메뉴 건너뛰기




Volumn 58, Issue , 2012, Pages 217-272

Time-of-Flight Mass Spectrometry Versus Orbitrap-Based Mass Spectrometry for the Screening and Identification of Drugs and Metabolites: Is There a Winner?

Author keywords

Doping control; Drug metabolism; Environmental analysis; Food analysis; Forensic toxicology; Metabolites; Orbitrap MS; Pharmaceuticals; Time of flight MS; Transformation products

Indexed keywords


EID: 84863863406     PISSN: 0166526X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-444-53810-9.00009-2     Document Type: Chapter
Times cited : (30)

References (99)
  • 1
    • 33645654439 scopus 로고    scopus 로고
    • Performance evaluation of a hybrid linear ion trap/orbitrap mass spectrometer
    • Makarov A., Denisov E., et al. Performance evaluation of a hybrid linear ion trap/orbitrap mass spectrometer. Anal Chem 2006, 78(7):2113-2120.
    • (2006) Anal Chem , vol.78 , Issue.7 , pp. 2113-2120
    • Makarov, A.1    Denisov, E.2
  • 2
    • 33745264884 scopus 로고    scopus 로고
    • Dynamic range of mass accuracy in LTQ Orbitrap hybrid mass spectrometer
    • Makarov A., Denisov E., et al. Dynamic range of mass accuracy in LTQ Orbitrap hybrid mass spectrometer. J Am Soc Mass Spectrom 2006, 17(7):977-982.
    • (2006) J Am Soc Mass Spectrom , vol.17 , Issue.7 , pp. 977-982
    • Makarov, A.1    Denisov, E.2
  • 3
    • 33750446330 scopus 로고    scopus 로고
    • Breakthrough technology for bottom-up proteomics and small molecule research
    • Makarov A., Muenster H. Breakthrough technology for bottom-up proteomics and small molecule research. Am Lab 2006, 38(14):32-34.
    • (2006) Am Lab , vol.38 , Issue.14 , pp. 32-34
    • Makarov, A.1    Muenster, H.2
  • 4
    • 33750319346 scopus 로고    scopus 로고
    • Orbitrap mass analyzer-overview and applications in proteomics
    • Scigelova M., Makarov A. Orbitrap mass analyzer-overview and applications in proteomics. Proteomics 2006, (6 Suppl. 1):16-21.
    • (2006) Proteomics , Issue.6 SUPPL. 1 , pp. 16-21
    • Scigelova, M.1    Makarov, A.2
  • 5
    • 77951741252 scopus 로고    scopus 로고
    • Advances in bioanalytical LC-MS using the Orbitrap™ mass analyzer
    • Scigelova M., Makarov A. Advances in bioanalytical LC-MS using the Orbitrap™ mass analyzer. Bioanalysis 2009, 1(4):741-754.
    • (2009) Bioanalysis , vol.1 , Issue.4 , pp. 741-754
    • Scigelova, M.1    Makarov, A.2
  • 6
    • 77957990113 scopus 로고    scopus 로고
    • Proteomics on an orbitrap benchtop mass spectrometer using all-ion fragmentation
    • Geiger T., Cox J., et al. Proteomics on an orbitrap benchtop mass spectrometer using all-ion fragmentation. Mol Cell Proteomics 2010, 9(10):2252-2261.
    • (2010) Mol Cell Proteomics , vol.9 , Issue.10 , pp. 2252-2261
    • Geiger, T.1    Cox, J.2
  • 7
    • 79960101179 scopus 로고    scopus 로고
    • Use of benchtop exactive high resolution and high mass accuracy orbitrap mass spectrometer for screening in horse doping control
    • Moulard Y., Bailly-Chouriberry L., et al. Use of benchtop exactive high resolution and high mass accuracy orbitrap mass spectrometer for screening in horse doping control. Anal Chim Acta 2011, 700(1-2):126-136.
    • (2011) Anal Chim Acta , vol.700 , Issue.1-2 , pp. 126-136
    • Moulard, Y.1    Bailly-Chouriberry, L.2
  • 8
    • 79955430010 scopus 로고    scopus 로고
    • Optimization of exactive Orbitrap™ acquisition parameters for quantitative bioanalysis
    • Wong R.L., Xin B., et al. Optimization of exactive Orbitrap™ acquisition parameters for quantitative bioanalysis. Bioanalysis 2011, 3(8):863-871.
    • (2011) Bioanalysis , vol.3 , Issue.8 , pp. 863-871
    • Wong, R.L.1    Xin, B.2
  • 9
    • 57249091714 scopus 로고    scopus 로고
    • Orbitrap mass spectrometry: instrumentation, ion motion and applications
    • Perry R.H., Cooks R.G., et al. Orbitrap mass spectrometry: instrumentation, ion motion and applications. Mass Spectrom Rev 2008, 27(6):661-699.
    • (2008) Mass Spectrom Rev , vol.27 , Issue.6 , pp. 661-699
    • Perry, R.H.1    Cooks, R.G.2
  • 10
    • 78650913099 scopus 로고    scopus 로고
    • HPLC-high resolution mass spectrometry in clinical laboratory?
    • Jiwan J.L.H., Wallemacq P., et al. HPLC-high resolution mass spectrometry in clinical laboratory?. Clin Biochem 2011, 44(1):136-147.
    • (2011) Clin Biochem , vol.44 , Issue.1 , pp. 136-147
    • Jiwan, J.L.H.1    Wallemacq, P.2
  • 11
    • 77953362009 scopus 로고    scopus 로고
    • Coupling liquid chromatography to Orbitrap mass spectrometry
    • Makarov A., Scigelova M. Coupling liquid chromatography to Orbitrap mass spectrometry. J Chromatogr A 2010, 1217(25):3938-3945.
    • (2010) J Chromatogr A , vol.1217 , Issue.25 , pp. 3938-3945
    • Makarov, A.1    Scigelova, M.2
  • 12
    • 0034852208 scopus 로고    scopus 로고
    • An introduction to quadrupole-time-of-flight mass spectrometry
    • Chernushevich I.V., Loboda A.V., et al. An introduction to quadrupole-time-of-flight mass spectrometry. J Mass Spectrom 2001, 36(8):849-865.
    • (2001) J Mass Spectrom , vol.36 , Issue.8 , pp. 849-865
    • Chernushevich, I.V.1    Loboda, A.V.2
  • 13
    • 56149091565 scopus 로고    scopus 로고
    • Rapid metabolite identification with sub parts-permillion mass accuracy from biological matrices by direct infusion nanoelectrospray ionization after clean-up on a ZipTip and LTQ/Orbitrap mass spectrometry
    • Erve J.C.L., DeMaio W., et al. Rapid metabolite identification with sub parts-permillion mass accuracy from biological matrices by direct infusion nanoelectrospray ionization after clean-up on a ZipTip and LTQ/Orbitrap mass spectrometry. Rapid Commun Mass Spectrom 2008, 22(19):3015-3026.
    • (2008) Rapid Commun Mass Spectrom , vol.22 , Issue.19 , pp. 3015-3026
    • Erve, J.C.L.1    DeMaio, W.2
  • 14
    • 77954195244 scopus 로고    scopus 로고
    • Evaluation of accurate mass and relative isotopic abundance measurements in the LTQ-Orbitrap mass spectrometer for further metabolomics database building
    • Xu Y., Heilier J.F., et al. Evaluation of accurate mass and relative isotopic abundance measurements in the LTQ-Orbitrap mass spectrometer for further metabolomics database building. Anal Chem 2010, 82(13):5490-5501.
    • (2010) Anal Chem , vol.82 , Issue.13 , pp. 5490-5501
    • Xu, Y.1    Heilier, J.F.2
  • 15
    • 84863876371 scopus 로고    scopus 로고
    • AGILENT. Agilent 6540 UHD Q-TOF produces more accurate isotope ratios than Thermo LTQ Orbitrap XL. Application note
    • AGILENT. Agilent 6540 UHD Q-TOF produces more accurate isotope ratios than Thermo LTQ Orbitrap XL. Application note; 2009.
    • (2009)
  • 16
    • 0033383635 scopus 로고    scopus 로고
    • Pharmaceuticals and personal care products in the environment: agents of subtle change?
    • Daughton C.G., Ternes T.A. Pharmaceuticals and personal care products in the environment: agents of subtle change?. Environ Health Perspect 1999, 107(Suppl. 6):907-938.
    • (1999) Environ Health Perspect , vol.107 , Issue.SUPPL. 6 , pp. 907-938
    • Daughton, C.G.1    Ternes, T.A.2
  • 17
    • 0033011062 scopus 로고    scopus 로고
    • Occurrence of antibiotics in the aquatic environment
    • Hirsch R., Ternes T., et al. Occurrence of antibiotics in the aquatic environment. Sci Total Environ 1999, 225(1-2):109-118.
    • (1999) Sci Total Environ , vol.225 , Issue.1-2 , pp. 109-118
    • Hirsch, R.1    Ternes, T.2
  • 18
    • 3042521214 scopus 로고    scopus 로고
    • Behavior of pharmaceuticals, cosmetics and hormones in a sewage treatment plant
    • Carballa M., Omil F., et al. Behavior of pharmaceuticals, cosmetics and hormones in a sewage treatment plant. Water Res 2004, 38(12):2918-2926.
    • (2004) Water Res , vol.38 , Issue.12 , pp. 2918-2926
    • Carballa, M.1    Omil, F.2
  • 19
    • 78149258956 scopus 로고    scopus 로고
    • Pharmaceuticals and personal care products in effluent matrices: a survey of transformation and removal during wastewater treatment and implications for wastewater management
    • Oulton R.L., Kohn T., et al. Pharmaceuticals and personal care products in effluent matrices: a survey of transformation and removal during wastewater treatment and implications for wastewater management. J Environ Monit 2010, 12(11):1956-1978.
    • (2010) J Environ Monit , vol.12 , Issue.11 , pp. 1956-1978
    • Oulton, R.L.1    Kohn, T.2
  • 20
    • 6044271633 scopus 로고    scopus 로고
    • Scrutinizing pharmaceuticals and personal care products in wastewater treatment
    • Ternes T.A., Joss A., et al. Scrutinizing pharmaceuticals and personal care products in wastewater treatment. Environ Sci Technol 2004, 38(20):392A-399A.
    • (2004) Environ Sci Technol , vol.38 , Issue.20
    • Ternes, T.A.1    Joss, A.2
  • 21
    • 56449083885 scopus 로고    scopus 로고
    • Fate and toxicity of emerging pollutants, their metabolites and transformation products in the aquatic environment
    • Farré M.l., Pérez S., et al. Fate and toxicity of emerging pollutants, their metabolites and transformation products in the aquatic environment. Trends Anal Chem 2008, 27(11):991-1007.
    • (2008) Trends Anal Chem , vol.27 , Issue.11 , pp. 991-1007
    • Farré, M.1    Pérez, S.2
  • 22
    • 55549128189 scopus 로고    scopus 로고
    • Applications of LC-MS to quantitation and evaluation of the environmental fate of chiral drugs and their metabolites
    • Pérez S., Barceló D. Applications of LC-MS to quantitation and evaluation of the environmental fate of chiral drugs and their metabolites. Trends Anal Chem 2008, 27(10):836-846.
    • (2008) Trends Anal Chem , vol.27 , Issue.10 , pp. 836-846
    • Pérez, S.1    Barceló, D.2
  • 23
    • 33645213334 scopus 로고    scopus 로고
    • Structural characterization of metabolites of the X-ray contrast agent iopromide in activated sludge using ion trap mass spectrometry
    • Pérez S., Eichhorn P., et al. Structural characterization of metabolites of the X-ray contrast agent iopromide in activated sludge using ion trap mass spectrometry. Anal Chem 2006, 78(6):1866-1874.
    • (2006) Anal Chem , vol.78 , Issue.6 , pp. 1866-1874
    • Pérez, S.1    Eichhorn, P.2
  • 24
    • 70349287621 scopus 로고    scopus 로고
    • Elucidation of phototransformation reactions of the X-ray contrast medium iopromide under simulated solar radiation using UPLC-ESI-QqTOF-MS
    • Pérez S., Eichhorn P., et al. Elucidation of phototransformation reactions of the X-ray contrast medium iopromide under simulated solar radiation using UPLC-ESI-QqTOF-MS. J Mass Spectrom 2009, 44(9):1308-1317.
    • (2009) J Mass Spectrom , vol.44 , Issue.9 , pp. 1308-1317
    • Pérez, S.1    Eichhorn, P.2
  • 25
    • 34447526597 scopus 로고    scopus 로고
    • Liquid chromatography-(tandem) mass spectrometry for the follow-up of the elimination of persistent pharmaceuticals during wastewater treatment applying biological wastewater treatment and advanced oxidation
    • Gebhardt W., Schröder H.F. Liquid chromatography-(tandem) mass spectrometry for the follow-up of the elimination of persistent pharmaceuticals during wastewater treatment applying biological wastewater treatment and advanced oxidation. J Chromatogr A 2007, 1160(1-2):34-43.
    • (2007) J Chromatogr A , vol.1160 , Issue.1-2 , pp. 34-43
    • Gebhardt, W.1    Schröder, H.F.2
  • 26
    • 33846888256 scopus 로고    scopus 로고
    • Multi-residue analytical methods using LC-tandem MS for the determination of pharmaceuticals in environmental and wastewater samples: a review
    • Gros M., Petrovié M., et al. Multi-residue analytical methods using LC-tandem MS for the determination of pharmaceuticals in environmental and wastewater samples: a review. Anal Bioanal Chem 2006, 386(4):941-952.
    • (2006) Anal Bioanal Chem , vol.386 , Issue.4 , pp. 941-952
    • Gros, M.1    Petrovié, M.2
  • 27
    • 77953357464 scopus 로고    scopus 로고
    • Recent trends in the liquid chromatography-mass spectrometry analysis of organic contaminants in environmental samples
    • Petrovic M., Farré M., et al. Recent trends in the liquid chromatography-mass spectrometry analysis of organic contaminants in environmental samples. J Chromatogr A 2010, 1217(25):4004-4017.
    • (2010) J Chromatogr A , vol.1217 , Issue.25 , pp. 4004-4017
    • Petrovic, M.1    Farré, M.2
  • 28
    • 57849119195 scopus 로고    scopus 로고
    • Accurate mass screening and identification of emerging contaminants in environmental samples by liquid chromatography-hybrid linear ion trap Orbitrap mass spectrometry
    • Hogenboom A.C., van Leerdam J.A., et al. Accurate mass screening and identification of emerging contaminants in environmental samples by liquid chromatography-hybrid linear ion trap Orbitrap mass spectrometry. J Chromatogr A 2009, 1216(3):510-519.
    • (2009) J Chromatogr A , vol.1216 , Issue.3 , pp. 510-519
    • Hogenboom, A.C.1    van Leerdam, J.A.2
  • 29
    • 77953532196 scopus 로고    scopus 로고
    • High-resolution mass spectrometric identification and quantification of glucocorticoid compounds in various wastewaters in the Netherlands
    • Schriks M., Van Leerdam J.A., et al. High-resolution mass spectrometric identification and quantification of glucocorticoid compounds in various wastewaters in the Netherlands. Environ Sci Technol 2010, 44(12):4766-4774.
    • (2010) Environ Sci Technol , vol.44 , Issue.12 , pp. 4766-4774
    • Schriks, M.1    Van Leerdam, J.A.2
  • 30
    • 70349118535 scopus 로고    scopus 로고
    • Identification of transformation products of organic contaminants in natural waters by computer-aided prediction and high-resolution mass spectrometry
    • Kern S., Fenner K., et al. Identification of transformation products of organic contaminants in natural waters by computer-aided prediction and high-resolution mass spectrometry. Environ Sci Technol 2009, 43(18):7039-7046.
    • (2009) Environ Sci Technol , vol.43 , Issue.18 , pp. 7039-7046
    • Kern, S.1    Fenner, K.2
  • 31
    • 79960088377 scopus 로고    scopus 로고
    • Influence of natural organic matter on the screening of pharmaceuticals in water by using liquid chromatography with full scan mass spectrometry
    • Herrera Rivera Z., Oosterink E., et al. Influence of natural organic matter on the screening of pharmaceuticals in water by using liquid chromatography with full scan mass spectrometry. Anal Chim Acta 2011, 700(1-2):114-125.
    • (2011) Anal Chim Acta , vol.700 , Issue.1-2 , pp. 114-125
    • Herrera Rivera, Z.1    Oosterink, E.2
  • 32
    • 60649092183 scopus 로고    scopus 로고
    • Screening of antibiotics in surface and wastewater samples by ultra-high-pressure liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry
    • Ibáñez M., Guerrero C., et al. Screening of antibiotics in surface and wastewater samples by ultra-high-pressure liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry. J Chromatogr A 2009, 1216(12):2529-2539.
    • (2009) J Chromatogr A , vol.1216 , Issue.12 , pp. 2529-2539
    • Ibáñez, M.1    Guerrero, C.2
  • 33
    • 80053361590 scopus 로고    scopus 로고
    • Rapid wide-scope screening of drugs of abuse, prescription drugs with potential for abuse and their metabolites in influent and effluent urban wastewater by ultrahigh pressure liquid chromatography-quadrupole-time-of-flight-mass spectrometry
    • Hernández F., Bijlsma L., et al. Rapid wide-scope screening of drugs of abuse, prescription drugs with potential for abuse and their metabolites in influent and effluent urban wastewater by ultrahigh pressure liquid chromatography-quadrupole-time-of-flight-mass spectrometry. Anal Chim Acta 2011, 684(1-2):87-97.
    • (2011) Anal Chim Acta , vol.684 , Issue.1-2 , pp. 87-97
    • Hernández, F.1    Bijlsma, L.2
  • 34
    • 77957876192 scopus 로고    scopus 로고
    • Rapid automated screening, identification and quantification of organic micro-contaminants and their main transformation products in wastewater and river waters using liquid chromatography-quadrupole-time-of-flight mass spectrometry with an accurate-mass database
    • Gómez M.J., Gómez-Ramos M.M., et al. Rapid automated screening, identification and quantification of organic micro-contaminants and their main transformation products in wastewater and river waters using liquid chromatography-quadrupole-time-of-flight mass spectrometry with an accurate-mass database. J Chromatogr A 2010, 1217(45):7038-7054.
    • (2010) J Chromatogr A , vol.1217 , Issue.45 , pp. 7038-7054
    • Gómez, M.J.1    Gómez-Ramos, M.M.2
  • 36
    • 77957306688 scopus 로고    scopus 로고
    • Identification of a new antidepressant and its glucuronide metabolite in water samples using liquid chromatography/quadrupole time-of-flight mass spectrometry
    • Ferrer I., Thurman E.M. Identification of a new antidepressant and its glucuronide metabolite in water samples using liquid chromatography/quadrupole time-of-flight mass spectrometry. Anal Chem 2010, 82(19):8161-8168.
    • (2010) Anal Chem , vol.82 , Issue.19 , pp. 8161-8168
    • Ferrer, I.1    Thurman, E.M.2
  • 37
    • 78650515955 scopus 로고    scopus 로고
    • Nontarget analysis of polar contaminants in freshwater sediments influenced by pharmaceutical industry using ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry
    • Terzic S., Ahel M. Nontarget analysis of polar contaminants in freshwater sediments influenced by pharmaceutical industry using ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry. Environ Pollut 2011, 159(2):557-566.
    • (2011) Environ Pollut , vol.159 , Issue.2 , pp. 557-566
    • Terzic, S.1    Ahel, M.2
  • 38
    • 77956157233 scopus 로고    scopus 로고
    • High-throughput identification of microbial transformation products of organic micropollutants
    • Helbling D.E., Hollender J., et al. High-throughput identification of microbial transformation products of organic micropollutants. Environ Sci Technol 2010, 44(17):6621-6627.
    • (2010) Environ Sci Technol , vol.44 , Issue.17 , pp. 6621-6627
    • Helbling, D.E.1    Hollender, J.2
  • 39
    • 79953235345 scopus 로고    scopus 로고
    • Biotransformation of the antiviral drugs acyclovir and penciclovir in activated sludge treatment
    • Prasse C., Wagner M., et al. Biotransformation of the antiviral drugs acyclovir and penciclovir in activated sludge treatment. Environ Sci Technol 2011, 45(7):2761-2769.
    • (2011) Environ Sci Technol , vol.45 , Issue.7 , pp. 2761-2769
    • Prasse, C.1    Wagner, M.2
  • 40
    • 79951905767 scopus 로고    scopus 로고
    • Behavior of amoxicillin in wastewater and river water: identification of its main transformation products by liquid chromatography/electrospray quadrupole time-of-flight mass spectrometry
    • Pérez-Parada A., Agüera A., et al. Behavior of amoxicillin in wastewater and river water: identification of its main transformation products by liquid chromatography/electrospray quadrupole time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 2011, 25(6):731-742.
    • (2011) Rapid Commun Mass Spectrom , vol.25 , Issue.6 , pp. 731-742
    • Pérez-Parada, A.1    Agüera, A.2
  • 41
    • 34547894225 scopus 로고    scopus 로고
    • Past, present and future of mass spectrometry in the analysis of residues of banned substances in meat-producing animals
    • De Brabander H.F., Le Bizec B., et al. Past, present and future of mass spectrometry in the analysis of residues of banned substances in meat-producing animals. J Mass Spectrom 2007, 42(8):983-998.
    • (2007) J Mass Spectrom , vol.42 , Issue.8 , pp. 983-998
    • De Brabander, H.F.1    Le Bizec, B.2
  • 42
    • 77953363543 scopus 로고    scopus 로고
    • Liquid chromatography-mass spectrometry in food safety
    • Malik A.K., Blasco C., et al. Liquid chromatography-mass spectrometry in food safety. J Chromatogr A 2010, 1217(25):4018-4040.
    • (2010) J Chromatogr A , vol.1217 , Issue.25 , pp. 4018-4040
    • Malik, A.K.1    Blasco, C.2
  • 43
    • 22544457880 scopus 로고    scopus 로고
    • LC-MS/MS analysis of organic toxics in food
    • Núñez O., Moyano E., et al. LC-MS/MS analysis of organic toxics in food. Trends Anal Chem 2005, 24(7):683-703.
    • (2005) Trends Anal Chem , vol.24 , Issue.7 , pp. 683-703
    • Núñez, O.1    Moyano, E.2
  • 44
    • 33846895151 scopus 로고    scopus 로고
    • Screening and confirmation criteria for hormone residue analysis using liquid chromatography accurate mass time-of-flight, Fourier transform ion cyclotron resonance and orbitrap mass spectrometry techniques
    • Nielen M.W.F., van Engelen M.C., et al. Screening and confirmation criteria for hormone residue analysis using liquid chromatography accurate mass time-of-flight, Fourier transform ion cyclotron resonance and orbitrap mass spectrometry techniques. Anal Chim Acta 2007, 586(1-2 Spec. Issue):122-129.
    • (2007) Anal Chim Acta , vol.586 , Issue.1-2 SPEC. ISSUE , pp. 122-129
    • Nielen, M.W.F.1    van Engelen, M.C.2
  • 45
    • 34548169105 scopus 로고    scopus 로고
    • Multiresidue analysis of β-agonists in pork by coupling polymer monolith microextraction to electrospray quadrupole time-of-flight mass spectrometry
    • Huang J.F., Zhang H.J., et al. Multiresidue analysis of β-agonists in pork by coupling polymer monolith microextraction to electrospray quadrupole time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 2007, 21(17):2895-2904.
    • (2007) Rapid Commun Mass Spectrom , vol.21 , Issue.17 , pp. 2895-2904
    • Huang, J.F.1    Zhang, H.J.2
  • 46
    • 44349104647 scopus 로고    scopus 로고
    • Quantitative multiresidue method for about 100 veterinary drugs in different meat matrices by sub 2-μm particulate high-performance liquid chromatography coupled to time of flight mass spectrometry
    • Kaufmann A., Butcher P., et al. Quantitative multiresidue method for about 100 veterinary drugs in different meat matrices by sub 2-μm particulate high-performance liquid chromatography coupled to time of flight mass spectrometry. J Chromatogr A 2008, 1194(1):66-79.
    • (2008) J Chromatogr A , vol.1194 , Issue.1 , pp. 66-79
    • Kaufmann, A.1    Butcher, P.2
  • 47
    • 79960097863 scopus 로고    scopus 로고
    • Development of an improved high resolution mass spectrometry based multi-residue method for veterinary drugs in various food matrices
    • Kaufmann A., Butcher P., et al. Development of an improved high resolution mass spectrometry based multi-residue method for veterinary drugs in various food matrices. Anal Chim Acta 2011, 700(1-2):86-94.
    • (2011) Anal Chim Acta , vol.700 , Issue.1-2 , pp. 86-94
    • Kaufmann, A.1    Butcher, P.2
  • 48
    • 79952810538 scopus 로고    scopus 로고
    • Quantitative and confirmative performance of liquid chromatography coupled to high-resolution mass spectrometry compared to tandem mass spectrometry
    • Kaufmann A., Butcher P., et al. Quantitative and confirmative performance of liquid chromatography coupled to high-resolution mass spectrometry compared to tandem mass spectrometry. Rapid Commun Mass Spectrom 2011, 25(7):979-992.
    • (2011) Rapid Commun Mass Spectrom , vol.25 , Issue.7 , pp. 979-992
    • Kaufmann, A.1    Butcher, P.2
  • 49
    • 77954145052 scopus 로고    scopus 로고
    • Comprehensive comparison of liquid chromatography selectivity as provided by two types of liquid chromatography detectors (high resolution mass spectrometry and tandem mass spectrometry): "Where is the crossover point"?
    • Kaufmann A., Butcher P., et al. Comprehensive comparison of liquid chromatography selectivity as provided by two types of liquid chromatography detectors (high resolution mass spectrometry and tandem mass spectrometry): "Where is the crossover point"? Anal Chim Acta 2010, 673(1):60-72.
    • (2010) Anal Chim Acta , vol.673 , Issue.1 , pp. 60-72
    • Kaufmann, A.1    Butcher, P.2
  • 50
    • 70350151878 scopus 로고    scopus 로고
    • Multi-residue screening of veterinary drugs in egg, fish and meat using high-resolution liquid chromatography accurate mass time-of-flight mass spectrometry
    • Peters R.J.B., Bolck Y.J.C., et al. Multi-residue screening of veterinary drugs in egg, fish and meat using high-resolution liquid chromatography accurate mass time-of-flight mass spectrometry. J Chromatogr A 2009, 1216(46):8206-8216.
    • (2009) J Chromatogr A , vol.1216 , Issue.46 , pp. 8206-8216
    • Peters, R.J.B.1    Bolck, Y.J.C.2
  • 51
    • 67650885622 scopus 로고    scopus 로고
    • Searching for in silico predicted metabolites and designer modifications of (cortico)steroids in urine by high-resolution liquid chromatography/time-of- flight mass spectrometry
    • Peters R.J.B., Van Engelen M.C., et al. Searching for in silico predicted metabolites and designer modifications of (cortico)steroids in urine by high-resolution liquid chromatography/time-of- flight mass spectrometry. Rapid Commun Mass Spectrom 2009, 23(15):2329-2337.
    • (2009) Rapid Commun Mass Spectrom , vol.23 , Issue.15 , pp. 2329-2337
    • Peters, R.J.B.1    Van Engelen, M.C.2
  • 52
    • 70349759697 scopus 로고    scopus 로고
    • Evaluating polymer monolith in-tube solid-phase microextraction coupled to liquid chromatography/quadrupole time-of-flight mass spectrometry for reliable quantification and confirmation of quinolone antibacterials in edible animal food
    • Zheng M.M., Ruan G.D., et al. Evaluating polymer monolith in-tube solid-phase microextraction coupled to liquid chromatography/quadrupole time-of-flight mass spectrometry for reliable quantification and confirmation of quinolone antibacterials in edible animal food. J Chromatogr A 2009, 1216(44):7510-7519.
    • (2009) J Chromatogr A , vol.1216 , Issue.44 , pp. 7510-7519
    • Zheng, M.M.1    Ruan, G.D.2
  • 53
    • 67650139656 scopus 로고    scopus 로고
    • Comprehensive fast multiresidue screening of 150 veterinary drugs in milk by ultra-performance liquid chromatography coupled to time of flight mass spectrometry
    • Ortelli D., Cognard E., et al. Comprehensive fast multiresidue screening of 150 veterinary drugs in milk by ultra-performance liquid chromatography coupled to time of flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2009, 877(23):2363-2374.
    • (2009) J Chromatogr B Analyt Technol Biomed Life Sci , vol.877 , Issue.23 , pp. 2363-2374
    • Ortelli, D.1    Cognard, E.2
  • 54
    • 79960578718 scopus 로고    scopus 로고
    • Analysis of veterinary drugs and metabolites in milk using quadrupole time-of-flight liquid chromatography-mass spectrometry
    • Turnipseed S.B., Storey J.M., et al. Analysis of veterinary drugs and metabolites in milk using quadrupole time-of-flight liquid chromatography-mass spectrometry. J Agric Food Chem 2011, 59:7569-7581.
    • (2011) J Agric Food Chem , vol.59 , pp. 7569-7581
    • Turnipseed, S.B.1    Storey, J.M.2
  • 55
    • 67650727050 scopus 로고    scopus 로고
    • Full scan MS in comprehensive qualitative and quantitative residue analysis in food and feed matrices: how much resolving power is required?
    • Kellmann M., Muenster H., et al. Full scan MS in comprehensive qualitative and quantitative residue analysis in food and feed matrices: how much resolving power is required?. J Am Soc Mass Spectrom 2009, 20(8):1464-1476.
    • (2009) J Am Soc Mass Spectrom , vol.20 , Issue.8 , pp. 1464-1476
    • Kellmann, M.1    Muenster, H.2
  • 56
    • 60649086153 scopus 로고    scopus 로고
    • Full-scan accurate mass selectivity of ultra-performance liquid chromatography combined with time-of-flight and orbitrap mass spectrometry in hormone and veterinary drug residue analysis
    • van der Heeft E., Bolck Y.J.C., et al. Full-scan accurate mass selectivity of ultra-performance liquid chromatography combined with time-of-flight and orbitrap mass spectrometry in hormone and veterinary drug residue analysis. J Am Soc Mass Spectrom 2009, 20(3):451-463.
    • (2009) J Am Soc Mass Spectrom , vol.20 , Issue.3 , pp. 451-463
    • van der Heeft, E.1    Bolck, Y.J.C.2
  • 57
    • 73449101882 scopus 로고    scopus 로고
    • Drug metabolism and pharmacokinetics
    • Benedetti M.S., Whomsley R., et al. Drug metabolism and pharmacokinetics. Drug Metab Rev 2009, 41(3):344-390.
    • (2009) Drug Metab Rev , vol.41 , Issue.3 , pp. 344-390
    • Benedetti, M.S.1    Whomsley, R.2
  • 58
    • 0038282311 scopus 로고    scopus 로고
    • The role of absorption, distribution, metabolism, excretion and toxicity in drug discovery
    • Lin J., Sahakian D.C., et al. The role of absorption, distribution, metabolism, excretion and toxicity in drug discovery. Curr Top Med Chem 2003, 3(10):1125-1154.
    • (2003) Curr Top Med Chem , vol.3 , Issue.10 , pp. 1125-1154
    • Lin, J.1    Sahakian, D.C.2
  • 59
    • 34247631742 scopus 로고    scopus 로고
    • The evolving role of drug metabolism in drug discovery and development
    • Yengi L.G., Leung L., et al. The evolving role of drug metabolism in drug discovery and development. Pharm Res 2007, 24(5):842-858.
    • (2007) Pharm Res , vol.24 , Issue.5 , pp. 842-858
    • Yengi, L.G.1    Leung, L.2
  • 60
    • 79953659132 scopus 로고    scopus 로고
    • Recent development in liquid chromatography/mass spectrometry and emerging technologies for metabolite identification
    • Liang Y., Wang G., et al. Recent development in liquid chromatography/mass spectrometry and emerging technologies for metabolite identification. Curr Drug Metab 2011, 12(4):329-344.
    • (2011) Curr Drug Metab , vol.12 , Issue.4 , pp. 329-344
    • Liang, Y.1    Wang, G.2
  • 61
    • 58849124556 scopus 로고    scopus 로고
    • Liquid chromatography-mass spectrometry in in vitro drug metabolite screening
    • Tolonen A., Turpeinen M., et al. Liquid chromatography-mass spectrometry in in vitro drug metabolite screening. Drug Discov Today 2009, 14(3-4):120-133.
    • (2009) Drug Discov Today , vol.14 , Issue.3-4 , pp. 120-133
    • Tolonen, A.1    Turpeinen, M.2
  • 62
    • 33847018050 scopus 로고    scopus 로고
    • Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies
    • Hewitt N.J., Lechón M.J.G., et al. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab Rev 2007, 39(1):159-234.
    • (2007) Drug Metab Rev , vol.39 , Issue.1 , pp. 159-234
    • Hewitt, N.J.1    Lechón, M.J.G.2
  • 63
    • 33750632169 scopus 로고    scopus 로고
    • The biochemistry of drug metabolism-an introduction: part 1. Principles and overview
    • Testa B., Krämer S.D. The biochemistry of drug metabolism-an introduction: part 1. Principles and overview. Chem Biodivers 2006, 3(10):1053-1101.
    • (2006) Chem Biodivers , vol.3 , Issue.10 , pp. 1053-1101
    • Testa, B.1    Krämer, S.D.2
  • 64
    • 33344464424 scopus 로고    scopus 로고
    • Application of a linear ion trap/orbitrap mass spectrometer in metabolite characterization studies: examination of the human liver microsomal metabolism of the non-tricyclic anti-depressant nefazodone using data-dependent accurate mass measurements
    • Peterman S.M., Duczak N., et al. Application of a linear ion trap/orbitrap mass spectrometer in metabolite characterization studies: examination of the human liver microsomal metabolism of the non-tricyclic anti-depressant nefazodone using data-dependent accurate mass measurements. J Am Soc Mass Spectrom 2006, 17(3):363-375.
    • (2006) J Am Soc Mass Spectrom , vol.17 , Issue.3 , pp. 363-375
    • Peterman, S.M.1    Duczak, N.2
  • 65
    • 37649024925 scopus 로고    scopus 로고
    • Complete profiling and characterization of in vitro nefazodone metabolites using two different tandem mass spectrometric platforms
    • Li A.C., Shou W.Z., et al. Complete profiling and characterization of in vitro nefazodone metabolites using two different tandem mass spectrometric platforms. Rapid Commun Mass Spectrom 2007, 21(24):4001-4008.
    • (2007) Rapid Commun Mass Spectrom , vol.21 , Issue.24 , pp. 4001-4008
    • Li, A.C.1    Shou, W.Z.2
  • 66
    • 69849089067 scopus 로고    scopus 로고
    • Two-injection workflow for a liquid chromatography/LTQ-Orbitrap system to complete in vivo biotransformation characterization: demonstration with buspirone metabolite identification
    • Li A.C., Ding J., et al. Two-injection workflow for a liquid chromatography/LTQ-Orbitrap system to complete in vivo biotransformation characterization: demonstration with buspirone metabolite identification. Rapid Commun Mass Spectrom 2009, 23(18):3003-3012.
    • (2009) Rapid Commun Mass Spectrom , vol.23 , Issue.18 , pp. 3003-3012
    • Li, A.C.1    Ding, J.2
  • 67
    • 39749201504 scopus 로고    scopus 로고
    • An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques: application to indinavir metabolite detection
    • Ruan Q., Peterman S., et al. An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques: application to indinavir metabolite detection. J Mass Spectrom 2008, 43(2):251-261.
    • (2008) J Mass Spectrom , vol.43 , Issue.2 , pp. 251-261
    • Ruan, Q.1    Peterman, S.2
  • 68
    • 59949084587 scopus 로고    scopus 로고
    • Structural characterization of in vitro rat liver microsomal metabolites of antihistamine desloratadine using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange HR-LC/MS
    • Chen G., Daaro I., et al. Structural characterization of in vitro rat liver microsomal metabolites of antihistamine desloratadine using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange HR-LC/MS. J Mass Spectrom 2009, 44(2):203-213.
    • (2009) J Mass Spectrom , vol.44 , Issue.2 , pp. 203-213
    • Chen, G.1    Daaro, I.2
  • 69
    • 42649118458 scopus 로고    scopus 로고
    • A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry
    • Lim H.K., Chen J., et al. A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry. Rapid Commun Mass Spectrom 2008, 22(8):1295-1311.
    • (2008) Rapid Commun Mass Spectrom , vol.22 , Issue.8 , pp. 1295-1311
    • Lim, H.K.1    Chen, J.2
  • 70
    • 77949592420 scopus 로고    scopus 로고
    • Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-orbitrap mass spectrometers in drug discovery phase metabolite screening and identification in vitro-amitriptyline and verapamil as model compounds
    • Rousu T., Herttuainen J., et al. Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-orbitrap mass spectrometers in drug discovery phase metabolite screening and identification in vitro-amitriptyline and verapamil as model compounds. Rapid Commun Mass Spectrom 2010, 24(7):939-957.
    • (2010) Rapid Commun Mass Spectrom , vol.24 , Issue.7 , pp. 939-957
    • Rousu, T.1    Herttuainen, J.2
  • 71
    • 41549117154 scopus 로고    scopus 로고
    • Metabolism of olaquindox in rat liver microsomes: structural elucidation of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry
    • Liu Z., Huang L., et al. Metabolism of olaquindox in rat liver microsomes: structural elucidation of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 2008, 22(7):1009-1016.
    • (2008) Rapid Commun Mass Spectrom , vol.22 , Issue.7 , pp. 1009-1016
    • Liu, Z.1    Huang, L.2
  • 72
    • 78650758574 scopus 로고    scopus 로고
    • Identification of carbadox metabolites formed by liver microsomes from rats, pigs and chickens using high-performance liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry
    • Liu Z.Y., Tao Y.F., et al. Identification of carbadox metabolites formed by liver microsomes from rats, pigs and chickens using high-performance liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 2011, 25(2):341-348.
    • (2011) Rapid Commun Mass Spectrom , vol.25 , Issue.2 , pp. 341-348
    • Liu, Z.Y.1    Tao, Y.F.2
  • 73
    • 58149333524 scopus 로고    scopus 로고
    • Fractional mass filtering as a means to assess circulating metabolites in early human clinical studies
    • Tiller P.R., Yu S., et al. Fractional mass filtering as a means to assess circulating metabolites in early human clinical studies. Rapid Commun Mass Spectrom 2008, 22(22):3510-3516.
    • (2008) Rapid Commun Mass Spectrom , vol.22 , Issue.22 , pp. 3510-3516
    • Tiller, P.R.1    Yu, S.2
  • 74
    • 78649402523 scopus 로고    scopus 로고
    • Enhanced metabolite identification with MSE and a semiautomated software for structural elucidation
    • Bonn B., Leandersson C., et al. Enhanced metabolite identification with MSE and a semiautomated software for structural elucidation. Rapid Commun Mass Spectrom 2010, 24(21):3127-3138.
    • (2010) Rapid Commun Mass Spectrom , vol.24 , Issue.21 , pp. 3127-3138
    • Bonn, B.1    Leandersson, C.2
  • 75
    • 63449106748 scopus 로고    scopus 로고
    • Generic dealkylation: a tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters
    • Mortishire-Smith R.J., Castro-Perez J.M., et al. Generic dealkylation: a tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters. Rapid Commun Mass Spectrom 2009, 23(7):939-948.
    • (2009) Rapid Commun Mass Spectrom , vol.23 , Issue.7 , pp. 939-948
    • Mortishire-Smith, R.J.1    Castro-Perez, J.M.2
  • 76
    • 78649394002 scopus 로고    scopus 로고
    • Sites of metabolic substitution: investigating metabolite structures utilising ion mobility and molecular modelling
    • Dear G.J., Munoz-Muriedas J., et al. Sites of metabolic substitution: investigating metabolite structures utilising ion mobility and molecular modelling. Rapid Commun Mass Spectrom 2010, 24(21):3157-3162.
    • (2010) Rapid Commun Mass Spectrom , vol.24 , Issue.21 , pp. 3157-3162
    • Dear, G.J.1    Munoz-Muriedas, J.2
  • 77
    • 60149101752 scopus 로고    scopus 로고
    • Pharmaceutical metabolite profiling using quadrupole/ion mobility spectrometry/time-of-flight mass spectrometry
    • Chan E.C.Y., Lee S.N., et al. Pharmaceutical metabolite profiling using quadrupole/ion mobility spectrometry/time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 2009, 23(3):384-394.
    • (2009) Rapid Commun Mass Spectrom , vol.23 , Issue.3 , pp. 384-394
    • Chan, E.C.Y.1    Lee, S.N.2
  • 78
    • 46849091191 scopus 로고    scopus 로고
    • Mass defect profiles of biological matrices and the general applicability of mass defect filtering for metabolite detection
    • Zhang H., Zhu M., et al. Mass defect profiles of biological matrices and the general applicability of mass defect filtering for metabolite detection. Rapid Commun Mass Spectrom 2008, 22(13):2082-2088.
    • (2008) Rapid Commun Mass Spectrom , vol.22 , Issue.13 , pp. 2082-2088
    • Zhang, H.1    Zhu, M.2
  • 79
    • 33748902567 scopus 로고    scopus 로고
    • Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data
    • Zhu M., Ma L., et al. Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data. Drug Metab Dispos 2006, 34(10):1722-1733.
    • (2006) Drug Metab Dispos , vol.34 , Issue.10 , pp. 1722-1733
    • Zhu, M.1    Ma, L.2
  • 80
    • 34250707998 scopus 로고    scopus 로고
    • Metabolite identification by data-dependent accurate mass spectrometric analysis at resolving power of 60 000 in external calibration mode using an LTQ/Orbitrap
    • Lim H.K., Chen J., et al. Metabolite identification by data-dependent accurate mass spectrometric analysis at resolving power of 60 000 in external calibration mode using an LTQ/Orbitrap. Rapid Commun Mass Spectrom 2007, 21(12):1821-1832.
    • (2007) Rapid Commun Mass Spectrom , vol.21 , Issue.12 , pp. 1821-1832
    • Lim, H.K.1    Chen, J.2
  • 81
    • 78349303963 scopus 로고    scopus 로고
    • A method for direct measurement of ion mobilities using a travelling wave ion guide
    • Giles K., Wildgoose J.L., et al. A method for direct measurement of ion mobilities using a travelling wave ion guide. Int J Mass Spectrom 2010, 298(1-3):10-16.
    • (2010) Int J Mass Spectrom , vol.298 , Issue.1-3 , pp. 10-16
    • Giles, K.1    Wildgoose, J.L.2
  • 82
    • 33846811132 scopus 로고    scopus 로고
    • An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument
    • Pringle S.D., Giles K., et al. An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument. Int J Mass Spectrom 2007, 261(1):1-12.
    • (2007) Int J Mass Spectrom , vol.261 , Issue.1 , pp. 1-12
    • Pringle, S.D.1    Giles, K.2
  • 83
    • 78650864016 scopus 로고    scopus 로고
    • Recent advances of liquid chromatography-(tandem) mass spectrometry in clinical and forensic toxicology
    • Peters F.T. Recent advances of liquid chromatography-(tandem) mass spectrometry in clinical and forensic toxicology. Clin Biochem 2011, 44(1):54-65.
    • (2011) Clin Biochem , vol.44 , Issue.1 , pp. 54-65
    • Peters, F.T.1
  • 84
    • 34547237752 scopus 로고    scopus 로고
    • Current role of LC-MS(/MS) in doping control
    • Thevis M., Schänzer W. Current role of LC-MS(/MS) in doping control. Anal Bioanal Chem 2007, 388(7):1351-1358.
    • (2007) Anal Bioanal Chem , vol.388 , Issue.7 , pp. 1351-1358
    • Thevis, M.1    Schänzer, W.2
  • 85
    • 79960556066 scopus 로고    scopus 로고
    • Current role of LC-MS(/MS) in doping control
    • Thevis M., Thomas A., et al. Current role of LC-MS(/MS) in doping control. Anal Bioanal Chem 2011, 401(2):405-420.
    • (2011) Anal Bioanal Chem , vol.401 , Issue.2 , pp. 405-420
    • Thevis, M.1    Thomas, A.2
  • 86
    • 33645510278 scopus 로고    scopus 로고
    • Isotopic pattern and accurate mass determination in urine drug screening by liquid chromatography/time-of-flight mass spectrometry
    • Ojanperä S., Pelander A., et al. Isotopic pattern and accurate mass determination in urine drug screening by liquid chromatography/time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 2006, 20(7):1161-1167.
    • (2006) Rapid Commun Mass Spectrom , vol.20 , Issue.7 , pp. 1161-1167
    • Ojanperä, S.1    Pelander, A.2
  • 87
    • 77953354051 scopus 로고    scopus 로고
    • Fast analysis of doping agents in urine by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry. II: confirmatory analysis
    • Badoud F., Grata E., et al. Fast analysis of doping agents in urine by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry. II: confirmatory analysis. J Chromatogr A 2010, 1217(25):4109-4119.
    • (2010) J Chromatogr A , vol.1217 , Issue.25 , pp. 4109-4119
    • Badoud, F.1    Grata, E.2
  • 88
    • 77952919521 scopus 로고    scopus 로고
    • Preventive doping control screening analysis of prohibited substances in human urine using rapid-resolution liquid chromatography/high-resolution time-of-flight mass spectrometry
    • Vonaparti A., Lyris E., et al. Preventive doping control screening analysis of prohibited substances in human urine using rapid-resolution liquid chromatography/high-resolution time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 2010, 24(11):1595-1609.
    • (2010) Rapid Commun Mass Spectrom , vol.24 , Issue.11 , pp. 1595-1609
    • Vonaparti, A.1    Lyris, E.2
  • 89
    • 47749089748 scopus 로고    scopus 로고
    • Introduction of HPLC/orbitrap mass spectrometry as screening method for doping control
    • Virus E.D., Sobolevsky T.G., et al. Introduction of HPLC/orbitrap mass spectrometry as screening method for doping control. J Mass Spectrom 2008, 43(7):949-957.
    • (2008) J Mass Spectrom , vol.43 , Issue.7 , pp. 949-957
    • Virus, E.D.1    Sobolevsky, T.G.2
  • 90
    • 77950984233 scopus 로고    scopus 로고
    • Comprehensive plasma-screening for known and unknown substances in doping controls
    • Thomas A., Guddat S., et al. Comprehensive plasma-screening for known and unknown substances in doping controls. Rapid Commun Mass Spectrom 2010, 24(8):1124-1132.
    • (2010) Rapid Commun Mass Spectrom , vol.24 , Issue.8 , pp. 1124-1132
    • Thomas, A.1    Guddat, S.2
  • 91
    • 79954441243 scopus 로고    scopus 로고
    • Development and practical application of a library of CID accurate mass spectra of more than 2,500 toxic compounds for systematic toxicological analysis by LC-QTOF-MS with data-dependent acquisition
    • Broecker S., Herre S., et al. Development and practical application of a library of CID accurate mass spectra of more than 2,500 toxic compounds for systematic toxicological analysis by LC-QTOF-MS with data-dependent acquisition. Anal Bioanal Chem 2011, 400(1):101-117.
    • (2011) Anal Bioanal Chem , vol.400 , Issue.1 , pp. 101-117
    • Broecker, S.1    Herre, S.2
  • 92
    • 77749242806 scopus 로고    scopus 로고
    • Screening for pharmaco-toxicologically relevant compounds in biosamples using high-resolution mass spectrometry: a 'metabolomic' approach to the discrimination between isomers
    • Liotta E., Gottardo R., et al. Screening for pharmaco-toxicologically relevant compounds in biosamples using high-resolution mass spectrometry: a 'metabolomic' approach to the discrimination between isomers. J Mass Spectrom 2010, 45(3):261-271.
    • (2010) J Mass Spectrom , vol.45 , Issue.3 , pp. 261-271
    • Liotta, E.1    Gottardo, R.2
  • 93
    • 33846624349 scopus 로고    scopus 로고
    • A general screening method for doping agents in human urine by solid phase extraction and liquid chromatography/time-of-flight mass spectrometry
    • Kolmonen M., Leinonen A., et al. A general screening method for doping agents in human urine by solid phase extraction and liquid chromatography/time-of-flight mass spectrometry. Anal Chim Acta 2007, 585(1):94-102.
    • (2007) Anal Chim Acta , vol.585 , Issue.1 , pp. 94-102
    • Kolmonen, M.1    Leinonen, A.2
  • 94
    • 78650177558 scopus 로고    scopus 로고
    • Comparison between triple quadrupole, time of flight and hybrid quadrupole time of flight analysers coupled to liquid chromatography for the detection of anabolic steroids in doping control analysis
    • Pozo O.J., Van Eenoo P., et al. Comparison between triple quadrupole, time of flight and hybrid quadrupole time of flight analysers coupled to liquid chromatography for the detection of anabolic steroids in doping control analysis. Anal Chim Acta 2011, 684(1-2):98-111.
    • (2011) Anal Chim Acta , vol.684 , Issue.1-2 , pp. 98-111
    • Pozo, O.J.1    Van Eenoo, P.2
  • 95
    • 63449101078 scopus 로고    scopus 로고
    • Quantitation of small molecules using high-resolution accurate mass spectrometers-a different approach for analysis of biological samples
    • Zhang N.R., Yu S., et al. Quantitation of small molecules using high-resolution accurate mass spectrometers-a different approach for analysis of biological samples. Rapid Commun Mass Spectrom 2009, 23(7):1085-1094.
    • (2009) Rapid Commun Mass Spectrom , vol.23 , Issue.7 , pp. 1085-1094
    • Zhang, N.R.1    Yu, S.2
  • 96
    • 60549107218 scopus 로고    scopus 로고
    • In silico methods for predicting metabolism and mass fragmentation applied to quetiapine in liquid chromatography/time-of-flight mass spectrometry urine drug screening
    • Pelander A., Tyrkkö E., et al. In silico methods for predicting metabolism and mass fragmentation applied to quetiapine in liquid chromatography/time-of-flight mass spectrometry urine drug screening. Rapid Commun Mass Spectrom 2009, 23(4):506-514.
    • (2009) Rapid Commun Mass Spectrom , vol.23 , Issue.4 , pp. 506-514
    • Pelander, A.1    Tyrkkö, E.2
  • 97
    • 76549094091 scopus 로고    scopus 로고
    • Simultaneous screening and quantification of 52 common pharmaceuticals and drugs of abuse in hair using UPLC-TOF-MS
    • Nielsen M.K.K., Johansen S.S., et al. Simultaneous screening and quantification of 52 common pharmaceuticals and drugs of abuse in hair using UPLC-TOF-MS. Forensic Sci Int 2010, 196(1-3):85-92.
    • (2010) Forensic Sci Int , vol.196 , Issue.1-3 , pp. 85-92
    • Nielsen, M.K.K.1    Johansen, S.S.2
  • 98
    • 84863870735 scopus 로고    scopus 로고
    • Evalution of performance and benefit of ultrahigh-resolution ESI-ToF-MS coupled to fast chromatography in the application of forensic screening
    • Kellersberger K.A., Pelander A., et al. Evalution of performance and benefit of ultrahigh-resolution ESI-ToF-MS coupled to fast chromatography in the application of forensic screening. ASMS 2010.
    • (2010) ASMS
    • Kellersberger, K.A.1    Pelander, A.2
  • 99
    • 79952508350 scopus 로고    scopus 로고
    • Evaluation of a high resolving power time-of-flight mass spectrometer for drug analysis in terms of resolving power and acquisition rate
    • Pelander A., Decker P., et al. Evaluation of a high resolving power time-of-flight mass spectrometer for drug analysis in terms of resolving power and acquisition rate. J Am Soc Mass Spectrom 2011, 22(2):379-385.
    • (2011) J Am Soc Mass Spectrom , vol.22 , Issue.2 , pp. 379-385
    • Pelander, A.1    Decker, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.