A PEST deletion mutant of ABCA1 shows impaired internalization and defective cholesterol efflux from late endosomes

Journal of Biological Chemistry

Volumn 280, Issue 32, 2005, Pages 29277-29281

  Chen, Wengen ^a   Wang, Nan ^a   Tall, Alan R ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; BIOLOGICAL MEMBRANES; CELLS; CHOLESTEROL; CYTOLOGY; FLUORESCENCE; IMMUNOLOGY; OPTICAL MICROSCOPY; PHOSPHOLIPIDS;

ENDOSOMES; IMMUNOFLUOROESCENCE CONFOCAL MICROSCOPY; LIPOPROTEINS; PLASMA MEMBRANES;

MUTAGENESIS;

ABC TRANSPORTER A1; ACETYL LOW DENSITY LIPOPROTEIN; APOLIPOPROTEIN A1; CHOLESTEROL; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MONENSIN; PHOSPHOLIPID;

AMINO ACID SEQUENCE; ARTICLE; CELL MEMBRANE; CELL STRAIN HEK293; CELL SURFACE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CYTOPLASM; EMBRYO; ENDOSOME; GENE DELETION; HUMAN; HUMAN CELL; HYPOTHESIS; INTERNALIZATION; ISOTOPE LABELING; LYSOSOME; PEST DOMAIN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; WILD TYPE;

ATP-BINDING CASSETTE TRANSPORTERS; BIOTINYLATION; CELL LINE; CELL MEMBRANE; CHOLESTEROL; CYTOPLASM; ENDOSOMES; GENE DELETION; HUMANS; LIGANDS; LIPOPROTEINS, LDL; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MONENSIN; PLASMIDS; PROTEIN BINDING; RECEPTORS, IMMUNOLOGIC; RECEPTORS, SCAVENGER; SCAVENGER RECEPTORS, CLASS A; TIME FACTORS; TRANSFECTION;

EID: 23844485910     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M505566200     Document Type: Article

References (19)

1. Brooks-Wilson, A., Mardi, M., Clee, S. M., Zhang, L. H., Roomp, K., van Dam, M., Yu, L., Brewer, C., Collins, J. A., Molhuizen, H. O., Loubser, O., Ouelette, B. F., Fichter, K., Ashbourne-Excoffon, K. J., Sensen, C. W., Scherer, S., Mott, S., Denis, M., Martindale, D., Frohlich, J., Morgan, K., Koop, B., Pimstone, S., Kastelein, J. J., and Hayden, M. R. (1999) Nat. Genet. 22, 336-345
2. Rust, S., Rosier, M., Funke, H., Real, J., Amoura, Z., Piette, J. C., Deleuze, J. F., Brewer, H. B., Duverger, N., Denefle, P., and Assmann, G. (1999) Nat. Genet. 22, 352-355
3. Bodzioch, M., Orso, E., Klucken, J., Langmann, T., Bottcher, A., Diederich, W., Drobnik, W., Barlage, S., Buchler, C., Porsch-Ozcurumez, M., Kaminski, W. E., Hahmann, H. W., Oette, K., Rothe, G., Aslanidis, C., Lackner, K. J., and Schmitz, G. (1999) Nat. Genet. 22, 347-351
4. Schaefer, E. J., Zech, L. A., Schwartz, D. E., and Brewer, H. B., Jr. (1980) Ann. Intern. Med. 93, 261-266
5. McNeish, J., Aiello, R. J., Guyot, D., Turi, T., Gabel, C., Aldinger, C., Hoppe, K. L., Roach, M. L., Royer, L. J., de Wet, J., Broccardo, C., Chimini, G., and Francone, O. L. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 4245-4250
6. Francis, G. A., Knopp, R. H., and Oram, J. F. (1995) J. Clin. Investig. 96, 78-87
7. Wang, N., Silver, D. L., Costet, P., and Tall, A. R. (2000) J. Biol. Chem. 275, 33053-33058
8. Oram, J. F., Lawn, R. M., Garvin, M. R., and Wade, D. P. (2000) J. Biol. Chem. 275, 34508-34511
9. Fitzgerald, M. L., Morris, A. L., Rhee, J. S., Andersson, L. P., Mendez, A. J., and Freeman, M. W. (2002) J. Biol. Chem. 277, 33178-33187
10. Chen, W., Sun, Y., Welch, C., Gorelik, A., Leventhal, A. R., Tabas, I., and Tall, A. R. (2001) J. Biol. Chem. 276, 43564-43569
11. Neufeld, E. B., Remaley, A. T., Demosky, S. J., Stonik, J. A., Cooney, A. M., Comly, M., Dwyer, N. K., Zhang, M., Blanchette-Mackie, J., Santamarina-Fojo, S., and Brewer, H. B., Jr. (2001) J. Biol. Chem. 276, 27584-27590
12. Wang, N., Chen, W., Linsel-Nitschke, P., Martinez, L. O., Agerholm-Larsen, B., Silver, D. L., and Tall, A. R. (2003) J. Clin. Investig. 111, 99-107
13. Martinez, L. O., Agerholm-Larsen, B., Wang, N., Chen, W., and Tall, A. R. (2003) J. Biol. Chem. 278, 37368-37374
14. Michaely, P., Li, W. P., Anderson, R. G., Cohen, J. C., and Hobbs, H. H. (2004) J. Biol. Chem. 279, 34023-34031
15. Goldstein, J. L., Ho, Y. K., Basu, S. K., and Brown, M. S. (1979) Proc. Natl. Acad. Sci. U. S. A. 76, 333-337
16. Takahashi, Y., and Smith, J. D. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11358-11363
17. Kounnas, M. Z., Chappell, D., Wong, H., Argraves, W. S., Strickland, D. K. (1995) J. Biol. Chem. 270, 9307-9312
18. Bonifacino, J. S., and Traub, L. M. (2003) Annu. Rev. Biochem. 72, 395-447
19. Neufeld, E. B., Stonik, J. A., Demosky, S. J., Jr., Knapper, C. L., Combs, C. A., Cooney, A., Comly, M., Dwyer, N., Blanchette-Mackie, J., Remaley, A. T., Santamarina-Fojo, S., and Brewer, H. B., Jr. (2004) J. Biol. Chem. 279, 15571-15578