Effect of calpain inhibitor I, an inhibitor of the proteolysis of IκB, on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat

British Journal of Pharmacology

Volumn 121, Issue 4, 1997, Pages 695-704

  Ruetten, Hartmut ^a   Thiemermann, Christoph ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Circulatory shock; Cyclo oxygenase 2; Endotoxin; Inducible nitric oxide synthase; Transcription factor

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BACTERIUM LIPOPOLYSACCHARIDE; BILIRUBIN; CALPASTATIN; CREATININE; CYSTEINE PROTEINASE INHIBITOR; DEXAMETHASONE; ENDOTOXIN; GAMMA GLUTAMYLTRANSFERASE; GLUCOCORTICOID; LACTIC ACID; NITRIC OXIDE SYNTHASE; NORADRENALIN; PROSTAGLANDIN SYNTHASE; TRIACYLGLYCEROL LIPASE; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CREATININE BLOOD LEVEL; ENDOTOXEMIA; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY FAILURE; LACTATE BLOOD LEVEL; MALE; MULTIPLE ORGAN FAILURE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SHOCK; UREA BLOOD LEVEL;

6-KETOPROSTAGLANDIN F1 ALPHA; ANIMALS; CALPAIN; CYSTEINE PROTEINASE INHIBITORS; DEXAMETHASONE; DNA-BINDING PROTEINS; ENDOTOXEMIA; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; MALE; MICE; MULTIPLE ORGAN FAILURE; NITRIC OXIDE SYNTHASE; PROTO-ONCOGENE PROTEINS; RATS; RATS, WISTAR; SHOCK, SEPTIC; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030986711     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701180     Document Type: Article

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