Structure-Based discovery of substituted 4,5′-bithiazoles as novel DNA gyrase inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 14, 2012, Pages 6413-6426

  Brvar, Matjaž ^a   Perdih, Andrej ^a   Renko, Miha ^b,c   Anderluh, Gregor ^a,d   Turk, Dušan ^b,c   Solmajer, Tom ^a  

^a NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^b JO EF STEFAN INSTITUTE   (Slovenia)

^c Center of Excellence for Chemistry and Biology of Proteins   (Slovenia)

^d UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

CEFUROXIME; CLOROBIOCIN; GENTAMICIN; GYRASE INHIBITOR; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME INHIBITION; FLUOROMETRY; NONHUMAN; REVIEW; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; ANTI-BACTERIAL AGENTS; DNA GYRASE; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; MODELS, MOLECULAR; NOVOBIOCIN; PROTEIN CONFORMATION; SMALL MOLECULE LIBRARIES; THIAZOLES;

EID: 84864268953     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300395d     Document Type: Review

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