Mitochondrial pathways governing stress resistance, life, and death in the fungal aging model Podospora anserina

Annals of the New York Academy of Sciences

Volumn 1197, Issue , 2010, Pages 54-66

  Osiewacz, Heinz D ^a   Brust, Diana ^a   Hamann, Andrea ^a   Kunstmann, Birgit ^a   Luce, Karin ^a   Müller Ohldach, Mathis ^a   Scheckhuber, Christian Q ^a   Servos, Jörg ^a   Strobel, Ingmar ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Aging; Mitochondria; Podospora anserina; Quality control

Indexed keywords

MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

ACCURACY; APOPTOSIS; AUTOPHAGY; CELL DEATH; CELL STRESS; CELL SURVIVAL; CONFERENCE PAPER; ENERGY TRANSFER; EXCISION REPAIR; GENE CONTROL; GENE EXPRESSION; GENE REARRANGEMENT; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PODOSPORA ANSERINA; QUALITY CONTROL; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY;

EID: 77953221733     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2010.05190.x     Document Type: Conference Paper

References (75)

1. Stahl, U. et al. 1978. Evidence for plasmid like DNA in a filamentous fungus, the ascomycete Podospora anserina. Mol. Gen. Genet. 162: 341-343.
2. Cummings,D.J., L. Belcour&C.Grandchamp. 1979.Mitochondrial DNA from Podospora anserina. I. Isolation and characterization. Mol. Gen. Genet. 171: 229-238.
3. Osiewacz, H.D. & K. Esser. 1984. The mitochondrial plasmid of Podospora anserina: a mobile intron of a mitochondrial gene. Curr. Genet. 8: 299-305.
4. Osiewacz, H.D., A. Clairmont & M. Huth. 1990. Electrophoretic karyotype of the ascomycete Podospora anserina. Curr. Genet. 18: 481-483.
5. Osiewacz, H.D. 1994. A versatile shuttle cosmid vector for the efficient construction of genomic libraries and for the cloning of fungal genes. Curr. Genet. 26: 87-90.
6. Hamann, A. et al. 2005. A two-step protocol for efficient deletion of genes in the filamentous ascomycete Podospora anserina. Curr. Genet. 48: 270-275.
7. Osiewacz, H.D., A. Skaletz & K. Esser. 1991. Integrative transformation of the ascomycete Podospora anserina: identification of the mating-type locus on chromosome VII of electrophoretically separated chromosomes. Appl. Microbiol. Biotechnol. 35: 38-45.
8. Rizet, G. 1953. Sur limpossibilit́e dobtenir lamultiplication v́eǵetative ininterrompue illimit́ee de lascomyc̀ete Podospora anserina. C. R. Acad. Sci. Paris 237: 838-855.
9. Esser, K. 1974. Podospora anserina. In Handbook of Genetics, Vol.I. King, R.C., Ed.: 531-551. Plenum Press. New York, NY.
10. Osiewacz, H.D. 2002. Mitochondrial functions and aging. Gene 286: 65-71.
11. Osiewacz, H.D. & C.Q. Scheckhuber. 2006. Impact of ROS on ageing of two fungal model systems: Saccharomyces cerevisiae and Podospora anserina. Free Radic. Res. 40: 1350-1358.
12. Scheckhuber, C.Q. & H.D. Osiewacz. 2008. Podospora anserina: a model organism to study mechanisms of healthy ageing. Mol. Genet. Genom. 280: 365-374.
13. Lorin, S., E. Dufour & A. Sainsard-Chanet. 2006. Mitochondrial metabolism and aging in the filamentous fungus Podospora anserina. Biochim. Biophys. Acta 1757: 604-610.
14. Osiewacz, H.D. 2002. Aging in fungi: role of mitochondria in Podospora anserina. Mech. Ageing Dev. 123: 755-764.
15. Osiewacz, H.D. 2002. Genes, mitochondria and aging in filamentous fungi. Ageing Res. Rev. 1: 425-442.
16. Osiewacz, H.D. & E. Kimpel. 1999. Mitochondrialnuclear interactions and lifespan control in fungi. Exp. Gerontol. 34: 901-909.
17. Harman, D. 1956. A theory based on free radical and radiation chemistry. J. Gerontol. 11: 298-300.
18. Prillinger, H. & K. Esser. 1977. The phenoloxidases of the ascomycete Podospora anserina. XIII. Action and interaction of genes controlling the formation of laccase. Mol. Gen. Genet. 156: 333-345.
19. Borghouts, C. & H.D. Osiewacz. 1998. Grisea, a coppermodulated transcription factor from Podospora anserina involved in senescence and morphogenesis, is an ortholog of MAC1 in Saccharomyces cerevisiae. Mol. Gen. Genet. 260: 492-502.
20. Borghouts, C. et al. 2002. Copper homeostasis and aging in the fungal model systemPodospora anserina: differential expression of PaCtr3 encoding a copper transporter. Int. J. Biochem. Cell Biol. 34: 1355-1371.
21. Stumpferl, S.W., O. Stephan & H.D. Osiewacz. 2004. Impact of a disruption of a pathway delivering copper to mitochondria on Podospora anserina metabolism and life span. Eukaryot. Cell 3: 200-211.
22. Schulte, E., U. K̈uck & K. Esser. 1988. Extrachromosomal mutants from Podospora anserina: permanent vegetative growth in spite of multiple recombination events in the mitochondrial genome.Mol. Gen. Genet. 211: 342-349.
23. Dufour, E. et al. 2000. A causal link between respiration and senescence in Podospora anserina. Proc. Natl. Acad. Sci. USA 97: 4138-4143.
24. Maxwell, D.P., Y. Wang & L. Mcintosh. 1999. The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells. Proc. Natl. Acad. Sci. USA 96: 8271-8276.
25. Nicholls, D.G. 2002. Mitochondrial function and dysfunction in the cell: its relevance to aging and agingrelated disease. Int. J. Biochem. Cell Biol. 34: 1372-1381.
26. Gredilla, R., J. Grief & H.D. Osiewacz. 2006. Mitochondrial free radical generation and lifespan control in the fungal aging model Podospora anserina. Exp. Gerontol. 41: 439-447.
27. Borghouts, C. et al. 2001. Copper-modulated gene expression and senescence in the filamentous fungus Podospora anserina. Mol. Cell. Biol. 21: 390-399.
28. Borghouts, C. et al. 2002.Respiration, copper availability and SOD activity in P. anserina strains with different lifespan. Biogerontology 3: 143-153.
29. Krause, F. et al. 2004. Supramolecular organization of cytochrome c oxidase- and alternative oxidase-dependent respiratory chains in the filamentous fungus Podospora anserina. J. Biol. Chem. 279: 26453-26461.
30. Groebe,K. et al. 2007. Differential proteomic profiling of mitochondria from Podospora anserina, rat and human reveals distinct patterns of age-related oxidative changes. Exp. Gerontol. 42: 887-898.
31. Rhee, S.G., H.Z. Chae & K. Kim. 2005. Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling. Free Radic. Biol. Med. 38: 1543-1552.
32. Doonan, R. et al. 2008. Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. Genes Dev. 22: 3236-3241.
33. Van Raamsdonk, J.M. & S.Hekimi. 2009. Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 5: e1000361.
34. Yanase, S. et al. 2009. SOD-1 deletions in Caenorhabditis elegans alter the localization of intracellular reactive oxygen species and show molecular compensation. J. Gerontol. A Biol. Sci. Med. Sci. 64: 530-539.
35. Cao, G., E. Sofic & R.L. Prior. 1997. Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radic. Biol. Med. 22: 749-760.
36. Schmalhausen et al. 2007. Antioxidant and prooxidant effects of quercetin on glyceraldehyde-3-phosphate dehydrogenase. Food Chem. Toxicol. 45: 1988-1993.
37. Cook, C.I. & B.P. Yu. 1998. Iron accumulation in aging: modulation by dietary restriction. Mech. AgeingDev. 102: 1-13.
38. Zatta, P. et al. 2008. Accumulation of copper and other metal ions, and metallothionein I/II expression in the bovine brain as a function of aging. J. Chem. Neuroanat. 36: 1-5.
39. Zhu, B.T., E.L. Ezell & J.G. Liehr. 1994. Catechol- O-methyltransferase-catalyzed rapid O-methylation of mutagenic flavonoids.Metabolic inactivation as a possible reason for their lack of carcinogenicity in vivo. J. Biol. Chem. 269: 292-299.
40. Tunbridge, E.M.,T.A. Lane&P.J.Harrison. 2007.Expression ofmultiple catechol-O-methyltransferase (COMT) mRNA variants in human brain. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B: 834-839.
41. Averbeck, N.B. et al. 2000. Identification and characterization of PaMTH1, a putative O-methyltransferase accumulating during senescence of Podospora anserina cultures. Curr. Genet. 37: 200-208.
42. Kunstmann, B. & H.D. Osiewacz. 2008. Over-expression of an S-adenosylmethionine-dependent methyltransferase leads to an extended lifespan of Podospora anserina without impairments in vital functions. Aging Cell 7: 651-662.
43. Kunstmann, B. & H.D. Osiewacz. 2009. The Sadenosylmethionine dependent O-methyltransferase PaMTH1: a longevity assurance factor protecting Podospora anserina against oxidative stress. Aging 1: 1-7.
44. Everett, S.A. et al. 1996. Scavenging of nitrogen dioxide, thiyl, and sulfonyl free radicals by the nutritional antioxidant beta-carotene. J. Biol. Chem. 271: 3988-3994.
45. Mortensen, A. & L.H. Skibsted. 1996. Kinetics of parallel electron transfer from beta-carotene to phenoxyl radical and adduct formation between phenoxyl radical and beta-carotene. Free Radic. Res. 25: 515-523.
46. Gruszecki,W.I. 1999. Carotenoids inmembranes. In The Photochemistry of Carotenoids. Frank, H.A., A.J. Young, G. Britton et al., Eds.: 363-379. Kluwer Academic. Dordrecht, The Netherlands.
47. Strobel, I. et al. 2009. Carotenoids and carotenogenic genes in Podospora anserina: engineering of the carotenoid composition extends the life span of the mycelium. Curr. Genet. 55: 175-184.
48. Stahl, W. et al. 1998. Carotenoid mixtures protect multilamellar liposomes against oxidative damage: synergistic effects of lycopene and lutein. FEBS Lett. 427: 305-308.
49. Shi, J., Y. Kakuda & D. Yeung. 2004. Antioxidative properties of lycopene and other carotenoids from tomatoes: synergistic effects. Biofactors 21: 203-210. (Pubitemid 40921855)
50. Robertson, A.B. et al. 2009. DNA repair in mammalian cells. Base excision repair: the long and short of it. Cell Mol. Life Sci. 66: 981-993.
51. Bohr, V.A. 2002. Repair of oxidative DNA damage in nuclear and mitochondrialDNA, and some changeswith aging in mammalian cells. Free Radic. Biol.Med. 32: 804-812.
52. Soerensen, M. et al. 2009. A potential impact of DNA repair on ageing and lifespan in the ageing model organism Podospora anserina: decrease in mitochondrial DNA repair activity during ageing. Mech. Ageing Dev. 130: 487-496.
53. Borghouts, C., S. Kerschner & H.D. Osiewacz. 2000. Copper-dependence of mitochondrial DNA rearrangements in Podospora anserina. Curr. Genet. 37: 268-275.
54. Bukau, B., J. Weissman & A. Horwich. 2006. Molecular chaperones and protein quality control. Cell 125: 443-451.
55. Luce, K. & H.D. Osiewacz. 2009. Increasing organismal healthspan by enhancing mitochondrial protein quality control. Nat. Cell Biol. 11: 852-858.
56. Suzuki, C.K. et al. 1994. Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration. Science 264: 891.
57. Lu, B. et al. 2007. Roles for the human ATP-dependent Lon protease in mitochondrial DNA maintenance. J. Biol. Chem. 282: 17363-17374.
58. Bota, D.A., J.K. Ngo & K.J. Davies. 2005. Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death. Free Radic. Biol. Med. 38: 665-677.
59. Rigas, S. et al. 2009. Role of Lon1 protease in postgerminative growth and maintenance of mitochondrial function in Arabidopsis thaliana. New Phytol. 181: 588-600.
60. Bota, D.A. & K.J. Davies. 2002. Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nat. Cell Biol. 4: 674-680.
61. Busch, K.B. et al. 2006. Mitochondrial dynamics generate equal distribution but patchwork localization of respiratory complex I. Mol. Membr. Biol. 23: 509-520.
62. Nakada, K. et al. 2001. Inter-mitochondrial complementation: mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA. Nat. Med. 7: 934-940.
63. Ono, T. et al. 2001. Human cells are protected from mitochondrial dysfunction by complementation ofDNA products in fused mitochondria. Nat. Genet. 28: 272-275.
64. Skulachev, V.P. 2001. Mitochondrial filaments and clusters as intracellular power-transmitting cables. Trends Biochem. Sci. 26: 23-29.
65. Scheckhuber, C.Q. et al. 2007. Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. Nat. Cell Biol. 9: 99-105.
66. Scheckhuber,C.Q., E. R̈odel & J.Ẅustehube. 2008. Regulation of mitochondrial dynamics: characterization of fusion and fission genes in the ascomycete Podospora anserina. Biotechnol. J. 3: 781-790.
67. Twig, G. et al. 2008. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 27: 433-446.
68. Scheckhuber, C.Q. 2009. Impact of mitochondrial dynamics on organismic aging. Sci. World J. 9: 250-254.
69. Hamann, A., D. Brust &H.D. Osiewacz. 2008. Apoptosis pathways in fungal growth, development and ageing. Trends Microbiol. 16: 276-283.
70. Pinan-Lucarŕe, B. et al. 2003. Autophagy is induced during cell death by incompatibility and is essential for differentiation in the filamentous fungus Podospora anserina. Mol. Microbiol. 47: 321-333.
71. Pinan-Lucarŕe, B., A. Balguerie & C. Clav́e. 2005. Accelerated cell death in Podospora autophagy mutants. Eukaryot. Cell 4: 1765-1774.
72. Hamann, A., D. Brust & H.D. Osiewacz. 2007. Deletion of putative apoptosis factors leads to lifespan extension in the fungal ageingmodel Podospora anserina. Mol.Microbiol. 65: 948-958.
73. Espagne, E. et al. 2008. The genome sequence of the model ascomycete fungus Podospora anserina. Genome Biol. 9: R77.
74. Lorin, S. et al. 2001. Overexpression of the alternative oxidase restores senescence and fertility in a long-lived respiration-deficientmutant of Podospora anserina. Mol. Microbiol. 42: 1259-1267.
75. Silar, P. et al. 2003. Characterization of the genomic organization of the region bordering the centromere of chromosome V of Podospora anserina by direct sequencing. Fungal Genet. Biol. 39: 250-263.