Tricin inhibits proliferation of human hepatic stellate cells in vitro by blocking tyrosine phosphorylation of PDGF receptor and its signaling pathways

Journal of Cellular Biochemistry

Volumn 113, Issue 7, 2012, Pages 2346-2355

  Seki, Naoko ^a,b   Toh, Uhi ^a,c   Kawaguchi, Koji ^d   Ninomiya, Masayuki ^e   Koketsu, Mamoru ^e   Watanabe, Kunitomo ^e   Aoki, Masatora ^b   Fujii, Teruhiko ^a,c,f   Nakamura, Anna ^a   Akagi, Yoshito ^c   Kusukawa, Jingo ^b   Kage, Masayoshi ^a,b   Shirouzu, Kazuo ^c   Yamana, Hideaki ^a,b,c  

^a KURUME UNIVERSITY   (Japan)

^b KURUME UNIVERSITY HOSPITAL   (Japan)

^c KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d TSURUMI UNIVERSITY   (Japan)

^e GIFU UNIVERSITY   (Japan)

^f NATIONAL HOSPITAL ORGANIZATION   (Japan)

Author keywords

Hepatic stellate cell; liver fibrosis; pdgf; signal transduction; tricin

Indexed keywords

FLAVONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN KINASE B; TRICIN; TYROSINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL MIGRATION; CELL PROLIFERATION; CHRONIC LIVER DISEASE; CONTROLLED STUDY; DISEASE COURSE; GROWTH DISORDER; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FIBROSIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STELLATE CELL;

CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; FLAVONOIDS; HEPATIC STELLATE CELLS; HUMANS; LIVER; LIVER CIRRHOSIS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-SIS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION;

MUS;

EID: 84861073336     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24107     Document Type: Article

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