Structural characterization of in vitro rat liver microsomal metabolites of antihistamine desloratadine using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange HR-LC/MS

Journal of Mass Spectrometry

Volumn 44, Issue 2, 2009, Pages 203-213

  Chen, Guodong ^a   Daaro, Ibrahim ^a   Pramanik, Birendra N ^a   Piwinski, John J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

H D exchange; High resolution LC MS; In vitro metabolite identification; LC MSn; Orbitrap MS

Indexed keywords

BIOCHEMISTRY; BIOMOLECULES; DEUTERIUM; HYDROGEN; HYDROXYLATION; LIVER; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; SPECTROMETERS; SPECTROMETRY;

H/D EXCHANGE; HIGH RESOLUTION LC/MS; IN VITRO METABOLITE IDENTIFICATION; LC/MSN; ORBITRAP MS;

METABOLISM;

DESLORATADINE; DEUTERIUM; DRUG METABOLITE;

ARTICLE; DRUG STRUCTURE; HYBRID; HYDROXYLATION; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETER; MASS SPECTROMETRY; METABOLITE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ANALYSIS;

ANIMALS; CHROMATOGRAPHY, LIQUID; CYCLIC N-OXIDES; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; LIVER; LORATADINE; MASS SPECTROMETRY; MICROSOMES; RATS; SENSITIVITY AND SPECIFICITY;

RATTUS;

EID: 59949084587     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1498     Document Type: Article

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