatory and neurotoxic. J. Virol. 70:1475-1480.
    • (1996) J. Virol. , vol.70 , pp. 1475-1480
    • Nath, A.1    Psooy, K.2    Martin, C.3    Knudsen, B.4    Magnuson, D.S.K.5    Haughey, N.6    Geiger, J.D.7
  • 31
    • 0029886367 scopus 로고    scopus 로고
    • Extracellular human immunodeficiency virus type-I TAT protein promotes aggregation and adhesion of cerebellar neurons
    • Orsini, M. J., C. M. Debouck, C. L. Webb, and P. G. Lysko. 1996. Extracellular human immunodeficiency virus type-I TAT protein promotes aggregation and adhesion of cerebellar neurons. J. Neurosci. 16:2546-2552.
    • (1996) J. Neurosci. , vol.16 , pp. 2546-2552
    • Orsini, M.J.1    Debouck, C.M.2    Webb, C.L.3    Lysko, P.G.4
  • 33
    • 0033948268 scopus 로고    scopus 로고
    • Messenger proteins: Homeoproteins, TAT et al
    • Prochiantz, A. 2000. Messenger proteins: homeoproteins, TAT et al. Curr. Opin. Cell Biol. 12:400-406.
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 400-406
    • Prochiantz, A.1
  • 34
    • 0033562094 scopus 로고    scopus 로고
    • Biochemical and functional interactions between HIV-1 TAT protein and TAR RNA
    • Rana, T. M., and K. T. Jeang. 1999. Biochemical and functional interactions between HIV-1 TAT protein and TAR RNA. Arch. Biochem. Biophys. 365:175-185.
    • (1999) Arch. Biochem. Biophys. , vol.365 , pp. 175-185
    • Rana, T.M.1    Jeang, K.T.2
  • 35
    • 0024343087 scopus 로고
    • Plasmid library for the transcription of RNA probes complementary to the entire genome of the human immunodeficiency virus type 1 (HIV-1)
    • Roy, C., C. Knaak, P. Garvie, B. Limmer, and J. Campione-Piccardo. 1989. Plasmid library for the transcription of RNA probes complementary to the entire genome of the human immunodeficiency virus type 1 (HIV-1). Biochem. Cell. Biol. 67:510-515.
    • (1989) Biochem. Cell. Biol. , vol.67 , pp. 510-515
    • Roy, C.1    Knaak, C.2    Garvie, P.3    Limmer, B.4    Campione-Piccardo, J.5
  • 39
    • 0028885704 scopus 로고
    • Recovery of virtually full-length HIV-1 provirus of diverse subtypes from primary virus cultures using the polymerase chain-reaction
    • Salminen, M. O., C. Koch, E. Sandersbuell, P. K. Ehrenberg, N. L. Michael, J. K. Carr, D. S. Burke, and F. E. McCutchan. 1995. Recovery of virtually full-length HIV-1 provirus of diverse subtypes from primary virus cultures using the polymerase chain-reaction. Virology. 213:80-86.
    • (1995) Virology , vol.213 , pp. 80-86
    • Salminen, M.O.1    Koch, C.2    Sandersbuell, E.3    Ehrenberg, P.K.4    Michael, N.L.5    Carr, J.K.6    Burke, D.S.7    McCutchan, F.E.8
  • 40
    • 0037063996 scopus 로고    scopus 로고
    • Nuclear targeting of macromolecular polyanions by an HIV-TAT derived peptide-role for cell-surface proteoglycans
    • Sandgren, S., F. Cheng, and M. Belting. 2002. Nuclear targeting of macromolecular polyanions by an HIV-TAT derived peptide-role for cell-surface proteoglycans. J. Biol. Chem. 277:38877-38883.
    • (2002) J. Biol. Chem. , vol.277 , pp. 38877-38883
    • Sandgren, S.1    Cheng, F.2    Belting, M.3
  • 41
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • Schwarze, S. R., A. Ho, A. Vocero Akbani, and S. F. Dowdy. 1999. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science. 285:1569-1572.
    • (1999) Science , vol.285 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Vocero Akbani, A.3    Dowdy, S.F.4
  • 42
    • 0034237577 scopus 로고    scopus 로고
    • Protein transduction: Unrestricted delivery into all cells?
    • Schwarze, S. R., K. A. Hruska, and S. F. Dowdy. 2000. Protein transduction: unrestricted delivery into all cells? Trends Cell Biol. 10:290-295.
    • (2000) Trends Cell Biol. , vol.10 , pp. 290-295
    • Schwarze, S.R.1    Hruska, K.A.2    Dowdy, S.F.3
  • 43
    • 0031567121 scopus 로고    scopus 로고
    • Titration calorimetry of lipid-peptide interactions
    • Seelig, J. 1997. Titration calorimetry of lipid-peptide interactions. Biochim. Biophys. Acta. Rev. Biomembr. 1331:103-116.
    • (1997) Biochim. Biophys. Acta. Rev. Biomembr. , vol.1331 , pp. 103-116
    • Seelig, J.1
  • 44
    • 0021839696 scopus 로고
    • Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III
    • Sodroski, J., R. Patarca, C. Rosen, F. Wong Staal, and W. Haseltine. 1985. Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III. Science. 229:74-77.
    • (1985) Science , vol.229 , pp. 74-77
    • Sodroski, J.1    Patarca, R.2    Rosen, C.3    Wong Staal, F.4    Haseltine, W.5
  • 45
    • 0032883128 scopus 로고    scopus 로고
    • A disulfide conjugate between anti-tetanus antibodies and HIV (37-72) TAT neutralizes tetanus toxin inside chromaffin cells
    • Stein, S., A. Weiss, K. Adermann, P. Lazarovici, J. Hochman, and H. Wellhoner. 1999. A disulfide conjugate between anti-tetanus antibodies and HIV (37-72) TAT neutralizes tetanus toxin inside chromaffin cells. FEBS Lett. 458:383-386.
    • (1999) FEBS Lett. , vol.458 , pp. 383-386
    • Stein, S.1    Weiss, A.2    Adermann, K.3    Lazarovici, P.4    Hochman, J.5    Wellhoner, H.6
  • 47
    • 0035902477 scopus 로고    scopus 로고
    • TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors
    • Torchilin, V. P., R. Rammohan, V. Weissig, and T. S. Levchenko. 2001. TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Proc. Natl. Acad. Sci. USA. 98:8786-8791.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8786-8791
    • Torchilin, V.P.1    Rammohan, R.2    Weissig, V.3    Levchenko, T.S.4
  • 48
    • 0035793619 scopus 로고    scopus 로고
    • Internalization of HIV-1 TAT requires cell surface heparan sulfate proteoglycans
    • Tyagi, M., M. Rusnati, M. Presta, and M. Giacca. 2001. Internalization of HIV-1 TAT requires cell surface heparan sulfate proteoglycans. J. Biol. Chem. 276:3254-3261.
    • (2001) J. Biol. Chem. , vol.276 , pp. 3254-3261
    • Tyagi, M.1    Rusnati, M.2    Presta, M.3    Giacca, M.4
  • 50
    • 0037159193 scopus 로고    scopus 로고
    • Evidence for a plasma membrane-mediated permeability barrier to TAT basic domain in well-differentiated epithelial cells: Lack of correlation with heparan sulfate
    • Violini, S., V. Sharma, J. L. Prior, M. Dyszlewski, and D. Piwnica-Worms. 2002. Evidence for a plasma membrane-mediated permeability barrier to TAT basic domain in well-differentiated epithelial cells: lack of correlation with heparan sulfate. Biochemistry. 41:12652-12661.
    • (2002) Biochemistry , vol.41 , pp. 12652-12661
    • Violini, S.1    Sharma, V.2    Prior, J.L.3    Dyszlewski, M.4    Piwnica-Worms, D.5
  • 51
    • 0030904245 scopus 로고    scopus 로고
    • A truncated HIV-1 TAT protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
    • Vives, E., P. Brodin, and B. Lebleu. 1997. A truncated HIV-1 TAT protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J. Biol. Chem. 272:16010-16017.
    • (1997) J. Biol. Chem. , vol.272 , pp. 16010-16017
    • Vives, E.1    Brodin, P.2    Lebleu, B.3
  • 53
    • 0025168740 scopus 로고
    • Fragments of the HIV-1 TAT protein specifically bind TAR RNA
    • Weeks, K. M., C. Ampe, S. C. Schultz, T. A. Steitz, and D. M. Crothers. 1990. Fragments of the HIV-1 TAT protein specifically bind TAR RNA. Science. 249:1281-1285.
    • (1990) Science , vol.249 , pp. 1281-1285
    • Weeks, K.M.1    Ampe, C.2    Schultz, S.C.3    Steitz, T.A.4    Crothers, D.M.5
  • 54
    • 0034700141 scopus 로고    scopus 로고
    • The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters
    • Wender, P. A., D. J. Mitchell, K. Pattabiraman, E. T. Pelkey, L. Steinman, and J. B. Rothbard. 2000. The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters. Proc. Natl. Acad. Sci. USA. 97:13003-13008.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13003-13008
    • Wender, P.A.1    Mitchell, D.J.2    Pattabiraman, K.3    Pelkey, E.T.4    Steinman, L.5    Rothbard, J.B.6
  • 55
    • 0024356301 scopus 로고
    • Rapid measurement of binding constants and heats of binding using a new titration calorimeter
    • Wiseman, T., S. Williston, J. F. Brandts, and L. N. Lin. 1989. Rapid measurement of binding constants and heats of binding using a new titration calorimeter. Anal. Biochem. 179:131-137.
    • (1989) Anal. Biochem. , vol.179 , pp. 131-137
    • Wiseman, T.1    Williston, S.2    Brandts, J.F.3    Lin, L.N.4
  • 56
    • 0043166977 scopus 로고    scopus 로고
    • Protein transduction domains of HIV-1 and SIV TAT interact with charged lipid vesicles. Binding mechanism and thermodynamic analysis
    • Ziegler, A., X. Li Blatter, A. Seelig, and J. Seelig. 2003. Protein transduction domains of HIV-1 and SIV TAT interact with charged lipid vesicles. Binding mechanism and thermodynamic analysis. Biochemistry. 41:9185-9194.
    • (2003) Biochemistry , vol.41 , pp. 9185-9194
    • Ziegler, A.1    Li Blatter, X.2    Seelig, A.3    Seelig, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.