A new class of highly potent and selective endomorphin-1 analogues containing α-methylene-β-aminopropanoic acids (map)

Journal of Medicinal Chemistry

Volumn 55, Issue 13, 2012, Pages 6224-6236

  Wang, Yuan ^a   Xing, Yanhong ^a   Liu, Xin ^a   Ji, Hong ^a   Kai, Ming ^a   Chen, Zongyao ^a   Yu, Jing ^a   Zhao, Depeng ^a   Ren, Hui ^a   Wang, Rui ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA METHYLENE BETA AMINOPROPANOIC ACID; AMINO ACID DERIVATIVE; ANALGESIC AGENT; ENDOMORPHIN 1; ENDOMORPHIN 2; ENDORPHIN 1 DERIVATIVE; ENDORPHIN DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MU OPIATE RECEPTOR; NALOXONE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BAYLIS HILLMAN REACTION; BINDING AFFINITY; CELL STRAIN HEK293; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ANTAGONISM; DRUG HALF LIFE; DRUG INHIBITION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HORNER WADSWORTH EMMONS REACTION; HUMAN; HUMAN CELL; MALE; MOLECULAR MODEL; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACIDS; AMINOISOBUTYRIC ACIDS; ANALGESICS; ANIMALS; CYCLIC AMP; GUINEA PIGS; HEK293 CELLS; HUMANS; ILEUM; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUSCLE CONTRACTION; OLIGOPEPTIDES; PAIN; PROTEIN BINDING; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP; VAS DEFERENS;

EID: 84863817191     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300664y     Document Type: Article

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