BACE1- and BACE2-expressing human cells: Characterization of β-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors

Journal of Biological Chemistry

Volumn 278, Issue 28, 2003, Pages 25859-25866

  Andrau, David ^a   Dumanchin Njock, Cécile ^a   Ayral, Erwan ^b,d   Vizzavona, Jean ^d   Farzan, Mike ^c   Boisbrun, Michel ^b   Fulcrand, Pierre ^b   Hernandez, Jean François ^b   Martinez, Jean ^b   Lefranc Jullien, Solveig ^a   Checler, Frédéric ^a,e  

^a CNRS   (France)

^b UNIVERSITÉ DE MONTPELLIER   (France)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^e INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MODULATION; PH EFFECTS; PROTEINS; QUENCHING; SUBSTRATES; TUMORS;

HUMAN CELLS;

CELLS;

AMYLOID BETA PROTEIN; BETA SECRETASE; BETA1 SECRETASE; BETA2 SECRETASE; CATHEPSIN D; ENZYME INHIBITOR; PRESENILIN 1; PRESENILIN 2; PROTEIN ADAM10; PROTEIN PRECURSOR; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; FLUOROMETRY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN STRUCTURE;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CATHEPSIN D; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; ENZYME INHIBITORS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; MUTATION; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE; TIME FACTORS; TRANSFECTION;

EID: 0037830752     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302622200     Document Type: Article

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