Evaluation of a high resolving power time-of-flight mass spectrometer for drug analysis in terms of resolving power and acquisition rate

Journal of the American Society for Mass Spectrometry

Volumn 22, Issue 2, 2011, Pages 379-385

  Pelander, Anna ^a   Decker, Petra ^b   Baessmann, Carsten ^b   Ojanperä, Ilkka ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b BRUKER DALTONIK GMBH   (Germany)

Author keywords

Acquisition rate; HR TOFMS; Resolving power

Indexed keywords

ACQUISITION RATES; AUTOMATED DATA ANALYSIS; BIOLOGICAL MATRIXES; BREMEN , GERMANY; DRUG ANALYSIS; FALSE NEGATIVES; FLOW INJECTION ANALYSIS; GRADIENT ELUTION; HR TOFMS; ISOTOPIC PATTERN; MASS ACCURACY; MASS DIFFERENCE; RELATIVE STANDARD DEVIATIONS; RESOLVING POWER; SMALL MOLECULES; TIME OF FLIGHT MASS SPECTROMETRY; TIME-OF-FLIGHT MASS SPECTROMETERS;

DATA REDUCTION; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

MASS SPECTROMETERS;

BENORILATE; CLOBUTINOL; DESVENLAFAXINE; DIBENZEPIN; DILTIAZEM; DIPHENHYDRAMINE; DONEPEZIL; ESMOLOL; FLECAINIDE; FLUNITRAZEPAM; MELPERONE; MESCALINE; MIANSERIN; OXYPERTINE; PHENETHYLAMINE DERIVATIVE; TETRACAINE; VARENICLINE;

ACCURACY; ACQUISITION RATE; ANALYTICAL PARAMETERS; ARTICLE; AUTOMATION; DATA ANALYSIS; DRUG MIXTURE; DRUG SCREENING; ELUTION; FLOW INJECTION ANALYSIS; LIQUID CHROMATOGRAPHY; OPTICAL RESOLUTION; REPRODUCIBILITY; SPECTROMETER; TIME OF FLIGHT MASS SPECTROMETER; TIME OF FLIGHT MASS SPECTROMETRY;

CHROMATOGRAPHY, LIQUID; DIBENZAZEPINES; FLOW INJECTION ANALYSIS; ISOTOPES; MASS SPECTROMETRY; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS;

EID: 79952508350     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-010-0046-z     Document Type: Article

References (15)

1. Ferrer, I., Thurman, E.M.: Liquid Chromatography Time-of-Flight Mass Spectrometry. Wiley, Hoboken (2009)
2. Ojanperä, S., Pelander, A., Pelzing, M., Krebs, I., Vuori, E., Ojanperä, I.: Isotopic pattern and accurate mass determination in urine drug screening by liquid chromatography/time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 20, 1161-1167 (2006)
3. Pelander, A., Ristimaa, J., Rasanen, I., Vuori, E., Ojanperä, I.: Screening for basic drugs in hair of drug addicts by liquid chromatography/ time-of-flight mass spectrometry. Ther. Drug Monit. 30, 717-724 (2008)
4. Pelander, A., Ristimaa, J., Ojanperä, I.: Vitreous humor as an alternative matrix for comprehensive drug screening in post-mortem toxicology by liquid chromatography time-of-flight mass spectrometry. J. Anal. Toxicol. 34, 312-318 (2010)
5. Sparkman, O.D.: Mass Spectrometry Desk Reference, 2nd edn, p. 55. Global View Publishing, Pittsburgh (2006)
6. Sleno, L., Volmer, D.A., Marshall, A.G.: Assigning product ions from complex MS/MS spectra: the importance of mass uncertainty and resolving power. J. Am. Soc. Mass Spectrom. 16, 183-198 (2005)
7. Cottingham, K.: Product review: FTMS: overcoming challenges. Anal. Chem. 78, 655-657 (2006)
8. Makarov, A., Denisov, E., Kholomeev, A., Balschun, W., Lange, O., Strupat, K., Horning, S.: Performance evaluation of a hybrid linear ion trap/orbitrap mass spectrometer. Anal. Chem. 78, 2113-2120 (2006)
9. Kellmann, M., Muenster, H., Zomer, P., Mol, H.: Full scan MS in comprehensive qualitative and quantitative residue analysis in food and feed matrices: how much resolving power is required? J. Am. Soc. Mass Spectrom. 20, 1464-1476 (2009)
10. Rainville, P.D., Stumpf, C.L., Shockcor, J.P., Plumb, R.S., Nicholson, J.K.: Novel application of reversed-phase UPLC-oaTOF-MS for lipid analysis in complex biological mixtures: a new tool for lipidomics. J. Proteome Res. 6, 552-558 (2007)
11. Wu, T., Wang, C., Wang, X., Xiao, H., Ma, Q., Zhang, Q.: Comparison of UPLC and HPLC for Analysis of 12 Phthalates. Chromatographia 68, 803-806 (2008)
12. Kind, T., Fiehn, O.: Metabolomic database annotations via query of elemental compositions: mass accuracy is insufficient even at less than 1 ppm. BMC Bioinform. 7, 234 (2006)
13. Nielen, M.W., van Engelen, M.C., Zuiderent, R., Ramaker, R.: Screening and confirmation criteria for hormone residue analysis using liquid chromatography accurate mass time-of-flight, fourier transform ion cyclotron resonance and orbitrap mass spectrometry techniques. Anal. Chim. Acta 586, 122-129 (2007)
14. Kind, T., Fiehn, O.: Seven golden rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry. BMC Bioinform. 8, 105 (2007)
15. Erve, J.C., Gu, M., Wang, Y., DeMaio, W., Talaat, R.E.: Spectral accuracy of molecular ions in an LTQ/orbitrap mass spectrometer and implications for elemental composition determination. J. Am. Soc. Mass Spectrom. 20, 2058-2069 (2009)