Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3′,4′,5′,5,7- pentamethoxyflavone and tricin (4′,5,7-trihydroxy-3′, 5′-dimethoxyflavone)

Cancer Chemotherapy and Pharmacology

Volumn 67, Issue 2, 2011, Pages 255-263

  Cai, Hong ^a   Sale, Stewart ^a   Britton, Robert G ^a   Brown, Karen ^a   Steward, William P ^a   Gescher, Andreas J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Chemoprevention; Flavones; Metabolism; Pharmacokinetics

Indexed keywords

3',4',5',5,7 PENTAMETHOXYFLAVONE; ADENOSINE 3' PHOSPHATE 5' PHOSPHOSULFATE; ANTINEOPLASTIC AGENT; FLAVONE DERIVATIVE; TRICIN; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCURONIC ACID; 5,7,3',4',5' PENTAMETHOXYFLAVONE; 5,7,3',4',5'-PENTAMETHOXYFLAVONE; ARYLSULFONIC ACID DERIVATIVE; FLAVONOID; GLUCURONIC ACID;

ADENOMA; ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CANCER PREVENTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIVER MICROSOME; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRAVIOLET RADIATION; ANIMAL; BIOCATALYSIS; BLOOD; C57BL MOUSE; CYTOSOL; INTESTINE MUCOSA; KINETICS; LIVER; METABOLISM; MIDDLE AGED;

ADULT; ANIMALS; AREA UNDER CURVE; ARYLSULFONATES; BIOCATALYSIS; BLOOD; CYTOSOL; FEMALE; FLAVONES; FLAVONOIDS; GLUCURONATES; HUMANS; INTESTINAL MUCOSA; KINETICS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICROSOMES, LIVER; MIDDLE AGED; YOUNG ADULT;

EID: 79952254710     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-010-1313-1     Document Type: Article

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