A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold. Synthesis and antibacterial properties

Journal of Medicinal Chemistry

Volumn 54, Issue 7, 2011, Pages 2207-2224

  Angehrn, Peter ^a   Goetschi, Erwin ^a   Gmuender, Hans ^a   Hebeisen, Paul ^a   Hennig, Michael ^a   Kuhn, Bernd ^a   Luebbers, Thomas ^a   Reindl, Peter ^a   Ricklin, Fabienne ^a   Schmitt Hoffmann, Anne ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE DERIVATIVE; CYCLOTHIALIDINE; GYRASE INHIBITOR; IMIPENEM; LACTAM; LACTONE; LINEZOLID; PENICILLIN G; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; GLUCURONIDATION; GRAM POSITIVE BACTERIUM; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; NONHUMAN; SEPTICEMIA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STENOTROPHOMONAS MALTOPHILIA; STREPTOCOCCUS PYOGENES;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; DNA GYRASE; ENZYME INHIBITORS; LACTAMS; LACTONES; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PEPTIDES, CYCLIC; PROTEIN CONFORMATION;

EID: 79953768958     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1014023     Document Type: Article

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