A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 29, 2009, Pages 11960-11965

  Mitra, Kasturi ^a   Wunder, Christian ^a   Roysam, Badrinath ^b   Lin, Gang ^b   Lippincott Schwartz, Jennifer ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

Cell cycle; Dynamin related protein 1; Mitochondrial morphology

Indexed keywords

CYCLIN E; DYNAMIN RELATED PROTEIN 1; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; DNA REPLICATION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT;

CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P21; G0 PHASE; G1 PHASE; GTP PHOSPHOHYDROLASES; HCT116 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; S PHASE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 67749089562     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0904875106     Document Type: Article

References (31)

1. Detmer SA, Chan DC (2007) Functions and dysfunctions of mitochondrial dynamics. Nat Rev Mol Cell Biol 8:870-879.
2. Karbowski M, Youle RJ (2003) Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death Differ 10:870-880.
3. Schieke SM, McCoy JP, Jr, Finkel T (2008) Coordination of mitochondrial bioenergetics with G1 phase cell cycle progression. Cell Cycle 7:1782-1787.
4. Mandal S, Guptan P, Owusu-Ansah E, Banerjee U (2005) Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila. Dev Cell 9:843-854.
5. Matoba S, et al. (2006) p53 regulates mitochondrial respiration. Science 312:1650-1653.
6. Wang C, et al. (2006) Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proc Natl Acad Sci USA 103:11567-11572.
7. Margineantu DH, et al. (2002) Cell cycle dependent morphology changes and associated mitochondrial DNA redistribution in mitochondria of human cell lines. Mitochondrion 1:425-435.
8. Arakaki N, et al. (2006) Dynamics of mitochondria during the cell cycle. Biol Pharm Bull 29:1962-1965.
9. Murray AW (2004) Recycling the cell cycle: Cyclins revisited. Cell 116:221-234.
10. Smirnova E, Shurland DL, Ryazantsev SN, van der Bliek AM (1998) A human dynamin-related protein controls the distribution of mitochondria. J Cell Biol 143:351-358.
11. Collins TJ, Bootman MD (2003) Mitochondria are morphologically heterogeneous within cells. J Exp Biol 206:1993-2000.
12. Chen LB (1988) Mitochondrial membrane potential in living cells. Annu Rev Cell Biol 4:155-181.
13. Amchenkova AA, Bakeeva LE, Chentsov YS, Skulachev VP, Zorov DB (1988) Coupling membranes as energy-transmitting cables. I. Filamentous mitochondria in fibroblasts and mitochondrial clusters in cardiomyocytes. J Cell Biol 107:481-495.
14. Nicholls DG, Budd SL (2000) Mitochondria and neuronal survival. Physiol Rev 80:315-360.
15. Jones RG, et al. (2005) AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 18:283-293.
16. Bunz F, et al. (1998) Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282:1497-1501.
17. Horn HF, Vousden KH (2007) Coping with stress: Multiple ways to activate p53. Oncogene 26:1306-1316.
18. 1 cyclin-dependent kinases in the mammalian cell cycle. Curr Opin Cell Biol 12:676-684.
19. Cassidy-Stone A, et al. (2008) Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell 14:193-204.
20. Zetterberg A, Larsson O, Wiman KG (1995) What is the restriction point? Curr Opin Cell Biol 7:835-842.
21. Cuenda A, Alessi DR (2000) Use of kinase inhibitors to dissect signaling pathways. Methods Mol Biol 99:161-175.
22. Keck JM, et al. (2007) Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1). J Cell Biol 178:371-385.
23. Ekholm-Reed S, et al. (2004) Deregulation of cyclin E in human cells interferes with prereplication complex assembly. J Cell Biol 165:789-800.
24. Chen H, et al. (2003) Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 160:189-200.
25. Geng Y, et al. (2003) Cyclin E ablation in the mouse. Cell 114:431-443.
26. Frezza C, et al. (2006) OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell 126:177-189.
27. Merkwirth C, et al. (2008) Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria. Genes Dev 22:476-488.
28. Stanton RC, Seifter JL, Boxer DC, Zimmerman E, Cantley LC (1991) Rapid release of bound glucose-6-phosphate dehydrogenase by growth factors. Correlation with increased enzymatic activity. J Biol Chem 266:12442-12448.
29. Donnellan R, Chetty R (1999) Cyclin E in human cancers. FASEB J 13:773-780.
30. Goodwin JS, Kenworthy AK (2005) Photobleaching approaches to investigate diffusional mobility and trafficking of Ras in living cells. Methods 37:154-164.
31. Lin G, et al. (2005) Hierarchical, model-based merging of multiple fragments for improved three-dimensional segmentation of nuclei. Cytometry A 63:20-33.