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Volumn 14, Issue 1, 2012, Pages 32-38

Molecular mechanisms of anti-inflammatory action of the flavonoid, tricin from Njavara rice (Oryza sativa L.) in human peripheral blood mononuclear cells: Possible role in the inflammatory signaling

Author keywords

Flavonoids; Inflammation; Lipopolysaccharide; Njavara; Signaling; Tricin

Indexed keywords

ANTIINFLAMMATORY AGENT; AUTACOID; CYCLOOXYGENASE 2; FLAVONOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MATRIX METALLOPROTEINASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; SYNAPTOTAGMIN I; TRICIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84863924369     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.06.005     Document Type: Article
Times cited : (68)

References (43)
  • 1
    • 0035409876 scopus 로고    scopus 로고
    • NF-κB transcription factor: Role in the pathogenesis of inflammatory, autoimmune and neoplastic diseases and therapy implications
    • C. Giuliani, G. Napolitano, I. Bucci, V. Montani, and F. Monaco NF-κB transcription factor: role in the pathogenesis of inflammatory, autoimmune and neoplastic diseases and therapy implications Clin Ter 152 2001 249 253
    • (2001) Clin ter , vol.152 , pp. 249-253
    • Giuliani, C.1    Napolitano, G.2    Bucci, I.3    Montani, V.4    Monaco, F.5
  • 2
    • 0038392976 scopus 로고    scopus 로고
    • Nitric oxide in inflammatory bowel disease
    • DOI 10.1097/00054725-200305000-00006
    • R.K. Cross, and K.T. Wilson Nitric oxide in inflammatory bowel disease Inflamm Bowel Dis 9 2003 179 189 (Pubitemid 36592449)
    • (2003) Inflammatory Bowel Diseases , vol.9 , Issue.3 , pp. 179-189
    • Cross, R.K.1    Wilson, K.T.2
  • 3
    • 0242438644 scopus 로고    scopus 로고
    • Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis
    • O.C. Trifan, and T. Hla Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis J Cell Mol Med 7 2003 207 222 (Pubitemid 37372041)
    • (2003) Journal of Cellular and Molecular Medicine , vol.7 , Issue.3 , pp. 207-222
    • Trifan, O.C.1    Hla, T.2
  • 4
    • 2142756588 scopus 로고    scopus 로고
    • Cyclooxygenase 2: From inflammation to carcinogenesis
    • 21526
    • A. Ristimaki Cyclooxygenase 2: from inflammation to carcinogenesis Novartis Found Symp 256 215-26 2004 259 269
    • (2004) Novartis Found Symp , vol.256 , pp. 259-269
    • Ristimaki, A.1
  • 5
    • 48349123905 scopus 로고    scopus 로고
    • Collecting and morphological evaluation of Njavara, a traditional medicinal rice (Oryza sativa L.), in Kerala, India
    • Sreejayan, V.R. Kumar, and G. Thomas Collecting and morphological evaluation of Njavara, a traditional medicinal rice (Oryza sativa L.), in Kerala, India Plant Genet Resour Newsl 135 2003 12 17
    • (2003) Plant Genet Resour Newsl , vol.135 , pp. 12-17
    • Sreejayan1    Kumar, V.R.2    Thomas, G.3
  • 6
    • 73349142974 scopus 로고    scopus 로고
    • Physicochemical and genetic analysis of an endemic rice variety, Njavara (Oryza sativa L.), in comparison to two popular south Indian cultivars, Jyothi (PTB 39) and IR 64
    • G. Deepa, L. Venkatachalam, N. Bhagyalakshmi, H.E. Shashidhar, V. Singh, and K.A. Naidu Physicochemical and genetic analysis of an endemic rice variety, Njavara (Oryza sativa L.), in comparison to two popular south Indian cultivars, Jyothi (PTB 39) and IR 64 J Agric Food Chem 57 2009 11476 11483
    • (2009) J Agric Food Chem , vol.57 , pp. 11476-11483
    • Deepa, G.1    Venkatachalam, L.2    Bhagyalakshmi, N.3    Shashidhar, H.E.4    Singh, V.5    Naidu, K.A.6
  • 7
    • 34548248218 scopus 로고    scopus 로고
    • Nutrient composition and physicochemical properties of Indian medicinal rice - Njavara
    • DOI 10.1016/j.foodchem.2007.05.062, PII S0308814607005225
    • G. Deepa, V. Singh, and K.A. Naidu Nutrient composition and physicochemical properties of Indian medicinal rice-Njavara Food Chem 106 2008 165 171 (Pubitemid 47332101)
    • (2008) Food Chemistry , vol.106 , Issue.1 , pp. 165-171
    • Deepa, G.1    Singh, V.2    Naidu, K.A.3
  • 8
    • 58849118997 scopus 로고    scopus 로고
    • Physicochemical rheological and thermal properties of Njavara rice (Oryza sativa) starch
    • C.K. Simi, and T.E. Abraham Physicochemical rheological and thermal properties of Njavara rice (Oryza sativa) starch J Agric Food Chem 56 2008 12105 12111
    • (2008) J Agric Food Chem , vol.56 , pp. 12105-12111
    • Simi, C.K.1    Abraham, T.E.2
  • 9
    • 84878524787 scopus 로고    scopus 로고
    • Chemical indices, anti-oxidant activity, anti-inflammatory effect of extracts of the medicinal rice 'Njavara' and staple varieties: A comparative study
    • 10.1111/j.1745-4514.2011.00646.x
    • Smitha Mohanlal, Rathnam Parvathy, Vasantha Shalini, Ratheesh Mohanan, Antony Helen, and Ananthasankaran Jayalekshmy Chemical indices, anti-oxidant activity, anti-inflammatory effect of extracts of the medicinal rice 'Njavara' and staple varieties: a comparative study J Food Biochem 2011 10.1111/j.1745-4514.2011.00646.x
    • (2011) J Food Biochem
    • Mohanlal, S.1    Parvathy, R.2    Shalini, V.3    Mohanan, R.4    Helen, A.5    Jayalekshmy, A.6
  • 10
    • 84863950182 scopus 로고    scopus 로고
    • Anti-inflammatory activity of Njavara (Oryza sativa Linn.)
    • V. Shalini, Bhaskar Shobha, and Antony Helen Anti-inflammatory activity of Njavara (Oryza sativa Linn.) J Nat Remedies 11/1 2011
    • (2011) J Nat Remedies , vol.111
    • Shalini, V.1    Shobha, B.2    Helen, A.3
  • 11
    • 79955064616 scopus 로고    scopus 로고
    • Isolation, characterization and quantification of tricin and flavonolignans in the medicinal rice Njavara (Oryza sativa L.), as compared to staple varieties
    • Smitha Mohanlal, Rathnam Parvathy, Vasantha Shalini, Antony Helen, and Ananthasankaran Jayalekshmy Isolation, characterization and quantification of tricin and flavonolignans in the medicinal rice Njavara (Oryza sativa L.), as compared to staple varieties Plants Foods Hum Nutr 66 1 2011 91 96
    • (2011) Plants Foods Hum Nutr , vol.66 , Issue.1 , pp. 91-96
    • Mohanlal, S.1    Parvathy, R.2    Shalini, V.3    Helen, A.4    Jayalekshmy, A.5
  • 12
    • 77956344127 scopus 로고    scopus 로고
    • Tricin - A potential multifunctional nutraceutical
    • J. Zhou, and R.K. Ibrahim Tricin - a potential multifunctional nutraceutical Phytochem Rev 9 2010 413 424
    • (2010) Phytochem Rev , vol.9 , pp. 413-424
    • Zhou, J.1    Ibrahim, R.K.2
  • 13
    • 0033749223 scopus 로고    scopus 로고
    • Characterization of potentially chemopreventive phenols in extracts of brown rice that inhibit the growth of human breast and colon cancer cells
    • E.A. Hudson, P.A. Dinh, T. Kokubun, M.S.J. Simmonds, and A. Gescher Characterization of potentially chemopreventive phenols in extracts of brown rice that inhibit the growth of human breast and colon cancer cells Cancer Epidemiol Biomarkers Prev 9 2000 1163 1170
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , pp. 1163-1170
    • Hudson, E.A.1    Dinh, P.A.2    Kokubun, T.3    Simmonds, M.S.J.4    Gescher, A.5
  • 14
  • 15
    • 0023022289 scopus 로고
    • An improved colourimetric assay for interleukin 2
    • H. Tada An improved colourimetric assay for interleukin 2 J Immunol Methods 93 1986 157 165
    • (1986) J Immunol Methods , vol.93 , pp. 157-165
    • Tada, H.1
  • 16
    • 0033134858 scopus 로고    scopus 로고
    • Modulation of neutral matrix metalloproteinases of involuting rat mammary gland by different cations and glycosammnoglycans
    • DOI 10.1002/(SICI)1097-4644(19990501)73:2<218::AID-JCB8>3.0.CO;2-C
    • M. Ambili, and P.R. Sudhakaran Modulation of neutral matrix metalloproteinases of involuting rat mammary gland by different cations and glycosaminoglycans J Cell Biochem 73 1999 218 226 (Pubitemid 29160189)
    • (1999) Journal of Cellular Biochemistry , vol.73 , Issue.2 , pp. 218-226
    • Ambili, M.1    Sudhakaran, P.R.2
  • 17
    • 0032227260 scopus 로고    scopus 로고
    • Assay of NOS activity by the measurements of conversion of oxy hemoglobin to met hemoglobin by NO
    • M.A. Titheradge, Humana Press Totowa, NJ
    • M. Salter, and R.G. Knowles Assay of NOS activity by the measurements of conversion of oxy hemoglobin to met hemoglobin by NO M.A. Titheradge, Methods in molecular biology nitric oxide protocol 100 1997 Humana Press Totowa, NJ 61 65
    • (1997) Methods in Molecular Biology Nitric Oxide Protocol , vol.100 , pp. 61-65
    • Salter, M.1    Knowles, R.G.2
  • 18
    • 0019508439 scopus 로고
    • Role of prostaglandin endoperoxidases in the serum thiobarbituric acid reaction
    • T. Shimizu, K. Kondo, and O. Hayaishi Role of prostaglandin endoperoxidases in the serum thiobarbituric acid reaction Arch Biochem Biophys 206 1984 271 276
    • (1984) Arch Biochem Biophys , vol.206 , pp. 271-276
    • Shimizu, T.1    Kondo, K.2    Hayaishi, O.3
  • 19
    • 6944244110 scopus 로고    scopus 로고
    • Growth-inhibitory and cell cycle-arresting properties of the rice bran constituent tricin in human-derived breast cancer cells in vitro and in nude mice in vivo
    • DOI 10.1038/sj.bjc.6602124
    • H. Cai, E.A. Hudson, P. Mann, R.D. Verschoyle, P. Greaves, and M.M. Manson Growth-inhibitory and cell cycle-arresting properties of the rice bran constituent tricin in human-derived breast cancer cells in vitro and in nude mice in vivo Br J Cancer 91 2004 1364 1371 (Pubitemid 39424799)
    • (2004) British Journal of Cancer , vol.91 , Issue.7 , pp. 1364-1371
    • Cai, H.1    Hudson, E.A.2    Mann, P.3    Verschoyle, R.D.4    Greaves, P.5    Manson, M.M.6    Steward, W.P.7    Gescher, A.J.8
  • 20
    • 70350014642 scopus 로고    scopus 로고
    • Flavones as colorectal cancer chemopreventive agents - Phenol-O-methylation enhances efficacy
    • Hong Cai, Stewart Sale, and Ralf Schmid Flavones as colorectal cancer chemopreventive agents - phenol-O-methylation enhances efficacy Cancer Prev Res (Phila) 2 2009 743 750
    • (2009) Cancer Prev Res (Phila) , vol.2 , pp. 743-750
    • Cai, H.1    Sale, S.2    Schmid, R.3
  • 21
    • 84861073336 scopus 로고    scopus 로고
    • Tricin inhibits proliferation of human hepatic stellate cells in vitro by blocking tyrosine phosphorylation of PDGF receptor and its signaling pathways
    • 10.1002/jcb.24107
    • N. Seki, U. Toh, K. Kawaguchi, M. Ninomiya, M. Koketsu, and K. Watanabe Tricin inhibits proliferation of human hepatic stellate cells in vitro by blocking tyrosine phosphorylation of PDGF receptor and its signaling pathways J Cell Biochem 2012 10.1002/jcb.24107
    • (2012) J Cell Biochem
    • Seki, N.1    Toh, U.2    Kawaguchi, K.3    Ninomiya, M.4    Koketsu, M.5    Watanabe, K.6
  • 22
    • 76549119214 scopus 로고    scopus 로고
    • Dietary tricin suppresses inflammation-related colon carcinogenesis in male Crj: CD-1 mice
    • T. Oyama, Y. Yasui, S. Sugie, M. Koketsu, K. Watanabe, and T. Tanaka Dietary tricin suppresses inflammation-related colon carcinogenesis in male Crj: CD-1 mice Cancer Prev Res (Phila) 2 12 2009 1031 1038
    • (2009) Cancer Prev Res (Phila) , vol.2 , Issue.12 , pp. 1031-1038
    • Oyama, T.1    Yasui, Y.2    Sugie, S.3    Koketsu, M.4    Watanabe, K.5    Tanaka, T.6
  • 23
    • 33748468361 scopus 로고    scopus 로고
    • Differential modulation of cyclooxygenase-mediated prostaglandin production by the putative cancer chemopreventive flavonoids tricin, apigenin and quercetin
    • DOI 10.1007/s00280-006-0228-3
    • M. Al-Fayez, H. Cai, R. Tunstall, W.P. Steward, and A.J. Gescher Differential modulation of cyclooxygenase-mediated prostaglandin production by the putative cancer chemopreventive flavonoids tricin, apigenin and quercetin Cancer Chemother Pharmacol 58 6 2006 816 825 (Pubitemid 44351263)
    • (2006) Cancer Chemotherapy and Pharmacology , vol.58 , Issue.6 , pp. 816-825
    • Al-Fayez, M.1    Cai, H.2    Tunstall, R.3    Steward, W.P.4    Gescher, A.J.5
  • 24
    • 33644663876 scopus 로고    scopus 로고
    • The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice
    • Hong Cai, Mohammad Al-Fayez, and Richard G. Tunstall The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice Mol Cancer Ther 4 2005 1287 1292
    • (2005) Mol Cancer Ther , vol.4 , pp. 1287-1292
    • Cai, H.1    Al-Fayez, M.2    Tunstall, R.G.3
  • 25
    • 34248350462 scopus 로고    scopus 로고
    • Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties
    • DOI 10.1007/s00280-006-0368-5
    • H. Cai, D.J. Boocock, W.P. Steward, and A.J. Gescher Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties Cancer Chemother Pharmacol 60 2 2007 257 266 (Pubitemid 46742541)
    • (2007) Cancer Chemotherapy and Pharmacology , vol.60 , Issue.2 , pp. 257-266
    • Cai, H.1    Boocock, D.J.2    Steward, W.P.3    Gescher, A.J.4
  • 26
    • 79952254710 scopus 로고    scopus 로고
    • Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3′,4′, 5′,5,7-pentamethoxyflavone and tricin (4′,5,7-trihydroxy-3′, 5′-dimethoxyflavone)
    • H. Cai, S. Sale, R.G. Britton, K. Brown, W.P. Steward, and A.J. Gescher Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3′,4′,5′,5,7- pentamethoxyflavone and tricin (4′,5,7-trihydroxy-3′,5′- dimethoxyflavone) Cancer Chemother Pharmacol 67 2 2011 255 263
    • (2011) Cancer Chemother Pharmacol , vol.67 , Issue.2 , pp. 255-263
    • Cai, H.1    Sale, S.2    Britton, R.G.3    Brown, K.4    Steward, W.P.5    Gescher, A.J.6
  • 27
    • 24944471223 scopus 로고    scopus 로고
    • Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV-visible detection
    • DOI 10.1002/bmc.473
    • H. Cai, W.P. Steward, and A.J. Gescher Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV-visible detection Biomed Chromatogr 19 7 2005 518 522 (Pubitemid 41320495)
    • (2005) Biomedical Chromatography , vol.19 , Issue.7 , pp. 518-522
    • Cai, H.1    Steward, W.P.2    Gescher, A.J.3
  • 28
    • 0033061032 scopus 로고    scopus 로고
    • Protein tyrosine kinase inhibitors as novel therapeutic agents
    • DOI 10.1016/S0163-7258(98)00066-7, PII S0163725898000667
    • A. Levitzki Protein tyrosine kinase inhibitors as novel therapeutic agents Pharmacol Ther 82 1999 231 239 (Pubitemid 29255918)
    • (1999) Pharmacology and Therapeutics , vol.82 , Issue.2-3 , pp. 231-239
    • Levitzki, A.1
  • 29
    • 84863945203 scopus 로고    scopus 로고
    • Protective effect of COX and NOS inhibitors on LPS induced oxidative stress in rat
    • R. Shukla, E. Tyagi, and R. Kumar Protective effect of COX and NOS inhibitors on LPS induced oxidative stress in rat Ann Neurosci 15 1 2008
    • (2008) Ann Neurosci , vol.15 , Issue.1
    • Shukla, R.1    Tyagi, E.2    Kumar, R.3
  • 30
    • 0030921169 scopus 로고    scopus 로고
    • Regulation of cyclooxygenase enzymes by nitric oxide
    • DOI 10.1007/s000180050074
    • D. Salvemini Regulation of cyclooxygenase enzymes by nitric oxide Cell Mol Life Sci 53 1997 576 582 (Pubitemid 27385181)
    • (1997) Cellular and Molecular Life Sciences , vol.53 , Issue.7 , pp. 576-582
    • Salvemini, D.1
  • 32
    • 0033377587 scopus 로고    scopus 로고
    • Cytokines as endogenous pyrogens
    • C.A. Dinarello Cytokines as endogenous pyrogens J Infect Dis 179 1999 294 304
    • (1999) J Infect Dis , vol.179 , pp. 294-304
    • Dinarello, C.A.1
  • 34
    • 0031224949 scopus 로고    scopus 로고
    • Down-regulation of tumor necrosis factor-α, moderate reduction of interleukin-1β, but not interleukin-6 or interleukin-10, by glucan immunomodulators curdlan sulfate and lentinan
    • DOI 10.1016/S0192-0561(97)00056-8, PII S0192056197000568
    • K.N. Masihi, K. Madaj, H. Hintelmann, G. Gast, and Y. Kaneko Down-regulation of tumor necrosis factor-alpha, moderate reduction of interleukin-1beta, but not interleukin-6 or interleukin-10, by glucan immunomodulators curdlan sulfate and lentinan Int J Immunopharmacol 19 1997 463 468 (Pubitemid 28261000)
    • (1997) International Journal of Immunopharmacology , vol.19 , Issue.9-10 , pp. 463-468
    • Masihi, K.N.1    Madaj, K.2    Hintelmann, H.3    Gast, G.4    Kaneko, Y.5
  • 36
    • 0028049994 scopus 로고
    • Secretion of TNF from a rat mast cell line is a brefeldin A-sensitive and a calcium/protein kinase C-regulated process
    • R.A. Baumgartner, K. Yamada, V.A. Deramo, and M.A. Beaven Secretion of TNF-α from a rat mast cell line is a Brefeldin A-sensitive and a calcium/protein kinase C-regulated process J Immunol 153 1994 2609 2617 (Pubitemid 24278130)
    • (1994) Journal of Immunology , vol.153 , Issue.6 , pp. 2609-2617
    • Baumgartner, R.A.1    Yamada, K.2    Deramo, V.A.3    Beaven, M.A.4
  • 38
    • 0035471778 scopus 로고    scopus 로고
    • Gelatinase B: A tuner and amplifier of immune functions
    • DOI 10.1016/S1471-4906(01)02023-3, PII S1471490601020233
    • G. Opdenakker, P.E. Van den Steen, and J. Van Damme Gelatinase B: a tuner and amplifier of immune functions Trends Immunol 22 2001 571 579 (Pubitemid 33016405)
    • (2001) Trends in Immunology , vol.22 , Issue.10 , pp. 571-579
    • Opdenakker, G.1    Van Den Steen, P.E.2    Van Damme, J.3
  • 39
    • 0025808816 scopus 로고
    • Purification and identification of 91-kDa neutrophil gelatinase: Release by the activating peptide interleukin-8
    • S. Masure, P. Proost, J. Van Damme, and G. Opdenakker Purification and identification of 91-kDa neutrophil gelatinase: release by the activating peptide interleukin-8 Eur J Biochem 198 1991 391 398
    • (1991) Eur J Biochem , vol.198 , pp. 391-398
    • Masure, S.1    Proost, P.2    Van Damme, J.3    Opdenakker, G.4
  • 40
    • 0025883322 scopus 로고
    • Cytokine mediated regulation of human leukocyte gelatinases and role in arthritis
    • G. Opdenakker, S. Masure, B. Grillet, and J. Van Damme Cytokine mediated regulation of human leukocyte gelatinases and role in arthritis Lymphokine Cytokine Res 10 1991 317 324
    • (1991) Lymphokine Cytokine Res , vol.10 , pp. 317-324
    • Opdenakker, G.1    Masure, S.2    Grillet, B.3    Van Damme, J.4
  • 41
    • 0028174061 scopus 로고
    • Function and activation of NF-kB in the immune system
    • P.A. Baeuerle, and T. Henkel Function and activation of NF-kB in the immune system Annu Rev Immunol 12 1994 141 179
    • (1994) Annu Rev Immunol , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 42
    • 0030271387 scopus 로고    scopus 로고
    • NF-kB: Ten years after
    • P.A. Baeuerle, and D. Baltimore NF-kB: ten years after Cell 87 1996 13 20
    • (1996) Cell , vol.87 , pp. 13-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 43
    • 0034175930 scopus 로고    scopus 로고
    • The IKK complex: An integrator of all signals that activate NF-κB?
    • DOI 10.1016/S0962-8924(00)01729-3, PII S0962892400017293
    • A. Israel The IKK complex: an integrator of all signals that activate NF-kB Trends Cell Biol 10 2000 129 133 (Pubitemid 30171300)
    • (2000) Trends in Cell Biology , vol.10 , Issue.4 , pp. 129-133
    • Israel, A.1


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