Cholesterol overloading leads to hepatic L02 cell damage through activation of the unfolded protein response

International Journal of Molecular Medicine

Volumn 24, Issue 4, 2009, Pages 459-464

  Li, Qi ^a,b   Liu, Zhiguo ^b   Guo, Jianli ^a   Chen, Jiangyuan ^a   Yang, Pu ^c   Tian, Jun ^a   Sun, Jun ^a   Zong, Yiqiang ^a   Qu, Shen ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b WUHAN POLYTECHNIC UNIVERSITY   (China)

^c SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Apoptosis; Cholesterol; Hepatocyte; Unfolded protein response

Indexed keywords

4 PHENYLBUTYRIC ACID; ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; BINDING PROTEIN; CASPASE 3; CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN HOMOLOGOUS PROTEIN 10; CHOLESTEROL ACYLTRANSFERASE; IMMUNOGLOBULIN BINDING PROTEIN; LOW DENSITY LIPOPROTEIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

APOPTOSIS; ARTICLE; CELL ACTIVATION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIVER CELL DAMAGE; NORMAL HUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UNFOLDED PROTEIN RESPONSE; UPREGULATION; WESTERN BLOTTING;

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL LINE; CHOLESTEROL; DNA-BINDING PROTEINS; ENZYME INHIBITORS; HEPATOCYTES; HUMANS; LIPOPROTEINS, LDL; PHENYLBUTYRATES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEROL O-ACYLTRANSFERASE; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

EID: 70350752060     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000253     Document Type: Article

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