Asp147 in the third transmembrane helix of the rat μ opioid receptor forms ion-pairing with morphine and naltrexone

Life Sciences

Volumn 65, Issue 2, 1999, Pages 175-185

  Li, Jian Guo ^a   Chen, Chongguang ^a   Yin, Jinling ^a   Rice, Kenner ^b   Zhang, Ying ^b   Matecka, Dorota ^b   De Riel, J Kim ^a   DesJarlais, Renee L ^c   Liu Chen, Lee Yuan ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Site directed mutagenesis; Structure function relationship; opioid receptor

Indexed keywords

CYCLOPROPYLCARBONYL NOROXYMORPHONE; DIPRENORPHINE; MORPHINE; MORPHINE DERIVATIVE; MU OPIATE RECEPTOR; N FORMYLNORMORPHINE; NALTREXONE; NALTREXONE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; DISSOCIATION CONSTANT; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; LIGAND BINDING; NONHUMAN; PROTEIN STRUCTURE; RAT; RECEPTOR OCCUPANCY; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 0033523062     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(99)00234-9     Document Type: Article

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