-
1
-
-
11144327663
-
Immunity's early warning system
-
O'Neill LA (2005) Immunity's early warning system. Sci Am 292 24-31
-
(2005)
Sci Am
, vol.292
, pp. 24-31
-
-
O'Neill, L.A.1
-
2
-
-
35649027495
-
Could Toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue
-
Sacre SM et al. (2007) Could Toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue. Ann Rheum Dis 66 (Suppl 3) 81-86
-
(2007)
Ann Rheum Dis
, vol.66
, Issue.SUPPL. 3
, pp. 81-86
-
-
Sacre, S.M.1
-
3
-
-
33749023888
-
Mechanisms of disease: The molecular and cellular basis of joint destruction in rheumatoid arthritis
-
Müller-Ladner U et al. (2005) Mechanisms of disease: The molecular and cellular basis of joint destruction in rheumatoid arthritis. Nat Clin Pract Rheumatol 1: 102-110
-
(2005)
Nat Clin Pract Rheumatol
, vol.1
, pp. 102-110
-
-
Müller-Ladner, U.1
-
4
-
-
33144467291
-
Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus
-
Lenert PS et al. (2006) Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus. Arthritis Res Ther 8: 203
-
(2006)
Arthritis Res Ther
, vol.8
, pp. 203
-
-
Lenert, P.S.1
-
5
-
-
26844467349
-
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
-
Barrat FJ et al. (2005) Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 202: 1131-1139
-
(2005)
J Exp Med
, vol.202
, pp. 1131-1139
-
-
Barrat, F.J.1
-
6
-
-
34547788305
-
The Troll in Toll: Mal and TRAM as bridges for TLR2 and TLR4 signaling
-
Sheedy F and O'Neill LA (2007) The Troll in Toll: Mal and TRAM as bridges for TLR2 and TLR4 signaling. J Leukoc Biol 82: 196-203
-
(2007)
J Leukoc Biol
, vol.82
, pp. 196-203
-
-
Sheedy, F.1
O'Neill, L.A.2
-
7
-
-
34247566510
-
The family of five: TIR-domain-containing adaptors in TLR signalling
-
O'Neill LA and Bowie AG (2007) The family of five: TIR-domain-containing adaptors in TLR signalling. Nat Rev Immunol 7: 353-364
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 353-364
-
-
O'Neill, L.A.1
Bowie, A.G.2
-
8
-
-
34249677845
-
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
-
Kanzler H et al. (2007) Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 13 552-559
-
(2007)
Nat Med
, vol.13
, pp. 552-559
-
-
Kanzler, H.1
-
9
-
-
23644456849
-
The matrix component biglycan is proinflammatory and signals via Toll-like receptors 4 and 2 in macrophages
-
Schaefer L et al. (2005) The matrix component biglycan is proinflammatory and signals via Toll-like receptors 4 and 2 in macrophages. J Clin Invest 115: 2223-2233
-
(2005)
J Clin Invest
, vol.115
, pp. 2223-2233
-
-
Schaefer, L.1
-
10
-
-
0037033364
-
Oligosaccharides of hyaluronan activate dendritic cells via Toll-like receptor-4
-
Termeer C et al. (2002) Oligosaccharides of hyaluronan activate dendritic cells via Toll-like receptor-4. J Exp Med 195: 99-111
-
(2002)
J Exp Med
, vol.195
, pp. 99-111
-
-
Termeer, C.1
-
11
-
-
33646882893
-
Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis
-
Roelofs MF et al. (2006) Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis. J Immunol 176: 7021-7027
-
(2006)
J Immunol
, vol.176
, pp. 7021-7027
-
-
Roelofs, M.F.1
-
12
-
-
33645461206
-
High mobility group box 1 protein interacts with multiple Toll-like receptors
-
Park JS et al. (2006) High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol 290: C917-C924
-
(2006)
Am J Physiol Cell Physiol
, vol.290
-
-
Park, J.S.1
-
13
-
-
0037094084
-
Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4
-
Johnson GB et al. (2002) Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J Immunol 168: 5233-5239
-
(2002)
J Immunol
, vol.168
, pp. 5233-5239
-
-
Johnson, G.B.1
-
14
-
-
0035971217
-
The extra domain A of fibronectin activates Toll-like receptor 4
-
Okamura Y et al. (2001) The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 276: 10229-10233
-
(2001)
J Biol Chem
, vol.276
, pp. 10229-10233
-
-
Okamura, Y.1
-
15
-
-
0035451118
-
Fibrinogen stimulates macrophage chemokine secretion through Toll-like receptor 4
-
Smiley ST et al. (2001) Fibrinogen stimulates macrophage chemokine secretion through Toll-like receptor 4. J Immunol 167: 2887-2894
-
(2001)
J Immunol
, vol.167
, pp. 2887-2894
-
-
Smiley, S.T.1
-
16
-
-
25444443335
-
RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3
-
Brentano F et al. (2005) RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3. Arthritis Rheum 52: 2656-2665
-
(2005)
Arthritis Rheum
, vol.52
, pp. 2656-2665
-
-
Brentano, F.1
-
17
-
-
28544449709
-
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
-
Vollmer J et al. (2005) Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J Exp Med 202: 1575-1585
-
(2005)
J Exp Med
, vol.202
, pp. 1575-1585
-
-
Vollmer, J.1
-
18
-
-
0037061453
-
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
-
Leadbetter EA et al. (2002) Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416: 603-607
-
(2002)
Nature
, vol.416
, pp. 603-607
-
-
Leadbetter, E.A.1
-
19
-
-
9144232901
-
Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands
-
Pierer M et al. (2004) Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands. J Immunol 172: 1256-1265
-
(2004)
J Immunol
, vol.172
, pp. 1256-1265
-
-
Pierer, M.1
-
20
-
-
34548608447
-
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
-
Jin MS et al. (2007) Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130: 1071-1082
-
(2007)
Cell
, vol.130
, pp. 1071-1082
-
-
Jin, M.S.1
-
21
-
-
40749097627
-
A dimer of Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
-
Núñez Miguel R et al. (2007) A dimer of Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins. PLoS ONE 2: E788
-
(2007)
PLoS ONE
, vol.2
-
-
Núñez Miguel, R.1
-
22
-
-
34250813748
-
Crystal structure of human MD2 and its complex with antiendotoxic lipid IVa
-
Ohto U et al. (2007) Crystal structure of human MD2 and its complex with antiendotoxic lipid IVa. Science 316: 1632-1634
-
(2007)
Science
, vol.316
, pp. 1632-1634
-
-
Ohto, U.1
-
23
-
-
13444280215
-
CD36 is a sensor of diacylglycerides
-
Hoebe K et al. (2005) CD36 is a sensor of diacylglycerides. Nature 433: 523-527
-
(2005)
Nature
, vol.433
, pp. 523-527
-
-
Hoebe, K.1
-
24
-
-
36448952375
-
CD1 antigen presentation: How it works
-
Barral DC and Brenner MB (2007) CD1 antigen presentation: How it works. Nat Rev Immunol 7: 929-941
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 929-941
-
-
Barral, D.C.1
Brenner, M.B.2
-
25
-
-
31344467156
-
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
-
Mansell A et al. (2006) Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol 7: 148-155
-
(2006)
Nat Immunol
, vol.7
, pp. 148-155
-
-
Mansell, A.1
-
26
-
-
33744543517
-
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
-
Gray P et al. (2006) MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J Biol Chem 281: 10489-10495
-
(2006)
J Biol Chem
, vol.281
, pp. 10489-10495
-
-
Gray, P.1
-
27
-
-
33847672241
-
NF-κB activation by the Toll-IL-1 receptor domain-containing protein Mal is regulated by caspase-1
-
Miggin S et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain-containing protein Mal is regulated by caspase-1. Proc Natl Acad Sci USA 104: 3372-3377
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 3372-3377
-
-
Miggin, S.1
-
28
-
-
33646908228
-
Phosphoinositide-mediated adapter recruitment controls Toll-like receptor signaling
-
Kagan JC and Medzhitov R (2006) Phosphoinositide-mediated adapter recruitment controls Toll-like receptor signaling. Cell 125: 943-955
-
(2006)
Cell
, vol.125
, pp. 943-955
-
-
Kagan, J.C.1
Medzhitov, R.2
-
29
-
-
4444258208
-
Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-κB activation by TLR2 and TLR4
-
Mansell A et al. (2004) Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-κB activation by TLR2 and TLR4. J Biol Chem 279: 37227-37230
-
(2004)
J Biol Chem
, vol.279
, pp. 37227-37230
-
-
Mansell, A.1
-
30
-
-
34047098731
-
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
-
Khor CC et al. (2007) A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat Genet 39: 523-528
-
(2007)
Nat Genet
, vol.39
, pp. 523-528
-
-
Khor, C.C.1
-
31
-
-
33646567507
-
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction
-
Rowe D et al. (2006) The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci USA 103: 6299-6304
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 6299-6304
-
-
Rowe, D.1
-
32
-
-
33745124663
-
Trif-related adapter molecule is phosphorylated by protein kinase C epsilon during Toll-like receptor 4 signaling
-
McGettrick A et al. (2006) Trif-related adapter molecule is phosphorylated by protein kinase C epsilon during Toll-like receptor 4 signaling. Proc Natl Acad Sci USA 103: 9196-9201
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 9196-9201
-
-
McGettrick, A.1
-
33
-
-
31344466165
-
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
-
Tabeta K et al. (2006) The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol 7: 156-164
-
(2006)
Nat Immunol
, vol.7
, pp. 156-164
-
-
Tabeta, K.1
-
34
-
-
34247484007
-
The interaction between the ER membrane protein UNC93B and TLR3, 7 and 9 is crucial for TLR signaling
-
Brinkmann MM et al. (2007) The interaction between the ER membrane protein UNC93B and TLR3, 7 and 9 is crucial for TLR signaling. J Cell Biol 177: 265-275
-
(2007)
J Cell Biol
, vol.177
, pp. 265-275
-
-
Brinkmann, M.M.1
-
35
-
-
31344476404
-
Recognition of double-stranded RNA by human Toll-like receptor 3 and downstream receptor signaling requires multimerisation and acidic pH
-
de Bouteiller O et al. (2005) Recognition of double-stranded RNA by human Toll-like receptor 3 and downstream receptor signaling requires multimerisation and acidic pH. J Biol Chem 280: 38133-38145
-
(2005)
J Biol Chem
, vol.280
, pp. 38133-38145
-
-
de Bouteiller, O.1
-
36
-
-
33748414196
-
Mode of action of hydroxychloroquine in RA - evidence of an inhibitory effect on Toll-like receptor signaling
-
Kyburz D et al. (2006) Mode of action of hydroxychloroquine in RA - evidence of an inhibitory effect on Toll-like receptor signaling. Nat Clin Pract Rheumatol 2: 458-459
-
(2006)
Nat Clin Pract Rheumatol
, vol.2
, pp. 458-459
-
-
Kyburz, D.1
-
37
-
-
38149048556
-
Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis
-
Abdollahi-Roodsaz S et al. (2008) Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest 118: 1-13
-
(2008)
J Clin Invest
, vol.118
, pp. 1-13
-
-
Abdollahi-Roodsaz, S.1
-
38
-
-
34848840994
-
Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis
-
Abdollahi-Roodsaz S et al. (2007) Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. Arthritis Rheum 56: 2957-2967
-
(2007)
Arthritis Rheum
, vol.56
, pp. 2957-2967
-
-
Abdollahi-Roodsaz, S.1
-
39
-
-
54349089048
-
Utility of animal models for identification of potential therapeutics for rheumatoid arthritis
-
doi:10.1136/ard.2007.076430
-
Hegen M et al. (2007) Utility of animal models for identification of potential therapeutics for rheumatoid arthritis. Ann Rheum Dis [doi:10.1136/ard.2007.076430]
-
(2007)
Ann Rheum Dis
-
-
Hegen, M.1
-
40
-
-
34848867207
-
Bartonella quintana lipopolysaccharide is a natural antagonist of Toll-like receptor 4
-
Popa C et al. (2007) Bartonella quintana lipopolysaccharide is a natural antagonist of Toll-like receptor 4. Infect Immun 75: 4831-4837
-
(2007)
Infect Immun
, vol.75
, pp. 4831-4837
-
-
Popa, C.1
-
41
-
-
33947545388
-
The Toll-like receptor adapter proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis
-
Sacre SM et al. (2007) The Toll-like receptor adapter proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis. Am J Pathol 170: 518-525
-
(2007)
Am J Pathol
, vol.170
, pp. 518-525
-
-
Sacre, S.M.1
-
42
-
-
37549066665
-
Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms
-
Barrat FJ et al. (2007) Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. Eur J Immunol 37: 3582-3586
-
(2007)
Eur J Immunol
, vol.37
, pp. 3582-3586
-
-
Barrat, F.J.1
-
43
-
-
24144465889
-
Molecular determinants of crosstalk between nuclear receptors and Toll-like receptors
-
Ogawa S et al. (2005) Molecular determinants of crosstalk between nuclear receptors and Toll-like receptors. Cell 122: 707-721
-
(2005)
Cell
, vol.122
, pp. 707-721
-
-
Ogawa, S.1
-
44
-
-
33747881274
-
Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: A double-blind randomised trial
-
Vanags D et al. (2006) Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: A double-blind randomised trial. Lancet 368: 855-863
-
(2006)
Lancet
, vol.368
, pp. 855-863
-
-
Vanags, D.1
-
45
-
-
21244503817
-
Differential involvement of BB loops of Toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4-versus TLR2-mediated signal transduction
-
Toshchakov V et al. (2005) Differential involvement of BB loops of Toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4-versus TLR2-mediated signal transduction. J Immunol 175 494-500
-
(2005)
J Immunol
, vol.175
, pp. 494-500
-
-
Toshchakov, V.1
-
46
-
-
0037596457
-
A low molecular weight mimic of the Toll/ IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses
-
Bartfai T et al. (2003) A low molecular weight mimic of the Toll/ IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc Natl Acad Sci USA 100: 7971-7976
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 7971-7976
-
-
Bartfai, T.1
-
47
-
-
34247171612
-
Functional cell permeable motifs within medically relevant peptides
-
Low W et al. (2007) Functional cell permeable motifs within medically relevant peptides. J Biotech 129: 555-564
-
(2007)
J Biotech
, vol.129
, pp. 555-564
-
-
Low, W.1
-
48
-
-
33644523710
-
MyD88-dependent and -independent signaling by IL-1 in neurons by bifunctional Toll/IL-1 receptor domain/BB loop mimetics
-
Davis CN et al. (2006) MyD88-dependent and -independent signaling by IL-1 in neurons by bifunctional Toll/IL-1 receptor domain/BB loop mimetics. Proc Natl Acad Sci USA 103: 2953-2958
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 2953-2958
-
-
Davis, C.N.1
-
49
-
-
33748871187
-
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
-
Carty M et al. (2006) The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol 7: 1074-1081
-
(2006)
Nat Immunol
, vol.7
, pp. 1074-1081
-
-
Carty, M.1
-
50
-
-
33750369226
-
Toll-like receptors in systemic lupus erythematosus
-
Marshak-Rothstein A (2006) Toll-like receptors in systemic lupus erythematosus. Nat Rev Immunol 6: 823-835
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 823-835
-
-
Marshak-Rothstein, A.1
-
51
-
-
36849033963
-
TAM receptors are pleiotropic inhibitors of the innate immune response
-
Rothlin CV et al. (2007) TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131: 1124-1136
-
(2007)
Cell
, vol.131
, pp. 1124-1136
-
-
Rothlin, C.V.1
|