Danthron triggers ROS and mitochondria-mediated apoptotic death in C6 rat glioma cells through caspase cascades, apoptosis-inducing factor and endonuclease G multiple signaling

Neurochemical Research

Volumn 37, Issue 8, 2012, Pages 1790-1800

  Chiou, Shang Ming ^a   Chiu, Chiz Hao ^b   Yang, Su Tso ^a,b   Yang, Jai Sing ^a   Huang, Hui Ying ^b   Kuo, Chao Lin ^b   Chen, Po Yuan ^b   Chung, Jing Gung ^b,c  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c ASIA UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; C6 rat glioma cells; Caspase cascades; Danthron; Mitochondria; ROS

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DANTRON; ENDONUCLEASE G; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DNA FRAGMENTATION; DRUG ACTIVITY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GLIOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION;

ACETYLCYSTEINE; ANIMALS; ANTHRAQUINONES; APOPTOSIS; APOPTOSIS INDUCING FACTOR; CASPASES; CELL DEATH; CELL LINE, TUMOR; CYTOCHROMES C; ENDODEOXYRIBONUCLEASES; GLIOMA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

RATTUS;

EID: 84864354012     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-012-0792-3     Document Type: Article

References (48)

1. Giese A, Westphal M (2001) Treatment of malignant glioma: a problem beyond the margins of resection. J Cancer Res Clin Oncol 127:217-225
2. Wen PY, Kesari S (2008) Malignant gliomas in adults. N Engl J Med 359:492-507
3. Lefranc F, Rynkowski M, DeWitte O, Kiss R (2009) Present and potential future adjuvant issues in high-grade astrocytic glioma treatment. Adv Tech Stand Neurosurg 34:3-35
4. Kao ST, Yeh CC, Hsieh CC, Yang MD, Lee MR, Liu HS et al (2001) The Chinese medicine Bu-Zhong-Yi-Qi-Tang inhibited proliferation of hepatoma cell lines by inducing apoptosis via G0/G1 arrest. Life Sci 69:1485-1496
5. Chiang JH, Yang JS, Ma CY, Yang MD, Huang HY, Hsia TC et al (2011) Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways. Chem Res Toxicol 24:20-29
6. Sawada M, Nakashima S, Banno Y, Yamakawa H, Hayashi K, Takenaka K et al (2000) Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells. Cell Death Differ 7:761-772
7. Kuo TC, Yang JS, Lin MW, Hsu SC, Lin JJ, Lin HJ et al (2009) Emodin has cytotoxic and protective effects in rat C6 glioma cells: roles of Mdr1a and nuclear factor kappaB in cell survival. J Pharmacol Exp Ther 330:736-744
8. Chen TC, Lai KC, Yang JS, Liao CL, Hsia TC, Chen GW et al (2009) Involvement of reactive oxygen species and caspasedependent pathway in berberine-induced cell cycle arrest and apoptosis in C6 rat glioma cells. Int J Oncol 34:1681-1690
9. Lung FD, Tsai JY (2003) Grb2 SH2 domain-binding peptide analogs as potential anticancer agents. Biopolymers 71:132-140
10. (2011) Danthron Rep Carcinog 128-129
11. (2002) Danthron (1,8-dihydroxyanthraquinone). Rep Carcinog 10:76-77
12. Gilbertson WE, Lessing M (1988) Danthron alarm, FDA response: crucial OTC drug control. Mil Med 153:487-488
13. (1990) IARC Monographs programme on the evaluation of the carcinogenic risk of chemicals to humans. Pharmaceutical Drugs IARC Monogr Eval Carcinog Risk Chem Hum 50:265-275
14. Zhang Z, Fu J, Yao B, Zhang X, Zhao P, Zhou Z (2011) In vitro genotoxicity of danthron and its potential mechanism. Mutat Res 722:39-43
15. Zhang H, Zhou R, Li L, Chen J, Chen L, Li C et al (2011) Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. J Biol Chem 286:1868-1875
16. Lu HF, Lai TY, Hsia TC, Tang YJ, Yang JS, Chiang JH et al (2010) Danthron induces DNA damage and inhibits DNA repair gene expressions in GBM 8401 human brain glioblastoma multiforms cells. Neurochem Res 35:1105-1110
17. Lu HF, Wang HL, Chuang YY, Tang YJ, Yang JS, Ma YS et al (2010) Danthron induced apoptosis through mitochondria- and caspase-3-dependent pathways in human brain glioblastoma multiforms GBM 8401 cells. Neurochem Res 35:390-398
18. Yu FS, Yang JS, Yu CS, Lu CC, Chiang JH, Lin CW et al (2011) Safrole induces apoptosis in human oral cancer HSC-3 cells. J Dent Res 90:168-174
19. Wu SH, Hang LW, Yang JS, Chen HY, Lin HY, Chiang JH et al (2010) Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascadeand mitochondria-dependent pathways. Anticancer Res 30:2125-2133
20. Lu CC, Yang JS, Huang AC, Hsia TC, Chou ST, Kuo CL et al (2010) Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells. Mol Nutr Food Res 54:967-976
21. Coder DM (2001) Assessment of cell viability. Curr Protoc Cytom. Editorial board: Paul Robinson J, managing editor... [et al.] Chapter 9:Unit 9.2
22. Lee JH, Li YC, Ip SW, Hsu SC, Chang NW, Tang NY et al (2008) The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway. Anticancer Res 28:1701-1711
23. Lin SS, Huang HP, Yang JS, Wu JY, Hsia TC, Lin CC et al (2008) DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascadeand mitochondrial-dependent pathway. Cancer Lett 272:77-90
24. Ji BC, Yu CC, Yang ST, Hsia TC, Yang JS, Lai KC et al (2012) Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells. Oncol Rep 27:959-964
25. Kuo CL, Wu SY, Ip SW, Wu PP, Yu CS, Yang JS et al (2011) Apoptotic death in curcumin-treated NPC-TW 076 human nasopharyngeal carcinoma cells is mediated through the ROS, mitochondrial depolarization and caspase-3-dependent signaling responses. Int J Oncol 39:319-328
26. Yeh RD, Chen JC, Lai TY, Yang JS, Yu CS, Chiang JH et al (2011) Gallic acid induces G0/G1 phase arrest and apoptosis in human leukemia HL-60 cells through inhibiting cyclin D and E, and activating mitochondria-dependent pathway. Anticancer Res 31:2821-2832
27. Chou ST, Peng HY, Chang CT, Yang JS, Chung HK, Yang ST et al (2011) Zanthoxylum ailanthoides Sieb and Zucc. extract inhibits growth and induces cell death through G2/M-phase arrest and activation of apoptotic signals in colo 205 human colon adenocarcinoma cells. Anticancer Res 31:1667-1676
28. Wu PP, Chung HW, Liu KC, Wu RS, Yang JS, Tang NY et al (2011) Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways. Int J Oncol 38:1605-1613
29. Ho YT, Yang JS, Li TC, Lin JJ, Lin JG, Lai KC et al (2009) Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9. Cancer Lett 279:155-162
30. Ji BC, Hsu WH, Yang JS, Hsia TC, Lu CC, Chiang JH et al (2009) Gallic acid induces apoptosis via caspase-3 and mitochondrion-dependent pathways in vitro and suppresses lung xenograft tumor growth in vivo. J Agric Food Chem 57: 7596-7604
31. Chen JC, Lu KW, Tsai ML, Hsu SC, Kuo CL, Yang JS et al (2009) Gypenosides induced G0/G1 arrest via CHk2 and apoptosis through endoplasmic reticulum stress and mitochondriadependent pathways in human tongue cancer SCC-4 cells. Oral Oncol 45:273-283
32. Chen YL, Lu HF, Hung FM, Huang AC, Hsueh SC, Liu CM et al (2011) Danthron inhibits murine WEHI-3 cells in vivo, and enhances macrophage phagocytosis and natural killer cell cytotoxic activity in leukemic mice. In Vivo 25:393-398
33. Lin CC, Chen JT, Yang JS, Lu HF, Hsu SC, Tan TW et al (2009) Danthron inhibits the migration and invasion of human brain glioblastoma multiforme cells through the inhibition of mRNA expression of focal adhesion kinase, Rho kinases-1 and metallo proteinase-9. Oncol Rep 22:1033-1037
34. Sun Y, Chen J, Rigas B (2009) Chemopreventive agents induce oxidative stress in cancer cells leading to COX-2 overexpression and COX-2-independent cell death. Carcinogenesis 30:93-100
35. Chen Y, McMillan-Ward E, Kong J, Israels SJ, Gibson SB (2008) Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ 15:171-182
36. Pathak N, Khandelwal S (2007) Role of oxidative stress and apoptosis in cadmium induced thymic atrophy and splenomegaly in mice. Toxicol Lett 169:95-108
37. Chatterjee S, Kundu S, Bhattacharyya A (2008) Mechanism of cadmium induced apoptosis in the immunocyte. Toxicol Lett 177:83-89
38. Kumar B, Kumar A, Pandey BN, Mishra KP, Hazra B (2009) Role of mitochondrial oxidative stress in the apoptosis induced by diospyrin diethylether in human breast carcinoma (MCF-7) cells. Mol Cell Biochem 320:185-195
39. Galluzzi L, Larochette N, Zamzami N, Kroemer G (2006) Mitochondria as therapeutic targets for cancer chemotherapy. Oncogene 25:4812-4830
40. Armstrong JS (2007) Mitochondrial medicine: pharmacological targeting of mitochondria in disease. Br J Pharmacol 151: 1154-1165
41. Pilkington GJ, Parker K, Murray SA (2008) Approaches to mitochondrially mediated cancer therapy. Semin Cancer Biol 18:226-235
42. Lee I, Bender E, Kadenbach B (2002) Control of mitochondrial membrane potential and ROS formation by reversible phosphorylation of cytochrome c oxidase. Mol Cell Biochem 234-235:63-70
43. Galluzzi L, Joza N, Tasdemir E, Maiuri MC, Hengartner M, Abrams JM et al (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ 15:1113-1123
44. Qi F, Li A, Zhao L, Xu H, Inagaki Y, Wang D et al (2010) Cinobufacini, an aqueous extract from Bufo bufo gargarizans Cantor, induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells. J Ethnopharmacol 128:654-661
45. Cheng AC, Tsai ML, Liu CM, Lee MF, Nagabhushanam K, Ho CT et al (2010) Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis. Food Funct 1:301-307
46. Muscolini M, Cianfrocca R, Sajeva A, Mozzetti S, Ferrandina G, Costanzo A et al (2008) Trichostatin A up-regulates p73 and induces Bax-dependent apoptosis in cisplatin-resistant ovarian cancer cells. Mol Cancer Ther 7:1410-1419
47. Lee DH, Kim C, Zhang L, Lee YJ (2008) Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells. Biochem Pharmacol 75:2020-2033
48. Yang SH, Chien CM, Lu MC, Lin YH, Hu XW, Lin SR (2006) Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-XL involved in cardiotoxin III-induced apoptosis in K562 cells. Exp Mol Med 38:435-444