Cross-talk between PI3K/Akt and MEK/ERK pathways mediates endoplasmic reticulum stress-induced cell cycle progression and cell death in human hepatocellular carcinoma cells

International Journal of Oncology

Volumn 34, Issue 6, 2009, Pages 1749-1757

  Dai, Rongyang ^a   Chen, Run ^a   Li, Hong ^a  

^a SOUTHWEST MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle; Cross talk; Endoplasmic reticulum stress; Human hepatocellular carcinoma; MEK ERK; P13K Akt

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; THAPSIGARGIN; TUNICAMYCIN;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DEATH; CELL SURVIVAL; DRUG SENSITIVITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ENGINEERING; PROTEIN PROTEIN INTERACTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; ENDOPLASMIC RETICULUM; HUMANS; LIVER NEOPLASMS; MAP KINASE KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 67649438633     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000306     Document Type: Article

References (40)

1. Gaut JR and Hendershot LM: The modification and assembly of proteins in the endoplasmic reticulum. Curr Opin Cell Biol 5: 589-595, 1993.
2. Kaufman RJ: Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 13: 1211-1233, 1999.
3. Mori K: Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell 101: 451-454, 2000.
4. Rutkowski DT and Kaufman RJ: A trip to the ER: coping with stress. Trends Cell Biol 14: 20-28, 2004.
5. Ron D and Walter P: Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519-529, 2007.
6. Schroder M and Kaufman RJ: The mammalian unfolded protein response. Annu Rev Biochem 74: 739-789, 2005.
7. Gething MJ and Sambrook J: Protein folding in the cell. Nature 355: 33-45, 1992.
8. Harding HP, Zhang Y and Ron D: Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397: 271-274, 1999.
9. Melero JA and Fincham V: Enhancement of the synthesis of specific cellular polypeptides in a temperature-sensitive Chinese hamster cell line (K12) defective for entry into S phase. J Cell Physiol 88: 355-365, 1978.
10. Brewer JW, Hendershot LM, Sherr CJ and Diehl JA: Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression. Proc Natl Acad Sci USA 96: 8505-8510, 1999.
11. Sherr CJ: G1 phase progression: cycling on cue. Cell 79: 551-555, 1994.
12. 1 cyclin-dependent kinases. Genes Dev 9: 1149-1163, 1995.
13. Morgan DO: Principles of CDK regulation. Nature 374: 131-134, 1995.
14. McCubrey JA, Lee JT, Steelman LS, et al: Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells. Cancer Detect Prev 25: 375-393, 2001.
15. Hu P, Han Z, Couvillon AD and Exton JH: Critical role of endogenous Akt/ IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death. J Biol Chem 279: 49420-49429, 2004.
16. Rommel C, Clarke BA, Zimmermann S, et al: Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science 286: 1738-1741, 1999.
17. Zimmermann S and Moelling K: Phosphorylation and regulation of Raf by Akt (protein kinase B). Science 286: 1741-1744, 1999.
18. Sood R, Porter AC, Ma K, Quilliam LA and Wek RC: Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress. Biochem J 346: 281-293, 2000.
19. Engelman JA, Luo J and Cantley LC: The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 7: 606-619, 2006.
20. Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE and McCubrey JA: JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 18: 189-218, 2004.
21. Shaul YD and Seger R: The MEK/ERK cascade: from signaling specificity to diverse functions. Biochim Biophys Acta 1773: 1213-1226, 2007.
22. Wennstrom S and Downward J: Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor. Mol Cell Biol 19: 4279-4288, 1999.
23. von Gise A, Lorenz P, Wellbrock C, Hemmings B, Berberich-Siebelt F, Rapp UR and Troppmair J: Apoptosis suppression by Raf-1 and MEK1 requires MEK-and phosphatidylinositol 3-kinase-dependent signals. Mol Cell Biol 21: 2324-2336, 2001.
24. Guan KL, Figueroa C, Brtva TR, Zhu T, Taylor J, Barber TD and Vojtek AB: Negative regulation of the serine/threonine kinase B-Raf by Akt. J Biol Chem 275: 27354-27359, 2000.
25. Stambolic V, Suzuki A, de la Pompa JL, et al: Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95: 29-39, 1998.
26. Backman SA, Stambolic V, Suzuki A, et al: Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet 29: 396-403, 2001.
27. Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S, Roberts TM and Sellers WR: Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci USA 96: 2110-2115, 1999.
28. Liu Q, Sasaki T, Kozieradzki I, Wakeham A, Itie A, Dumont DJ and Penninger JM: SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev 13: 786-791, 1999.
29. Aman MJ, Lamkin TD, Okada H, Kurosaki T and Ravichandran KS: The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells. J Biol Chem 273: 33922-33928, 1998.
30. Meier R, Thelen M and Hemmings BA: Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress. EMBO J 17: 7294-7303, 1998.
31. Nawa M, Kanekura K, Hashimoto Y, Aiso S and Matsuoka M: A novel Akt/ PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Cell Signal 20: 493-505, 2008.
32. Auger KR, Serunian LA, Soltoff SP, Libby P and Cantley LC: PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 57: 167-175, 1989.
33. Roche S, Koegl M and Courtneidge SA: The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors. Proc Natl Acad Sci USA 91: 9185-9189, 1994.
34. Takuwa N and Takuwa Y: Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts. Mol Cell Biol 17: 5348-5358, 1997.
35. Treinies I, Paterson HF, Hooper S, Wilson R and Marshall CJ: Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal to stimulate DNA synthesis. Mol Cell Biol 19: 321-329, 1999.
36. 2/M phase of the cell cycle. Curr Biol 12: 919-924, 2002.
37. Kandel ES, Skeen J, Majewski N, et al: Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Mol Cell Biol 22: 7831-7841, 2002.
38. Chambard JC, Lefloch R, Pouysségur J and Lenormand P: ERK implication in cell cycle regulation. Biochim Biophys Acta 1773: 1299-1310, 2007.
39. Liu JF, Chevet E, Kebache S, Lemaitre G, Barritault D, Larose L and Crépin M: Functional Rac-1 and Nck signaling networks are required for FGF-2-induced DNA synthesis in MCF-7 cells. Oncogene 18: 6425-6433, 1999.
40. Dufourny B, Alblas J, van Teeffelen HA, van Schaik FM, van der Burg B, Steenbergh PH and Sussenbach JS: Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase. J Biol Chem 272: 31163-31171, 1997.