Design, synthesis, pharmacological evaluation, and structure-activity study of novel endomorphin analogues with multiple structural modifications

Journal of Medicinal Chemistry

Volumn 54, Issue 5, 2011, Pages 1462-1472

  Mallareddy, Jayapal Reddy ^a   Borics, Attila ^a   Keresztes, Attila ^a   Kövér, Katalin E ^b   Tourwé, Dirk ^c   Tóth, Géza ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2',6' DIMETHYLTYROSINE 2 AMINOCYCLOHEXANECARBOXYLIC ACID PHENYLALANYL 4 FLUOROPHENYLALANINE AMIDE; 2',6' DIMETHYLTYROSINE 2 AMINOCYCLOHEXANECARBOXYLIC ACID PHENYLALANYL BETA METHYLPHENYLALANINE AMIDE; 2',6' DIMETHYLTYROSINE 2 AMINOCYCLOHEXANECARBOXYLIC ACID TRYPTOPHYL 4 FLUOROPHENYLALANINE AMIDE; 2',6' DIMETHYLTYROSINE 2 AMINOCYCLOHEXANECARBOXYLIC ACID TRYPTOPHYL BETA METHYLPHENYLALANINE AMIDE; ENDORPHIN DERIVATIVE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MU OPIATE RECEPTOR; TYROSYL 2 AMINOCYCLOHEXANECARBOXYLIC ACID PHENYLALANYL 4 FLUOROPHENYLALANINE AMIDE; TYROSYL 2 AMINOCYCLOHEXANECARBOXYLIC ACID PHENYLALANYL BETA METHYLPHENYLALANINE AMIDE; TYROSYL 2 AMINOCYCLOHEXANECARBOXYLIC ACID TRYPTOPHYL 4 FLUOROPHENYLALANINE AMIDE; TYROSYL 2 AMINOCYCLOHEXANECARBOXYLIC ACID TRYPTOPHYL BETA METHYLPHENYLALANINE AMIDE; TYROSYLPROPYLPHENYLALANYLPHENYLALANINE AMIDE; TYROSYLPROPYLTRYPTOPHYLPHENYLALANINE AMIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; ANIMALS; BRAIN; DRUG STABILITY; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HYDROLYSIS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OLIGOPEPTIDES; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, OPIOID, MU; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79952256084     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101515v     Document Type: Article

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