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Volumn 12, Issue 8, 2012, Pages 1113-1124

Expression of concern: Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials (Expert Opinion on Biological Therapy, (2012), 12, 8, (1113-24), 10.1517/14712598.2012.704014);Berberine on metabolic and cardiovascular risk factors: An analysis from preclinical evidences to clinical trials

Author keywords

berberine; glycemic control; insulin resistance; lipid profile

Indexed keywords

ANTILIPEMIC AGENT; BERBERINE; LIPID;

EID: 84863789913     PISSN: 14712598     EISSN: 17447682     Source Type: Journal    
DOI: 10.1080/14712598.2018.1475325     Document Type: Erratum
Times cited : (159)

References (92)
  • 1
    • 82955247909 scopus 로고    scopus 로고
    • IDF diabetes atlas: Global estimates of the prevalence of diabetes for 2011 and 2030
    • Whiting DR, Guariguata L, Weil C, et al. IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011;94:311-21
    • (2011) Diabetes Res. Clin. Pract. , Issue.94 , pp. 311-321
    • Whiting, D.R.1    Guariguata, L.2    Weil, C.3
  • 2
    • 42649102640 scopus 로고    scopus 로고
    • An update on regional variation in cardiovascular mortality within Europe
    • Muller-Nordhorn J, Binting S, Roll S, et al. An update on regional variation in cardiovascular mortality within Europe. Eur. Heart J 2008;29:1316-26
    • (2008) Eur. Heart J. , vol.29 , pp. 1316-1326
    • Muller-Nordhorn, J.1    Binting, S.2    Roll, S.3
  • 3
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • Cholesterol Treatment Trialists' (CTT) Collaborators
    • Baigent C, Keech A, Kearney PM, et al. Cholesterol Treatment Trialists' (CTT) Collaborators. Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 2005;366:1267-78
    • (2005) Lancet , vol.366 , pp. 1267-1278
    • Baigent, C.1    Keech, A.2    Kearney, P.M.3
  • 4
    • 84855185039 scopus 로고    scopus 로고
    • Standards of medical care in diabetes-2012
    • American Diabetes Association.S11-63
    • American Diabetes Association. Standards of medical care in diabetes-2012. Diabetes Care 2012;35:S11-63
    • (2012) Diabetes Care , pp. 35
  • 5
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49
    • UK Prospective Diabetes Study (UKPDS) Group
    • Turner RC, Cull CA, Frighi V, et al. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA 1999;281:2005-12
    • (1999) JAMA , vol.281 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3
  • 6
    • 64249094799 scopus 로고    scopus 로고
    • Limitations of statin monotherapy for the treatment of dyslipidemia: A projection based on the Canadian lipid study-observational
    • Senecal M, Fodor G, Gagne C, et al. Limitations of statin monotherapy for the treatment of dyslipidemia: A projection based on the Canadian lipid study-observational. Curr Med Res Opin 2009;25:47-55
    • (2009) Curr. Med. Res. Opin. , vol.25 , pp. 47-55
    • Senecal, M.1    Fodor, G.2    Gagne, C.3
  • 7
    • 80054920652 scopus 로고    scopus 로고
    • Meta-analysis of the effect of herbal supplement on glycemic control in type 2 diabetes
    • Suksomboon N, Poolsup N, Boonkaew S, et al. Meta-analysis of the effect of herbal supplement on glycemic control in type 2 diabetes. J Ethnopharmacol 2011;137:1328-33
    • (2011) J. Ethnopharmacol. , vol.137 , pp. 1328-1333
    • Suksomboon, N.1    Poolsup, N.2    Boonkaew, S.3
  • 8
    • 81755166732 scopus 로고    scopus 로고
    • Berberine: Metabolic and cardiovascular effects in preclinical and clinical trials
    • Cicero AFG, Ertek S. Berberine: Metabolic and cardiovascular effects in preclinical and clinical trials. Nutr Diet Suppl 2009;1:1-10
    • (2009) Nutr. Diet Suppl. , vol.1 , pp. 1-10
    • Cicero, A.F.G.1    Ertek, S.2
  • 9
    • 0002258030 scopus 로고    scopus 로고
    • Berberine: Therapeutic potential of an alkaloid found in several medicinal plants
    • Birdsall TC, Kelly GS. Berberine: Therapeutic potential of an alkaloid found in several medicinal plants. Altern Med Rev 1997;2: 94-103
    • (1997) Altern. Med. Rev. , vol.2 , pp. 94-103
    • Birdsall, T.C.1    Kelly, G.S.2
  • 10
    • 57049090579 scopus 로고    scopus 로고
    • Berberine reduces insulin resistance through protein kinase C-dependent upregulation of insulin receptor expression
    • Kong WJ, Zhang H, Song DQ, et al. Berberine reduces insulin resistance through protein kinase C-dependent upregulation of insulin receptor expression. Metabolism 2009;58:109-19
    • (2009) Metabolism , vol.58 , pp. 109-119
    • Kong, W.J.1    Zhang, H.2    Song, D.Q.3
  • 11
    • 25644447977 scopus 로고    scopus 로고
    • Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma
    • Ko BS, Choi SB, Park SK, et al. Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma. Biol Pharm Bull 2005;28:1431-7
    • (2005) Biol. Pharm. Bull. , vol.28 , pp. 1431-1437
    • Ko, B.S.1    Choi, S.B.2    Park, S.K.3
  • 12
    • 58149360797 scopus 로고    scopus 로고
    • Antidiabetic effects of cinnamaldehyde and berberine and their impacts on retinol binding protein 4 expression in rats with type 2 diabetes mellitus
    • Zhang W, Xu YC, Guo FJ, et al. Antidiabetic effects of cinnamaldehyde and berberine and their impacts on retinol binding protein 4 expression in rats with type 2 diabetes mellitus. Chin Med J 2008;121:2124-8
    • (2008) Chin. Med. J. , vol.121 , pp. 2124-2128
    • Zhang, W.1    Xu, Y.C.2    Guo, F.J.3
  • 13
    • 0036833480 scopus 로고    scopus 로고
    • Effects of berberine on glucose metabolism in vitro
    • Yin J, Hu R, Chen M, et al. Effects of berberine on glucose metabolism in vitro. Metabolism 2002;51:1439-43
    • (2002) Metabolism , vol.51 , pp. 1439-1443
    • Yin, J.1    Hu, R.2    Chen, M.3
  • 14
    • 67449164807 scopus 로고    scopus 로고
    • Berberine promotes glucagons like peptide-1(7-36 amide) secretion in streptozocin-induced diabetic rats
    • Lu SS, Yu YL, Zhu HJ, et al. Berberine promotes glucagons like peptide-1(7-36 amide) secretion in streptozocin-induced diabetic rats. J Endocrinol 2009;200:159-65
    • (2009) J. Endocrinol. , vol.200 , pp. 159-165
    • Lu, S.S.1    Yu, Y.L.2    Zhu, H.J.3
  • 15
    • 59849110456 scopus 로고    scopus 로고
    • Facilitating effects of berberine on rat pancreatic islets Through modulating hepatic nuclear factor 4 alpha expression and glucokinase activity
    • Wang ZQ, Lu FE, Leng SH, et al. Facilitating effects of berberine on rat pancreatic islets Through modulating hepatic nuclear factor 4 alpha expression and glucokinase activity. World J Gastroenterol 2008;14:6004-11
    • (2008) World J. Gastroenterol. , vol.14 , pp. 6004-6011
    • Wang, Z.Q.1    Lu, F.E.2    Leng, S.H.3
  • 16
    • 1842708890 scopus 로고    scopus 로고
    • Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion
    • Leng S, Lu F, Xu L. Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion. Acta Pharmacol Sin 2004;25:496-502
    • (2004) Acta. Pharmacol. Sin. , vol.25 , pp. 496-502
    • Leng, S.1    Lu, F.2    Xu, L.3
  • 17
    • 78649658091 scopus 로고    scopus 로고
    • Targeting metabolic syndrome: Candidate natural agents
    • Xia X, Weng J. Targeting metabolic syndrome: Candidate natural agents. J Diabetes 2010;2:243-9
    • (2010) J. Diabetes , vol.2 , pp. 243-249
    • Xia, X.1    Weng, J.2
  • 18
    • 50449090523 scopus 로고    scopus 로고
    • Berberine acutely inhibits insulin secretion from beta-cells through 3¢,5¢-cyclic adenosine 5¢-monophosphate signaling pathway
    • Zhou L, Wang X, Shao L, et al. Berberine acutely inhibits insulin secretion from beta-cells through 3¢,5¢-cyclic adenosine 5¢-monophosphate signaling pathway. Endocrinology 2008;149:4510-18
    • (2008) Endocrinology , vol.149 , pp. 4510-4518
    • Zhou, L.1    Wang, X.2    Shao, L.3
  • 19
    • 60949108484 scopus 로고    scopus 로고
    • Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats
    • Zhou J, Zhou S, Tang J, et al. Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats. Eur J Pharmacol 2009;606:262-8
    • (2009) Eur. J. Pharmacol. , vol.606 , pp. 262-268
    • Zhou, J.1    Zhou, S.2    Tang, J.3
  • 20
    • 48449084609 scopus 로고    scopus 로고
    • Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action
    • Turner N, Li JY, Gosby A, et al. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes 2008;57:1414-18
    • (2008) Diabetes , vol.57 , pp. 1414-1418
    • Turner, N.1    Li, J.Y.2    Gosby, A.3
  • 21
    • 79751496044 scopus 로고    scopus 로고
    • Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis
    • Xia X, Yan J, Shen Y, et al. Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis. PLoS one 2011;6:e16556
    • (2011) Plos one , vol.6
    • Xia, X.1    Yan, J.2    Shen, Y.3
  • 22
    • 78049234765 scopus 로고    scopus 로고
    • Berberine-induced activation of 5¢-adenosine monophosphate-activated protein kinase and glucose transport in rat skeletal muscles
    • Ma X, Egawa T, Kimura H, et al. Berberine-induced activation of 5¢-adenosine monophosphate-activated protein kinase and glucose transport in rat skeletal muscles. Metabolism 2010;59:1619-27
    • (2010) Metabolism , vol.59 , pp. 1619-1627
    • Ma, X.1    Egawa, T.2    Kimura, H.3
  • 23
    • 80053923650 scopus 로고    scopus 로고
    • Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of Akt signaling pathway
    • Xie X, Li W, Lan T, et al. Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of Akt signaling pathway. Endocr J 2011;58:761-8
    • (2011) Endocr. J. , vol.58 , pp. 761-768
    • Xie, X.1    Li, W.2    Lan, T.3
  • 24
    • 50149108987 scopus 로고    scopus 로고
    • Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine
    • Imanshahidi M, Hosseinzadeh H. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother Res 2008;22:999-1012
    • (2008) Phytother. Res. , vol.22 , pp. 999-1012
    • Imanshahidi, M.1    Hosseinzadeh, H.2
  • 26
    • 40149095921 scopus 로고    scopus 로고
    • Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta
    • Yi P, Lu FE, Xu LJ, et al. Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta. World J Gastroenterol 2008;14:876-83
    • (2008) World J. Gastroenterol. , vol.14 , pp. 876-883
    • Yi, P.1    Lu, F.E.2    Xu, L.J.3
  • 27
    • 80053572802 scopus 로고    scopus 로고
    • Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (nafld) rat liver
    • Xing LJ, Zhang L, Liu T, et al. Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (NAFLD) rat liver. Eur J Pharmacol 2011;668:467-1
    • (2011) Eur. J. Pharmacol. , vol.668 , pp. 467-461
    • Xing, L.J.1    Zhang, L.2    Liu, T.3
  • 28
    • 36049038044 scopus 로고    scopus 로고
    • Berberine activated GLUT-1-mediated glucose uptake in 3T3-L1 adipocytes
    • Kim SH, Shin EJ, Kim ED, et al. Berberine activated GLUT-1-mediated glucose uptake in 3T3-L1 adipocytes. Biol Pharm Bull 2007;30:2120-5
    • (2007) Biol. Pharm. Bull. , vol.30 , pp. 2120-2125
    • Kim, S.H.1    Shin, E.J.2    Kim, E.D.3
  • 29
    • 38349006242 scopus 로고    scopus 로고
    • Berberine improves glucose metabolism through induction of glycolysis
    • Yin J, Gao Z, Liu D, et al. Berberine improves glucose metabolism through induction of glycolysis. Am J Physiol Endocrinol Metab 2008;294:E148-56
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.294
    • Yin, J.1    Gao, Z.2    Liu, D.3
  • 30
    • 33846845952 scopus 로고    scopus 로고
    • Berberine stimulates glucose transport through a mechanism distinct from insulin
    • Zhou L, Yang Y, Wang X, et al. Berberine stimulates glucose transport through a mechanism distinct from insulin. Metabolism 2007;56:405-12
    • (2007) Metabolism , vol.56 , pp. 405-412
    • Zhou, L.1    Yang, Y.2    Wang, X.3
  • 31
    • 33750519660 scopus 로고    scopus 로고
    • Berberine stimulated glucose uptake in L6 myotubes includes both AMPK and p 38 MAPK
    • Cheng Z, Pang T, Gu M, et al. Berberine stimulated glucose uptake in L6 myotubes includes both AMPK and p 38 MAPK. Biochim Biophys Acta 2006;1760:1682-9
    • (2006) Biochim. Biophys. Acta , vol.1760 , pp. 1682-1689
    • Cheng, Z.1    Pang, T.2    Gu, M.3
  • 32
    • 45749144363 scopus 로고    scopus 로고
    • Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats
    • Zhou JY, Zhou SW, Zhang KB, et al. Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats. Biol Pharm Bull 2008;31:1169-76
    • (2008) Biol. Pharm. Bull. , vol.31 , pp. 1169-1176
    • Zhou, J.Y.1    Zhou, S.W.2    Zhang, K.B.3
  • 33
    • 33747079990 scopus 로고    scopus 로고
    • Berberine inhibits 3T3L1 adipocyte differentiation through the PPARgamma pathway
    • Huang C, Zhang Y, Gong Z, et al. Berberine inhibits 3T3L1 adipocyte differentiation through the PPARgamma pathway. Biochem Biophys Res Commun 2006;348:571-8
    • (2006) Biochem. Biophys. Res. Commun. , vol.348 , pp. 571-578
    • Huang, C.1    Zhang, Y.2    Gong, Z.3
  • 34
    • 16644395777 scopus 로고    scopus 로고
    • Effects of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytes
    • Wang SH, Wang WJ, Wang XF, et al. Effects of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytes. Zhongguo Zhong Xi Yi Jie He Za Zhi 2004;24:926-8
    • (2004) Zhongguo. Zhong. Xi. Yi. Jie. He. Za. Zhi. , vol.24 , pp. 926-928
    • Wang, S.H.1    Wang, W.J.2    Wang, X.F.3
  • 35
    • 79959964544 scopus 로고    scopus 로고
    • Modulating gut microbiota as an anti-diabetic mechanism of berberine
    • Han J, Lin H, Huang W. Modulating gut microbiota as an anti-diabetic mechanism of berberine. Med Sci Monit 2011;17:RA164-7
    • (2011) Med. Sci. Monit. , vol.17
    • Han, J.1    Lin, H.2    Huang, W.3
  • 36
    • 80052479571 scopus 로고    scopus 로고
    • Effects and action mechanisms of berberine and Rhizoma coptidis on gut microbes and obesity in high-fat diet-fed C57BL/6J mice
    • Xie W, Gu D, Li J, et al. Effects and action mechanisms of berberine and Rhizoma coptidis on gut microbes and obesity in high-fat diet-fed C57BL/6J mice. PLoS one 2011;6:e24520
    • (2011) Plos One , vol.6
    • Xie, W.1    Gu, D.2    Li, J.3
  • 37
    • 51149101181 scopus 로고    scopus 로고
    • Berberine ameliorates renal injury in streptozocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase
    • Liu WH, Hei ZQ, Nie H, et al. Berberine ameliorates renal injury in streptozocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase. Chin Med J 2008;121:706-12
    • (2008) Chin. Med. J. , vol.121 , pp. 706-712
    • Liu, W.H.1    Hei, Z.Q.2    Nie, H.3
  • 38
    • 64249162482 scopus 로고    scopus 로고
    • Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose condition
    • Liu W, Tang F, Deng Y, et al. Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose condition. Mol Cell Biochem 2009;325:99-105
    • (2009) Mol. Cell Biochem. , vol.325 , pp. 99-105
    • Liu, W.1    Tang, F.2    Deng, Y.3
  • 39
    • 26244452375 scopus 로고    scopus 로고
    • Extracellular signal regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine
    • Abidi P, Zhou Y, Jiang JD, et al. Extracellular signal regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine. Arterioscler Thromb Vasc Biol 2005;25:2170-6
    • (2005) Arterioscler Thromb. Vasc. Biol. , vol.25 , pp. 2170-2176
    • Abidi, P.1    Zhou, Y.2    Jiang, J.D.3
  • 40
    • 34548591723 scopus 로고    scopus 로고
    • Berberine induced LDLR up-regulation involves JNK pathway
    • Lee S, Lim HJ, Park JH, et al. Berberine induced LDLR up-regulation involves JNK pathway. Biochem Biophys Res Commun 2007;362:853-7
    • (2007) Biochem. Biophys. Res. Commun. , vol.362 , pp. 853-857
    • Lee, S.1    Lim, H.J.2    Park, J.H.3
  • 41
    • 56649086377 scopus 로고    scopus 로고
    • Berberine decreases PCSK9 expression in HepG2 cells
    • Cameron J, Ranheim T, Kulseth MA, et al. Berberine decreases PCSK9 expression in HepG2 cells. Atherosclerosis 2008;201:266-73
    • (2008) Atherosclerosis , vol.201 , pp. 266-273
    • Cameron, J.1    Ranheim, T.2    Kulseth, M.A.3
  • 42
    • 70350389729 scopus 로고    scopus 로고
    • HNF1alpha plays a critical role in pcsk9 gene transcription and regulation by a natural hypocholesterolemic compound berberine
    • Li H, Park S, Lee H-S, Liu J. HNF1alpha plays a critical role in pcsk9 gene transcription and regulation by a natural hypocholesterolemic compound berberine. J Biol Chem 2009;284:28885-95
    • (2009) J. Biol. Chem. , vol.284 , pp. 28885-28895
    • Li, H.1    Park, S.2    Lee, H.-S.3    Liu, J.4
  • 43
    • 67649729571 scopus 로고    scopus 로고
    • Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements
    • Li H, Chen W, Zhou Y, et al. Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements. J Lipid Res 2009;50:820-31
    • (2009) J. Lipid. Res. , vol.50 , pp. 820-831
    • Li, H.1    Chen, W.2    Zhou, Y.3
  • 44
    • 33846185097 scopus 로고    scopus 로고
    • Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte
    • Choi BH, Ahn IS, Kim YH, et al. Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte. Exp Mol Med 2006;38:599-605
    • (2006) Exp. Mol. Med. , vol.38 , pp. 599-605
    • Choi, B.H.1    Ahn, I.S.2    Kim, Y.H.3
  • 45
    • 33744804815 scopus 로고    scopus 로고
    • Inhibition of lipid synthesis through activation of AMP kinase: An additional mechanism for the hypolipidemic effects of berberine
    • Brusq JM, Ancellin N, Grondin P, et al. Inhibition of lipid synthesis through activation of AMP kinase: An additional mechanism for the hypolipidemic effects of berberine. J Lipid Res 2006;47:1281-8
    • (2006) J. Lipid. Res. , vol.47 , pp. 1281-1288
    • Brusq, J.M.1    Ancellin, N.2    Grondin, P.3
  • 46
    • 20444461961 scopus 로고    scopus 로고
    • The antihypertensive and vasodilator effects of aqueous extract from Berberis vulgaris fruit on hypertensive rats
    • Fatehi-Hassanabad Z, Jafarzadeh M, Tarhini A, et al. The antihypertensive and vasodilator effects of aqueous extract from Berberis vulgaris fruit on hypertensive rats. Phytother Res 2005;19:222-5
    • (2005) Phytother. Res. , vol.19 , pp. 222-225
    • Fatehi-Hassanabad, Z.1    Jafarzadeh, M.2    Tarhini, A.3
  • 47
    • 21244480934 scopus 로고    scopus 로고
    • Pharmacological investigation on the cardiovascular effects of berberine vulgaris on tested animals
    • Peychev L. Pharmacological investigation on the cardiovascular effects of berberine vulgaris on tested animals. Pharmacia 2005;52:118-21
    • (2005) Pharmacia , vol.52 , pp. 118-121
    • Peychev, L.1
  • 48
    • 0018770670 scopus 로고
    • A biochemical study on hypotensive effects of berberine in rats
    • Chun YT, Yip TT, Lau KL, et al. A biochemical study on hypotensive effects of berberine in rats. Gen Pharmacol 1979;10:177-82
    • (1979) Gen. Pharmacol. , vol.10 , pp. 177-182
    • Chun, Y.T.1    Yip, T.T.2    Lau, K.L.3
  • 49
    • 0032423183 scopus 로고    scopus 로고
    • Mechanism of the aortic relaxation induced by low concentrations of berberine
    • Wong KK. Mechanism of the aortic relaxation induced by low concentrations of berberine. Planta Med 1998;64:756-7
    • (1998) Planta. Med. , vol.64 , pp. 756-757
    • Wong, K.K.1
  • 50
    • 0034617436 scopus 로고    scopus 로고
    • Vasorelaxant and antiproliferative effects of berberine
    • Ko WH, Yao XQ, Lau CW, et al. Vasorelaxant and antiproliferative effects of berberine. Eur J Pharmacol 2000;399:187-96
    • (2000) Eur. J. Pharmacol. , vol.399 , pp. 187-196
    • Ko, W.H.1    Yao, X.Q.2    Lau, C.W.3
  • 51
    • 0038309889 scopus 로고    scopus 로고
    • Effects of berberine on angiotensin-converting enzyme and NO/cGMP system in vessels
    • Kang DG, Sohn EJ, Kwon EK, et al. Effects of berberine on angiotensin-converting enzyme and NO/cGMP system in vessels. Vascul Pharmacol 2002;39:281-6
    • (2002) Vascul Pharmacol. , vol.39 , pp. 281-286
    • Kang, D.G.1    Sohn, E.J.2    Kwon, E.K.3
  • 52
    • 0026655710 scopus 로고
    • Evaluation of the alpha-adrenoceptor antagonistic action of berberine in isolated organs
    • Olmez E, Ilhan M. Evaluation of the alpha-adrenoceptor antagonistic action of berberine in isolated organs. Arzneimittelforschung 1992;42:1095-7
    • (1992) Arzneimittelforschung , vol.42 , pp. 1095-1097
    • Olmez, E.1    Ilhan, M.2
  • 53
    • 0025940104 scopus 로고
    • Mechanism of vasodilatory effect of berberine in rat mesenteric artery
    • Chiou WE, Yen MH, Chen CF. Mechanism of vasodilatory effect of berberine in rat mesenteric artery. Eur J Pharmacol 1991;204:35-40
    • (1991) Eur. J. Pharmacol. , vol.204 , pp. 35-40
    • Chiou, W.E.1    Yen, M.H.2    Chen, C.F.3
  • 54
    • 27744444956 scopus 로고    scopus 로고
    • Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice
    • Pan LR, Tang Q, Fu Q, et al. Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice. Acta Pharmacol Sin 2005;26:1334-8
    • (2005) Acta. Pharmacol. Sin. , vol.26 , pp. 1334-1338
    • Pan, L.R.1    Tang, Q.2    Fu, Q.3
  • 55
    • 0034617436 scopus 로고    scopus 로고
    • Vasorelaxant and antiproliferative effects of berberine
    • Ko WH, Yao XO, Lau CW, et al. Vasorelaxant and antiproliferative effects of berberine. Eur J Pharmacol 2000;399:187-96
    • (2000) Eur. J. Pharmacol. , vol.399 , pp. 187-196
    • Ko, W.H.1    Yao, X.O.2    Lau, C.W.3
  • 56
    • 48049113458 scopus 로고    scopus 로고
    • Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells
    • Liang KW, Yin SC, Ting CT, et al. Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells. Eur J Pharmacol 2008;590:343-54
    • (2008) Eur. J. Pharmacol. , vol.590 , pp. 343-354
    • Liang, K.W.1    Yin, S.C.2    Ting, C.T.3
  • 57
    • 32144461376 scopus 로고    scopus 로고
    • Berberine suppresses mek/erkdependent egr-1 signalling pathway and inhibits vascular smooth muscle regrowth after in vitro mechanical injury
    • Liang KW, Ting CT, Yin SC, et al. Berberine suppresses MEK/ERKdependent Egr-1 signalling pathway and inhibits vascular smooth muscle regrowth after in vitro mechanical injury. Biochem Pharmacol 2006;71:806-17
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 806-817
    • Liang, K.W.1    Ting, C.T.2    Yin, S.C.3
  • 58
    • 33644859302 scopus 로고    scopus 로고
    • Berberine inhibits the production of lysophosphatidylcholine-induced reactive oxygen species and the ERK1,2 pathway in smooth muscle cells
    • Cho BJ, Im EK, Kwon JH, et al. Berberine inhibits the production of lysophosphatidylcholine-induced reactive oxygen species and the ERK1,2 pathway in smooth muscle cells. Mol Cells 2005;20:429-34
    • (2005) Mol. Cells , vol.20 , pp. 429-434
    • Cho, B.J.1    Im, E.K.2    Kwon, J.H.3
  • 59
    • 0037453202 scopus 로고    scopus 로고
    • Effect of berberine on catecholamine levels in rats with experimental cardiac hypertrophy
    • Hong Y, Hui SS, Chan BT, et al. Effect of berberine on catecholamine levels in rats with experimental cardiac hypertrophy. Life Sci 2003;72:2499-507
    • (2003) Life Sci. , vol.72 , pp. 2499-2507
    • Hong, Y.1    Hui, S.S.2    Chan, B.T.3
  • 60
    • 0012359001 scopus 로고    scopus 로고
    • Effect of berberine on regression of pressure overload induced cardiac hypertrophy in rats
    • Hong Y, Hui SC, Chan TY, et al. Effect of berberine on regression of pressure overload induced cardiac hypertrophy in rats. Am J Chin Med 2002;30:589-99
    • (2002) Am. J. Chin. Med. , vol.30 , pp. 589-599
    • Hong, Y.1    Hui, S.C.2    Chan, T.Y.3
  • 61
    • 0027092049 scopus 로고
    • Beneficial effects of berberine on hemodynamics during acute ischemic left ventricular failure in dogs
    • Huang WM, Yan H, Jin JM, et al. Beneficial effects of berberine on hemodynamics during acute ischemic left ventricular failure in dogs. Chin Med J 1992;105:1014-19
    • (1992) Chin. Med. J. , vol.105 , pp. 1014-1019
    • Huang, W.M.1    Yan, H.2    Jin, J.M.3
  • 62
    • 0030571555 scopus 로고    scopus 로고
    • Inhibitory effects of berberine on ATP-sensitive K+ channels in cardiac myocytes
    • Wang YX, Zheng YM, Zhou XB. Inhibitory effects of berberine on ATP-sensitive K+ channels in cardiac myocytes. Eur J Pharmacol 1996;316:307-15
    • (1996) Eur. J. Pharmacol. , vol.316 , pp. 307-315
    • Wang, Y.X.1    Zheng, Y.M.2    Zhou, X.B.3
  • 63
    • 79960555687 scopus 로고    scopus 로고
    • Anti-cancer natural products isolated from Chinese medicinal herbs
    • Tan W, Lu J, Huang M, et al. Anti-cancer natural products isolated from Chinese medicinal herbs. Chin Med 2011;6:27
    • (2011) Chin. Med. , vol.6 , pp. 27
    • Tan, W.1    Lu, J.2    Huang, M.3
  • 64
    • 80255123371 scopus 로고    scopus 로고
    • Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice
    • Guo Y, Pope C, Cheng X, et al. Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice. J Ethnopharmacol 2011;138:111-18
    • (2011) J. Ethnopharmacol. , vol.138 , pp. 111-118
    • Guo, Y.1    Pope, C.2    Cheng, X.3
  • 65
    • 1842589296 scopus 로고    scopus 로고
    • Hepatobiliary excretion of berberine
    • Tsai PL, Tsai TH. Hepatobiliary excretion of berberine. Drug Metab Dispos 2004;32:405-12
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 405-412
    • Tsai, P.L.1    Tsai, T.H.2
  • 66
    • 77956339397 scopus 로고    scopus 로고
    • Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway
    • Lan T, Shen X, Liu P, et al. Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway. Arch Biochem Biophys 2010;502(2):112-20
    • (2010) Arch. Biochem. Biophys. , vol.502 , Issue.2 , pp. 112-120
    • Lan, T.1    Shen, X.2    Liu, P.3
  • 67
    • 77953231411 scopus 로고    scopus 로고
    • Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study
    • Liu L, Yu YL, Yang JS, et al. Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study. Naunyn Schmiedebergs Arch Pharmacol 2010;381:371-81
    • (2010) Naunyn. Schmiedebergs Arch. Pharmacol. , vol.381 , pp. 371-381
    • Liu, L.1    Yu, Y.L.2    Yang, J.S.3
  • 68
    • 42949145899 scopus 로고    scopus 로고
    • Efficacy of berberine in patients with type 2 diabetes mellitus
    • Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57:712-17
    • (2008) Metabolism , vol.57 , pp. 712-717
    • Yin, J.1    Xing, H.2    Ye, J.3
  • 69
    • 74049139484 scopus 로고    scopus 로고
    • Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression
    • Zhang H, Wei J, Xue R, et al. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism 2010;59:285-92
    • (2010) Metabolism , vol.59 , pp. 285-292
    • Zhang, H.1    Wei, J.2    Xue, R.3
  • 70
    • 77949336458 scopus 로고    scopus 로고
    • Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics
    • Gu Y, Zhang Y, Shi X, et al. Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics. Talanta 2010;81:766-72
    • (2010) Talanta , vol.81 , pp. 766-772
    • Gu, Y.1    Zhang, Y.2    Shi, X.3
  • 71
    • 47549100864 scopus 로고    scopus 로고
    • Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine
    • Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93(7):2559-65
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , Issue.7 , pp. 2559-2565
    • Zhang, Y.1    Li, X.2    Zou, D.3
  • 72
    • 78049406766 scopus 로고    scopus 로고
    • Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study
    • Affuso F, Ruvolo A, Micillo F, et al. Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study. Nutr Metab Cardiovasc Dis 2010;20:656-61
    • (2010) Nutr. Metab. Cardiovasc. Dis. , vol.20 , pp. 656-661
    • Affuso, F.1    Ruvolo, A.2    Micillo, F.3
  • 73
    • 84863790638 scopus 로고    scopus 로고
    • A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome
    • Affuso F, Mercurio V, Ruvolo A, et al. A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome. World J Cardiol 2012;4:77-83
    • (2012) World J. Cardiol. , Issue.4 , pp. 77-83
    • Affuso, F.1    Mercurio, V.2    Ruvolo, A.3
  • 74
    • 84880924053 scopus 로고    scopus 로고
    • Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans
    • doi: 10.1016/j.ijcard.2012.03.090
    • Cheng F, Wang Y, Li J, et al. Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans. Int J Cardiol 2012;doi: 10.1016/j.ijcard.2012.03.090
    • (2012) Int. J. Cardiol.
    • Cheng, F.1    Wang, Y.2    Li, J.3
  • 75
    • 84874662800 scopus 로고    scopus 로고
    • Long-term effects of a berberine based nutraceutical on body weight and insulin-sensitivity in nondiabetic hyperlipidaemic patients
    • e-Suppl A
    • Cicero A, Derosa G, Maffioli P, et al. Long-term effects of a berberine based nutraceutical on body weight and insulin-sensitivity in nondiabetic hyperlipidaemic patients. J Hypert 2011;29(e-Suppl A):e160
    • (2011) J. Hypert , vol.29
    • Cicero, A.1    Derosa, G.2    Maffioli, P.3
  • 76
    • 33846799217 scopus 로고    scopus 로고
    • Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents a single-blind clinical investigation
    • Cicero AF, Rovati LC, Setnikar I. Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. A single-blind clinical investigation. Arzneimittelforschung 2007;57:26-30
    • (2007) Arzneimittelforschung , vol.57 , pp. 26-30
    • Cicero, A.F.1    Rovati, L.C.2    Setnikar, I.3
  • 77
    • 47149089693 scopus 로고    scopus 로고
    • Combination of simvastatin with berberine improves the lipid-lowering efficacy
    • Kong WJ, Wei J, Zuo ZY, et al. Combination of simvastatin with berberine improves the lipid-lowering efficacy. Metabolism 2008;57:1029-37
    • (2008) Metabolism , vol.57 , pp. 1029-1037
    • Kong, W.J.1    Wei, J.2    Zuo, Z.Y.3
  • 78
    • 52249113546 scopus 로고    scopus 로고
    • Berberine-induced upregulation of endothelial progenitor cells in related to nitric oxide production in healthy subjects
    • Xu MG, Wang JM, Chen L, et al. Berberine-induced upregulation of endothelial progenitor cells in related to nitric oxide production in healthy subjects. Cardiology 2008;112:279-86
    • (2008) Cardiology , vol.112 , pp. 279-286
    • Xu, M.G.1    Wang, J.M.2    Chen, L.3
  • 79
    • 44049106706 scopus 로고    scopus 로고
    • Berberine-induced mobilization of circulating endothelial progenitor cells improves human small artery elasticity
    • Xu MG, Wang JM, Chen L, et al. Berberine-induced mobilization of circulating endothelial progenitor cells improves human small artery elasticity. J Hum Hypertens 2008;22:389-93
    • (2008) J. Hum. Hypertens , vol.22 , pp. 389-393
    • Xu, M.G.1    Wang, J.M.2    Chen, L.3
  • 80
    • 67349206613 scopus 로고    scopus 로고
    • Berberine induced decline in circulating CD31(+)/CD42(-) microparticles is associated with improvement of endothelial function in humans
    • Wang JM, Yang Z, Xu MG, et al. Berberine induced decline in circulating CD31(+)/CD42(-) microparticles is associated with improvement of endothelial function in humans. Eur J Pharmacol 2009;614:77-83
    • (2009) Eur. J. Pharmacol. , vol.614 , pp. 77-83
    • Wang, J.M.1    Yang, Z.2    Xu, M.G.3
  • 81
    • 0023889930 scopus 로고
    • Cardiovascular effects of berberine in patients with severe congestive heart failure
    • Marin-Neto JA, Maciel BC, Secches AL, et al. Cardiovascular effects of berberine in patients with severe congestive heart failure. Clin Cardiol 1988;11:253-60
    • (1988) Clin. Cardiol. , vol.11 , pp. 253-260
    • Marin-Neto, J.A.1    Maciel, B.C.2    Secches, A.L.3
  • 82
    • 0037969021 scopus 로고    scopus 로고
    • Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    • Zeng XH, Zeng XJ, Li YY. Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 2003;92:173-6
    • (2003) Am. J. Cardiol. , vol.92 , pp. 173-176
    • Zeng, X.H.1    Zeng, X.J.2    Li, Y.Y.3
  • 84
    • 0037092641 scopus 로고    scopus 로고
    • Effects of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells
    • Huang CG, Chu ZL, Wei SJ, et al. Effects of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells. Thromb Res 2002;106(4-5):223-7
    • (2002) Thromb. Res. , vol.106 , Issue.4-5 , pp. 223-227
    • Huang, C.G.1    Chu, Z.L.2    Wei, S.J.3
  • 85
    • 0005208570 scopus 로고
    • The progress in pharmacological researches on berberine
    • Huang CG, Chu ZL, Yang ZM. The progress in pharmacological researches on berberine. Comun Inform Pharm 1991;9:10-12
    • (1991) Comun. Inform. Pharm. , vol.9 , pp. 10-112
    • Huang, C.G.1    Chu, Z.L.2    Yang, Z.M.3
  • 86
    • 58149311042 scopus 로고    scopus 로고
    • Berberine a natural lipid-lowering drug, exerts prothrombic effects on vascular cells
    • Hoy EW, Akhmedov A, Luscher TF, et al. Berberine a natural lipid-lowering drug, exerts prothrombic effects on vascular cells. J Mol Cell Cardiol 2009;46:234-40
    • (2009) J. Mol. Cell Cardiol. , vol.46 , pp. 234-240
    • Hoy, E.W.1    Akhmedov, A.2    Luscher, T.F.3
  • 87
    • 50549086519 scopus 로고    scopus 로고
    • Biochemical pathways in the antiatherosclerotic effect of berberine
    • Guo Y, Wang QZ, Li FM, et al. Biochemical pathways in the antiatherosclerotic effect of berberine. Chin Med J (Eng) 2008;121:1197-203
    • (2008) Chin. Med. J. (Eng) , vol.121 , pp. 1197-1203
    • Guo, Y.1    Wang, Q.Z.2    Li, F.M.3
  • 88
    • 48549105216 scopus 로고    scopus 로고
    • Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappa-Bregulated antiapoptotic gene products, and potentiates apoptosis
    • Pandey MK, Sung B, Kunnumakkara AB, et al. Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappa-Bregulated antiapoptotic gene products, and potentiates apoptosis. Cancer Res 2008;68:5370-9
    • (2008) Cancer Res. , vol.68 , pp. 5370-5379
    • Pandey, M.K.1    Sung, B.2    Kunnumakkara, A.B.3
  • 89
    • 0036460068 scopus 로고    scopus 로고
    • Inhibitory effect of berberine on tertbutyl-hydroperoxide-induced oxidative damage in rat liver
    • Hwang JM, Wang CJ, Chou FP, et al. Inhibitory effect of berberine on tertbutyl-hydroperoxide-induced oxidative damage in rat liver. Arch Toxicol 2002;76:664-70
    • (2002) Arch. Toxicol. , vol.76 , pp. 664-670
    • Hwang, J.M.1    Wang, C.J.2    Chou, F.P.3
  • 90
    • 19944374769 scopus 로고    scopus 로고
    • Berberine is a novel cholesterol lowering drug working through a unique mechanism distinct from statins
    • Kong W, Wei J, Abidi P, et al. Berberine is a novel cholesterol lowering drug working through a unique mechanism distinct from statins. Nat Med 2004;10(12):1344-51
    • (2004) Nat. Med. , vol.10 , Issue.12 , pp. 1344-1351
    • Kong, W.1    Wei, J.2    Abidi, P.3
  • 91
    • 56049101177 scopus 로고    scopus 로고
    • Reduction of blood lipid by berberine in hyperlipidemic patients with chronic hepatitis or liver cirrhosis
    • Zhao W, Xue R, Zhou ZX, et al. Reduction of blood lipid by berberine in hyperlipidemic patients with chronic hepatitis or liver cirrhosis. Biomed Pharmacother 2008;62(10):730-1
    • (2008) Biomed. Pharmacother , vol.62 , Issue.10 , pp. 730-731
    • Zhao, W.1    Xue, R.2    Zhou, Z.X.3
  • 92
    • 77649113271 scopus 로고    scopus 로고
    • Natural sources of antidyslipidaemic agents is there an evidence-based approach for their prescription
    • Cicero AFG, Ertek S. Natural sources of antidyslipidaemic agents: Is there an evidence-based approach for their prescription? Med J Nutr Metab 2008;1(2):85-93
    • (2008) Med. J. Nutr. Metab. , vol.1 , Issue.2 , pp. 85-93
    • Cicero, A.F.G.1    Ertek, S.2


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