Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ-selective partial agonists by disruption of molecular planarity/symmetry

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 20, 2010, Pages 7164-7173

  Kasuga, Jun Ichi ^a   Ishikawa, Minoru ^a   Yonehara, Mitsuhiro ^a   Makishima, Makoto ^b   Hashimoto, Yuichi ^a   Miyachi, Hiroyuki ^c  

^a UNIVERSITY OF TOKYO   (Japan)

^b NIHON UNIVERSITY   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

Aqueous solubility; Molecular design; Nuclear receptor; PPAR agonist

Indexed keywords

4' BUTOXY 3' [[2 FLUORO 4 (TRIFLUOROMETHYL)PHENYLAMIDO]METHYL]BIPHENYL 3 CARBOXYLIC ACID; 4' BUTOXY 3' [[2 FLUORO 4 (TRIFLUOROMETHYL)PHENYLAMIDO]METHYL]BIPHENYL 4 CARBOXYLIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG SYNTHESIS; SOLUBILITY;

BINDING SITES; CARBOXYLIC ACIDS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; PPAR DELTA; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 77957574845     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.08.041     Document Type: Article

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