Matrix Metalloproteinase 9, Apoptosis, and Vascular Morphology in Early Arthritis

Arthritis and Rheumatism

Volumn 44, Issue 9, 2001, Pages 2024-2028

  Fraser, Alexander ^a   Fearon, Ursula ^a   Reece, Richard ^a   Emery, Paul ^a   Veale, Douglas J ^a,b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b Rheumatology Rehab Research Unit   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL CELL GROWTH FACTOR; GELATINASE B; LYMPHOKINE; VASCULOTROPIN; VASCULOTROPIN A;

ADULT; AGED; APOPTOSIS; ARTHRITIS; ARTICLE; BIOPSY; CELL CULTURE; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; NICK END LABELING; OSTEOARTHRITIS; PATHOLOGY; PSORIATIC ARTHRITIS; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; SYNOVIUM; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ADULT; AGED; APOPTOSIS; ARTHRITIS; ARTHRITIS, PSORIATIC; ARTHRITIS, RHEUMATOID; BIOPSY; CELLS, CULTURED; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; IN SITU NICK-END LABELING; LYMPHOKINES; MALE; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; OSTEOARTHRITIS; SYNOVIAL FLUID; SYNOVIAL MEMBRANE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035463151     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200109)44:9<2024::AID-ART351>3.0.CO;2-K     Document Type: Article

References (15)

1. Recce RJ, Canete JD, Parsons WJ, Emery P, Veale DJ. Distinct vascular patterns of early synovitis in psoriatic, reactive, and rheumatoid arthritis. Arthritis Rheum 1999;42:1481-4.
2. Koch AE. Angiogenesis: implications for rheumatoid arthritis. Arthritis Rheum 1998;41:951-62.
3. Lowe PM, Lee ML, Jackson CJ, To SS, Cooper AJ, Schreiber L. The endothelium in psoriasis. Br J Rheumatol 1995;132:497-505.
4. Shalinsky DR, Brekken J, Zou H, McDermott CD, Forsyth P, Edwards D, et al. Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology trials. Ann N Y Acad Sci 1999;878:236-70.
5. Sang QX. Complex role of matrix metalloproteinases in angiogenesis [review]. Cell Res 1998;8:171-7.
6. Folkman J. Angiogenesis and angiogenesis inhibition: an overview. EXS 1997;79:1-8.
7. Fava RA, Olsen NJ, Spencer-Green G, Yeo KT, Yeo TK, Berse B, et al. Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med 1994;180:341-6.
8. Fearon U, Reece R, Smith J, Emery P, Veale DJ. Synovial cytokine and growth factor regulation of MMPs/TIMPs: implications for erosions and angiogenesis in early rheumatoid and psoriatic arthritis patients. Ann N Y Acad Sci 1999;878:619-21.
9. Wang H, Keiser JA. Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: role of flt-1. Circ Res 1998;83:832-40.
10. Vaishnaw AK, McNally JD, Elkon KB. Apoptosis in the rheumatic diseases. Arthritis Rheum 1997;40:1917-27.
11. Nor JE, Christensen J, Mooney DJ, Polverini PJ. Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am J Pathol 1999;154:375-84.
12. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
13. Cunnane G, Fitzgerald O, Hummel KM, Gay RE, Gay S, Bresnihan B. Collagenase, cathepsin B and Cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis. Rheumatology (Oxford) 1999;38:32-42.
14. Himelstein BP, Canete-Soler R, Bernhard EJ, Dilks DW, Muschel RJ. Metalloproteinases in tumor progression: the contribution of MMP-9. Invasion Metastasis 1994;14:246-58.
15. Vu TH, Shipley JM, Bergers G, Berger JE, Helms JA, Hanahan D, et al. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophie chondrocytes. Cell 1998;93:411-22.