Suppression of collagen-induced arthritis by intra-articular lentiviral vector-mediated delivery of Toll-like receptor 7 short hairpin RNA gene

Gene Therapy

Volumn 19, Issue 7, 2012, Pages 752-760

  Chen, S Y ^a   Shiau, A L ^a   Li, Y T ^a   Lin, Y S ^a   Lee, C H ^b   Wu, C L ^a   Wang, C R ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

angiogenesis; collagen induced arthritis; rheumatoid arthritis; short hairpin RNA; TLR7

Indexed keywords

BENZONASE; CHLOROQUINE; COLLAGEN; CYTOKINE; IMIQUIMOD; INTERLEUKIN 1BETA; INTERLEUKIN 6; LENTIVIRUS VECTOR; RIBONUCLEASE; SHORT HAIRPIN RNA; TOLL LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTHROPOMETRIC PARAMETERS; ARTHRITIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FIBROBLAST; GENE EXPRESSION; GENETIC TRANSFECTION; HISTOPATHOLOGY; MALE; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; RAT; SCORING SYSTEM; SYNOVIUM; T LYMPHOCYTE; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; ANKLE JOINT; ARTHRITIS, EXPERIMENTAL; CYTOKINES; GENETIC VECTORS; INJECTIONS, INTRA-ARTICULAR; LENTIVIRUS; MALE; MICROCIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SYNOVIAL MEMBRANE; TOLL-LIKE RECEPTOR 7; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

RATTUS;

EID: 84863726250     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.173     Document Type: Article

References (42)

1. Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 2011; 34: 637-650.
2. Drexler SK, Foxwell BM. The role of toll-like receptors in chronic inflammation. Int J Biochem Cell Biol 2010; 42: 506-518.
3. Hall JC, Rosen A. Type I interferons: crucial participants in disease amplification in autoimmunity. Nat Rev Rheumatol 2010; 6: 40-49.
4. Spranger S, Javorovic M, Bü rdek M, Wilde S, Mosetter B, Tippmer S et al. Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J Immunol 2010; 185: 738-747.
5. Reynolds JM, Pappu BP, Peng J, Martinez GJ, Zhang Y, Chung Y et al. Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease. Immunity 2010; 32: 692-702.
6. Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol 2006; 6: 823-835. (Pubitemid 44631651)
7. Brentano F, Kyburz D, Schorr O, Gay R, Gay S. The role of Toll-like receptor signalling in the pathogenesis of arthritis. Cell Immunol 2005; 233: 90-96. (Pubitemid 41074060)
8. Cromartie WJ, Craddock JG, Schwab JH, Anderle SK, Yang CH. Arthritis in rats after systemic injection of streptococcal cells or cell walls. J ExpMed 1977; 146: 1585-1602. (Pubitemid 8245443)
9. Abdollahi-Roodsaz S, Joosten LA, Roelofs MF, Radstake TR, Matera G, Popa C et al. Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. Arthritis Rheum 2007; 56: 2957-2967. (Pubitemid 47502742)
10. Drexler SK, Kong P, Inglis J, Williams RO, Garlanda C, Mantovani A et al. SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis. Arthritis Rheum 2010; 62: 2249-2261.
11. van der Heijden IM, Wilbrink B, Tchetverikov I, Schrijver IA, Schouls LM, Hazenberg MP et al. Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritis. Arthritis Rheum 2000; 43: 593-598. (Pubitemid 30394951)
12. O'Neill LA. Primer: Toll-like receptor signaling pathways-what do rheumatologists need to know? Nat Clin Pract Rheumatol 2008; 4: 319-327. (Pubitemid 351791443)
13. Deng GM, Nilsson IM, Verdrengh M, Collins LV, Tarkowski A. Intraarticularly localized bacterial DNA containing CpG motifs induces arthritis. Nat Med 1999; 5: 702-705. (Pubitemid 29289436)
14. Liu ZQ, Deng GM, Foster S, Tarkowski A. Staphlococcal peptidoglycans induce arthritis. Arthritis Res 2001; 3: 375-380.
15. Zare F, Bokarewa M, Nenonen N, Bergstrom T, Alexopoulou L, Flavell RA et al. Arthritogenic properties of double stranded (viral) RNA. J Immunol 2004; 172: 5656-5663. (Pubitemid 38542069)
16. Yoshino S, Ohsawa M. The role of lipopolysaccharide injected systemically in the reactivation of collagen-induced arthritis in mice. Br J Pharmacol 2000; 129: 1309-1314. (Pubitemid 30175702)
17. Yoshino S, Yamaki K, Taneda S, Yanagisawa R, Takano H. Reactivation of antigeninduced arthritis in mice by oral administration of lipopolysaccharide. Scand J Immunol 2005; 62: 117-122. (Pubitemid 41176493)
18. Huang QQ, Ma Y, Adebayo A, Pope RM. Increased macrophage activation mediated through Toll-like receptors in rheumatoid arthritis. Arthritis Rheum 2007; 56: 2192-2201. (Pubitemid 47173566)
19. Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 2002; 416: 603-607. (Pubitemid 34406754)
20. Roelofs MF, Joosten LA, Abdollahi-Roodsaz S, van lieshout AW, Sprong T, van den Hoogen FH et al. The expression of Toll-like receptors 3and 7 in rheumatoid arthritis synovium is increased and costimulation of Toll-like receptors 3, 4 and 7/8 results in synergistic cytokine production by dendritic cells. Arthritis Rheum 2005; 52: 2313-2322. (Pubitemid 41117415)
21. Kim KW, Cho ML, Lee SH, Oh HJ, Kang CM, Ju JH et al. Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation. Immunol Lett 2007; 110: 54-64. (Pubitemid 46695759)
22. Roelofs MF, Wenink MH, Brentano F, Abdollahi-Roodsaz S, Oppers-Walgreen B, Barrera P et al. Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis. Ann Rheum Dis 2009; 68: 1486-1493.
23. Gouze E, Pawliuk R, Gouze JN et al. Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation. Mol Ther 2003; 7: 460-466. (Pubitemid 36553414)
24. Wang CR, Shiau AL, Chen SY, Cheng ZS, Li YT, Lee CH et al. Intra-articular lentivirusmediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collageninduced arthritis. Gene Therapy 2010; 17: 1225-1233.
25. Evans CH, Ghivizzani SC, Robbins PD. Getting arthritis gene therapy into the clinic. Nat Rev Rheumatol 2011; 7: 244-249.
26. Fraser A, Fearon U, Reece R, Emery P, Veale DJ. Matrix metalloproteinase 9, apoptosis, and vascular morphology in early arthritis. Arthritis Rheum 2001; 44: 2024-2028. (Pubitemid 33644044)
27. Hong-Geller E, Chaudhary A, Lauer S. Targeting toll-like receptor signaling pathways for design of novel immune therapeutics. Curr Drug Discov Technol 2008; 5: 29-38. (Pubitemid 351364571)
28. O'Neill LA, Bryant CE, Doyle SL. Therapeutic targeting of toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev 2009; 61: 177-197.
29. Lenert PS. Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9. Mediators Inflamm 2010; 2010: 986596.
30. Kalali BN, Kö llisch G, Mages J, Muller T, Bauer S, Wagner H et al. Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling. J Immunol 2008; 181: 2694-2704.
31. Radstake TR, Roelofs MF, Jenniskens YM, Oppers-Walgreen B, van Riel PL, Barrera P et al. Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. Arthritis Rheum 2004; 50: 3856-3865. (Pubitemid 39643932)
32. Ehlers M, Ravetch JV. Opposing effects of Toll-like receptor stimulation induce autoimmunity or tolerance. TRENDS Immunol 2007; 28: 74-79. (Pubitemid 46176735)
33. Pinhal-Enfield G, Ramanathan M, Hasko G, Vogel SN, Salzman AL, Boons GJ et al. An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors. Am J Pathol 2003; 163: 711-721. (Pubitemid 36909432)
34. Gibson SJ, Lindh JM, Riter TR, Gleason RM, Rogers LM, Fuller AE et al. Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod. Cell Immunol 2002; 218: 74-86. (Pubitemid 36027092)
35. Proost P, Vynckier AK, Mahieu F, Put W, Grillet B, Struyf S et al. Microbial Toll-like receptor ligands differentially regulate CXCL10/IP-10 expression in fibroblasts and mononuclear leukocytes in synergy with IFN-gamma and provide a mechanism for enhanced synovial chemokine levels in septic arthritis. Eur J Immunol 2003; 33: 3146-3153. (Pubitemid 37428347)
36. Wiznerowicz M, Trono D. Conditional suppression of cellular genes: lentivirus vectormediated drug-inducible RNA interference. J Virol 2003; 77: 8957-8961. (Pubitemid 36936105)
37. Salmon P, Trono D. Production and titration of lentiviral vectors. In: Haines JL, Korf BR, Morton CC, Seidman CE, Seidman JG, Smith DR (eds). Current Protocols in Human Genetics. John Wiley and Sons: New York, 2007, Unit 12.10.1-12.10.24.
38. Wang CR, Chen SY, Wu CL, Liu MF, Jin YT, Chao L et al. Prophylactic adenovirusmediated human kallistatin gene therapy suppresses rat arthritis by inhibiting angiogenesis and inflammation. Arthritis Rheum 2005; 52: 1319-1324. (Pubitemid 40530143)
39. Shiau AL, Chen SY, Chang MY, Su CH, Chung SY, Yo YT et al. Prothymosin a lacking the nuclear localization signal as an effective gene therapeutic strategy in collagen-induced arthritis. J Immunol 2007; 178: 4688-4694.
40. Chen SY, Wu CL, Lai MD, Lin CC, Yo YT, Jou IM et al. Amelioration of rat collagen-induced arthritis through CD4+ T cells apoptosis and synovial interleukin-17 reduction by indoleamine 2,3-dioxygenase gene therapy. Hum Gene Ther 2011; 22: 145-154.
41. Boyle DL, Nguyen KHY, Zhuang S, Shi Y, McCormack JE, Chada S et al. Intra-articular IL-4 gene therapy in arthritis: anti-inflammatory effect and enhanced Th2 activity. Gene Therapy 1999; 6: 1911-1918. (Pubitemid 30076861)
42. Woods JM, Katschke Jr KJ, Volin MV, Ruth JH, Woodruff DC, Amin MA et al. IL-4 adenoviral gene therapy reduces inflammation, proinflammatory cytokines, vascularization, and bony destruction in rat adjuvant-induced arthritis. J Immunol 2001; 166: 1214-1222. (Pubitemid 32060282)