Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury

Biochemical Pharmacology

Volumn 71, Issue 6, 2006, Pages 806-817

  Liang, Kae Woei ^a,b   Ting, Chih Tai ^a,b   Yin, Sui Chu ^b   Chen, Ying Tsung ^a,b,c   Lin, Shing Jong ^a,d   Liao, James K ^e   Hsu, Shih Lan ^a,b,f  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Berberine; Early growth response gene (Egr 1); Extracellular signal regulated kinase (ERK); MEK1 2 (mitogen activated protein kinase kinase 1 2); Platelet derived growth factor (PDGF); Vascular smooth muscle cell

Indexed keywords

BERBERINE; CYCLIN D1; EARLY GROWTH RESPONSE FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR A; PROTEIN C FOS;

ANIMAL CELL; AORTA; ARTICLE; CELL ASSAY; CELL DAMAGE; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG EFFECT; ENZYME ACTIVATION; GENETIC REGULATION; GROWTH INHIBITION; IN VITRO STUDY; MECHANICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PIPETTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ANIMALS; AORTA, THORACIC; BERBERINE; CELL PROLIFERATION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; EARLY GROWTH RESPONSE PROTEIN 1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION; MITOGEN-ACTIVATED PROTEIN KINASE 1; MUSCLE, SMOOTH, VASCULAR; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIGNAL TRANSDUCTION; WOUND HEALING;

EID: 32144461376     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.12.028     Document Type: Article

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