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Volumn 16, Issue 8, 2012, Pages 1739-1749

The Akt1 isoform is an essential mediator of ischaemic preconditioning

Author keywords

Akt isoforms; in vivo myocardial ischaemia reperfusion injury; Ischaemic preconditioning

Indexed keywords

AKT1 PROTEIN, MOUSE; AKT2 PROTEIN, MOUSE; ISOENZYME; PROTEIN KINASE B;

EID: 84864378837     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2011.01491.x     Document Type: Article
Times cited : (30)

References (57)
  • 1
    • 7044274426 scopus 로고    scopus 로고
    • Signal transduction of the protective effect of insulin like growth factor-1 on adriamycin-induced apoptosis in cardiac muscle cells
    • Chae HJ, Kim HR, Bae J, et al. Signal transduction of the protective effect of insulin like growth factor-1 on adriamycin-induced apoptosis in cardiac muscle cells. Arch Pharm Res. 2004; 27: 324-33.
    • (2004) Arch Pharm Res. , vol.27 , pp. 324-333
    • Chae, H.J.1    Kim, H.R.2    Bae, J.3
  • 2
    • 0035951395 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 protects H9c2 cardiac myoblasts from oxidative stress-induced apoptosis via phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways
    • Hong F, Kwon SJ, Jhun BS, et al. Insulin-like growth factor-1 protects H9c2 cardiac myoblasts from oxidative stress-induced apoptosis via phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways. Life Sci. 2001; 68: 1095-105.
    • (2001) Life Sci. , vol.68 , pp. 1095-1105
    • Hong, F.1    Kwon, S.J.2    Jhun, B.S.3
  • 3
    • 0032510947 scopus 로고    scopus 로고
    • Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle
    • Brozinick JTJr, Birnbaum MJ. Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle. J Biol Chem. 1998; 273: 14679-82.
    • (1998) J Biol Chem. , vol.273 , pp. 14679-14682
    • Brozinick Jr., J.T.1    Birnbaum, M.J.2
  • 4
    • 0033534088 scopus 로고    scopus 로고
    • Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro
    • Matsui T, Li L, del M, et al. Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation. 1999; 100: 2373-9.
    • (1999) Circulation. , vol.100 , pp. 2373-2379
    • Matsui, T.1    Li, L.2    del, M.3
  • 5
    • 77953812567 scopus 로고    scopus 로고
    • MG53 constitutes a primary determinant of cardiac ischemic preconditioning
    • Cao CM, Zhang Y, Weisleder N, et al. MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation. 2010; 121: 2565-74.
    • (2010) Circulation. , vol.121 , pp. 2565-2574
    • Cao, C.M.1    Zhang, Y.2    Weisleder, N.3
  • 6
    • 70349124966 scopus 로고    scopus 로고
    • Propofol protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via Akt activation and Bcl-2 up-regulation
    • Wang B, Shravah J, Luo H, et al. Propofol protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via Akt activation and Bcl-2 up-regulation. Biochem Biophys Res Commun. 2009; 389: 105-11.
    • (2009) Biochem Biophys Res Commun. , vol.389 , pp. 105-111
    • Wang, B.1    Shravah, J.2    Luo, H.3
  • 7
    • 0032189381 scopus 로고    scopus 로고
    • Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation
    • Coffer PJ, Jin J, Woodgett JR. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J. 1998; 335: 1-13.
    • (1998) Biochem J. , vol.335 , pp. 1-13
    • Coffer, P.J.1    Jin, J.2    Woodgett, J.R.3
  • 8
    • 0034065651 scopus 로고    scopus 로고
    • Mapping of AKT3, encoding a member of the Akt/protein kinase B family, to human and rodent chromosomes by fluorescence in situ hybridization
    • Murthy SS, Tosolini A, Taguchi T, et al. Mapping of AKT3, encoding a member of the Akt/protein kinase B family, to human and rodent chromosomes by fluorescence in situ hybridization. Cytogenet Cell Genet. 2000; 88: 38-40.
    • (2000) Cytogenet Cell Genet. , vol.88 , pp. 38-40
    • Murthy, S.S.1    Tosolini, A.2    Taguchi, T.3
  • 9
    • 0035499454 scopus 로고    scopus 로고
    • Ten years of protein kinase B signalling: a hard Akt to follow
    • Brazil DP, Hemmings BA. Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci. 2001; 26: 657-64.
    • (2001) Trends Biochem Sci. , vol.26 , pp. 657-664
    • Brazil, D.P.1    Hemmings, B.A.2
  • 10
    • 0035448879 scopus 로고    scopus 로고
    • Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
    • Chen WS, Xu PZ, Gottlob K, et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 2001; 15: 2203-8.
    • (2001) Genes Dev. , vol.15 , pp. 2203-2208
    • Chen, W.S.1    Xu, P.Z.2    Gottlob, K.3
  • 11
    • 0035914388 scopus 로고    scopus 로고
    • Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
    • Cho H, Thorvaldsen JL, Chu Q, et al. Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem. 2001; 276: 38349-52.
    • (2001) J Biol Chem. , vol.276 , pp. 38349-38352
    • Cho, H.1    Thorvaldsen, J.L.2    Chu, Q.3
  • 12
    • 0042357084 scopus 로고    scopus 로고
    • Protein kinase B alpha/Akt1 regulates placental development and foetal growth
    • Yang ZZ, Tschopp O, Hemmings-Mieszczak M, et al. Protein kinase B alpha/Akt1 regulates placental development and foetal growth. J Biol Chem. 2003; 278: 32124-31.
    • (2003) J Biol Chem. , vol.278 , pp. 32124-32131
    • Yang, Z.Z.1    Tschopp, O.2    Hemmings-Mieszczak, M.3
  • 13
    • 0035368548 scopus 로고    scopus 로고
    • Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
    • Cho H, Mu J, Kim JK, et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science. 2001; 292: 1728-31.
    • (2001) Science. , vol.292 , pp. 1728-1731
    • Cho, H.1    Mu, J.2    Kim, J.K.3
  • 14
    • 85047693348 scopus 로고    scopus 로고
    • Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta
    • Garofalo RS, Orena SJ, Rafidi K, et al. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J Clin Invest. 2003; 112: 197-208.
    • (2003) J Clin Invest. , vol.112 , pp. 197-208
    • Garofalo, R.S.1    Orena, S.J.2    Rafidi, K.3
  • 15
    • 20044382806 scopus 로고    scopus 로고
    • Role for Akt3/protein kinase Bgamma in attainment of normal brain size
    • Easton RM, Cho H, Roovers K, et al. Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol. 2005; 25: 1869-78.
    • (2005) Mol Cell Biol. , vol.25 , pp. 1869-1878
    • Easton, R.M.1    Cho, H.2    Roovers, K.3
  • 16
    • 23144449547 scopus 로고    scopus 로고
    • Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis
    • Tschopp O, Yang ZZ, Brodbeck D, et al. Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development. 2005; 132: 2943-54.
    • (2005) Development. , vol.132 , pp. 2943-2954
    • Tschopp, O.1    Yang, Z.Z.2    Brodbeck, D.3
  • 17
    • 27944493875 scopus 로고    scopus 로고
    • Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice
    • Yang ZZ, Tschopp O, Di Poi N, et al. Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice. Mol Cell Biol. 2005; 25: 10407-18.
    • (2005) Mol Cell Biol. , vol.25 , pp. 10407-10418
    • Yang, Z.Z.1    Tschopp, O.2    Di Poi, N.3
  • 18
    • 33750380920 scopus 로고    scopus 로고
    • Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies
    • Dummler B, Tschopp O, Hynx D, et al. Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol. 2006; 26: 8042-51.
    • (2006) Mol Cell Biol. , vol.26 , pp. 8042-8051
    • Dummler, B.1    Tschopp, O.2    Hynx, D.3
  • 19
    • 0033214101 scopus 로고    scopus 로고
    • Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3
    • Masure S, Haefner B, Wesselink JJ, et al. Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3. Eur J Biochem. 1999; 265: 353-60.
    • (1999) Eur J Biochem. , vol.265 , pp. 353-360
    • Masure, S.1    Haefner, B.2    Wesselink, J.J.3
  • 20
    • 33646449520 scopus 로고    scopus 로고
    • Akt1 is required for physiological cardiac growth
    • DeBosch B, Treskov I, Lupu TS, et al. Akt1 is required for physiological cardiac growth. Circulation. 2006; 113: 2097-104.
    • (2006) Circulation. , vol.113 , pp. 2097-2104
    • DeBosch, B.1    Treskov, I.2    Lupu, T.S.3
  • 21
    • 33845703636 scopus 로고    scopus 로고
    • Akt2 regulates cardiac metabolism and cardiomyocyte survival
    • DeBosch B, Sambandam N, Weinheimer C, et al. Akt2 regulates cardiac metabolism and cardiomyocyte survival. J Biol Chem. 2006; 281: 32841-51.
    • (2006) J Biol Chem. , vol.281 , pp. 32841-32851
    • DeBosch, B.1    Sambandam, N.2    Weinheimer, C.3
  • 22
    • 1142309743 scopus 로고    scopus 로고
    • New directions for protecting the heart against ischaemia-reperfusion injury: targeting the reperfusion injury salvage kinase (RISK)-pathway
    • Hausenloy DJ, Yellon DM. New directions for protecting the heart against ischaemia-reperfusion injury: targeting the reperfusion injury salvage kinase (RISK)-pathway. Cardiovasc Res. 2004; 61: 448-60.
    • (2004) Cardiovasc Res. , vol.61 , pp. 448-460
    • Hausenloy, D.J.1    Yellon, D.M.2
  • 23
    • 12344311866 scopus 로고    scopus 로고
    • Ischemic preconditioning protects by activating prosurvival kinases at reperfusion
    • Hausenloy DJ, Tsang A, Mocanu MM, et al. Ischemic preconditioning protects by activating prosurvival kinases at reperfusion. Am J Physiol Heart Circ Physiol. 2005; 288: H971-6.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Hausenloy, D.J.1    Tsang, A.2    Mocanu, M.M.3
  • 24
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • Burgering BM, Coffer PJ. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature. 1995; 376: 599-602.
    • (1995) Nature. , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 25
    • 0032493729 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway
    • Pap M, Cooper GM. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem. 1998; 273: 19929-32.
    • (1998) J Biol Chem. , vol.273 , pp. 19929-19932
    • Pap, M.1    Cooper, G.M.2
  • 26
    • 85047692700 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore
    • Juhaszova M, Zorov DB, Kim SH, et al. Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J Clin Invest. 2004; 113: 1535-49.
    • (2004) J Clin Invest. , vol.113 , pp. 1535-1549
    • Juhaszova, M.1    Zorov, D.B.2    Kim, S.H.3
  • 27
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 1997; 91: 231-41.
    • (1997) Cell. , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3
  • 28
    • 1642301562 scopus 로고    scopus 로고
    • An in vivo model of ischaemia-reperfusion injury and ischaemic preconditioning in the mouse heart
    • Fisher SG, Marber MS. An in vivo model of ischaemia-reperfusion injury and ischaemic preconditioning in the mouse heart. J Pharmacol Toxicol Methods. 2002; 48: 161-9.
    • (2002) J Pharmacol Toxicol Methods. , vol.48 , pp. 161-169
    • Fisher, S.G.1    Marber, M.S.2
  • 29
    • 34447507839 scopus 로고    scopus 로고
    • Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore
    • Lim SY, Davidson SM, Hausenloy DJ, et al. Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore. Cardiovasc Res. 2007; 75: 530-5.
    • (2007) Cardiovasc Res. , vol.75 , pp. 530-535
    • Lim, S.Y.1    Davidson, S.M.2    Hausenloy, D.J.3
  • 30
    • 0034683064 scopus 로고    scopus 로고
    • Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C
    • Tong H, Chen W, Steenbergen C, et al. Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C. Circ Res. 2000; 87: 309-15.
    • (2000) Circ Res. , vol.87 , pp. 309-315
    • Tong, H.1    Chen, W.2    Steenbergen, C.3
  • 31
    • 0037040856 scopus 로고    scopus 로고
    • Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase- dependent pathway is cardioprotective
    • Tong H, Imahashi K, Steenbergen C, et al. Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase- dependent pathway is cardioprotective. Circ Res. 2002; 90: 377-9.
    • (2002) Circ Res. , vol.90 , pp. 377-379
    • Tong, H.1    Imahashi, K.2    Steenbergen, C.3
  • 32
    • 23644447741 scopus 로고    scopus 로고
    • Preconditioning the diabetic heart: the importance of Akt phosphorylation
    • Tsang A, Hausenloy DJ, Mocanu MM, et al. Preconditioning the diabetic heart: the importance of Akt phosphorylation. Diabetes. 2005; 54: 2360-4.
    • (2005) Diabetes. , vol.54 , pp. 2360-2364
    • Tsang, A.1    Hausenloy, D.J.2    Mocanu, M.M.3
  • 33
    • 3142566467 scopus 로고    scopus 로고
    • Cross-talk between the survival kinases during early reperfusion: its contribution to ischemic preconditioning
    • Hausenloy DJ, Mocanu MM, Yellon DM. Cross-talk between the survival kinases during early reperfusion: its contribution to ischemic preconditioning. Cardiovasc Res. 2004; 63: 305-12.
    • (2004) Cardiovasc Res. , vol.63 , pp. 305-312
    • Hausenloy, D.J.1    Mocanu, M.M.2    Yellon, D.M.3
  • 34
    • 0035902451 scopus 로고    scopus 로고
    • Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo
    • Matsui T, Tao J, del Monte F, et al. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation. 2001; 104: 330-5.
    • (2001) Circulation. , vol.104 , pp. 330-335
    • Matsui, T.1    Tao, J.2    del Monte, F.3
  • 35
    • 0037151104 scopus 로고    scopus 로고
    • Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart
    • Matsui T, Li L, Wu JC, et al. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem. 2002; 277: 22896-901.
    • (2002) J Biol Chem. , vol.277 , pp. 22896-22901
    • Matsui, T.1    Li, L.2    Wu, J.C.3
  • 36
    • 38149119513 scopus 로고    scopus 로고
    • Sex differences in the mechanism of Met5-enkephalin-induced cardioprotection: role of PI3K/Akt
    • Cao Z, Liu L, Packwood W, et al. Sex differences in the mechanism of Met5-enkephalin-induced cardioprotection: role of PI3K/Akt. Am J Physiol Heart Circ Physiol. 2008; 294: H302-10.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Cao, Z.1    Liu, L.2    Packwood, W.3
  • 37
    • 61549095530 scopus 로고    scopus 로고
    • The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning
    • Dreixler JC, Hemmert JW, Shenoy SK, et al. The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning. Exp Eye Res. 2009; 88: 512-21.
    • (2009) Exp Eye Res. , vol.88 , pp. 512-521
    • Dreixler, J.C.1    Hemmert, J.W.2    Shenoy, S.K.3
  • 38
    • 44449133771 scopus 로고    scopus 로고
    • Inhibition of GSK3beta by postconditioning is required to prevent opening of the mitochondrial permeability transition pore during reperfusion
    • Gomez L, Paillard M, Thibault H, et al. Inhibition of GSK3beta by postconditioning is required to prevent opening of the mitochondrial permeability transition pore during reperfusion. Circulation. 2008; 117: 2761-8.
    • (2008) Circulation. , vol.117 , pp. 2761-2768
    • Gomez, L.1    Paillard, M.2    Thibault, H.3
  • 39
    • 35348988663 scopus 로고    scopus 로고
    • Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection
    • Nishihara M, Miura T, Miki T, et al. Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection. J Mol Cell Cardiol. 2007; 43: 564-70.
    • (2007) J Mol Cell Cardiol. , vol.43 , pp. 564-570
    • Nishihara, M.1    Miura, T.2    Miki, T.3
  • 40
    • 33746837190 scopus 로고    scopus 로고
    • Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3 beta
    • Nishihara M, Miura T, Miki T, et al. Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3 beta. Am J Physiol Heart Circ Physiol. 2006; 291: H748-55.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Nishihara, M.1    Miura, T.2    Miki, T.3
  • 41
    • 0031724425 scopus 로고    scopus 로고
    • Ischemic preconditioning triggers tyrosine kinase signaling: a potential role for MAPKAP kinase 2
    • Maulik N, Yoshida T, Zu YL, et al. Ischemic preconditioning triggers tyrosine kinase signaling: a potential role for MAPKAP kinase 2. Am J Physiol. 1998; 275: H1857-64.
    • (1998) Am J Physiol , vol.275
    • Maulik, N.1    Yoshida, T.2    Zu, Y.L.3
  • 42
    • 73449146667 scopus 로고    scopus 로고
    • Differential role of Pim-1 kinase in anesthetic-induced and ischemic preconditioning against myocardial infarction
    • Stumpner J, Redel A, Kellermann A, et al. Differential role of Pim-1 kinase in anesthetic-induced and ischemic preconditioning against myocardial infarction. Anesthesiology. 2009; 111: 1257-64.
    • (2009) Anesthesiology. , vol.111 , pp. 1257-1264
    • Stumpner, J.1    Redel, A.2    Kellermann, A.3
  • 43
    • 42449095582 scopus 로고    scopus 로고
    • Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons
    • Miyawaki T, Mashiko T, Ofengeim D, et al. Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons. Proc Natl Acad Sci USA. 2008; 105: 4892-7.
    • (2008) Proc Natl Acad Sci USA. , vol.105 , pp. 4892-4897
    • Miyawaki, T.1    Mashiko, T.2    Ofengeim, D.3
  • 44
    • 3042511840 scopus 로고    scopus 로고
    • Role of Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning
    • Uchiyama T, Engelman RM, Maulik N, et al. Role of Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning. Circulation. 2004; 109: 3042-9.
    • (2004) Circulation. , vol.109 , pp. 3042-3049
    • Uchiyama, T.1    Engelman, R.M.2    Maulik, N.3
  • 45
    • 33644876126 scopus 로고    scopus 로고
    • Pharmacological preconditioning with tumour necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase)
    • Lecour S, Suleman N, Deuchar GA, et al. Pharmacological preconditioning with tumour necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase). Circulation. 2005; 112: 3911-8.
    • (2005) Circulation. , vol.112 , pp. 3911-3918
    • Lecour, S.1    Suleman, N.2    Deuchar, G.A.3
  • 46
    • 0036623989 scopus 로고    scopus 로고
    • PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning
    • Mocanu MM, Bell RM, Yellon DM. PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning. J Mol Cell Cardiol. 2002; 34: 661-8.
    • (2002) J Mol Cell Cardiol. , vol.34 , pp. 661-668
    • Mocanu, M.M.1    Bell, R.M.2    Yellon, D.M.3
  • 47
    • 0035141233 scopus 로고    scopus 로고
    • Differential activation of extracellular signal regulated kinase isoforms in preconditioning and opioid-induced cardioprotection
    • Fryer RM, Pratt PF, Hsu AK, et al. Differential activation of extracellular signal regulated kinase isoforms in preconditioning and opioid-induced cardioprotection. J Pharmacol Exp Ther. 2001; 296: 642-9.
    • (2001) J Pharmacol Exp Ther. , vol.296 , pp. 642-649
    • Fryer, R.M.1    Pratt, P.F.2    Hsu, A.K.3
  • 48
    • 33644798286 scopus 로고    scopus 로고
    • Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt
    • Solenkova NV, Solodushko V, Cohen MV, et al. Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt. Am J Physiol Heart Circ Physiol. 2006; 290: H441-9.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Solenkova, N.V.1    Solodushko, V.2    Cohen, M.V.3
  • 49
    • 77954250539 scopus 로고    scopus 로고
    • ERK-MAPK signaling opposes rho-kinase to reduce cardiomyocyte apoptosis in heart ischemic preconditioning
    • Zhang J, Bian HJ, Li XX, et al. ERK-MAPK signaling opposes rho-kinase to reduce cardiomyocyte apoptosis in heart ischemic preconditioning. Mol Med. 2010; 16: 307-15.
    • (2010) Mol Med. , vol.16 , pp. 307-315
    • Zhang, J.1    Bian, H.J.2    Li, X.X.3
  • 50
    • 66349106496 scopus 로고    scopus 로고
    • Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice
    • Chen WS, Peng XD, Wang Y, et al. Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Mol Cell Biol. 2009; 29: 3151-62.
    • (2009) Mol Cell Biol. , vol.29 , pp. 3151-3162
    • Chen, W.S.1    Peng, X.D.2    Wang, Y.3
  • 51
    • 0029892187 scopus 로고    scopus 로고
    • The evolution of diabetic response to ischemia/reperfusion and preconditioning in isolated working rat hearts
    • Tosaki A, Engelman DT, Engelman RM, et al. The evolution of diabetic response to ischemia/reperfusion and preconditioning in isolated working rat hearts. Cardiovasc Res. 1996; 31: 526-36.
    • (1996) Cardiovasc Res. , vol.31 , pp. 526-536
    • Tosaki, A.1    Engelman, D.T.2    Engelman, R.M.3
  • 52
  • 53
    • 51549121088 scopus 로고    scopus 로고
    • Rosiglitazone is cardioprotective in a murine model of myocardial I/R
    • Mersmann J, Tran N, Zacharowski PA, et al. Rosiglitazone is cardioprotective in a murine model of myocardial I/R. Shock. 2008; 30: 64-8.
    • (2008) Shock. , vol.30 , pp. 64-68
    • Mersmann, J.1    Tran, N.2    Zacharowski, P.A.3
  • 54
    • 65449133560 scopus 로고    scopus 로고
    • Glimepiride treatment upon reperfusion limits infarct size via the phosphatidylinositol 3-kinase/Akt pathway in rabbit hearts
    • Nishida H, Sato T, Nomura M, et al. Glimepiride treatment upon reperfusion limits infarct size via the phosphatidylinositol 3-kinase/Akt pathway in rabbit hearts. J Pharmacol Sci. 2009; 109: 251-6.
    • (2009) J Pharmacol Sci. , vol.109 , pp. 251-256
    • Nishida, H.1    Sato, T.2    Nomura, M.3
  • 55
    • 42249101542 scopus 로고    scopus 로고
    • Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening
    • Bhamra GS, Hausenloy DJ, Davidson SM, et al. Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening. Basic Res Cardiol. 2008; 103: 274-84.
    • (2008) Basic Res Cardiol. , vol.103 , pp. 274-284
    • Bhamra, G.S.1    Hausenloy, D.J.2    Davidson, S.M.3
  • 56
    • 66249138889 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 and myocardial protection: more than glycemic control
    • Fields AV, Patterson B, Karnik AA, et al. Glucagon-like peptide-1 and myocardial protection: more than glycemic control. Clin Cardiol. 2009; 32: 236-43.
    • (2009) Clin Cardiol. , vol.32 , pp. 236-243
    • Fields, A.V.1    Patterson, B.2    Karnik, A.A.3
  • 57
    • 33748030752 scopus 로고    scopus 로고
    • Leptin, the obesity-associated hormone, exhibits direct cardioprotective effects
    • Smith CC, Mocanu MM, Davidson SM, et al. Leptin, the obesity-associated hormone, exhibits direct cardioprotective effects. Br J Pharmacol. 2006; 149: 5-13.
    • (2006) Br J Pharmacol. , vol.149 , pp. 5-13
    • Smith, C.C.1    Mocanu, M.M.2    Davidson, S.M.3


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