Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 24, 2011, Pages 7416-7420

  Sherer, Brian A ^a   Hull, Kenneth ^a   Green, Oluyinka ^a   Basarab, Gregory ^a   Hauck, Sheila ^a   Hill, Pamela ^a   Loch III, James T ^a   Mullen, George ^a   Bist, Shanta ^a   Bryant, Joanna ^a   Boriack Sjodin, Ann ^a   Read, Jon ^a   Degrace, Nancy ^a   Uria Nickelsen, Maria ^a   Illingworth, Ruth N ^a   Eakin, Ann E ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Antibacterial; Gyrase; Pyrrolamide

Indexed keywords

3 CYANOPYRROLE; 3 FLUOROPIPERIDINE DERIVATIVE; ANTIBIOTIC AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING); ESTER; ETHYL 2 METHYL 5 CARBOXYLATE PYRROLE; ETHYL 5 METHYL 1H PYRROLE 2 CARBOXYLATE; PIPERIDINE; PYRROLAMIDE DERIVATIVE; PYRROLAMIDE DNA GYRASE; PYRROLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL ANALYSIS; DNA SYNTHESIS; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HYDROLYSIS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; X RAY ANALYSIS;

AMIDES; ANTI-BACTERIAL AGENTS; BACTERIA; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA GYRASE; ENZYME INHIBITORS; MICROBIAL SENSITIVITY TESTS; PROTEIN STRUCTURE, TERTIARY; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS);

EID: 81255154494     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.010     Document Type: Article

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